Publications by authors named "Juliana Oliveira"

324 Publications

Is it possible to use behavior characters for evolutionary reconstruction in marine invertebrates? A methodological approach using Ethokit Logger.

An Acad Bras Cienc 2021 19;93(3):e20191468. Epub 2021 Jul 19.

Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP), Laboratório de Evolução e Diversidade Aquática (LEDA), Departamento de Ciências Biológicas, FCL/Assis, Av. Dom Antonio, 2100, 19806-900 Assis, SP, Brazil.

The use of behavioral data is quite common in studies of chordate animals and some groups of arthropods; however, these data are usually used in ecological and conservation studies. Their use remains uncommon in phylogenetic reconstructions, especially for non-model groups in behavioral studies. This study aims to evaluate the methodological use of behavioral (feeding process) data with EthoKit Logger in the phylogenetic reconstruction of the Cnidaria, a group in the so-called 'lower' Metazoa. The results indicate considerable cohesion with reconstructions based on molecular data available in previous studies. We therefore suggest that the use of behavioral characters can possible be a useful secondary tool or a proof test for molecular evolutionary reconstructions.
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http://dx.doi.org/10.1590/0001-3765202120191468DOI Listing
July 2021

A scoping review of physical activity interventions for older adults.

Int J Behav Nutr Phys Act 2021 Jun 30;18(1):82. Epub 2021 Jun 30.

Institute for Musculoskeletal Health, The University of Sydney and Sydney Local Health District, Camperdown, NSW, 2050, Australia.

Background: To inform implementation and future research, this scoping review investigates the volume of evidence for physical activity interventions among adults aged 60+. Our research questions are: (1) what is the evidence regarding interventions designed to increase total physical activity in adults aged 60+ years, in accordance with three of the four strategic objectives of GAPPA (active societies, active environments, active people); (2) what is the current evidence regarding the effectiveness of physical activity programmes and services designed for older adults?; and (3) What are the evidence gaps requiring further research?

Methods: We searched PEDro, MEDLINE, CINAHL and Cochrane from 1 January 2010 to 1 November 2020 for systematic reviews and meta-analyses of physical activity interventions in adults aged 60+. We identified interventions designed to: (1) increase physical activity; and (2) deliver physical activity programmes and services in home, community or outpatient settings. We extracted and coded data from eligible reviews according to our proposed framework informed by TIDieR, Prevention of Falls Network Europe (PROFANE), and WHO's International Classification of Functioning, Disability and Health (ICF). We classified the overall findings as positive, negative or inconclusive.

Results: We identified 39 reviews of interventions to increase physical activity and 342 reviews of programmes/services for older adults. Interventions were predominantly structured exercise programmes, including balance strength/resistance training, and physical recreation, such as yoga and tai chi. There were few reviews of health promotion/coaching and health professional education/referral, and none of sport, workplace, sociocultural or environmental interventions. Fewer reported outcomes of total physical activity, social participation and quality of life/well-being. We noted insufficient coverage in diverse and disadvantaged samples and low-middle income countries.

Conclusions: There is a modest but growing volume of evidence regarding interventions designed to increase total physical activity in older adults, although more interventional studies with long term follow-up are needed, particularly for GAPPA 1. Active Societies and GAPPA 2. Active Environments. By comparison, there is abundant evidence for GAPPA 3. specific programmes and services, but coverage of sport and workplace interventions, and diverse samples and settings is lacking. Comprehensive reviews of individual studies are now needed as well as research targeting neglected outcomes, populations and settings.
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http://dx.doi.org/10.1186/s12966-021-01140-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243293PMC
June 2021

Spatiotemporal distribution and temporal trends of brucellosis and tuberculosis in water buffalo (Bubalus bubalis) in Brazil.

Prev Vet Med 2021 Aug 24;193:105417. Epub 2021 Jun 24.

Veterinary Department, Universidade Federal de Viçosa (UFV), Viçosa, MG, Brazil.

The buffalo herds in Brazil have been an alternative for increasing the economy in different biomes. For this reason, knowledge of the spatial distribution of diseases of mandatory notification in buffalo herds, such as brucellosis and tuberculosis, is essential to guarantee the quality of exported animal products, as well as assist in strategies of national control and eradication programs. In the present study, we aimed to evaluate the spatiotemporal distribution and temporal trends of brucellosis and tuberculosis in buffalo in Brazilian states between 2012-2019. During this period, 474 cases of brucellosis and 604 cases of tuberculosis were observed in buffalo in Brazil, with no significant differences between the total number of cases and incidence risk. The spatial distribution for the states was mostly heterogeneous, showing similarities of occurrences for both diseases in the south, north, and the states of Minas Gerais and Pernambuco. In the eight years evaluated, tuberculosis showed cyclical variation every 1-2 years; however, for brucellosis, there was a cyclical trend only between 2012-2015, with a significant decrease until 2018. Among Brazilian states, Pará had greater disease case numbers, with 34 % for brucellosis and 40.6 % for tuberculosis. Temporal trend analysis showed an increase for Pernambuco (annual percentage change [APC]: 21.0 [CI = 20.3; 21.8]), Paraná (APC: 27.1 [CI = 5.6; 53.0]), and Santa Catarina (APC: 10.4 [CI = 0.8; 21.0]) for brucellosis, and for tuberculosis, only for Santa Catarina state (APC: 24.1 [CI = 15.5; 33.3]). Spatiotemporally, there were four high-risk brucellosis clusters with a primary cluster, cluster A (relative risk [RRs] = 53.42, P < 0.001), involving the state of Amazonas between 2014-2015. For tuberculosis, there were three states of high risk, with a primary cluster, cluster E (RRs = 28.18, P < 0.001), involving the states of Pará, Roraima, Amazonas, Rondônia, and Acre in 2014. In conclusion, brucellosis and tuberculosis in buffalo in Brazil are heterogeneously distributed, with well-defined regions of high historical risk of infection. Among these regions, the states of Amazonas, Pará, Amapá, and Minas Gerais stand out due to the higher risk of infection for both brucellosis and tuberculosis, alerting Brazilian authorities to the need for disease control actions.
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http://dx.doi.org/10.1016/j.prevetmed.2021.105417DOI Listing
August 2021

Renal Health: Providing Information and Technological Tools to Empower Patients to Live Better with Kidney Disease.

Stud Health Technol Inform 2021 May;281:674-678

Applied Informatics Graduate Program, Technology Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil.

Chronic kidney disease (CKD) is a growing Public Health problem. Recent evidence points that low education and poor socio-economic conditions are associated with higher risk of developing CKD and progressing to dialysis or transplantation need. Hence patient empowerment through health education and qualification with technological tools that allows better treatment adherence may play an important role in the achievement of optimal clinical outcomes. The Renal Health is a multidisciplinary project created at the University of Fortaleza, northeast Brazil, in 2015, aiming to create novel educational material and technological tools for people with CKD, in different treatment modalities, including dialysis and transplant. The products developed so far in the project include an application for smartphones aiming to help patients in dialysis and transplant in their treatments, including schedule for medications, with alarms, water ingestion control, laboratory tests results, and medical appointments' agenda, besides all information regarding CKD. The other tools include a medication box, an insole for weight control (both are in the prototype phase), connection with smartbands (for vital signs monitoring) and multimedia educational tools, including a profile in the Instagram and a channel in YouTube. Since the first release of the application in the virtual stores, there were more than 1,000 downloads, predominantly in Brazil, although the app is also available in English and Spanish. All these tools represent innovative ways of patient empowerment and may be increasingly present in daily life. Further studies are required to assess the impact of these tools in patients' outcomes, including CKD progression and mortality.
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http://dx.doi.org/10.3233/SHTI210257DOI Listing
May 2021

MiR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity in patients with head and neck cancer.

BMC Cancer 2021 May 19;21(1):575. Epub 2021 May 19.

School of Medical Science, University of Campinas, Campinas, São Paulo, Brazil.

Background: No biomarker is available for identifying cancer patients at risk of developing nephrotoxicity when treated with cisplatin.

Methods: We performed microRNA (miRNA) sequencing using plasma collected 5 days after cisplatin treatment (D5) from twelve patients with head and neck cancer with and without nephrotoxicity (grade ≥ 2 increased serum creatinine). The most differentially expressed miRNAs between the two groups were selected for quantification at baseline and D5 in a larger cohort of patients. The association between miRNAs and nephrotoxicity was evaluated by calculating the odds ratio (OR) from univariate logistic regression. Receiver operating characteristic curves (ROC) were used to estimate the area under the curve (AUC), sensitivity, and specificity.

Results: MiR-3168 (p = 1.98 × 10), miR-4718 (p = 4.24 × 10), and miR-6125 (p = 6.60 × 10) were the most differentially expressed miRNAs and were further quantified in 43, 48, and 53 patients, respectively. The baseline expression of miR-3168 (p = 0.0456, OR = 1.03, 95% CI: 1.00-1.06) and miR-4718 (p = 0.0388, OR = 1.56, 95% CI: 1.03-2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p = 0.0618, OR = 1.73, 95% CI: 0.98-3.29). MiR-4718 showed the highest AUC (0.77, 95% CI: 0.61-0.93) with sensitivity of 66.76 and specificity of 79.49.

Conclusions: We have provided evidence of baseline plasmatic expression of miR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity.
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http://dx.doi.org/10.1186/s12885-021-08317-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136168PMC
May 2021

Phosphodiesterase 4 inhibition restrains muscle proteolysis in diabetic rats by activating PKA and EPAC/Akt effectors and inhibiting FoxO factors.

Life Sci 2021 Aug 27;278:119563. Epub 2021 Apr 27.

São Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, São Paulo, Brazil. Electronic address:

Aim: There is growing evidence about the ability of cyclic adenosine monophosphate (cAMP) signaling and nonselective phosphodiesterase (PDE) inhibitors on mitigate muscle atrophy. PDE4 accounts for the major cAMP hydrolyzing activity in skeletal muscles, therefore advances are necessary about the consequences of treatment with PDE4 inhibitors on protein breakdown in atrophied muscles. We postulated that rolipram (selective PDE4 inhibitor) may activate cAMP downstream effectors, inhibiting proteolytic systems in skeletal muscles of diabetic rats.

Main Methods: Streptozotocin-induced diabetic rats were treated with 2 mg/kg rolipram for 3 days. Changes in the levels of components belonging to the proteolytic machineries in soleus and extensor digitorum longus (EDL) muscles were investigated, as well as cAMP effectors.

Key Findings: Treatment of diabetic rats with rolipram decreased the levels of atrogin-1 and MuRF-1 in soleus and EDL, and reduced the activities of calpains and caspase-3; these findings partially explains the low ubiquitin conjugates levels and the decreased proteasome activity. The inhibition of muscle proteolysis may be occurring due to phosphorylation and inhibition of forkhead box O (FoxO) factors, probably as a consequence of the increased cAMP levels, followed by the activation of PKA and Akt effectors. Akt activation may be associated with the increased levels of exchange protein directly activated by cAMP (EPAC). As a result, rolipram treatment spared muscle mass in diabetic rats.

Significance: The antiproteolytic responses associated with PDE4 inhibition may be helpful to motivate future investigations about the repositioning of PDE4 inhibitors for the treatment of muscle wasting conditions.
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http://dx.doi.org/10.1016/j.lfs.2021.119563DOI Listing
August 2021

Incidence of diabetic ketoacidosis and its trends in patients with type 1 diabetes mellitus identified using a U.S. claims database, 2007-2019.

J Diabetes Complications 2021 Jul 20;35(7):107932. Epub 2021 Apr 20.

Epidemiology & Benefit-Risk Evaluation, Sanofi, 55 Corporate Drive, Bridgewater, NJ 08807, USA.

Diabetic ketoacidosis (DKA) is a common complication of type 1 diabetes mellitus (T1DM). We found that the incidence of DKA was 55.5 per 1000 person-years in US commercially insured patients with T1DM; age-sex-standardized incidence decreased at an average annual rate of 6.1% in 2018-2019 after a steady increase since 2011.
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http://dx.doi.org/10.1016/j.jdiacomp.2021.107932DOI Listing
July 2021

Hospital contingency in coping with COVID-19 in Brazil: governmental problems and alternatives.

Cien Saude Colet 2021 Apr 13;26(4):1407-1418. Epub 2020 Dec 13.

Instituto de Saúde Coletiva, Universidade Federal da Bahia. Salvador BA Brasil.

This paper analyzes the government's strategic agenda for coping with COVID-19 in Brazil, focusing on hospital care. Twenty-eight Contingency Plans were analyzed in full, one national, 26 at state level, and one from the Federal District. The Public Policy Cycle's theoretical framework was used, specifically governmental pre-decision and decision to face the pandemic. The evidence revealed convergences between the national and state levels concerning proposals for reorienting care flow, detecting cases, and indicating referral hospitals. However, the state agendas revealed weaknesses in acquiring mechanical ventilation devices, sizing human resources, and regionalizing hospital care. Moreover, few states have established a method for calculating back-end beds, mainly regarding the outlook of opening hospitals of reference or contracting additional ICU beds. We can conclude that the heterogeneous actions explained in the plans show the complex process of coping with COVID-19 in Brazil with its regional inequalities, weaknesses in the state health systems, and reduced coordination by the Ministry of Health.
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http://dx.doi.org/10.1590/1413-81232021264.43472020DOI Listing
April 2021

Dietary patterns and chronic kidney disease outcomes: A systematic review.

Nephrology (Carlton) 2021 Jul 28;26(7):603-612. Epub 2021 Apr 28.

Public Health Post-Graduation Program, Health Sciences Center, University of Fortaleza (UNIFOR). Fortaleza, Ceará, Brazil.

Chronic kidney disease (CKD) is a serious public health problem and its prevalence is growing in many countries, often related to issues resulting from the lifestyle in growing economies and the population's life expectancy. Nutritional therapy is a beneficial but still neglected strategy for preventing CKD and delaying disease progression. The aim of this study was to assess the association of dietary patterns with CKD development and progression. Observational studies conducted in adult humans and the correlation between the adopted dietary pattern and prevalent and incident cases of CKD were assessed. A significant association was observed between unhealthy dietary patterns and an increased risk of developing or worsening CKD, as well as an adverse effect. Whereas healthy eating patterns characterized by the consumption of fruit, vegetables and dietary fibre showed nephroprotective outcomes.
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http://dx.doi.org/10.1111/nep.13883DOI Listing
July 2021

Water intake and ingestive behavior of sheep fed diets based on silages of cactus pear and tropical forages.

Trop Anim Health Prod 2021 Apr 4;53(2):244. Epub 2021 Apr 4.

Universidade Federal do Vale do São Francisco, Petrolina, PE, 56304-917, Brazil.

The objective was to evaluate the water intake and ingestive behavior of sheep fed diets containing silages of cactus pear combined with tropical forages. Forty sheep without defined breed, intact, with initial average weight of 22.65 ± 1.01 kg were distributed in a completely randomized design with 5 treatments and 8 replications. The experimental diets consisted of cactus pear silage (CPS), cactus pear + buffel grass silage (CPBS), cactus pear + gliricidia silage (CPGS), cactus pear + pornunça silage (CPPS), and corn silage (CS). CPGS provided higher water intake via food, total water intake, metabolic water, and excretion via feces and urine (P < 0.05). Animals that received diets containing CS showed higher water intake via drinking fountain, less efficient feeding and rumination of dry matter, less efficient rumination of neutral detergent fiber, grams of dry matter per cud, grams of neutral detergent fiber per cud, and the shortest average time spent in chewing per cud (P < 0.05). CPGS, CPPS, and CS provided longer times for rumination and numbers of cuds per day (P < 0.05). CPS showed animals spending more time in idleness, lower quantity of cuds per minute, higher concentration of crystals in urine, with a higher frequency of ammonia-magnesium phosphate and calcium oxalate. Silages based on cactus pear are an alternative to the supply of water via food for sheep in semi-arid.
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http://dx.doi.org/10.1007/s11250-021-02686-3DOI Listing
April 2021

Excess weight in adolescents and associated factors: data from the ERICA study.

J Pediatr (Rio J) 2021 Mar 26. Epub 2021 Mar 26.

Universidade Federal de Pernambuco, Centro de Ciências da Saúde, Departamento de Nutrição, Recife, PE, Brazil.

Objective: To estimate the prevalence of excessive weight and to identify associations with socioeconomic, demographic, biological, and lifestyle factors in adolescents.

Methods: It is a cross-sectional school-based study, with a stratified and complex sample. The evaluated individuals were adolescents (2404), aged 12-17 years old, participating in the Study of Cardiovascular Risk Factors in Adolescents (ERICA). Demographic, socioeconomic, biological, anthropometric, and lifestyle variables were assessed. Poisson regression was used to verify the association between excess weight and independent variables.

Results: The prevalence of excessive weight was 26.3% in the study population, being 16.3% for overweight and 10% for obesity. In the multivariate analysis (hierarchical model), were associated with excessive weight: private education network, a higher number of televisions in the residence, eating habits related to the breakfast consumption, snacks purchase in the canteen, snacks in front to screens consumption and consumption of carbohydrates and lipids, in addition to age group (12-14 years) and sexual maturation (post-pubertal).

Conclusions: The prevalence of excessive weight among the school adolescents studied is high, with a value higher than the national average and the results of previous studies with adolescents. Its distribution is associated with different factors, which are socioeconomic, demographic, biological, and related to lifestyle, reinforcing the complexity of this condition, which deserves a broad coping approach, involving not only individual efforts but social and public ones as well.
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http://dx.doi.org/10.1016/j.jped.2021.02.008DOI Listing
March 2021

Spineless cactus use management on microbiological quality, performance, and nutritional disorders in sheep.

Trop Anim Health Prod 2021 Feb 16;53(1):168. Epub 2021 Feb 16.

Federal University of Paraíba (UFPB), Areia, Paraíba, 58397-000, Brazil.

The physically effective neutral detergent fiber content alone has not been able to explain the appearance of diarrhea in ruminants fed diets with large volumes of spineless cactus, so the proliferation of enterobacteria in spineless cactus may be associated with cases of diarrhea in sheep. In the in vitro test, used two varieties of spineless cactus, both of which were chopped to particles of 4 and 2 cm. For the in vivo test, 15 lambs were allocated to three treatment groups, namely, spineless cactus crushed and immediately supplied to the animals; spineless cactus crushed 8 h before supply; and silage of spineless cactus. The variables evaluated were dry matter intake, weight gain, fecal score, hemogram, and fecal colony count. In the in vitro test, higher Enterobacteriaceae and lactic acid bacteria counts were found both at 12 h and 24 h when the spineless cactus was crushed to 2 cm in both varieties. The sheep fed the spineless cactus crushed 8 h prior to supply showed the highest Enterobacteriaceae count in the feces (8.48 CFU/g), compared to animals fed silage of spineless cactus (4.95 CFU/g). It can thus be concluded that the management of spineless cactus influences the development of total and fecal coliforms, especially when it is chopped to 2 cm and exposed to the environment for periods longer than 7 h, and that the bacterial population can be controlled by administering the spineless cactus in the form of silage.
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http://dx.doi.org/10.1007/s11250-021-02594-6DOI Listing
February 2021

The use of bioelectrical impedance vector analysis for a nutritional evaluation of older adults in the community.

Exp Gerontol 2021 05 8;147:111276. Epub 2021 Feb 8.

Department of Nutrition, Federal University of Sergipe, Lagarto, Sergipe, Brazil. Electronic address:

Introduction: The body composition of an older adult person is characterized by an increase in body fat, as well as by a reduction in both muscle mass and total body water. The bioelectrical impedance vector analysis (BIVA) overcomes the limits imposed by bioelectrical impedance, since it only requires the resistance (R) and reactance (Xc) values, standardized by the individual's height, which makes the method more individualized and accurate. The aim of this study was to evaluate the body composition using the BIVA of the community-living older adults, with regard to sex and body mass index (BMI) classification, and compare the results with the reference population.

Methods: Cross-sectional study with the community-living older adults of both sexes. Bioimpedance was carried out and the R and Xc data analyzed, based on height, and plotted on RXc graphs.

Results: One hundred and forty-four older adults (n = 33 men; n = 111 women; mean age of 80.2 ± 9.2 years) participated in the study. Low weight (<23 kg/m) was the most prevalent in BMI classification. The older adult women presented a higher average BMI, body fat percentage and R/Height values, while the older adult men presented a higher average for fat-free mass and the phase angle (p < 0.05). The older adult, regardless of their BMI, located in the right quadrant, indicated cachexia; those with low weight were dehydrated, and those with overweight (BMI ≥ 28 kg/m) presented hyperhydration.

Conclusion: The majority of the older adults with normal weight or overweight has impedance vectors indicating loss of muscle mass and water imbalance (dehydration or hyperhydration).
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http://dx.doi.org/10.1016/j.exger.2021.111276DOI Listing
May 2021

Independent predictors of insulin resistance in Brazilian adolescents: Results of the study of cardiovascular risk in adolescents-Brazil.

PLoS One 2021 9;16(2):e0246445. Epub 2021 Feb 9.

Departamento de Nutrição, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.

Considering the current changes in dietary patterns and the increasing prevalence of excess weight throughout the world, several studies have reported insulin resistance, which is a key driver of many chronic diseases, to be an important public health problem in all age groups. Therefore, the aim of the present study was to identify the prevalence and independent predictors of insulin resistance in Brazilian adolescents. A cross-sectional study was conducted with a probabilistic, representative sample of Brazilian adolescents (n = 37,023) who participated in the Study of Cardiovascular Risk in Adolescents. Data were collected on demographic, socioeconomic, lifestyle, anthropometric, and biochemical characteristics as well as antioxidant micronutrient intake (vitamins A, C, E, zinc, and selenium). Insulin resistance was determined using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and classified based on the 75th percentile of the sample distribution. Insulin resistance was detected in 27% of the adolescents and was more prevalent among those aged 12 to 14 years (PR: 1.26 [95%CI: 1.13;1.41]), those residing in the southern and south-eastern regions of the country (PR: 1.47 [95%CI: 1.27;1.70]), those who were physically inactive (PR: 1.12 [95%CI: 1.02;1.23]), and those did not consume alcohol (PR: 1.50 [95%CI: 1.13;1.99]). The prevalence of insulin resistance was 2.5-fold higher among individuals with severe obesity (PR: 2.49 [95%CI: 2.07;3.00]). Waist circumference indicative of cardiovascular risk and high serum triglyceride levels increased the likelihood of insulin resistance (PR: 1.37 [95%CI: 1.19;1.59] and 1.60 [95%CI: 1.45;1.78], respectively). The prevalence of the outcome was higher among adolescents in the lower quartiles of vitamin E intake (p<0.05). In the present study, the prevalence of insulin resistance was high among Brazilian adolescents and we identified sociodemographic, lifestyle, anthropometric, biochemical, and dietary predictors of this outcome.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0246445PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872259PMC
February 2021

[Lifestyle of adolescent students from public and private schools in Recife: ERICA].

Cien Saude Colet 2021 Jan 17;26(1):221-232. Epub 2019 Apr 17.

Universidade Federal do Oeste da Bahia. Barreiras BA Brasil.

This study analyzes the behavior patterns related to the lifestyle of adolescents in Recife, Brazil. A cross-sectional study was conducted with data from the Cardiovascular Risk Study among Adolescents (ERICA) and 2400 students aged 12 to 17 were interviewed. The prevalence of physical activity, eating behavior, smoking and alcohol consumption were analyzed. The Chi-square test and 95% confidence interval (95%CI) were used to evaluate the statistical significance of the measurements. It was observed that 60% of the adolescents presented inadequate eating behaviors regarding the consumption of breakfast, daily water intake and meals eaten in front of the TV. About 40% (95%CI: 39.7-45) did not sit down to meals with their parents or guardians. The prevalence of physical inactivity was 52.4% (95%CI: 50-55). Female adolescents were more inactive (68.7%, 95%CI: 65-72) than males (36.4%, 95%CI: 33-40). Teenagers of economic classes D and E were the most inactive (60.7%, 95%CI: 46-73). Alcohol consumption was 18.7% (95%CI: 2.6-5.6) and smoking was prevalent in 3.8% (95%CI: 2-6) of the individuals. Inadequate eating behaviors and physical inactivity were the main areas responsible for an unhealthy lifestyle, followed by alcohol consumption and smoking.
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http://dx.doi.org/10.1590/1413-81232020261.34622018DOI Listing
January 2021

Tucumã (Astrocaryum aculeatum) prevents memory loss and oxidative imbalance in the brain of rats with hyperlipidemia.

J Food Biochem 2021 04 3;45(4):e13636. Epub 2021 Feb 3.

Laboratório de Imunobiologia Experimental e Aplicada (LABIBIO), Departamento de Microbiologia e Parasitologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, Brazil.

Hyperlipidemia generates deposition of lipids, inflammation, and oxidative damage in cells and tissues, including those of the brain. Tucumã (Astrocaryum aculeatum) fruits contain bioactive compounds with antioxidant and anti-inflammatory effects. We evaluated the action of Tucumã extract on memory and brain cortex redox balance in hyperlipidemic rats. For 30 days, Wistar rats received Tucumã extract (250 mg/kg). Then, hyperlipidemia was induced by intraperitoneal administration of Poloxamer-407. Twenty-four hours later, the object recognition index was measured. The animals were euthanized for sample collection 36 hr postinduction. Hyperlipidemic animals showed memory loss and an imbalance between reactive species and intrinsic antioxidants. We found that Tucumã prevented memory loss and protein and lipid oxidative damage and prompted a better antioxidant response in the cerebral cortex of rats with hyperlipidemia. These findings suggest a neuroprotective effect and nutraceutical potential of Tucumã. PRACTICAL APPLICATIONS: In the present work, we demonstrated that induced hyperlipidemia in rats caused memory loss and redox unbalance, both factors prevented by the administration of Tucumã (Astrocaryum aculeatum) extract. Two aims were fulfilled with these results. The first was to show that hyperlipidemia affected brain function through oxidative damage and concerned basic research. The second was to offer a therapy that prevented this harm and could be applied in the clinic. Tucumã has ethnopharmacological importance through the consumption of fruits or the administration of extracts and oils by a population that was shown to enjoy improved health and longevity. Here, we show evidence that Tucumã contributes to the maintenance of brain health by preventing memory loss and oxidative damage, a nutraceutical supplement that may aid the prevention of vascular, inflammatory, and brain diseases.
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http://dx.doi.org/10.1111/jfbc.13636DOI Listing
April 2021

Effect of different blend levels of spineless cactus and Mombasa hay as roughage on intake, digestibility, ingestive behavior, and performance of lambs.

Trop Anim Health Prod 2021 Jan 26;53(1):140. Epub 2021 Jan 26.

Center of Health and Agricultural Technology, Federal University of Campina Grande, Avenida Universitária, s/n - Jatobá, Patos - PB, Patos, Paraíba, 58708110, Brazil.

This study aimed to determine the best level of the blend of spineless cactus (Nopalea cochenillifera) and Mombasa (Panicum maximum) hay as roughage in the diet of lambs based on intake, digestibility, ingestive behavior, and lamb performance. Forty-eight uncastrated crossbred Santa Ines breed lambs with an average age of 4 months old and an average initial BW of 20.5 kg ± 2.8 kg were distributed in two experiments using a completely randomized design: experiment 1: 16 lambs (four treatments and four replicates) for in vivo digestibility trial in metabolic cage; experiment 2: 32 lambs (four treatments and eight replicates) in feedlot to determine intake, ingestive behavior, and performance. As the amount of cactus in the roughage increased, there was a linear reduction (P <0.001) on intake (g/day) of dry matter (DM), crude protein (CP), neutral detergent fiber (NDF), non-fibrous carbohydrates (NFC) digestibility, time spent ruminating, feeding efficiency of NDF (P = 0.0153), NDF rumination efficiency rate (P = 0.032), final BW, TWG, and ADG of lamb. However, there was a linear increase (P <0.001) on the intake of the NFC and TDN, digestibility coefficient of DM, CP, total carbohydrates (TC) and NDF gross energy, metabolizable energy, and time spent idling when spineless cactus increased in the roughage blend. The least amount of cactus in the roughage (112-637 g/kg DM) promoted higher intake of DM and CP, improving lamb performance. However, the blend up to 450-300 g/kg DM improved digestibility and energy production as well as it did not affect the feed efficiency.
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http://dx.doi.org/10.1007/s11250-021-02585-7DOI Listing
January 2021

Are musculoskeletal conditions neglected in national health surveys?

Rheumatology (Oxford) 2021 01 25. Epub 2021 Jan 25.

Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Objective: To describe the proportion of national health surveys that contained questions on the prevalence and consequences of musculoskeletal conditions.

Methods: We used a comprehensive search strategy to obtain national health surveys from the 218 countries listed by the World Bank. Two authors independently extracted information from each national health survey. Outcomes were the proportion of surveys that: (i) contained questions on the prevalence of musculoskeletal conditions using the Global Burden of Disease categorisation of rheumatoid arthritis, osteoarthritis, low back pain, neck pain, gout and other; (ii) contained condition-specific questions about activity limitation, severity of pain, and work absence. We also measured how frequently prevalence of low back pain was measured using a consensus-based standard definition for low back pain prevalence studies.

Results: We identified national health surveys from 170 countries. Sixty-two (36.4%), the majority from high-income countries (N = 43), measured prevalence of at least one musculoskeletal condition. Osteoarthritis (53, 85.4%), low back pain (39, 62.9%) and neck pain (37, 59.7%) were the most commonly measured, while rheumatoid arthritis and gout prevalence were only measured in 10 (5.9%) and 3 (1.8%) surveys, respectively. A minority of surveys assessed condition-specific activity limitation (6, 3.6%), pain severity (5, 2.9%) and work absence (1, 0.6%). Only one survey used the consensus-based standard definition for low back pain.

Conclusion: Musculoskeletal conditions are being neglected in the majority of national health surveys. Monitoring musculoskeletal conditions through ongoing surveys is crucial for the development and evaluation of health policies to reduce their burden.
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http://dx.doi.org/10.1093/rheumatology/keab025DOI Listing
January 2021

BIRTH WEIGHT AND OVERWEIGHT IN ADOLESCENTS: THE ERICA PROJECT IN THE CITY OF RECIFE, PERNAMBUCO.

Rev Paul Pediatr 2021 11;39:e2019380. Epub 2021 Jan 11.

Universidade Federal de Pernambuco, Recife, PE, Brazil.

Objective: To verify the association of anthropometric parameters at birth, socioeconomic and biological variables, physical activity, and parental nutritional status with overweight and abdominal obesity in adolescents.

Methods: A cross-sectional study was carried out on 39 public and private schools in Recife (state of Pernambuco, Brazil). The sample consisted of 1,081 teenagers aged from 12 to 17 years. Data were collected from the Study of Cardiovascular Risks in Adolescents (ERICA). Body mass index according to age (BMI-for-age), waist circumference (WC), and waist-to-height ratio (WtHR) were considered as outcome variables, whereas the explanatory variables were birth weight, Röhrer's Ponderal Index (RPI), biological and socioeconomic variables, physical activity, and parental nutritional status. The crude and adjusted prevalence ratios (PR) for the studied association were estimated by Poisson Regression.

Results: The multivariate Poisson regression showed that the variable that remained significantly associated with overweight in adolescence was maternal overweight, PR=1.86 (95% confidence interval [95%CI] 1.09-3.17). High birth weight also remained significantly associated with abdominal obesity assessed by WC, PR=3.25 (95%CI 1.0-9.74).

Conclusions: High birth weight may be a marker for abdominal obesity in adolescence; and high maternal BMI, for overweight.
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http://dx.doi.org/10.1590/1984-0462/2021/39/2019380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802994PMC
January 2021

A list of land plants of Parque Nacional do Caparaó, Brazil, highlights the presence of sampling gaps within this protected area.

Biodivers Data J 2020 31;8:e59664. Epub 2020 Dec 31.

Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Brazil Universidade Estadual do Norte Fluminense Darcy Ribeiro Campos dos Goytacazes Brazil.

Background: Brazilian protected areas are essential for plant conservation in the Atlantic Forest domain, one of the 36 global biodiversity hotspots. A major challenge for improving conservation actions is to know the plant richness, protected by these areas. Online databases offer an accessible way to build plant species lists and to provide relevant information about biodiversity. A list of land plants of "Parque Nacional do Caparaó" (PNC) was previously built using online databases and published on the website "Catálogo de Plantas das Unidades de Conservação do Brasil." Here, we provide and discuss additional information about plant species richness, endemism and conservation in the PNC that could not be included in the List. We documented 1,791 species of land plants as occurring in PNC, of which 63 are cited as threatened (CR, EN or VU) by the Brazilian National Red List, seven as data deficient (DD) and five as priorities for conservation. Fifity-one species were possible new ocurrences for ES and MG states.

New Information: "Parque Nacional do Caparaó" houses 8% of the land plant species endemic to the Brazilian Atlantic Forest, including 6% of its angiosperms, 31% of its lycophytes and ferns and 14% of its avascular plants. Twelve percent of the threatened species listed for the State of Espírito Santo and 7% listed for the State of Minas Gerais are also protected by PNC. Surprisingly, 79% of the collections analysed here were carried out in Minas Gerais, which represents just 21% of the total extension of the Park. The compiled data uncover a huge botanical collection gap in this federally-protected area.
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http://dx.doi.org/10.3897/BDJ.8.e59664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790809PMC
December 2020

Ethanol production process driving changes on industrial strains.

FEMS Yeast Res 2021 01;21(1)

Laboratório de Genômica e BioEnergia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Universidade Estadual de Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Campinas, São Paulo, 13083-970, Brazil.

Ethanol production has key differences between the two largest producing countries of this biofuel, Brazil and the USA, such as feedstock source, sugar concentration and ethanol titers in industrial fermentation. Therefore, it is highly probable that these specificities have led to genome adaptation of the Saccharomyces cerevisiae strains employed in each process to tolerate different environments. In order to identify particular adaptations, in this work, we have compared the genomes of industrial yeast strains widely used to produce ethanol from sugarcane, corn and sweet sorghum, and also two laboratory strains as reference. The genes were predicted and then 4524 single-copy orthologous were selected to build the phylogenetic tree. We found that the geographic location and industrial process were shown as the main evolutionary drivers: for sugarcane fermentation, positive selection was identified for metal homeostasis and stress response genes, whereas genes involved in membrane modeling have been connected with corn fermentation. In addition, the corn specialized strain Ethanol Red showed an increased number of copies of MAL31, a gene encoding a maltose transporter. In summary, our work can help to guide new strain chassis selection for engineering strategies, to produce more robust strains for biofuel production and other industrial applications.
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http://dx.doi.org/10.1093/femsyr/foaa071DOI Listing
January 2021

-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response.

Oxid Med Cell Longev 2020 12;2020:8820651. Epub 2020 Dec 12.

Neuroscience and Cellular Biology Post-Graduation Program, Biology Science Institute, Federal University of Pará/UFPA, Belém 66075-900, Brazil.

Sepsis is characterized by a dysregulated immune response to infection characterized by an early hyperinflammatory and oxidative response followed by a subsequent immunosuppression phase. Although there have been some advances in the treatment of sepsis, mortality rates remain high, urging for the search of new therapies. -Lapachone (-Lap) is a natural compound obtained from Lorentz ex Griseb. with several pharmacological properties including bactericidal, anti-inflammatory, and antioxidant activity. Thus, the aim of this study was to evaluate the effects of -Lap in a mouse sepsis model. To this, we tested two therapeutic protocols in mice submitted to cecal ligation and puncture- (CLP-) induced sepsis. First, we found that in pretreated animals, -Lap reduced the systemic inflammatory response and improved bacterial clearance and mouse survival. Moreover, -Lap also decreased lipid peroxidation and increased the total antioxidant capacity in the serum and peritoneal cavity of septic animals. In the model of severe sepsis, the posttreatment with -Lap was able to increase the survival of animals and maintain the antioxidant defense function. In conclusion, the -Lap was able to increase the survival of septic animals by a mechanism involving immunomodulatory and antioxidant protective effects.
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http://dx.doi.org/10.1155/2020/8820651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749764PMC
December 2020

American cutaneous leishmaniasis associated with degradation of native forest, regardless of economic, social and infrastructure vulnerability.

Zoonoses Public Health 2021 Jun 19;68(4):327-343. Epub 2020 Dec 19.

Departamento de Medicina Veterinária Preventiva da, Universidade Estadual de Londrina, Londrina, Brazil.

American cutaneous leishmaniasis (ACL) is a notifiable dermatozoonosis with relevant morbidity. The present study aimed to evaluate the epidemiological aspects of cases of ACL reported in Northern Paraná (2007-2016), as well as to georeference and analyse the influence of economic, social and environmental variables. Data from ACL notification forms were obtained and the patients' houses were georeferenced. Descriptive statistics, calculations of disease incidence and proportion of vegetation cover by municipality, spatial analysis, multiple linear regression and vulnerability analysis by census sector (CS) were performed. One thousand four hundred fifty-one cases of ACL were reported in the 89 municipalities of four regional health (RH). The average incidence of cases per 10,000 inhabitants was as follows: 11.58, 8.79, 4.92 and 4.03 in 18thRH, 15thRH, 16thRH and 17thRH. Peaks of incident cases were observed in 2008, 2012 and 2015. There was a statistically significant difference between the HR when comparing the proportions of the variables gender, age, education level, area of residence, clinical form, diagnostic criteria, response to treatment and drug used in case of failure. It was observed that the lower the proportion of remaining Atlantic Forest, the greater the incidence of ACL in the municipality. With regard to clusters analysis, treatment abandonment clusters were observed in the 15thRH and mucous form clusters were observed in the 15thRH, 16thRH and 17thRH. The vulnerability analysis by CS allowed us to observe a statistically significant difference in all vulnerability indicators: economic and social in 15thRH and 17thRH; home infrastructure in 15thRH and 18thRH, urban infrastructure in 15thRH and 18thRH and compound vulnerability index in 15thRH and 18thRH. However, the most vulnerable areas did not always have the highest number of cases. The data presented demonstrate that preventive and health education measures must be mainly directed to areas of greater degradation of native forest; regardless of the vulnerability situation.
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http://dx.doi.org/10.1111/zph.12793DOI Listing
June 2021

Translational evaluation of training structures in equivalence-based instruction.

J Exp Anal Behav 2021 Jan 16;115(1):393-404. Epub 2020 Dec 16.

Texas Christian University.

We used a laboratory preparation to evaluate the claim that equivalence-based instruction (EBI) is an efficient form of instruction due to eliminating the need for emergent relations to be taught. Three groups of college students received training to establish 3 stimulus classes with 4 members in each class. Two groups received either a linear series (EBI-LS) or a 1-to-many training structure (EBI-OTM group). A control group received complete instruction (CI) that targeted all possible relations between the members of each class. The EBI-OTM group required fewer trials to complete instruction compared to CI, whereas EBI-LS did not. The EBI-OTM and the CI groups performed equally well on a posttest that followed initial attainment of the mastery criterion, whereas the EBI-LS group performed more poorly than the other 2. The groups' performance on a function transfer test did not differ. The results support the claim that compared to CI, EBI is an efficient form of instruction when it follows an OTM structure. However, they also suggest this efficiency advantage cannot be attributed to the fewer relations that need to be taught in EBI, as the EBI-OTM and the EBI-LS groups were trained on the same number of relations.
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http://dx.doi.org/10.1002/jeab.657DOI Listing
January 2021

Effect of air pollution on the autonomic modulation of heart rate in overweight adults.

Einstein (Sao Paulo) 2020 7;18:eAO5100. Epub 2020 Dec 7.

Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Objective: To analyze the effect of air pollution on heart rate variability in overweight individuals.

Methods: A total of 46 adult individuals, both sexes, aged between 18 and 49 years and with body mass index >25kg/m2 were analyzed. All volunteers were students from public schools of two cities in the state of São Paulo. The clinical, demographic and anthropometric data of each individual, as well as heart rate variability through time domain, geometric and frequency indices were collected. For the air quality analysis, the following variables were investigated: concentration of carbon dioxide, particulate matter, temperature and relative humidity. The analysis was carried out with descriptive and analytical statistics, adopting a level of significance of 5%.

Results: There was a reduction in overall heart rate variability in overweight individuals by the following indices: mean standard deviation of all normal RR intervals, long-term standard deviation of continuous RR intervals, ratio of short-and long-term standard deviation of continuous RR intervals. In addition, the indices responsible for parasympathetic control showed a downward trend in their values, as well as the low frequency index, which represented sympathetic action, although not significant.

Conclusion: Overweight individuals exposed to air pollution had lower heart rate variability than the Control Group.
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http://dx.doi.org/10.31744/einstein_journal/2020AO5100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690934PMC
December 2020

Evidence on physical activity and osteoporosis prevention for people aged 65+ years: a systematic review to inform the WHO guidelines on physical activity and sedentary behaviour.

Int J Behav Nutr Phys Act 2020 11 26;17(1):150. Epub 2020 Nov 26.

Institute for Musculoskeletal Health, The University of Sydney and Sydney Local Health District, Sydney, Australia.

Background: Various physical activity interventions for prevention and treatment of osteoporosis have been designed and evaluated, but the effect of such interventions on the prevention of osteoporosis in older people is unclear. The aim of this review was to investigate the association between physical activity and osteoporosis prevention in people aged 65 years and above.

Methods: A systematic review was conducted and searches for individual studies were conducted in PubMed (January 2010 to March 2020) and for systematic reviews were conducted in PubMed, Embase, CINAHL and SPORTDiscus (January 2008 to July 2020). Records were screened according to the following eligibility criteria: i) population: adults aged 65 years and older; ii) exposure: greater volume, duration, frequency, or intensity of physical activity; iii) comparison: no physical activity or lesser volume, duration, frequency, or intensity of physical activity; iv) outcome: osteoporosis related measures (e.g., bone mineral density). The methodological quality of included studies was assessed and meta-analysis summarised study effects. The GRADE approach was used to rate certainty of evidence.

Results: We included a total of 59 studies, including 12 observational studies and 47 trials. Within the included trials, 40 compared physical activity with no intervention controls, 11 compared two physical activity programs, and six investigated different doses of physical activity. Included studies suggest that physical activity interventions probably improve bone health among older adults and thus prevent osteoporosis (standardised effect size 0.15, 95% CI 0.05 to 0.25, 20 trials, moderate-certainty evidence, main or most relevant outcome selected for each of the included studies). Physical activity interventions probably improve lumbar spine bone mineral density (standardised effect size 0.17, 95% CI 0.04 to 0.30, 11 trials, moderate-certainty evidence) and may improve hip (femoral neck) bone mineral density (standardised effect size 0.09, 95% CI - 0.03 to 0.21, 14 trials, low-certainty evidence). Higher doses of physical activity and programs involving multiple exercise types or resistance exercise appear to be most effective. Typical programs for which significant intervention impacts were detected in trials were undertaken for 60+ mins, 2-3 times/week for 7+ months. Observational studies suggested a positive association between long-term total and planned physical activity on bone health.

Conclusions: Physical activity probably plays a role in the prevention of osteoporosis. The level of evidence is higher for effects of physical activity on lumbar spine bone mineral density than for hip. Higher dose programs and those involving multiple exercises and resistance exercises appear to be more effective.
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http://dx.doi.org/10.1186/s12966-020-01040-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690138PMC
November 2020

Swine cysticercosis and associated risk factors in non-technified pig breeding in semi-arid region of Sergipe state, Brazil.

Trop Anim Health Prod 2020 Nov 23;53(1):37. Epub 2020 Nov 23.

Department of Veterinary Medicine, Universidade Federal Rural de Pernambuco (UFRPE), Recife, PE, Brazil.

The aim of this study was to determine the frequency of Taenia solium anti-metacestode antibodies in slaughtered pigs in a semi-arid region of the "Alto Sertão" of Sergipe state, Brazil, and verify the risk factors associated with swine cysticercosis. For this, 230 samples of swine blood from two slaughterhouses were collected and analyzed by indirect ELISA. The pigs came from five non-technical properties in the semi-arid region of the Alto Sertão of Sergipe state. Searches for cysts in the skeletal muscles of the pigs were performed during slaughter. In addition, an epidemiological questionnaire was applied to the pigs' original properties to determine risk factors. Besides that, the official health services database was evaluated for confirmed cases of neurocysticercosis and taeniasis in humans in the last 5 years, living in the studied region. Seropositivity in pigs was 12.6%, with no significant difference between males and females. No cysts were found in the carcasses of the slaughtered pigs. A positive association was found for properties that discharge domestic sewage into the environment, in river or streams, increasing the risk of positivity by 5.72 times. When analyzing the database of official agencies, there were no records of cases of neurocysticercosis or taeniasis in the resident population in the last 5 years. However, there were frequent cases of idiopathic epilepsy. The results demonstrate that study area is endemic for swine cysticercosis and serves as a warning of the possibility of the occurrence of the taeniasis-cysticercosis complex.
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http://dx.doi.org/10.1007/s11250-020-02441-0DOI Listing
November 2020

Effects of the Dietary Inclusion of Buriti Oil on Lamb Performance, Carcass Traits, Digestibility, Nitrogen Balance, Ingestive Behavior and Blood Metabolites.

Animals (Basel) 2020 Oct 28;10(11). Epub 2020 Oct 28.

Department of Animal Science, Federal University of Bahia, Av. Adhemar de Barros, 500, Ondina, Salvador 40170110, Bahia, Brazil.

Buriti ( L.) oil (BO) is a byproduct that can be incorporated into the diet of lambs, thus increasing the energy density. The study aimed to evaluate the optimum BO inclusion level in lamb diets. Sixty-five Santa Ines lambs were distributed in two completely randomized experiments with five treatments each (BO inclusion at 0 (control), 12, 24, 36 and 48 g/kg dry matter (DM) total). The BO supplementation to partially replace ground corn linearly decreased the nutrient intake and digestibility of DM, ether extract and neutral detergent fiber (NDF), N° chews/bolus, DM and NDF rumination or eating efficiencies, the N intake and N balance, carcass weights and yields, and dressing content of lamb carcasses ( < 0.05). The addition of BO responded quadratically to DM eating efficiency and N-fecal and N-urinary excretion ( < 0.05). The linear response plateau (LRP) analysis demonstrated that the levels of 0 and 12 g/kg of BO were similar, and improved intake and digestibility and consequently performance ( < 0.001). There was a linear increase in feed efficiency and shrinkage after chilling with the BO inclusion replacing ground corn. The inclusion of 12 g/kg BO in the total DM of diet is recommended, because it improves feeding intake, digestibility and performance of lambs.
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http://dx.doi.org/10.3390/ani10111973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693342PMC
October 2020

Toxoplasma gondii and Neospora caninum infections and factors associated in goats in the Parana state, Southern Brazil.

Rev Bras Parasitol Vet 2020 9;29(4):e003620. Epub 2020 Oct 9.

Departamento de Medicina Veterinária Preventiva, Universidade Estadual de Londrina - UEL, Londrina, PR, Brasil.

The aim of this study was to determine the occurrence of anti-Toxoplasma gondii and anti-Neospora caninum antibodies and their associated factors among goats in farms from the Paraná state, South Brazil. The serological analysis was performed by indirect ELISA on 629 goat serum samples collected from 32 farms distributed in five mesorregions from the state. Seropositivity was observed in 30.7% of the animals for T. gondii, 6.3% for N. caninum, and 3.0% for both agents. Final multiple regression models showed that the use of assisted reproduction decreased the chance of seropositivity for T. gondii (PR=0.70) and the slaughtering site on the farm (PR=2.03) increased it. To N. caninum, the supplying concentrated feed to animals (OR=4.80) and animal pre-weaning death (OR=9.96) increased the chance of seropositivity. The variables associated with these seropositivities suggest deficiencies in sanitation and reproductive management. In addition, it recognizes critical points of infection for animal production management.
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http://dx.doi.org/10.1590/S1984-29612020076DOI Listing
January 2021

Yoga-based exercise to prevent falls in community-dwelling people aged 60 years and over: study protocol for the Successful AGEing (SAGE) yoga randomised controlled trial.

BMJ Open Sport Exerc Med 2020 29;6(1):e000878. Epub 2020 Sep 29.

Institute for Musculoskeletal Health, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.

Introduction: Falls significantly reduce independence and quality of life in older age. Balance-specific exercise prevents falls in people aged 60+ years. Yoga is growing in popularity and can provide a high challenge to balance; however, the effect of yoga on falls has not been evaluated. This trial aims to establish the effect on falls of a yoga exercise programme compared with a yoga relaxation programme in community-dwellers aged 60+ years.

Method And Analysis: This randomised controlled trial will involve 560 community-dwelling people aged 60+ years. Participants will be randomised to either: (1) the Successful AGEing () yoga exercise programme or (2) a yoga relaxation programme. Primary outcome is rate of falls in the 12 months post randomisation. Secondary outcomes include mental well-being, physical activity, health-related quality of life, balance self-confidence, physical function, pain, goal attainment and sleep quality at 12 months after randomisation. The number of falls per person-year will be analysed using negative binomial regression models to estimate between-group difference in fall rates. Generalised linear models will assess the effect of group allocation on the continuously scored secondary outcomes, adjusting for baseline scores. An economic analysis will compare the cost-effectiveness and cost-utility of the two yoga programmes.

Ethics And Dissemination: Protocol was approved by the Human Research Ethics Committee at The University of Sydney, Australia (approval 2019/604). Trial results will be disseminated via peer-reviewed articles, conference presentations, lay summaries.

Trial Registration Number: The protocol for this trial is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12619001183178).
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http://dx.doi.org/10.1136/bmjsem-2020-000878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534729PMC
September 2020