Publications by authors named "Juliana Robledo"

11 Publications

  • Page 1 of 1

Microsecretory Adenocarcinoma of Salivary Glands: An Expanded Series of 24 Cases.

Head Neck Pathol 2021 May 12. Epub 2021 May 12.

Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA.

Microsecretory adenocarcinoma (MSA) is a recently described salivary gland tumor with a characteristic histologic and immunophenotypic profile and recurrent MEF2C-SS18 fusions. Because only six cases of MSA have been published, its complete clinicopathologic spectrum is unclear, and its biologic behavior has not been documented. Here, we present an updated and expanded experience of 24 MSA cases. All cases of MSA were obtained from the authors' files. Immunohistochemistry for S100, SOX10, p63, p40, SMA, calponin, and mammaglobin was performed. Molecular analysis was performed by targeted RNA sequencing, SS18 break apart fluorescence in situ hybridization, and/or reverse transcriptase polymerase chain reaction for MEF2C-SS18 fusion. Clinical follow-up was obtained from medical records. A total of 24 MSA cases were collected, from 13 women and 11 men, ranging from 17 to 83 years (mean 49.5 years). The vast majority (23 of 24) arose in the oral cavity, with the palate (n = 14) and buccal mucosa (n = 6) as the most frequent subsites. Tumors showed consistent histologic features including: (1) microcystic tubules, (2) flattened intercalated duct-like cells, (3) monotonous oval hyperchromatic nuclei, (4) abundant basophilic luminal secretions, (5) fibromyxoid stroma, and (6) circumscribed borders with subtle infiltration. The tumors were very consistently positive for S100 (24 of 24), p63 (24 of 24), and SOX10 (14 of 14) and negative for p40 (0 of 21), calponin (0 of 12) and mammaglobin (0 of 16), while SMA (4 of 20) was variable. MEF2C-SS18 fusion was demonstrated in 21 of 24 cases; in the remaining 3 cases with insufficient RNA, SS18 break apart FISH was positive. Treatment information was available in 17 cases, all of which were managed with surgery only. In 14 cases with follow-up (1-216 months, mean 30), no cases recurred or metastasized. MSA is a distinct salivary gland neoplasm with remarkably consistent clinical, histologic, immunophenotypic, and genetic features that generally behaves in an indolent manner following surgery alone. These observations solidify MSA as a unique, low-grade salivary gland carcinoma that warrants inclusion in the next version of the WHO classification of head and neck tumors.
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http://dx.doi.org/10.1007/s12105-021-01331-7DOI Listing
May 2021

Oral and Maxillofacial Pathology Case of the Month: Nasopalatine Cyst.

Tex Dent J 2016 09;133(9):522-23, 548-49

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September 2016

Oral and Maxillofacial Pathology. Case of the Month. Primary Syphillis.

J Mich Dent Assoc 2016 Feb;98(2):56-9

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February 2016

Oral and Maxillofacial Pathology. Case of the Month. Primary Syphilis.

Tex Dent J 2015 Jun;132(6):360-1, 398-9

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June 2015

Case of the month. Pyogenic granuloma.

Tex Dent J 2013 May;130(5):404-5, 456

South Texas Oral Pathology, San Antonio, Texas, USA.

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May 2013

Oral and maxillofacial pathology case of the month. Adenomatoid odontogenic tumor.

Tex Dent J 2011 Mar;128(3):308-9, 314-5

South Texas Oral Pathology, San Antonio, Texas, USA.

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March 2011

Clinico-pathologic conference: case 4.

Head Neck Pathol 2009 Dec 17;3(4):290-4. Epub 2009 Oct 17.

Universidad Autónoma de Baja California, Tijuana, Mexico.

A 45 years old male patient presented with an asymptomatic right mandibular mass that extended from the angle to the premolar area. It had been present for 3 months at the time of the initial presentation. Panoramic radiograph revealed an ill-defined unilocular radiolucency. Previous dental treatment included molar extractions and antibiotic therapy. Considerable bleeding was encountered during incisional biopsy.
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http://dx.doi.org/10.1007/s12105-009-0143-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811570PMC
December 2009

Diffuse large B-cell lymphoma of the oral cavity.

Tex Dent J 2010 Mar;127(3):317, 322-3

South Texas Oral Pathology, San Antonio, TX, USA.

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March 2010

Oral and maxillofacial pathology case of the month. Buccal bifurcation cyst.

Tex Dent J 2004 Feb;121(2):166, 172

University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.

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February 2004

Oral and maxillofacial pathology case of the month. Odontogenic myxoma.

Tex Dent J 2003 Jul;120(7):616, 621

Department of Pathology, University of Texas Health Science Center, San Antonio.

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July 2003