Julian Sale

Julian Sale

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Julian Sale

Publications by authors named "Julian Sale"

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PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells.

Mol Cell 2020 Feb 29;77(3):461-474.e9. Epub 2019 Oct 29.

Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007862PMC
February 2020

Replication of G Quadruplex DNA.

Genes (Basel) 2019 01 29;10(2). Epub 2019 Jan 29.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.

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http://dx.doi.org/10.3390/genes10020095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409989PMC
January 2019

Local epigenetic reprogramming induced by G-quadruplex ligands.

Nat Chem 2017 11 31;9(11):1110-1117. Epub 2017 Jul 31.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

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http://dx.doi.org/10.1038/nchem.2828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669467PMC
November 2017

The Effects of Replication Stress on S Phase Histone Management and Epigenetic Memory.

J Mol Biol 2017 06 19;429(13):2011-2029. Epub 2016 Nov 19.

Division of Protein & Nucleic Acid Chemistry, Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.11.011DOI Listing
June 2017

In vivo evidence for translesion synthesis by the replicative DNA polymerase δ.

Nucleic Acids Res 2016 09 16;44(15):7242-50. Epub 2016 May 16.

Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo-ku, Kyoto 606-8501, Japan

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkw439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009730PMC
September 2016

Starting over: Primpol reprimes after chain termination.

Authors:
Julian E Sale

Cell Cycle 2016 08 6;15(16):2099-2100. Epub 2016 Jul 6.

a MRC Laboratory of Molecular Biology , Cambridge , UK.

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http://dx.doi.org/10.1080/15384101.2016.1204855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993428PMC
August 2016

Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA.

EMBO J 2016 07 23;35(13):1452-64. Epub 2016 May 23.

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK

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http://dx.doi.org/10.15252/embj.201693958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883027PMC
July 2016

Editorial.

Expert Rev Mol Med 2016 May 10;18:e10. Epub 2016 May 10.

Department of Medicine,University of Cambridge,UK.

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http://dx.doi.org/10.1017/erm.2016.10DOI Listing
May 2016

The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability.

Cell Rep 2016 Apr 14;15(4):724-734. Epub 2016 Apr 14.

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.03.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850358PMC
April 2016

Directed evolution of human scFvs in DT40 cells.

Protein Eng Des Sel 2016 Feb 30;29(2):39-48. Epub 2015 Oct 30.

Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK

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http://dx.doi.org/10.1093/protein/gzv058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840456PMC
February 2016

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

Mol Cell 2016 Feb 31;61(3):449-460. Epub 2015 Dec 31.

Genome Stability and Tumourigenesis Group, CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747901PMC
February 2016

PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells.

Mol Cell 2016 Jan 25;61(1):161-9. Epub 2015 Nov 25.

Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.10.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712188PMC
January 2016

Clock-like mutational processes in human somatic cells.

Nat Genet 2015 Dec 9;47(12):1402-7. Epub 2015 Nov 9.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.3441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783858PMC
December 2015

Nucleotide Pool Depletion Induces G-Quadruplex-Dependent Perturbation of Gene Expression.

Cell Rep 2015 Dec 10;13(11):2491-2503. Epub 2015 Dec 10.

Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.11.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695339PMC
December 2015

REV7/MAD2L2: the multitasking maestro emerges as a barrier to recombination.

Authors:
Julian E Sale

EMBO J 2015 Jun 20;34(12):1609-11. Epub 2015 Apr 20.

MRC Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.15252/embj.201591697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475396PMC
June 2015

Contributions of the specialised DNA polymerases to replication of structured DNA.

DNA Repair (Amst) 2015 May 11;29:83-90. Epub 2015 Feb 11.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15687864150001
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http://dx.doi.org/10.1016/j.dnarep.2015.01.004DOI Listing
May 2015

Histone H3.3 is required to maintain replication fork progression after UV damage.

Curr Biol 2014 Sep 4;24(18):2195-2201. Epub 2014 Sep 4.

Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.07.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175177PMC
September 2014

Retrospective. Michael Neuberger (1953-2013).

Science 2013 Dec;342(6164):1335

MRC Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1126/science.1248808DOI Listing
December 2013

Directed evolution of an angiopoietin-2 ligand trap by somatic hypermutation and cell surface display.

J Biol Chem 2013 Nov 8;288(46):33205-12. Epub 2013 Oct 8.

From the Departments of Cardiovascular Sciences and Biochemistry, University of Leicester, Leicester LE1 9HN, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M113.510578
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http://dx.doi.org/10.1074/jbc.M113.510578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829167PMC
November 2013

Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset.

J Cell Biol 2013 Oct 7;203(1):87-100. Epub 2013 Oct 7.

Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, England, UK.

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http://dx.doi.org/10.1083/jcb.201302060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798251PMC
October 2013

Translesion DNA synthesis and mutagenesis in eukaryotes.

Authors:
Julian E Sale

Cold Spring Harb Perspect Biol 2013 Mar 1;5(3):a012708. Epub 2013 Mar 1.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a012708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578355PMC
March 2013

Monitoring I-SceI-induced double-strand break repair in DT40 cells.

Methods Mol Biol 2012 ;920:371-7

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1007/978-1-61779-998-3_26DOI Listing
January 2013

Measurement of diversification in the immunoglobulin light chain gene of DT40 cells.

Authors:
Julian E Sale

Methods Mol Biol 2012 ;920:417-32

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1007/978-1-61779-998-3_29DOI Listing
January 2013

Unwinding to recombine.

Mol Cell 2012 Aug;47(4):493-4

MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S10972765120069
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http://dx.doi.org/10.1016/j.molcel.2012.08.006DOI Listing
August 2012

Competition, collaboration and coordination--determining how cells bypass DNA damage.

Authors:
Julian E Sale

J Cell Sci 2012 Apr 12;125(Pt 7):1633-43. Epub 2012 Apr 12.

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1242/jcs.094748DOI Listing
April 2012

Propagation of histone marks and epigenetic memory during normal and interrupted DNA replication.

Cell Mol Life Sci 2012 Mar 2;69(5):697-716. Epub 2011 Oct 2.

Division of Protein and Nucleic Acid Chemistry, Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1007/s00018-011-0824-1DOI Listing
March 2012

Cellular epigenetic stability and cancer.

Trends Genet 2012 Mar 5;28(3):118-27. Epub 2012 Jan 5.

Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Hills Road, Cambridge, CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.tig.2011.11.005DOI Listing
March 2012

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA.

Nucleic Acids Res 2012 Feb 22;40(4):1485-98. Epub 2011 Oct 22.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1093/nar/gkr868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287192PMC
February 2012

Y-family DNA polymerases and their role in tolerance of cellular DNA damage.

Nat Rev Mol Cell Biol 2012 Feb 23;13(3):141-52. Epub 2012 Feb 23.

Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://www.nature.com/articles/nrm3289
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http://dx.doi.org/10.1038/nrm3289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630503PMC
February 2012

Epigenetic instability due to defective replication of structured DNA.

Mol Cell 2010 Dec;40(5):703-13

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.molcel.2010.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145961PMC
December 2010

The Werner's Syndrome protein collaborates with REV1 to promote replication fork progression on damaged DNA.

DNA Repair (Amst) 2010 Oct 5;9(10):1064-72. Epub 2010 Aug 5.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.dnarep.2010.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956782PMC
October 2010

Visualisation of PCNA monoubiquitination in vivo by single pass spectral imaging FRET microscopy.

PLoS One 2010 Feb 2;5(2):e9008. Epub 2010 Feb 2.

Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009008PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814862PMC
February 2010

Be prepared: DNA polymerase eta gets ready for action--in G1.

Cell Cycle 2009 Oct 15;8(20):3258-9. Epub 2009 Oct 15.

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October 2009

REV1 restrains DNA polymerase zeta to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo.

Nucleic Acids Res 2008 Dec 25;36(21):6767-80. Epub 2008 Oct 25.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, UK.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkn651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588525PMC
December 2008

The 9-1-1 DNA clamp is required for immunoglobulin gene conversion.

Mol Cell Biol 2008 Oct 28;28(19):6113-22. Epub 2008 Jul 28.

Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Yoshida-konoe, Sakyo-ku, Kyoto 606-8501, Japan.

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http://dx.doi.org/10.1128/MCB.00156-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2547007PMC
October 2008

PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40.

Mol Cell 2008 May;30(4):519-29

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S109727650800324
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http://dx.doi.org/10.1016/j.molcel.2008.03.024DOI Listing
May 2008

Analysis of DNA replication damage bypass and its role in immunoglobulin repertoire development.

Subcell Biochem 2006 ;40:271-94

M.R.C. Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH.

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http://dx.doi.org/10.1007/978-1-4020-4896-8_16DOI Listing
July 2007

Stable non-targeted transfection of DT40.

Authors:
Julian E Sale

Subcell Biochem 2006 ;40:341-4

M.R.C. Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1007/978-1-4020-4896-8_20DOI Listing
July 2007

Transient transfection of DT40.

Subcell Biochem 2006 ;40:379-82

M.R.C. Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1007/978-1-4020-4896-8_29DOI Listing
July 2007

Retroviral transduction of DT40.

Subcell Biochem 2006 ;40:383-6

M.R.C. Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1007/978-1-4020-4896-8_30DOI Listing
July 2007

Colony survival assay.

Subcell Biochem 2006 ;40:387-91

M.R.C. Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1007/978-1-4020-4896-8_31DOI Listing
July 2007

Subnuclear immunofluorescence.

Subcell Biochem 2006 ;40:395-8

M.R.C. Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH.

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http://dx.doi.org/10.1007/978-1-4020-4896-8_33DOI Listing
July 2007

Sister chromatid exchange assay.

Subcell Biochem 2006 ;40:399-403

M.R.C. Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1007/978-1-4020-4896-8_34DOI Listing
July 2007

2D cell cycle analysis.

Subcell Biochem 2006 ;40:405-8

M.R.C. Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1007/978-1-4020-4896-8_35DOI Listing
July 2007

Radiation resistance: resurrection by recombination.

Authors:
Julian E Sale

Curr Biol 2007 Jan;17(1):R12-4

MRC Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1016/j.cub.2006.11.037DOI Listing
January 2007

Role for RAD18 in homologous recombination in DT40 cells.

Mol Cell Biol 2006 Nov 21;26(21):8032-41. Epub 2006 Aug 21.

Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1128/MCB.01291-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636725PMC
November 2006

RAD18-independent ubiquitination of proliferating-cell nuclear antigen in the avian cell line DT40.

EMBO Rep 2006 Sep 4;7(9):927-32. Epub 2006 Aug 4.

Medical Research Council Laboratory of Molecular Biology, Division of Protein & Nucleic Acid Chemistry, Hills Road, Cambridge CB2 2QH, UK.

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http://embor.embopress.org/cgi/doi/10.1038/sj.embor.7400777
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http://dx.doi.org/10.1038/sj.embor.7400777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559672PMC
September 2006

REV3 and REV1 play major roles in recombination-independent repair of DNA interstrand cross-links mediated by monoubiquitinated proliferating cell nuclear antigen (PCNA).

J Biol Chem 2006 May 29;281(20):13869-72. Epub 2006 Mar 29.

Department of Experimental Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.C600071200DOI Listing
May 2006

The catalytic activity of REV1 is employed during immunoglobulin gene diversification in DT40.

Mol Immunol 2006 Apr 2;43(10):1587-94. Epub 2005 Nov 2.

Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Hills Road, Cambridge, CB2 2QH, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S016158900500352
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http://dx.doi.org/10.1016/j.molimm.2005.09.017DOI Listing
April 2006

UBE2V2 (MMS2) is not required for effective immunoglobulin gene conversion or DNA damage tolerance in DT40.

DNA Repair (Amst) 2005 Apr 21;4(4):503-10. Epub 2005 Jan 21.

MRC Laboratory of Molecular Biology, Division of Protein & Nucleic Acid Chemistry, Hills Road, Cambridge, CB2 2QH, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S156878640400349
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http://dx.doi.org/10.1016/j.dnarep.2004.12.002DOI Listing
April 2005

Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1.

Nucleic Acids Res 2005 1;33(4):1280-9. Epub 2005 Mar 1.

Medical Research Council Laboratory of Molecular Biology Hills Road, Cambridge, CB2 2QH, UK.

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http://dx.doi.org/10.1093/nar/gki279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC552965PMC
March 2005

Immunoglobulin diversification in DT40: a model for vertebrate DNA damage tolerance.

Authors:
Julian E Sale

DNA Repair (Amst) 2004 Jul;3(7):693-702

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1016/j.dnarep.2004.03.042DOI Listing
July 2004

Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line.

EMBO J 2003 Apr;22(7):1654-64

Medical Research Council Laboratory of Molecular Biology, Division of Protein & Nucleic Acid Chemistry, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1093/emboj/cdg161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152905PMC
April 2003

Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines.

Nat Biotechnol 2002 Nov 15;20(11):1129-34. Epub 2002 Oct 15.

Medical Research Laboratory of Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://www.nature.com/articles/nbt752
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http://dx.doi.org/10.1038/nbt752DOI Listing
November 2002

AID is essential for immunoglobulin V gene conversion in a cultured B cell line.

Curr Biol 2002 Mar;12(5):435-8

Medical Research Council Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/s0960-9822(02)00717-0DOI Listing
March 2002