Julie A Chowen

Julie A Chowen

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Julie A Chowen

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Blocking of Estradiol Receptors ERα, ERβ and GPER During Development, Differentially Alters Energy Metabolism in Male and Female Rats.

Neuroscience 2020 Feb 2;426:59-68. Epub 2019 Dec 2.

Departamento de Psicobiología, Universidad Nacional de Educación a Distancia (UNED), C/ Juan del Rosal n° 10, 28040 Madrid, Spain, Instituto Mixto de Investigación Escuela Nacional de Sanidad (IMIENS). Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2019.11.008DOI Listing
February 2020

Sex differences in the peripubertal response to a short-term, high-fat diet intake.

J Neuroendocrinol 2020 Jan 1;32(1):e12756. Epub 2019 Jul 1.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación la Princesa, Madrid, Spain.

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http://dx.doi.org/10.1111/jne.12756DOI Listing
January 2020

Microglia, neurodegeneration and loss of neuroendocrine control.

Prog Neurobiol 2020 Jan 9;184:101720. Epub 2019 Nov 9.

Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain; CIBER de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.

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http://dx.doi.org/10.1016/j.pneurobio.2019.101720DOI Listing
January 2020

Sex, puberty, and ethnicity have a strong influence on growth and metabolic comorbidities in children and adolescents with obesity: Report on 1300 patients (the Madrid Cohort).

Pediatr Obes 2019 12 2;14(12):e12565. Epub 2019 Aug 2.

Department of Endocrinology, Research Institute "La Princesa", Hospital Infantil Universitario Niño Jesús, Avenida Menéndez Pelayo, 65E-28009, Madrid, Spain.

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http://dx.doi.org/10.1111/ijpo.12565DOI Listing
December 2019

Temperature as a Control of Obesity: Can We Target Thermogenesis?

Endocrinology 2019 11;160(11):2717-2718

Department of Endocrinology, Fundación Investigación Biomédica del Hospital Infantil Universitario Niño Jesús, Instituto de Investigación la Princesa, Madrid, Spain.

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http://dx.doi.org/10.1210/en.2019-00613DOI Listing
November 2019

Specific Deletion of the Astrocyte Leptin Receptor Induces Changes in Hippocampus Glutamate Metabolism, Synaptic Transmission and Plasticity.

Neuroscience 2019 Nov 6. Epub 2019 Nov 6.

Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad CEU-San Pablo, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2019.10.005DOI Listing
November 2019

Perinatal free-choice of a high-calorie low-protein diet affects leptin signaling through IRS1 and AMPK dephosphorylation in the hypothalami of female rat offspring in adulthood.

Acta Physiol (Oxf) 2019 06 21;226(2):e13244. Epub 2019 Jan 21.

Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain.

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http://doi.wiley.com/10.1111/apha.13244
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http://dx.doi.org/10.1111/apha.13244DOI Listing
June 2019

Neurobiological characteristics underlying metabolic differences between males and females.

Prog Neurobiol 2019 05 5;176:18-32. Epub 2018 Sep 5.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación la Princesa, Department of Pediatrics, Universidad Autónoma de Madrid, CIBEROBN (Centro de Investigación Biomédica en Red sobre Fisiopatología de la Obesidad y Nutrición), Instituto de Salud Carlos III. Madrid, Spain; IMDEA Food Institute, CEI UAM + CSIC, Madrid, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S03010082183008
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http://dx.doi.org/10.1016/j.pneurobio.2018.09.001DOI Listing
May 2019

Physiological and pathophysiological roles of hypothalamic astrocytes in metabolism.

J Neuroendocrinol 2019 May 21;31(5):e12671. Epub 2019 Jan 21.

Instituto Pluridisciplinar UCM y Departamento de Farmacología, Farmacognosia y Botánica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.

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http://dx.doi.org/10.1111/jne.12671DOI Listing
May 2019

Metabolomics changes in patients with PAPP-A2 deficiency in response to rhIGF1 treatment.

Growth Horm IGF Res 2018 Oct - Dec;42-43:28-31. Epub 2018 Aug 12.

Departments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain; La Princesa Research Institute, Madrid, Spain; Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutriciόn (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; IMDEA Food Institute, CEI UAM & CSIC, Madrid, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10966374183006
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http://dx.doi.org/10.1016/j.ghir.2018.08.002DOI Listing
March 2019

Heterozygous rare genetic variants in non-syndromic early-onset obesity.

Int J Obes (Lond) 2019 Mar 29. Epub 2019 Mar 29.

Hospital Infantil Universitario Niño Jesús, Department of Endocrinology, Instituto de Investigación La Princesa, Universidad Autónoma de Madrid, Department of Pediatrics, Avenida Menéndez Pelayo, 65, 28009, Madrid, Spain.

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http://dx.doi.org/10.1038/s41366-019-0357-5DOI Listing
March 2019

Physiological and brain alterations produced by high-fat diet in male and female rats can be modulated by increased levels of estradiol during critical periods of development.

Nutr Neurosci 2019 Jan 11;22(1):29-39. Epub 2017 Jul 11.

a Departamento de Psicobiología , Universidad Nacional de Educación a Distancia (UNED) , C/ Juan del Rosal n° 10, 28040 Madrid , Spain.

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http://dx.doi.org/10.1080/1028415X.2017.1349574DOI Listing
January 2019

Editorial: Hormones and Neural Aging: Lessons From Experimental Models.

Front Aging Neurosci 2018 15;10:374. Epub 2018 Nov 15.

Instituto Cajal, CSIC and Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto Carlos III, Madrid, Spain.

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http://dx.doi.org/10.3389/fnagi.2018.00374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249339PMC
November 2018

rhIGF-1 Treatment Increases Bone Mineral Density and Trabecular Bone Structure in Children with PAPP-A2 Deficiency.

Horm Res Paediatr 2018 16;89(3):200-204. Epub 2018 Feb 16.

Department of Pediatrics and Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, Madrid, Spain.

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http://dx.doi.org/10.1159/000486336DOI Listing
September 2018

The increase in fiber size in male rat gastrocnemius after chronic central leptin infusion is related to activation of insulin signaling.

Mol Cell Endocrinol 2018 07 27;470:48-59. Epub 2017 Sep 27.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, E-28009, Madrid, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, E-28009, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2017.09.029DOI Listing
July 2018

Cholecystokinin is involved in triglyceride fatty acid uptake by rat adipose tissue.

J Endocrinol 2018 03 16;236(3):137-150. Epub 2018 Jan 16.

Departamento de Ciencias Farmacéuticas y de la SaludFacultad de Farmacia, Universidad San Pablo-CEU, Madrid, Spain

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http://dx.doi.org/10.1530/JOE-17-0580DOI Listing
March 2018

The Protective Effects of IGF-I against β-Amyloid-related Downregulation of Hippocampal Somatostatinergic System Involve Activation of Akt and Protein Kinase A.

Neuroscience 2018 03 3;374:104-118. Epub 2018 Feb 3.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación Sanitaria La Princesa, Madrid, Spain; CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2018.01.041DOI Listing
March 2018

Resveratrol Intake During Pregnancy and Lactation Modulates the Early Metabolic Effects of Maternal Nutrition Differently in Male and Female Offspring.

Endocrinology 2018 02;159(2):810-825

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, Madrid, Spain.

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http://dx.doi.org/10.1210/en.2017-00610DOI Listing
February 2018

Sex differences in the neuroendocrine control of metabolism and the implication of astrocytes.

Front Neuroendocrinol 2018 01 25;48:3-12. Epub 2017 May 25.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación la Princesa, 28009 Madrid, Spain; CIBEROBN (Centro de Investigación Biomédica en Red: Fisiopatología de la Obesidad y Nutrición), 28009 Madrid, Spain; Department of Pediatrics, Facultad de Medicina, Universidad Autónoma de Madrid, 28009 Madrid, Spain; IMDEA Food Institute, CEI UAM + CSIC, Carretera de Cantoblanco 8., 28049 Madrid, Spain.

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http://dx.doi.org/10.1016/j.yfrne.2017.05.003DOI Listing
January 2018

Differential vulnerability to adverse nutritional conditions in male and female rats: Modulatory role of estradiol during development.

Front Neuroendocrinol 2018 01 25;48:13-22. Epub 2017 Jul 25.

Departamento de Psicobiología, Universidad Nacional de Educación a Distancia (UNED), C/ Juan del Rosal n° 10, 28040 Madrid, Spain; Instituto Mixto de Investigación-Escuela Nacional de Sanidad (IMIENS), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.yfrne.2017.07.009DOI Listing
January 2018

The Hypothalamic Inflammatory/Gliosis Response to Neonatal Overnutrition Is Sex and Age Dependent.

Endocrinology 2018 01;159(1):368-387

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación la Princesa, Madrid, Spain.

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http://dx.doi.org/10.1210/en.2017-00539DOI Listing
January 2018

Administration of a leptin antagonist during the neonatal leptin surge induces alterations in the redox and inflammatory state in peripubertal /adolescent rats.

Mol Cell Endocrinol 2017 10 19;454:125-134. Epub 2017 Jun 19.

Department of Physiology (Animal Physiology II), Faculty of Biology, Complutense University, Madrid, Spain.

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http://dx.doi.org/10.1016/j.mce.2017.06.018DOI Listing
October 2017

One level up: abnormal proteolytic regulation of IGF activity plays a role in human pathophysiology.

EMBO Mol Med 2017 10;9(10):1338-1345

Department of Molecular Biology & Genetics, Aarhus University, Aarhus C, Denmark.

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http://dx.doi.org/10.15252/emmm.201707950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623872PMC
October 2017

Free-choice high-fat diet alters circadian oscillation of energy intake in adolescent mice: role of prefrontal cortex.

Eur J Nutr 2017 Aug 14;56(5):1833-1844. Epub 2016 May 14.

Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad CEU-San Pablo, Campus de Montepríncipe, Boadilla del Monte, 28668, Madrid, Spain.

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http://dx.doi.org/10.1007/s00394-016-1225-xDOI Listing
August 2017

Ghrelin: A Link Between Energy Homeostasis and the Immune System.

Endocrinology 2017 07;158(7):2077-2081

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación la Princesa, 28009 Madrid, Spain.

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http://dx.doi.org/10.1210/en.2017-00350DOI Listing
July 2017

Microglial Proliferation in Obesity: When, Where, Why, and What Does It Mean?

Diabetes 2017 04;66(4):804-805

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación del Hospital de la Princesa, Centro de Investigación Biomédica en Red de Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.

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http://dx.doi.org/10.2337/dbi16-0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360305PMC
April 2017

Involvement of Astrocytes in Mediating the Central Effects of Ghrelin.

Int J Mol Sci 2017 Mar 2;18(3). Epub 2017 Mar 2.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación la Princesa, CIBER de Obesidad Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28009 Madrid, Spain.

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http://dx.doi.org/10.3390/ijms18030536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372552PMC
March 2017

Non-Neuronal Cells in the Hypothalamic Adaptation to Metabolic Signals.

Front Endocrinol (Lausanne) 2017 21;8:51. Epub 2017 Mar 21.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación la Princesa, Madrid, Spain; Centro de Investigación Biomédica en Red: Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Madrid, Spain.

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http://dx.doi.org/10.3389/fendo.2017.00051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359311PMC
March 2017

Glial cells and energy balance.

J Mol Endocrinol 2017 01 18;58(1):R59-R71. Epub 2016 Nov 18.

Departments of Pediatrics & Pediatric EndocrinologyHospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, Department of Pediatrics, Universidad Autónoma de Madrid, CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain

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http://dx.doi.org/10.1530/JME-16-0182DOI Listing
January 2017

Blockage of neonatal leptin signaling induces changes in the hypothalamus associated with delayed pubertal onset and modifications in neuropeptide expression during adulthood in male rats.

Peptides 2016 12 14;86:63-71. Epub 2016 Oct 14.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación Sanitaria Princesa (IP), Madrid, Spain; CIBER Fisiopatología de Obesidad y Nutrición, Instituto Carlos III, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2016.10.003DOI Listing
December 2016

Treatment With Recombinant Human Insulin-Like Growth Factor-1 Improves Growth in Patients With PAPP-A2 Deficiency.

J Clin Endocrinol Metab 2016 Nov 20;101(11):3879-3883. Epub 2016 Sep 20.

Department of Pediatrics and Pediatric Endocrinology (M.T.M.-C., V.B., J.P., J.A.C., G.A.M.-M., J.A.) Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, Universidad Autónoma de Madrid, Department of Pediatrics, Centro de Investigación Biomédica en Red (CIBEROBN), Instituto de Salud Carlos III, 28009 Madrid, Spain; Department of Endocrinology (F.H.), Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, 28040 Madrid, Spain; Cincinnati Center for Growth Disorders (A.D.), Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229; Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (CEDIE) (H.M.D.), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), FEI, División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, C1425EFD Buenos Aires, Argentina; Department of Basic Science and Craniofacial Biology (S.Y.), New York University College of Dentistry, New York, New York 10010; Oregon Health and Science University (R.G.R.), Portland, Oregon 97239; Stat5 LLC (R.G.R.), Los Altos, California 94022; Genetics Unit (L.A.P.-J.), Universitat Pompeu Fabra, Hospital del Mar Research Institute (IMIM), and CIBER de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 08003 Barcelona, Spain; Department of Molecular Biology and Genetics (C.O.), Aarhus University, 8000 Aarhus, Denmark; and Medical Research Laboratory (J.F.), Department of Clinical Medicine, Faculty of Health, Aarhus University and Department of Endocrinology and Internal Medicine, Aarhus University Hospital, 8000 Aarhus, Denmark.

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http://dx.doi.org/10.1210/jc.2016-2751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393598PMC
November 2016

The role of astrocytes in the hypothalamic response and adaptation to metabolic signals.

Prog Neurobiol 2016 09 18;144:68-87. Epub 2016 Mar 18.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación la Princesa, CIBER de Obesidad Fisiopatología de la Obesidad y Nutrición (CIBEROBN). Instituto de Salud Carlos III, Madrid, Spain; Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain.

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http://dx.doi.org/10.1016/j.pneurobio.2016.03.001DOI Listing
September 2016

Hypothalamic Leptin and Ghrelin Signaling as Targets for Improvement in Metabolic Control.

Curr Pharm Des 2015 ;21(25):3596-605

Department of Endocrinology Hospital Infantil Universitario Niño Jesús. Avenida Menéndez Pelayo 65 28009 Madrid, Spain.

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http://dx.doi.org/10.2174/1381612821666150710145428DOI Listing
June 2016

Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model.

Dis Model Mech 2016 05 24;9(5):573-83. Epub 2016 Mar 24.

Department of Paediatrics, Universidad Autónoma de Madrid, Av. Menéndez Pelayo, 65, Madrid 28009, Spain Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Av. Menéndez Pelayo, 65, Madrid 28009, Spain Instituto de Investigación Sanitaria Princesa, IIS-IP, Madrid E-28006, Spain Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid E-28029, Spain

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http://dx.doi.org/10.1242/dmm.023515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892662PMC
May 2016

Age and sex dependent effects of early overnutrition on metabolic parameters and the role of neonatal androgens.

Biol Sex Differ 2016 18;7:26. Epub 2016 May 18.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, Avenida Menéndez Pelayo 65, Madrid, 28009 Spain ; Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.

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http://dx.doi.org/10.1186/s13293-016-0079-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870809PMC
May 2016

Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability.

EMBO Mol Med 2016 04;8(4):363-74

Department of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús Instituto de Investigación La Princesa Universidad Autónoma de Madrid, Madrid, Spain Program of Pediatric Obesity, CIBEROBN Instituto de Salud Carlos III, Madrid, Spain

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http://dx.doi.org/10.15252/emmm.201506106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818753PMC
April 2016

Improvement in glycemia after glucose or insulin overload in leptin-infused rats is associated with insulin-related activation of hepatic glucose metabolism.

Nutr Metab (Lond) 2016 1;13:19. Epub 2016 Mar 1.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, Avda. Menéndez Pelayo, 65, E-28009 Madrid, Spain ; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, E-28009 Spain.

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http://dx.doi.org/10.1186/s12986-016-0079-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774133PMC
March 2016

Ghrelin Regulates Glucose and Glutamate Transporters in Hypothalamic Astrocytes.

Sci Rep 2016 Mar 30;6:23673. Epub 2016 Mar 30.

Hospital Infantil Universitario Niño Jesús, Department of Endocrinology, Instituto de Investigación La Princesa, University Autónoma of Madrid and Centro de Investigación Biomédica en Red (CIBER) de la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.

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http://dx.doi.org/10.1038/srep23673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812252PMC
March 2016

Interaction between neonatal maternal deprivation and serum leptin levels on metabolism, pubertal development, and sexual behavior in male and female rats.

Biol Sex Differ 2016 11;7. Epub 2016 Jan 11.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación la Princesa, Avenida Menéndez Pelayo, 65, Madrid, 28009 Spain ; CIBEROBN, Instituto Carlos III Madrid, Madrid, Spain.

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http://dx.doi.org/10.1186/s13293-015-0054-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710050PMC
January 2016

Chronic central leptin infusion modulates the glycemia response to insulin administration in male rats through regulation of hepatic glucose metabolism.

Mol Cell Endocrinol 2015 Nov 18;415:157-72. Epub 2015 Aug 18.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, E-28009, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, E-28009, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2015.08.014DOI Listing
November 2015

Blockage of the Neonatal Leptin Surge Affects the Gene Expression of Growth Factors, Glial Proteins, and Neuropeptides Involved in the Control of Metabolism and Reproduction in Peripubertal Male and Female Rats.

Endocrinology 2015 Jul 9;156(7):2571-81. Epub 2015 Apr 9.

Department of Physiology (Animal Physiology II) (V.M., A.B.L.-R., M.-P.V.), Faculty of Biology, Universidad Complutense, 28040 Madrid, Spain; Department of Endocrinology (F.D., J.A., J.A.C.), Hospital Infantil Universitario Niño Jesús, Department of Pediatrics, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria Princesa, 28009 Madrid, Spain; Centro de Investigación Biomédica en Red (CIBER) Fisiopatología de Obesidad y Nutrición (F.D., M.J.V., J.A., M.T.-S., J.A.C.), Instituto Carlos III, 28903 Madrid, Spain; Department of Cell Biology, Physiology, and Immunology (M.J.V., M.T.-S.), University of Córdoba and Instituto Maimónides de Investigación Biomédica, Hospital Universitario Reina Sofia, 14004 Córdoba, Spain; and The Robert H. Smith Faculty of Agriculture, Food and Environment (A.G.), The Hebrew University of Jerusalem, Rehovot, Israel 76100.

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http://dx.doi.org/10.1210/en.2014-1981DOI Listing
July 2015

A proteomic approach to obesity and type 2 diabetes.

J Cell Mol Med 2015 Jul 9;19(7):1455-70. Epub 2015 May 9.

Departments of Endocrinology and Pediatrics, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Madrid, Spain.

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http://dx.doi.org/10.1111/jcmm.12600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511345PMC
July 2015

Increased prepubertal body weight enhances leptin sensitivity in proopiomelanocortin and neuropeptide y neurons before puberty onset in female rats.

Endocrinology 2015 Apr 9;156(4):1272-82. Epub 2015 Jan 9.

Department of Endocrinology (D.C.-G., E.F.-M., P.A.-A., V.B., J.A.C., J.A.), Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa (D.C.-G., E.F.-M., P.A.-A., V.B., J.A.C., J.A.), 3Department of Pediatrics (D.C.-G., E.F.-M., P.A.-A., J.A.), Universidad Autónoma de Madrid, E-28049 Madrid, Spain; Centros de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (D.C.-G., E.F.-M., M.A.S.-G., P.A.-A., M.T.-S., V.B., J.A.C., J.A.), Instituto de Salud Carlos III, E-28009 Madrid, Spain; and Department of Cell Biology, Physiology and Immunology (M.A.S.-G., M.T.-S.), University of Córdoba, Instituto Maimónides de Investigacion Biomédicas de Córdoba/ Hospital Universitario Reina Sofia, 14004 Córdoba, Spain.

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http://dx.doi.org/10.1210/en.2014-1759DOI Listing
April 2015

Role of non-neuronal cells in body weight and appetite control.

Front Endocrinol (Lausanne) 2015 26;6:42. Epub 2015 Mar 26.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa , Madrid , Spain ; Fisiopatología de la Obesidad y Nutrición (CIBERobn), Centros de Investigación Biomédica en Red, Instituto de Salud Carlos III , Madrid , Spain.

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http://dx.doi.org/10.3389/fendo.2015.00042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374626PMC
April 2015

The absence of GH signaling affects the susceptibility to high-fat diet-induced hypothalamic inflammation in male mice.

Endocrinology 2014 Dec 19;155(12):4856-67. Epub 2014 Sep 19.

Department of Pediatrics (E.B., A.M.R.-L., J.A.C., L.M.F., J.A.), Universidad Autónoma de Madrid; Department of Endocrinology, Hospital Infantil Universitario Niño Jesús 28009, Madrid, Spain; Instituto de Investigación Sanitaria Princesa; and Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 28009 Madrid, Spain; and The Edison Biotechnology Institute (E.G.S., J.H., E.O.L., J.J.K.) and Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701.

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http://dx.doi.org/10.1210/en.2014-1367DOI Listing
December 2014

The opposing effects of ghrelin on hypothalamic and systemic inflammatory processes are modulated by its acylation status and food intake in male rats.

Endocrinology 2014 Aug 21;155(8):2868-80. Epub 2014 May 21.

Hospital Infantil Universitario Niño Jesús, Department of Endocrinology, Instituto de Investigación La Princesa, Universidad Autónoma de Madrid and Centro de Investigación Biomédica en Red (CIBER) de la Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 28009 Madrid, Spain.

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http://dx.doi.org/10.1210/en.2014-1074DOI Listing
August 2014

Morphological changes in glial fibrillary acidic protein immunopositive astrocytes in the hippocampus of dietary-induced obese mice.

Neuroreport 2014 Aug;25(11):819-822

Departamento de Ciencias Farmacéticas y de la Salud, Facultad de Farmacia, Universidad CEU San Pablo.

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http://dx.doi.org/10.1097/WNR.0000000000000180DOI Listing
August 2014

Principles and pitfalls in the differential diagnosis and management of childhood obesities.

Adv Nutr 2014 May 14;5(3):299S-305S. Epub 2014 May 14.

Department of Pediatrics and Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús; Instituto de Investigación La Princesa; Department of Pediatrics, Universidad Autónoma de Madrid; CIBER Fisiopatología Obesidad y Nutrición; Instituto de Salud Carlos III, Madrid, Spain

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http://dx.doi.org/10.3945/an.113.004853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013186PMC
May 2014

Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency.

EMBO Mol Med 2014 03 30;6(3):299-306. Epub 2014 Jan 30.

Departments of Endocrinology and Pediatrics, Hospital Infantil Universitario Niño Jesús Universidad Autónoma de Madrid, Madrid, Spain.

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http://dx.doi.org/10.1002/emmm.201303573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958305PMC
March 2014

Adipokines in childhood obesity.

Vitam Horm 2013 ;91:107-42

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, Madrid, Spain.

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http://dx.doi.org/10.1016/B978-0-12-407766-9.00006-7DOI Listing
December 2013

Emerging role of glial cells in the control of body weight.

Mol Metab 2012 9;1(1-2):37-46. Epub 2012 Aug 9.

Institute of Diabetes and Obesity, Helmholtz Center Munich, German Research Center for Environmental Health (GmbH), Munich, Germany ; CIBER de Fisiopatología de Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.

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http://dx.doi.org/10.1016/j.molmet.2012.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757650PMC
September 2013

Differential effects of GH and GH-releasing peptide-6 on astrocytes.

J Endocrinol 2013 Sep 29;218(3):263-74. Epub 2013 Jul 29.

Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain.

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http://dx.doi.org/10.1530/JOE-13-0053DOI Listing
September 2013

Uncovering novel roles of nonneuronal cells in body weight homeostasis and obesity.

Endocrinology 2013 Sep 24;154(9):3001-7. Epub 2013 Jun 24.

Hospital Infantil Universitario Niño Jesús, Department of Endocrinology, Instituto de Investigación La Princesa, 28009 Madrid, Spain.

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http://dx.doi.org/10.1210/en.2013-1303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749483PMC
September 2013

Hypothalamic inflammation without astrogliosis in response to high sucrose intake is modulated by neonatal nutrition in male rats.

Endocrinology 2013 Jul 13;154(7):2318-30. Epub 2013 May 13.

Hospital Infantil Universitario Niño Jesús, Department of Endocrinology, Instituto de Investigación La Princesa, 28009 Madrid, Spain.

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http://dx.doi.org/10.1210/en.2012-2196DOI Listing
July 2013

Sex differences in adipose tissue: It is not only a question of quantity and distribution.

Adipocyte 2013 Jul 1;2(3):128-34. Epub 2013 Aug 1.

Department of Pediatric Endocrinology; Hospital Infantil Universitario Niño Jesús; Instituto de Investigación La Princesa; Madrid, Spain ; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn); Instituto de Salud Carlos III; Madrid, Spain.

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http://dx.doi.org/10.4161/adip.24075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756100PMC
July 2013

Maternal deprivation exacerbates the response to a high fat diet in a sexually dimorphic manner.

PLoS One 2012 7;7(11):e48915. Epub 2012 Nov 7.

Department of Physiology (Animal Physiology II), Faculty of Biology, Universidad Complutense, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048915PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492147PMC
May 2013

Maternal stress alters the developmental program of embryonic hippocampal neurons growing in vitro.

Psychoneuroendocrinology 2013 Mar 24;38(3):455-9. Epub 2012 Jul 24.

Instituto Cajal, CSIC, E-28002 Madrid, Spain.

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http://dx.doi.org/10.1016/j.psyneuen.2012.07.001DOI Listing
March 2013

Leptin-induced downregulation of the rat hippocampal somatostatinergic system may potentiate its anorexigenic effects.

Neurochem Int 2012 Dec 13;61(8):1385-96. Epub 2012 Oct 13.

Neurobiochemistry Unit, Department of Biochemistry and Molecular Biology, Facultad de Medicina, Universidad de Alcalá, Alcalá de Henares, E-28871 Madrid, Spain.

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http://dx.doi.org/10.1016/j.neuint.2012.09.019DOI Listing
December 2012

Leptin in early life: a key factor for the development of the adult metabolic profile.

Obes Facts 2012 2;5(1):138-50. Epub 2012 Mar 2.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, Department of Pediatrics, Universidad Autónoma de Madrid and CIBER Fisiopatología de Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.

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http://dx.doi.org/10.1159/000336967DOI Listing
July 2012

Early nutritional changes induce sexually dimorphic long-term effects on body weight gain and the response to sucrose intake in adult rats.

Metabolism 2012 Jun 29;61(6):812-22. Epub 2011 Dec 29.

Hospital Infantil Universitario Niño Jesús, Department of Endocrinology, Instituto de Investigación La Princesa, Madrid, Spain.

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http://dx.doi.org/10.1016/j.metabol.2011.11.003DOI Listing
June 2012

Early postnatal overnutrition increases adipose tissue accrual in response to a sucrose-enriched diet.

Am J Physiol Endocrinol Metab 2012 Jun 17;302(12):E1586-98. Epub 2012 Apr 17.

Hospital Infantil Universitario Niño Jesús, Department of Endocrinology, Instituto de Investigación Sanitaria La Princesa, Madrid, Spain.

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http://www.physiology.org/doi/10.1152/ajpendo.00618.2011
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http://dx.doi.org/10.1152/ajpendo.00618.2011DOI Listing
June 2012

Effects of acute changes in neonatal leptin levels on food intake and long-term metabolic profiles in rats.

Endocrinology 2011 Nov 20;152(11):4116-26. Epub 2011 Sep 20.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, and Department of Pediatrics, Universidad Autónoma de Madrid, Avenida Menéndez Pelayo, 65, 28009 Madrid, Spain.

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http://dx.doi.org/10.1210/en.2011-1233DOI Listing
November 2011

Neuroprotective actions of ghrelin and growth hormone secretagogues.

Front Mol Neurosci 2011 28;4:23. Epub 2011 Sep 28.

Department of Pediatrics, Universidad Autónoma de Madrid Madrid, Spain.

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http://dx.doi.org/10.3389/fnmol.2011.00023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182030PMC
November 2011

Leptin and the brain.

Horm Mol Biol Clin Investig 2011 Oct;7(2):351-60

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http://dx.doi.org/10.1515/HMBCI.2011.113DOI Listing
October 2011

A role for astrocytes in the central control of metabolism.

Neuroendocrinology 2011 4;93(3):143-9. Epub 2011 Mar 4.

Metabolic Diseases Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1159/000324888DOI Listing
July 2011

Differential acute and chronic effects of leptin on hypothalamic astrocyte morphology and synaptic protein levels.

Endocrinology 2011 May 22;152(5):1809-18. Epub 2011 Feb 22.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Avenida Menéndez Pelayo, 65, 28009 Madrid, Spain.

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http://dx.doi.org/10.1210/en.2010-1252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860256PMC
May 2011

Chronic central leptin infusion modifies the response to acute central insulin injection by reducing the interaction of the insulin receptor with IRS2 and increasing its association with SOCS3.

J Neurochem 2011 Apr 9;117(1):175-85. Epub 2011 Feb 9.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto Investigación Sanitaria Princesa, Madrid, Spain.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07191.xDOI Listing
April 2011

Gender differences in the long-term effects of chronic prenatal stress on the HPA axis and hypothalamic structure in rats.

Psychoneuroendocrinology 2010 Nov 16;35(10):1525-35. Epub 2010 Jun 16.

Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, CIBER Fisiopatología de Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid 28009, Spain.

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http://dx.doi.org/10.1016/j.psyneuen.2010.05.006DOI Listing
November 2010

Maternal deprivation has sexually dimorphic long-term effects on hypothalamic cell-turnover, body weight and circulating hormone levels.

Horm Behav 2010 Nov 11;58(5):808-19. Epub 2010 Aug 11.

Department of Physiology (Animal Physiology II), Faculty of Biology, Universidad Complutense, Madrid, Spain.

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http://dx.doi.org/10.1016/j.yhbeh.2010.08.003DOI Listing
November 2010

Regional and temporal differences in leptin signaling in rat brain.

Gen Comp Endocrinol 2010 May 4;167(1):143-52. Epub 2010 Feb 4.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Madrid E-28009, Spain.

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http://dx.doi.org/10.1016/j.ygcen.2010.01.021DOI Listing
May 2010

The positive effects of growth hormone-releasing peptide-6 on weight gain and fat mass accrual depend on the insulin/glucose status.

Endocrinology 2010 May 10;151(5):2008-18. Epub 2010 Mar 10.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Avenida Menéndez Pelayo, Madrid, Spain.

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http://dx.doi.org/10.1210/en.2009-1394DOI Listing
May 2010

The weight gain response to stress during adulthood is conditioned by both sex and prenatal stress exposure.

Psychoneuroendocrinology 2010 Apr 1;35(3):403-13. Epub 2009 Sep 1.

Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, CIBER Fisiopatología de Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 28009 Madrid, Spain.

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http://dx.doi.org/10.1016/j.psyneuen.2009.08.001DOI Listing
April 2010

Maternal deprivation induces a rapid decline in circulating leptin levels and sexually dimorphic modifications in hypothalamic trophic factors and cell turnover.

Horm Behav 2010 Apr 25;57(4-5):405-14. Epub 2010 Jan 25.

Department of Physiology (Animal Physiology II), Faculty of Biology, Universidad Complutense, Madrid, Spain.

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http://dx.doi.org/10.1016/j.yhbeh.2010.01.009DOI Listing
April 2010

17Beta-estradiol protects depletion of rat temporal cortex somatostatinergic system by beta-amyloid.

Neurobiol Aging 2007 Sep 14;28(9):1396-409. Epub 2006 Jul 14.

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Avda. Menéndez Pelayo, Madrid, Spain.

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http://dx.doi.org/10.1016/j.neurobiolaging.2006.06.009DOI Listing
September 2007

Reduction in the number of astrocytes and their projections is associated with increased synaptic protein density in the hypothalamus of poorly controlled diabetic rats.

Endocrinology 2006 Nov 27;147(11):5314-24. Epub 2006 Jul 27.

Hospital Infantil Universitario Niño Jesús, Departamento de Endocrinología, Avenida Menéndez Pelayo, 65, 28009 Madrid, Spain.

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http://dx.doi.org/10.1210/en.2006-0766DOI Listing
November 2006

Growth hormone releasing peptide-6 acts as a survival factor in glutamate-induced excitotoxicity.

J Neurochem 2006 Nov;99(3):839-49

Universidad Autónoma de Madrid. Departament of Pediatrics. Hospital Infantil Universitario Niño Jesús, Departament of Endocrinology, Madrid, Spain.

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http://dx.doi.org/10.1111/j.1471-4159.2006.04122.xDOI Listing
November 2006

Increased apoptosis of lactotrophs in streptozotocin-induced diabetic rats is followed by increased proliferation.

J Endocrinol 2006 Oct;191(1):55-63

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Madrid, Spain.

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http://dx.doi.org/10.1677/joe.1.06908DOI Listing
October 2006

Basic physiology of the growth hormone/insulin-like growth factor axis.

Adv Exp Med Biol 2005 ;567:1-25

Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Departamento de Endocrinología, Spain.

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http://dx.doi.org/10.1007/0-387-26274-1_1DOI Listing
January 2006

Activation of caspase 8 in the pituitaries of streptozotocin-induced diabetic rats: implication in increased apoptosis of lactotrophs.

Endocrinology 2005 Oct 23;146(10):4417-24. Epub 2005 Jun 23.

Hospital Infantil Universitario Niño Jesús, Universidad Autónoma, Department of Endocrinology, Madrid, Spain.

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http://dx.doi.org/10.1210/en.2005-0517DOI Listing
October 2005

The regulation of GH secretion by sex steroids.

Eur J Endocrinol 2004 Nov;151 Suppl 3:U95-100

Department of Endocrinology, Laboratory of Investigation, Hospital Infantil Universitario Nino Jesus, Universidad Autonoma de Madrid, Madrid, Spain.

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http://dx.doi.org/10.1530/eje.0.151u095DOI Listing
November 2004

Effect of oral glucose administration on ghrelin levels in obese children.

Eur J Endocrinol 2004 Jul;151(1):119-21

Department of Pediatric Endocrinology and Laboratory of Research, Universidad Autónoma, Hospital Infantil Universitario Niño Jesús, Avda. Menéndez Pelayo 65, E-28009 Madrid, Spain.

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http://dx.doi.org/10.1530/eje.0.1510119DOI Listing
July 2004