Publications


Chronic Deep Brain Stimulation Decreases Blood Pressure and Sympathetic Nerve Activity in a Drug- and Device-Resistant Hypertensive Patient.
Hypertension 2017 Apr 27;69(4):522-528. Epub 2017 Feb 27.
From the School of Physiology and Pharmacology (E.L.O'C., E.C.H., J.F.R.P.), CardioNomics, Clinical Research and Imaging Centre (E.C.H., A.E.B., A.K.N., J.F.R.P.), University of Bristol, United Kingdom; Department of Neurosurgery (H.S.-W., S.J., N.K.P.), Department of Cardiology (M.P.), North Bristol NHS Trust, Southmead Hospital, United Kingdom; Department of Cardiology, Bristol Heart Institute, United Kingdom (A.E.B., A.K.N.); Institute for Clinical Pharmacology (J.T., K.H., J.J.) and Department of Nephrology (J.M., H.H.), Hannover Medical School, Germany; and Institute for Aerospace Medicine, German Center for Aerospace Medicine, Cologne, Germany (J.T., J.J.).

Hypertensive heart disease versus hypertrophic cardiomyopathy: multi-parametric cardiovascular magnetic resonance discriminators when end-diastolic wall thickness ≥ 15 mm.
Eur Radiol 2017 Mar 1;27(3):1125-1135. Epub 2016 Jul 1.
NIHR Bristol Cardiovascular Biomedical Research Unit, Cardiac Magnetic Resonance Department, Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, Upper Maudlin Street, Bristol, BS2 8HW, UK.



Comprehensive First-Line Magnetic Resonance Imaging in Hypertension: Experience From a Single-Center Tertiary Referral Clinic.
J Clin Hypertens (Greenwich) 2017 Jan 19;19(1):13-22. Epub 2016 Oct 19.
CardioNomics Research Group, Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, University of Bristol, Bristol, UK.

Prevalence and predictors of asymmetric hypertensive heart disease: insights from cardiac and aortic function with cardiovascular magnetic resonance.
Eur Heart J Cardiovasc Imaging 2016 Dec 24;17(12):1405-1413. Epub 2015 Dec 24.
NIHR Bristol Cardiovascular Biomedical Research Unit, Cardiac Magnetic Resonance Department, Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, Upper Maudlin Street, Bristol BS2 8HW, UK.

Is High Blood Pressure Self-Protection for the Brain?
Circ Res 2016 Dec 26;119(12):e140-e151. Epub 2016 Sep 26.
From the Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, United Kingdom (E.A.H.W., R.G.W.); CardioNomics Research Group, Clinical Research and Imaging Centre (J.C.L.R., A.E.B., S.N., L.E.K.R., N.E.M., A.K.N., J.F.R.P., E.C.H.) and School of Physiology, Pharmacology, and Neuroscience, Biomedical Sciences (J.C.L.R., S.N., L.E.K.R., Z.A., J.F.R.P., E.C.H.), University of Bristol, United Kingdom; University Hospitals Bristol NHS Foundation Trust, United Kingdom (S.N., L.E.K.R., Z.A., J.F.R.P., E.C.H.); Department of Radiology, University of Calgary, Canada (A.D.H.); and CAIR Program, Alberta Children's Hospital Research Institute, University of Calgary, Hotchkiss Brain Institute, Canada (A.D.H.).


Systemic leukotriene B4 receptor antagonism lowers arterial blood pressure and improves autonomic function in the spontaneously hypertensive rat.
J Physiol 2016 Oct 8;594(20):5975-5989. Epub 2016 Jul 8.
School of Physiology, Pharmacology & Neuroscience, Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK.

Comprehensive characterisation of hypertensive heart disease left ventricular phenotypes.
Heart 2016 Oct 3;102(20):1671-9. Epub 2016 Jun 3.
NIHR Bristol Cardiovascular Biomedical Research Unit, Cardiac Magnetic Resonance Department, Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, Bristol, UK Department of Cardiology, Bristol Royal Infirmary, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.

Reversing gene expression in cardiovascular target organs following chronic depression of the paraventricular nucleus of hypothalamus and rostral ventrolateral medulla in spontaneous hypertensive rats.
Brain Res 2016 Sep 27;1646:109-115. Epub 2016 May 27.
Institute of Physiology, Faculty of Medicine and Cardiovascular Centre of University of Lisbon, Portugal. Electronic address:


Controversies Surrounding Renal Denervation: Lessons Learned From Real-World Experience in Two United Kingdom Centers.
J Clin Hypertens (Greenwich) 2016 Jun 9;18(6):585-92. Epub 2016 Feb 9.
CardioNomics Research Group, Clinical Research & Imaging Centre-Bristol, Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, University of Bristol, Bristol, UK.

Control of Polyamine Biosynthesis by Antizyme Inhibitor 1 Is Important for Transcriptional Regulation of Arginine Vasopressin in the Male Rat Hypothalamus.
Endocrinology 2015 Aug 11;156(8):2905-17. Epub 2015 May 11.
School of Clinical Sciences (M.P.G., M.G., D.M.), University of Bristol, Bristol BS1 3NY, United Kingdom; School of Physiology and Pharmacology (J.F.R.P.), University of Bristol, Bristol BS8 1TD, United Kingdom; and Department of Physiology (D.M.), University of Malaya, Kuala Lumpur, Malaysia 50603.

A comparison of physiological and transcriptome responses to water deprivation and salt loading in the rat supraoptic nucleus.
Am J Physiol Regul Integr Comp Physiol 2015 Apr 28;308(7):R559-68. Epub 2015 Jan 28.
School of Clinical Sciences, University of Bristol, Bristol, United Kingdom; Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;

Brainstem hypoxia contributes to the development of hypertension in the spontaneously hypertensive rat.
Hypertension 2015 Apr 23;65(4):775-83. Epub 2015 Feb 23.
From the Centre for Cardiovascular and Metabolic Neuroscience (N.M., R.A., A.M., V.K., A.K., P.S.H., A.V.G.), Department of Clinical Pharmacology and Experimental Therapeutics (N.M., P.S.H.), and Neuroscience, Physiology and Pharmacology (R.A., A.M., V.K., A.K., A.V.G.), University College London, London, United Kingdom; School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom (V.M., A.G.T., J.F.R.P., S.K.); and Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland (P.V.).

Joint UK societies' 2014 consensus statement on renal denervation for resistant hypertension.
Heart 2015 Jan 27;101(1):10-6. Epub 2014 Nov 27.
On behalf of the British Hypertension Society Barts NIHR Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Queen Mary University of London, London, UK Department of Cardiovascular Medicine, Barts Health NHS Trust, London, UK.

Arteriovenous anastomosis: is this the way to control hypertension?
Hypertension 2014 Jul 7;64(1):6-12. Epub 2014 Apr 7.
From the CardioNomics Research Group, Clinical Research & Imaging Centre-Bristol, Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust (A.E.B., J.F.R.P.) and School of Clinical Sciences (A.E.B.), University of Bristol, UK; William Harvey Heart Centre, NIHR Cardiovascular Biomedical Research Unit, Centre for Clinical Pharmacology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK (M.D.L.); Barts Hypertension Clinic, Department of Clinical Pharmacology, Barts Health NHS Trust, London, UK (M.D.L.); Eastbourne DG Hospital, Kings Drive, Eastbourne, East Sussex, UK (N.S.); Rox Medical Inc. & The Ohio State University, St Paul, MN (P.A.S.); and School of Physiology & Pharmacology, Bristol CardioVascular, Medical Sciences Building, University of Bristol, UK (J.F.R.P.).

Mapping the cellular electrophysiology of rat sympathetic preganglionic neurones to their roles in cardiorespiratory reflex integration: a whole cell recording study in situ.
J Physiol 2014 May 24;592(10):2215-36. Epub 2014 Mar 24.
School of Physiology & Pharmacology, Bristol Heart Institute, Medical Sciences Building, University Walk, University of Bristol, Bristol, BS8 1TD, UK Department of Anaesthesia, University Hospitals Bristol, Bristol, BS2 8HW, UK

Dissociation between blood pressure and heart rate response to hypoxia after bilateral carotid body removal in men with systolic heart failure.
Exp Physiol 2014 Mar 15;99(3):552-61. Epub 2013 Nov 15.
* Department of Cardiology, Centre for Heart Disease, 4th Military Hospital, 4 Wojskowy Szpital Kliniczny, Ul. Weigla 5, Wroclaw 50-981, Poland.   

Transcription factor CREB3L1 regulates vasopressin gene expression in the rat hypothalamus.
J Neurosci 2014 Mar;34(11):3810-20
School of Clinical Sciences, University of Bristol, Bristol BS1 3NY, United Kingdom, Department of Physiology and Pathology, School of Dentistry, São Paulo State University, Araraquara, São Paulo 14801-385, Brazil, School of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, United Kingdom, and Department of Physiology, University of Malaya, Kuala Lumpur 50603, Malaysia.

Carotid body removal for treatment of chronic systolic heart failure.
Int J Cardiol 2013 Oct 29;168(3):2506-9. Epub 2013 Mar 29.
Department of Cardiology, Centre for Heart Disease, 4th Military Hospital, Wroclaw, Poland. Electronic address:


The carotid body as a therapeutic target for the treatment of sympathetically mediated diseases.
Hypertension 2013 Jan 19;61(1):5-13. Epub 2012 Nov 19.
School of Physiology and Pharmacology, Bristol Heart Institute, University of Bristol, Bristol BS8 1TD, United Kingdom.

Upregulation of junctional adhesion molecule-A is a putative prognostic marker of hypertension.
Cardiovasc Res 2012 Dec 22;96(3):552-60. Epub 2012 Aug 22.
School of Physiology and Pharmacology, Bristol Heart Institute, Medical Sciences Building, University of Bristol, Bristol BS8 1TD, UK.

Switching control of sympathetic activity from forebrain to hindbrain in chronic dehydration.
J Physiol 2011 Sep 27;589(Pt 18):4457-71. Epub 2011 Jun 27.
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK.

Temporal profile of arginine vasopressin release from the neurohypophysis in response to hypertonic saline and hypotension measured using a fluorescent fusion protein.
J Neurosci Methods 2011 Sep 10;201(1):191-5. Epub 2011 Aug 10.
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol BS1 3NY, UK.

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