Publications by authors named "Julian Hohm"

3 Publications

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Mammary analogue secretory carcinoma of a salivary gland of the hard palate with contralateral cervical lymph node metastases: A case report.

Mol Clin Oncol 2021 Nov 6;15(5):226. Epub 2021 Sep 6.

Department of Maxillofacial and Plastic Surgery of The University of Wuerzburg, D-97070 Wuerzburg, Germany.

Mammary analogue secretory carcinoma (MASC) is a rare malignant tumour of the salivary glands, with only few cases reported in the literature to date. Initial preoperative staging is crucial for all patients with an oral malignancy to visualize the tumour, detect lymph node or distant metastases and plan therapeutic interventions. In the case presented herein, radiological imaging revealed a tumour of the right hard palate with suspected positive contralateral lymph nodes. Therefore, local tumour resection comprising hemimaxillectomy and bilateral neck dissection was performed. The diagnosis of MASC was finally based on characteristic histopathological and immunohistochemical findings, such as S100 protein and mammaglobin positivity. The diagnosis of MASC may be challenging, as such findings lack specificity. To confirm the diagnosis, molecular genetic examinations may be performed to detect a highly specific ETV6-NTRK3 fusion gene. Depending on the results of these examinations, surgery, alone or combined with adjuvant radiation or chemoradiation, is the recommended approach. In summary, MASC should be treated similarly to other low-grade salivary gland tumours, such as acinic cell carcinoma, as they exhibit biological and histopathological similarities.
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http://dx.doi.org/10.3892/mco.2021.2389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8506652PMC
November 2021

Targeting fibroblast activation protein in newly diagnosed squamous cell carcinoma of the oral cavity - initial experience and comparison to [F]FDG PET/CT and MRI.

Eur J Nucl Med Mol Imaging 2021 11 29;48(12):3951-3960. Epub 2021 May 29.

Comprehensive Cancer Center Mainfranken, University Hospital of Würzburg, Josef-Schneider-Str. 6, 97080, Würzburg, Germany.

Purpose: While [F]-fluorodeoxyglucose ([F]FDG) is the standard for positron emission tomography/computed tomography (PET/CT) imaging of oral squamous cell carcinoma (OSCC), diagnostic specificity is hampered by uptake in inflammatory cells such as neutrophils or macrophages. Recently, molecular imaging probes targeting fibroblast activation protein α (FAP), which is overexpressed in a variety of cancer-associated fibroblasts, have become available and might constitute a feasible alternative to FDG PET/CT.

Methods: Ten consecutive, treatment-naïve patients (8 males, 2 females; mean age, 62 ± 9 years) with biopsy-proven OSCC underwent both whole-body [F]FDG and [Ga]FAPI-04 (FAP-directed) PET/CT for primary staging prior to tumor resection and cervical lymph node dissection. Detection of the primary tumor, as well as the presence and number of lymph node and distant metastases was analysed. Intensity of tracer accumulation was assessed by means of maximum (SUV) and peak (SUV) standardized uptake values. Histological work-up including immunohistochemical staining for FAP served as standard of reference.

Results: [F]FDG and FAP-directed PET/CT detected all primary tumors with a SUV of 25.5 ± 13.2 (FDG) and 20.5 ± 6.4 (FAP-directed) and a SUV of 16.1 ± 10.3 ([F]FDG) and 13.8 ± 3.9 (FAP-directed), respectively. Regarding cervical lymph node metastases, FAP-directed PET/CT demonstrated comparable sensitivity (81.3% vs. 87.5%; P = 0.32) and specificity (93.3% vs. 81.3%; P = 0.16) to [F]FDG PET/CT. FAP expression on the cell surface of cancer-associated fibroblasts in both primary lesions as well as lymph nodes metastases was confirmed in all samples.

Conclusion: FAP-directed PET/CT in OSCC seems feasible. Future research to investigate its potential to improve patient staging is highly warranted.
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http://dx.doi.org/10.1007/s00259-021-05422-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484183PMC
November 2021

Influence of F0 and Sequence Length of Audio and Electroglottographic Signals on Perturbation Measures for Voice Assessment.

J Voice 2015 Jul 2;29(4):517.e11-21. Epub 2015 May 2.

Department for Phoniatrics and Pediatric Audiology, University Hospital Erlangen, Erlangen, Germany. Electronic address:

Objective: Within the functional assessment of voice disorders, an objective analysis of measured parameters from audio, electroglottographic (EGG), or visual signals is desired. In a typical clinical situation, reliable objective analysis is not always possible due to missing standardization and unknown stability of the clinical parameters. The aim of this study was to investigate the robustness/stability of measured clinical parameters of the audio and EGG signals in a typical clinical setting to ensure a reliable objective analysis. In particular, the influence of F0 and of the sequence length on several definitions of jitter and shimmer will be analyzed.

Patients And Methods: Seventy-four young healthy women produced a sustained vowel /a/ and an upward triad with abrupt changeovers. Different sequence lengths (100, 150, 500, and 1000 ms) of sustained phonation and triads (100 and 150 ms) were extracted from the audio and EGG signals. In total, six variations of jitter and four variations of shimmer parameters were analyzed.

Results: Jitter%, Jitter11p, and JitterPPQ of the audio signal as well as Jittermean, Shimmer, and Shimmer11p of the EGG signal are unaffected by both sequence length and F0.

Conclusions: Influence of F0 and sequence length on several perturbation measures of the audio and EGG signals was identified. For an objective clinical voice assessment, unaffected definitions of jitter and shimmer should be preferred and applied to enable comparability between different recordings, examinations, and studies.
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http://dx.doi.org/10.1016/j.jvoice.2014.10.001DOI Listing
July 2015
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