Julian L Griffin

Julian L Griffin

UNVERIFIED PROFILE

Are you Julian L Griffin?   Register this Author

Register author
Julian L Griffin

Julian L Griffin

Publications by authors named "Julian L Griffin"

Are you Julian L Griffin?   Register this Author

100Publications

2778Reads

21Profile Views

A model for determining cardiac mitochondrial substrate utilisation using stable C-labelled metabolites.

Metabolomics 2019 Nov 26;15(12):154. Epub 2019 Nov 26.

Department of Biochemistry and the Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11306-019-1618-yDOI Listing
November 2019

A Combination of Metabolites Predicts Adherence to the Mediterranean Diet Pattern and Its Associations with Insulin Sensitivity and Lipid Homeostasis in the General Population: The Fenland Study, United Kingdom.

J Nutr 2019 Oct 26. Epub 2019 Oct 26.

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jn/nxz263DOI Listing
October 2019

A Comprehensive UHPLC Ion Mobility Quadrupole Time-of-Flight Method for Profiling and Quantification of Eicosanoids, Other Oxylipins, and Fatty Acids.

Anal Chem 2019 Jul 18;91(13):8025-8035. Epub 2019 Jun 18.

Department of Biochemistry and Cambridge Systems Biology Centre , University of Cambridge , Cambridge CB2 1GA , United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.8b04615DOI Listing
July 2019

XBP-1 Remodels Lipid Metabolism to Extend Longevity.

Cell Rep 2019 Jul;28(3):581-589.e4

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.06.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656787PMC
July 2019

Dysbiosis associated with acute helminth infections in herbivorous youngstock - observations and implications.

Sci Rep 2019 Jul 31;9(1):11121. Epub 2019 Jul 31.

Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-47204-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668452PMC
July 2019

Inter-individual variability in the production of flavan-3-ol colonic metabolites: preliminary elucidation of urinary metabotypes.

Eur J Nutr 2019 Jun 3;58(4):1529-1543. Epub 2018 Apr 3.

Human Nutrition Unit, Department of Food and Drugs, University of Parma, Medical School Building C, Via Volturno, 39, 43125, Parma, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00394-018-1683-4DOI Listing
June 2019

A dietary pattern derived using B-vitamins and its relationship with vascular markers over the life course.

Clin Nutr 2019 Jun 28;38(3):1464-1473. Epub 2018 Jun 28.

MRC Elsie Widdowson Laboratory, Cambridge CB1 9NL, United Kingdom; NNEdPro Global Centre for Nutrition and Health (Affiliated with: Cambridge University Health Partners, Wolfson College Cambridge and the British Dietetic Association), St John's Innovation Centre, Cowley Road, Cambridge CB4 0WS, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clnu.2018.06.969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546956PMC
June 2019

A randomized 3-way crossover study indicates that high-protein feeding induces de novo lipogenesis in healthy humans.

JCI Insight 2019 Jun 30;4(12). Epub 2019 May 30.

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/jci.insight.124819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629161PMC
June 2019

The Metabolomics Society-Current State of the Membership and Future Directions.

Metabolites 2019 May 3;9(5). Epub 2019 May 3.

Bioinformatics Group, Plant Sciences Group, Wageningen University, 6708 PB Wageningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/metabo9050089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572628PMC
May 2019

Ice-Age Climate Adaptations Trap the Alpine Marmot in a State of Low Genetic Diversity.

Curr Biol 2019 May 9;29(10):1712-1720.e7. Epub 2019 May 9.

Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK; Department of Biochemistry, Charitè, Am Chariteplatz 1, 10117 Berlin, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2019.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538971PMC
May 2019

Metabolic Profiling of the Diabetic Heart: Toward a Richer Picture.

Front Physiol 2019 31;10:639. Epub 2019 May 31.

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2019.00639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555155PMC
May 2019

Ten years of Genome Medicine.

Genome Med 2019 02 15;11(1). Epub 2019 Feb 15.

Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstraße, 70376, Stuttgart, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13073-019-0618-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376775PMC
February 2019

NMR-Based Metabolomics in Cardiac Research.

Methods Mol Biol 2019 ;2037:189-194

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-9690-2_11DOI Listing
January 2019

Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs.

Circulation 2018 11;138(21):2367-2378

Department of Systems Pharmacology and Translational Therapeutics and the Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, Philadelphia, PA (E.R., S.Y.T., D.M., S.D.R., H.M., X.L., N.F.L., A.M.W., G.A.F.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.118.033540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291350PMC
November 2018

Deletion of Stearoyl-CoA Desaturase-1 From the Intestinal Epithelium Promotes Inflammation and Tumorigenesis, Reversed by Dietary Oleate.

Gastroenterology 2018 11 29;155(5):1524-1538.e9. Epub 2018 Jul 29.

Clinica Medica Cesare Frugoni, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italia; IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italia. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00165085183482
Publisher Site
http://dx.doi.org/10.1053/j.gastro.2018.07.032DOI Listing
November 2018

Metabolomic Alterations in Thyrospheres and Adherent Parental Cells in Papillary Thyroid Carcinoma Cell Lines: A Pilot Study.

Int J Mol Sci 2018 Sep 27;19(10). Epub 2018 Sep 27.

Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms19102948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213810PMC
September 2018

KniMet: a pipeline for the processing of chromatography-mass spectrometry metabolomics data.

Metabolomics 2018 16;14(4):52. Epub 2018 Mar 16.

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11306-018-1349-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856871PMC
March 2018

The potential of Ion Mobility Mass Spectrometry for high-throughput and high-resolution lipidomics.

Curr Opin Chem Biol 2018 02 13;42:42-50. Epub 2017 Nov 13.

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbpa.2017.10.018DOI Listing
February 2018

Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes.

PLoS Pathog 2018 01 29;14(1):e1006835. Epub 2018 Jan 29.

Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, SE, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1006835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805360PMC
January 2018

The use of stable isotopes in the study of human pathophysiology.

Int J Biochem Cell Biol 2017 12 20;93:102-109. Epub 2017 Jul 20.

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biocel.2017.07.012DOI Listing
December 2017

Metabolomics applied to diabetes-lessons from human population studies.

Int J Biochem Cell Biol 2017 12 23;93:136-147. Epub 2017 Oct 23.

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biocel.2017.10.011DOI Listing
December 2017

How to bridge metabolomics and genomics.

Int J Biochem Cell Biol 2017 12 8;93:87-88. Epub 2017 Nov 8.

University of Cambridge, Cambridge, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biocel.2017.11.001DOI Listing
December 2017

Lipidomics Profiling of Human Adipose Tissue Identifies a Pattern of Lipids Associated with Fish Oil Supplementation.

J Proteome Res 2017 09 16;16(9):3168-3179. Epub 2017 Aug 16.

MRC Human Nutrition Research, Elsie Widdowson Laboratory , Cambridge CB1 9NL, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.7b00161DOI Listing
September 2017

: an R package for annotation and interpretation of mass spectrometry imaging data for lipidomics.

Metabolomics 2017 21;13(11):128. Epub 2017 Sep 21.

MRC Human Nutrition Research, 120 Fulbourn Road, Cambridge, CB1 9NL UK.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11306-017-1252-5
Publisher Site
http://dx.doi.org/10.1007/s11306-017-1252-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608769PMC
September 2017

Alterations in endo-lysosomal function induce similar hepatic lipid profiles in rodent models of drug-induced phospholipidosis and Sandhoff disease.

J Lipid Res 2017 07 4;58(7):1306-1314. Epub 2017 Apr 4.

Department of Biochemistry, Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.M073395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496029PMC
July 2017

Liquid Extraction Surface Analysis Mass Spectrometry Method for Identifying the Presence and Severity of Nonalcoholic Fatty Liver Disease.

Anal Chem 2017 05 19;89(9):5161-5170. Epub 2017 Apr 19.

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge , 80 Tennis Court Road, Cambridge CB2 1GA, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.7b01097DOI Listing
May 2017

IsotopicLabelling: an R package for the analysis of MS isotopic patterns of labelled analytes.

Bioinformatics 2017 01 14;33(2):300-302. Epub 2016 Sep 14.

Edmund Mach Foundation, Research and Innovation Centre, Computational Biology Unit, I-38010 San Michele All'Adige (TN), Italy.

View Article

Download full-text PDF

Source
https://academic.oup.com/bioinformatics/article-lookup/doi/1
Publisher Site
http://dx.doi.org/10.1093/bioinformatics/btw588DOI Listing
January 2017

Integration of metabolomics, lipidomics and clinical data using a machine learning method.

BMC Bioinformatics 2016 Nov 22;17(Suppl 15):440. Epub 2016 Nov 22.

Medical Research Council, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB1 9NL, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12859-016-1292-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133491PMC
November 2016

Metabolomics dataset of PPAR-pan treated rat liver.

Data Brief 2016 Sep 10;8:196-202. Epub 2016 May 10.

Medical Research Council, Human Nutrition Research, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge CB1 9NL, UK; The Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK; The Cambridge Systems Biology Centre (CSBC), University of Cambridge, Cambridge CB2 1QR, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dib.2016.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898904PMC
September 2016

Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer.

Cancer Res 2016 08 22;76(16):4608-18. Epub 2016 Jun 22.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom. MRC Human Nutrition Research, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-15-3403DOI Listing
August 2016

PPAR-pan activation induces hepatic oxidative stress and lipidomic remodelling.

Free Radic Biol Med 2016 06 30;95:357-68. Epub 2015 Nov 30.

Medical Research Council, Human Nutrition Research, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge CB1 9NL, UK; The Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK; The Cambridge Systems Biology Centre (CSBC), University of Cambridge, Cambridge CB2 1QR, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2015.11.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891066PMC
June 2016

De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose.

Biol Rev Camb Philos Soc 2016 May 4;91(2):452-68. Epub 2015 Mar 4.

MRC Human Nutrition Research, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge CB1 9NL, U.K.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/brv.12178
Publisher Site
http://dx.doi.org/10.1111/brv.12178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832395PMC
May 2016

Mechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes.

Genome Med 2015 28;7:63. Epub 2015 Jun 28.

MRC Human Nutrition Research, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB1 9NL UK ; Department of Biochemistry and the Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13073-015-0179-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535665PMC
May 2016

Blood triacylglycerols: a lipidomic window on diet and disease.

Biochem Soc Trans 2016 Apr;44(2):638-44

Medical Research Council Human Nutrition Research, 120 Fulbourn Road, Cambridge CB1 9NL, U.K. Department of Biochemistry, Tennis Court Road, University of Cambridge, Cambridge CB2 1GA, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BST20150235DOI Listing
April 2016

Response to Comment on Lee et al. Diabetes 2015;64:2836-2846. Comment on Roberts et al. Diabetes 2015;64:471-484.

Diabetes 2016 Mar;65(3):e16

Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, U.K. Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, U.K.

View Article

Download full-text PDF

Source
http://diabetes.diabetesjournals.org/lookup/doi/10.2337/dbi1
Publisher Site
http://dx.doi.org/10.2337/dbi15-0024DOI Listing
March 2016

MetaboLights: An Open-Access Database Repository for Metabolomics Data.

Curr Protoc Bioinformatics 2016 Mar 24;53:14.13.1-14.13.18. Epub 2016 Mar 24.

European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/0471250953.bi1413s53DOI Listing
March 2016

A targeted metabolomics assay for cardiac metabolism and demonstration using a mouse model of dilated cardiomyopathy.

Metabolomics 2016;12:59. Epub 2016 Mar 7.

The Department of Biochemistry & The Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA UK ; The Elsie Widdowson Laboratory, Medical Research Council Human Nutrition Research, 120 Fulbourn Road, Cambridge, CB1 9NL UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11306-016-0956-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781888PMC
March 2016

Dietary inorganic nitrate: From villain to hero in metabolic disease?

Mol Nutr Food Res 2016 Jan 26;60(1):67-78. Epub 2015 Aug 26.

Elsie Widdowson Laboratory, Medical Research Council - Human Nutrition Research, Cambridge, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/mnfr.201500153
Publisher Site
http://dx.doi.org/10.1002/mnfr.201500153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863140PMC
January 2016

Conditional iron and pH-dependent activity of a non-enzymatic glycolysis and pentose phosphate pathway.

Sci Adv 2016 Jan 15;2(1):e1501235. Epub 2016 Jan 15.

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.; The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London NW7 1AA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciadv.1501235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730858PMC
January 2016

From genomic medicine to precision medicine: highlights of 2015.

Genome Med 2016 Jan 29;8(1):12. Epub 2016 Jan 29.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376, Stuttgart, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13073-016-0265-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733269PMC
January 2016

Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6.

Cell Rep 2015 Dec 25;13(10):2039-47. Epub 2015 Nov 25.

University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22111247150129
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2015.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688035PMC
December 2015

Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance.

Sci Rep 2015 Dec 17;5:18366. Epub 2015 Dec 17.

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, MDU MRC. Addenbrooke's Hospital, Cambridge, CB2 0QQ.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep18366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683622PMC
December 2015

Hyphenating size-exclusion chromatography with electrospray mass spectrometry; using on-line liquid-liquid extraction to study the lipid composition of lipoprotein particles.

Rapid Commun Mass Spectrom 2015 Nov;29(21):1969-76

Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB1 9NL, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/rcm.7301
Publisher Site
http://dx.doi.org/10.1002/rcm.7301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973665PMC
November 2015

NMR-Based Metabolomics Separates the Distinct Stages of Disease in a Chronic Relapsing Model of Multiple Sclerosis.

J Neuroimmune Pharmacol 2015 Sep 9;10(3):435-44. Epub 2015 Jul 9.

Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, Radiobiology Research Institute, Churchill Hospital, University of Oxford, Oxford, OX3 7LJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11481-015-9622-0DOI Listing
September 2015

Regulation of mitochondrial morphology and function by stearoylation of TFR1.

Nature 2015 Sep 27;525(7567):124-8. Epub 2015 Jul 27.

German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature14601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561519PMC
September 2015

Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD.

Semin Liver Dis 2015 Aug 17;35(3):250-61. Epub 2015 Sep 17.

Department of Clinical Biochemistry and University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0035-1562945
Publisher Site
http://dx.doi.org/10.1055/s-0035-1562945DOI Listing
August 2015

Comprehensive Metabolic Profiling of Age-Related Mitochondrial Dysfunction in the High-Fat-Fed ob/ob Mouse Heart.

J Proteome Res 2015 Jul 22;14(7):2849-62. Epub 2015 Jun 22.

‡MRC, Human Nutrition Research, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB1 9NL, U.K.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.jproteome.5b00128
Publisher Site
http://dx.doi.org/10.1021/acs.jproteome.5b00128DOI Listing
July 2015

Quorum Sensing Is Accompanied by Global Metabolic Changes in the Opportunistic Human Pathogen Pseudomonas aeruginosa.

J Bacteriol 2015 Jun 13;197(12):2072-82. Epub 2015 Apr 13.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

View Article

Download full-text PDF

Source
http://jb.asm.org/lookup/doi/10.1128/JB.02557-14
Publisher Site
http://dx.doi.org/10.1128/JB.02557-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438216PMC
June 2015

Mitochondrial responses to extreme environments: insights from metabolomics.

Extrem Physiol Med 2015 4;4. Epub 2015 May 4.

Centre of Human & Aerospace Physiological Sciences, King's College London, London, UK ; Fibrosis Drug Performance Unit, GlaxoSmithKline Medicines Research Centre, Stevenage, UK.

View Article

Download full-text PDF

Source
http://extremephysiolmed.biomedcentral.com/articles/10.1186/
Publisher Site
http://dx.doi.org/10.1186/s13728-015-0026-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422479PMC
May 2015

Suppression of erythropoiesis by dietary nitrate.

FASEB J 2015 Mar 24;29(3):1102-12. Epub 2014 Nov 24.

*Department of Physiology, Development, and Neuroscience and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom; and Faculty of Medicine, Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.14-263004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422362PMC
March 2015

Inorganic nitrate promotes the browning of white adipose tissue through the nitrate-nitrite-nitric oxide pathway.

Diabetes 2015 Feb 23;64(2):471-484. Epub 2014 Sep 23.

Medical Research Council - Human Nutrition Research, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB2 9NL, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db14-0496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351918PMC
February 2015

A role for vaccinia virus protein C16 in reprogramming cellular energy metabolism.

J Gen Virol 2015 Feb 28;96(Pt 2):395-407. Epub 2014 Oct 28.

Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK

View Article

Download full-text PDF

Source
http://jgv.microbiologyresearch.org/content/journal/jgv/10.1
Publisher Site
http://dx.doi.org/10.1099/vir.0.069591-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298679PMC
February 2015

Does our gut microbiome predict cardiovascular risk? A review of the evidence from metabolomics.

Circ Cardiovasc Genet 2015 Feb;8(1):187-91

From the Department of Lipid Profiling and Signalling, MRC Human Nutrition Research, Elsie Widdowson Laboratory (J.L.G., X.W., E.S.); and Department of Biochemistry, Cambridge Systems Biology Centre (J.L.G., X.W.), University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/CIRCGENETICS.114.000
Publisher Site
http://dx.doi.org/10.1161/CIRCGENETICS.114.000219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333723PMC
February 2015

Metabolomic analysis of akt1-mediated muscle hypertrophy in models of diet-induced obesity and age-related fat accumulation.

J Proteome Res 2015 Jan 22;14(1):342-52. Epub 2014 Oct 22.

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge , Cambridge CB2 1GA, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/pr500756uDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286153PMC
January 2015

Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy.

Circ Cardiovasc Imaging 2014 Nov 8;7(6):895-904. Epub 2014 Sep 8.

Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom (M.S.D., H.J.A., C.A.C., G.K.R., K.C., L.C.H., D.J.T.); Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom (D.J.S.); and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom (J.A.W., J.L.G.).

View Article

Download full-text PDF

Source
http://heart.bmj.com/content/99/suppl_2/A118.1.full.pdf
Web Search
http://circimaging.ahajournals.org/cgi/doi/10.1161/CIRCIMAGI
Publisher Site
http://dx.doi.org/10.1161/CIRCIMAGING.114.001857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450075PMC
November 2014

Methods for performing lipidomics in white adipose tissue.

Methods Enzymol 2014 ;538:211-31

MRC Human Nutrition Research, The Elsie Widdowson Laboratory, Cambridge, United Kingdom; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/B97801280028030
Publisher Site
http://dx.doi.org/10.1016/B978-0-12-800280-3.00012-8DOI Listing
October 2014

Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes.

Mol Cell Biol 2014 Oct 4;34(20):3800-16. Epub 2014 Aug 4.

Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom

View Article

Download full-text PDF

Source
http://mcb.asm.org/cgi/doi/10.1128/MCB.00110-14
Publisher Site
http://dx.doi.org/10.1128/MCB.00110-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187719PMC
October 2014

A type 2 biomarker separates relapsing-remitting from secondary progressive multiple sclerosis.

Neurology 2014 Oct 24;83(17):1492-9. Epub 2014 Sep 24.

From the CR-UK/MRC Gray Institute for Radiation Oncology and Biology (A.M.D., J.R.L., N.R.S.), Department of Pharmacology (A.M.D., D.C.A.), Department of Chemistry (A.M.D., B.G.D., T.D.W.C.), Nuffield Department of Clinical Neurosciences (A.C., L.M., M.R.T.), and Nuffield Department of Medicine (G.K.W.), University of Oxford; and the Department of Biochemistry (J.L.G., J.P.), University of Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000000905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222850PMC
October 2014

The development and validation of a fast and robust dried blood spot based lipid profiling method to study infant metabolism.

Metabolomics 2014 11;10(5):1018-1025. Epub 2014 Feb 11.

Department of Paediatrics, Addenbrooke's Hospital, University of Cambridge, Cambridge, CB2 0QQ UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11306-014-0628-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145199PMC
February 2014

Towards metabolic biomarkers of insulin resistance and type 2 diabetes: progress from the metabolome.

Lancet Diabetes Endocrinol 2014 Jan 3;2(1):65-75. Epub 2013 Dec 3.

Medical Research Council (MRC) Human Nutrition Research (HNR), Cambridge CB1 9NL, UK; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-8587(13)70143-8DOI Listing
January 2014

A metabolomics investigation of non-genotoxic carcinogenicity in the rat.

J Proteome Res 2013 Dec 7;12(12):5775-90. Epub 2013 Nov 7.

Medical Research Council Human Nutrition Research (MRC HNR), Elsie Widdowson Laboratory , 120 Fulbourn Road, Cambridge CB1 9NL, U.K. , The Department of Biochemistry, University of Cambridge , 80 Tennis Court Road, Cambridge CB2 1GA, U.K. , and Cambridge Systems Biology Centre (CSBC), University of Cambridge , Cambridge CB2 1QR, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/pr4007766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980845PMC
December 2013

Betaine acts on a ligand-gated ion channel in the nervous system of the nematode C. elegans.

Nat Neurosci 2013 Dec 10;16(12):1794-801. Epub 2013 Nov 10.

1] Department of Biology and Howard Hughes Medical Institute, University of Utah, Utah, USA. [2].

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nn.3575
Publisher Site
http://dx.doi.org/10.1038/nn.3575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955162PMC
December 2013