Publications by authors named "Julian L Griffin"

100Publications

Metabolomic Analysis in Inflammatory Bowel Disease: A Systematic Review.

J Crohns Colitis 2020 Nov 11. Epub 2020 Nov 11.

Department of Metabolism Digestion and Reproduction, Imperial College London, United Kingdom.

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November 2020

Downregulation of Keap1 Confers Features of a Fasted Metabolic State.

iScience 2020 Oct 6;23(10):101638. Epub 2020 Oct 6.

Jacqui Wood Cancer Centre, Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee, Scotland DD1 9SY, UK.

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October 2020

Unnecessary obstacles to COVID-19 mass testing.

Lancet 2020 11 16;396(10263):1633. Epub 2020 Oct 16.

Faculty of Medicine, Imperial College London, London, UK.

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November 2020

Myc linked to dysregulation of cholesterol transport and storage in nonsmall cell lung cancer.

J Lipid Res 2020 Nov 4;61(11):1390-1399. Epub 2020 Aug 4.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

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November 2020

Consequences of Lipid Remodeling of Adipocyte Membranes Being Functionally Distinct from Lipid Storage in Obesity.

J Proteome Res 2020 10 31;19(10):3919-3935. Epub 2020 Aug 31.

Department of Biochemistry & Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, U.K.

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October 2020

hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice.

Mol Genet Metab Rep 2020 Jun 24;23:100580. Epub 2020 Mar 24.

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.

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June 2020

Effects of Germline VHL Deficiency on Growth, Metabolism, and Mitochondria.

N Engl J Med 2020 02;382(9):835-844

From the Departments of Woman, Child, and General and Specialized Surgery (S.P., D.R., M. Caiazza, S.S., I.T., M. Casale), Precision Medicine (D.B., E.S., A.B., F.D.R.), and Advanced Medical and Surgical Sciences (A.A.S.), University of Campania Luigi Vanvitelli, Naples, and the Departments of Pharmacology and Biomolecular Science, University of Milan, Milan (P.C., A.M.R.) - both in Italy; the Departments of Physiology, Development, and Neuroscience (K.A.O., A.J.M.) and Biochemistry (J.A.W., J.L.G.), University of Cambridge, Cambridge, the Centre for Ultrastructural Imaging (L.A., R.A.F.) and the Centre for Human and Applied Physiological Sciences, Faculty of Life Sciences and Medicine (F.F.), King's College London, London, and the Department of Physiology, Anatomy, and Genetics (P.A.R., F.F.) and Nuffield Division of Anaesthetics (F.F.), University of Oxford, Oxford - all in the United Kingdom; and the Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia (C.F.-A.).

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February 2020

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle.

Cell 2020 01;180(2):278-295.e23

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. Electronic address:

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January 2020

Twenty years of metabonomics: so what has metabonomics done for toxicology?

Authors:
Julian L Griffin

Xenobiotica 2020 Jan 12;50(1):110-114. Epub 2019 Dec 12.

Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Medicine, Imperial College London, The Sir Alexander Fleming Building, London, UK.

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January 2020

A model for determining cardiac mitochondrial substrate utilisation using stable C-labelled metabolites.

Metabolomics 2019 11 26;15(12):154. Epub 2019 Nov 26.

Department of Biochemistry and the Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK.

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November 2019

NMR-Based Metabolomics in Cardiac Research.

Methods Mol Biol 2019 ;2037:189-194

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK.

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April 2020

Dysbiosis associated with acute helminth infections in herbivorous youngstock - observations and implications.

Sci Rep 2019 07 31;9(1):11121. Epub 2019 Jul 31.

Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.

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July 2019

XBP-1 Remodels Lipid Metabolism to Extend Longevity.

Cell Rep 2019 07;28(3):581-589.e4

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK. Electronic address:

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July 2019

Metabolic Profiling of the Diabetic Heart: Toward a Richer Picture.

Front Physiol 2019 31;10:639. Epub 2019 May 31.

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.

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May 2019

A randomized 3-way crossover study indicates that high-protein feeding induces de novo lipogenesis in healthy humans.

JCI Insight 2019 06 30;4(12). Epub 2019 May 30.

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom.

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June 2019

Ice-Age Climate Adaptations Trap the Alpine Marmot in a State of Low Genetic Diversity.

Curr Biol 2019 05 9;29(10):1712-1720.e7. Epub 2019 May 9.

Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK; Department of Biochemistry, Charitè, Am Chariteplatz 1, 10117 Berlin, Germany. Electronic address:

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May 2019

The Metabolomics Society-Current State of the Membership and Future Directions.

Metabolites 2019 May 3;9(5). Epub 2019 May 3.

Bioinformatics Group, Plant Sciences Group, Wageningen University, 6708 PB Wageningen, The Netherlands.

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May 2019

Ten years of Genome Medicine.

Genome Med 2019 02 15;11(1). Epub 2019 Feb 15.

Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstraße, 70376, Stuttgart, Germany.

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February 2019

Metabolomic Alterations in Thyrospheres and Adherent Parental Cells in Papillary Thyroid Carcinoma Cell Lines: A Pilot Study.

Int J Mol Sci 2018 Sep 27;19(10). Epub 2018 Sep 27.

Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.

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September 2018

Deletion of Stearoyl-CoA Desaturase-1 From the Intestinal Epithelium Promotes Inflammation and Tumorigenesis, Reversed by Dietary Oleate.

Gastroenterology 2018 11 29;155(5):1524-1538.e9. Epub 2018 Jul 29.

Clinica Medica Cesare Frugoni, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italia; IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italia. Electronic address:

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November 2018

A dietary pattern derived using B-vitamins and its relationship with vascular markers over the life course.

Clin Nutr 2019 06 28;38(3):1464-1473. Epub 2018 Jun 28.

MRC Elsie Widdowson Laboratory, Cambridge CB1 9NL, United Kingdom; NNEdPro Global Centre for Nutrition and Health (Affiliated with: Cambridge University Health Partners, Wolfson College Cambridge and the British Dietetic Association), St John's Innovation Centre, Cowley Road, Cambridge CB4 0WS, United Kingdom. Electronic address:

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June 2019

Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs.

Circulation 2018 11;138(21):2367-2378

Department of Systems Pharmacology and Translational Therapeutics and the Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, Philadelphia, PA (E.R., S.Y.T., D.M., S.D.R., H.M., X.L., N.F.L., A.M.W., G.A.F.).

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November 2018

Inter-individual variability in the production of flavan-3-ol colonic metabolites: preliminary elucidation of urinary metabotypes.

Eur J Nutr 2019 Jun 3;58(4):1529-1543. Epub 2018 Apr 3.

Human Nutrition Unit, Department of Food and Drugs, University of Parma, Medical School Building C, Via Volturno, 39, 43125, Parma, Italy.

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June 2019

KniMet: a pipeline for the processing of chromatography-mass spectrometry metabolomics data.

Metabolomics 2018 16;14(4):52. Epub 2018 Mar 16.

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK.

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March 2018

Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes.

PLoS Pathog 2018 01 29;14(1):e1006835. Epub 2018 Jan 29.

Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, SE, Sweden.

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January 2018

The potential of Ion Mobility Mass Spectrometry for high-throughput and high-resolution lipidomics.

Curr Opin Chem Biol 2018 02 13;42:42-50. Epub 2017 Nov 13.

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, UK. Electronic address:

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February 2018

How to bridge metabolomics and genomics.

Int J Biochem Cell Biol 2017 12 8;93:87-88. Epub 2017 Nov 8.

University of Cambridge, Cambridge, United Kingdom. Electronic address:

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December 2017

Metabolomics applied to diabetes-lessons from human population studies.

Int J Biochem Cell Biol 2017 12 23;93:136-147. Epub 2017 Oct 23.

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.

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December 2017

: an R package for annotation and interpretation of mass spectrometry imaging data for lipidomics.

Metabolomics 2017 21;13(11):128. Epub 2017 Sep 21.

MRC Human Nutrition Research, 120 Fulbourn Road, Cambridge, CB1 9NL UK.

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September 2017

The use of stable isotopes in the study of human pathophysiology.

Int J Biochem Cell Biol 2017 12 20;93:102-109. Epub 2017 Jul 20.

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK. Electronic address:

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December 2017

Alterations in endo-lysosomal function induce similar hepatic lipid profiles in rodent models of drug-induced phospholipidosis and Sandhoff disease.

J Lipid Res 2017 07 4;58(7):1306-1314. Epub 2017 Apr 4.

Department of Biochemistry, Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom

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July 2017

Liquid Extraction Surface Analysis Mass Spectrometry Method for Identifying the Presence and Severity of Nonalcoholic Fatty Liver Disease.

Anal Chem 2017 05 19;89(9):5161-5170. Epub 2017 Apr 19.

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge , 80 Tennis Court Road, Cambridge CB2 1GA, U.K.

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May 2017

Integration of metabolomics, lipidomics and clinical data using a machine learning method.

BMC Bioinformatics 2016 Nov 22;17(Suppl 15):440. Epub 2016 Nov 22.

Medical Research Council, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB1 9NL, UK.

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November 2016

IsotopicLabelling: an R package for the analysis of MS isotopic patterns of labelled analytes.

Bioinformatics 2017 01 14;33(2):300-302. Epub 2016 Sep 14.

Edmund Mach Foundation, Research and Innovation Centre, Computational Biology Unit, I-38010 San Michele All'Adige (TN), Italy.

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January 2017

Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer.

Cancer Res 2016 08 22;76(16):4608-18. Epub 2016 Jun 22.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom. MRC Human Nutrition Research, Cambridge, United Kingdom.

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August 2016

Metabolomics dataset of PPAR-pan treated rat liver.

Data Brief 2016 Sep 10;8:196-202. Epub 2016 May 10.

Medical Research Council, Human Nutrition Research, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge CB1 9NL, UK; The Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK; The Cambridge Systems Biology Centre (CSBC), University of Cambridge, Cambridge CB2 1QR, UK.

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September 2016

A targeted metabolomics assay for cardiac metabolism and demonstration using a mouse model of dilated cardiomyopathy.

Metabolomics 2016;12:59. Epub 2016 Mar 7.

The Department of Biochemistry & The Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA UK ; The Elsie Widdowson Laboratory, Medical Research Council Human Nutrition Research, 120 Fulbourn Road, Cambridge, CB1 9NL UK.

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March 2016

Blood triacylglycerols: a lipidomic window on diet and disease.

Biochem Soc Trans 2016 Apr;44(2):638-44

Medical Research Council Human Nutrition Research, 120 Fulbourn Road, Cambridge CB1 9NL, U.K. Department of Biochemistry, Tennis Court Road, University of Cambridge, Cambridge CB2 1GA, U.K.

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April 2016

MetaboLights: An Open-Access Database Repository for Metabolomics Data.

Curr Protoc Bioinformatics 2016 Mar 24;53:14.13.1-14.13.18. Epub 2016 Mar 24.

European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, United Kingdom.

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March 2016

Response to Comment on Lee et al. Diabetes 2015;64:2836-2846. Comment on Roberts et al. Diabetes 2015;64:471-484.

Diabetes 2016 Mar;65(3):e16

Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, U.K. Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, U.K.

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March 2016

From genomic medicine to precision medicine: highlights of 2015.

Genome Med 2016 Jan 29;8(1):12. Epub 2016 Jan 29.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376, Stuttgart, Germany.

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January 2016

Conditional iron and pH-dependent activity of a non-enzymatic glycolysis and pentose phosphate pathway.

Sci Adv 2016 Jan 15;2(1):e1501235. Epub 2016 Jan 15.

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.; The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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January 2016

Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance.

Sci Rep 2015 Dec 17;5:18366. Epub 2015 Dec 17.

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, MDU MRC. Addenbrooke's Hospital, Cambridge, CB2 0QQ.

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December 2015

PPAR-pan activation induces hepatic oxidative stress and lipidomic remodelling.

Free Radic Biol Med 2016 06 30;95:357-68. Epub 2015 Nov 30.

Medical Research Council, Human Nutrition Research, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge CB1 9NL, UK; The Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK; The Cambridge Systems Biology Centre (CSBC), University of Cambridge, Cambridge CB2 1QR, UK. Electronic address:

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June 2016

Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6.

Cell Rep 2015 Dec 25;13(10):2039-47. Epub 2015 Nov 25.

University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK. Electronic address:

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December 2015

Hyphenating size-exclusion chromatography with electrospray mass spectrometry; using on-line liquid-liquid extraction to study the lipid composition of lipoprotein particles.

Rapid Commun Mass Spectrom 2015 Nov;29(21):1969-76

Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB1 9NL, UK.

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November 2015

Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD.

Semin Liver Dis 2015 Aug 17;35(3):250-61. Epub 2015 Sep 17.

Department of Clinical Biochemistry and University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge, United Kingdom.

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August 2015

Mechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes.

Genome Med 2015 28;7:63. Epub 2015 Jun 28.

MRC Human Nutrition Research, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB1 9NL UK ; Department of Biochemistry and the Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge, UK.

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May 2016

Dietary inorganic nitrate: From villain to hero in metabolic disease?

Mol Nutr Food Res 2016 Jan 26;60(1):67-78. Epub 2015 Aug 26.

Elsie Widdowson Laboratory, Medical Research Council - Human Nutrition Research, Cambridge, UK.

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January 2016

Regulation of mitochondrial morphology and function by stearoylation of TFR1.

Nature 2015 Sep 27;525(7567):124-8. Epub 2015 Jul 27.

German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

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September 2015

NMR-Based Metabolomics Separates the Distinct Stages of Disease in a Chronic Relapsing Model of Multiple Sclerosis.

J Neuroimmune Pharmacol 2015 Sep 9;10(3):435-44. Epub 2015 Jul 9.

Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, Radiobiology Research Institute, Churchill Hospital, University of Oxford, Oxford, OX3 7LJ, UK.

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September 2015

Comprehensive Metabolic Profiling of Age-Related Mitochondrial Dysfunction in the High-Fat-Fed ob/ob Mouse Heart.

J Proteome Res 2015 Jul 22;14(7):2849-62. Epub 2015 Jun 22.

‡MRC, Human Nutrition Research, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB1 9NL, U.K.

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July 2015

Mitochondrial responses to extreme environments: insights from metabolomics.

Extrem Physiol Med 2015 4;4. Epub 2015 May 4.

Centre of Human & Aerospace Physiological Sciences, King's College London, London, UK ; Fibrosis Drug Performance Unit, GlaxoSmithKline Medicines Research Centre, Stevenage, UK.

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May 2015

Quorum Sensing Is Accompanied by Global Metabolic Changes in the Opportunistic Human Pathogen Pseudomonas aeruginosa.

J Bacteriol 2015 Jun 13;197(12):2072-82. Epub 2015 Apr 13.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

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June 2015