Julian C Knight

Julian C Knight

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Julian C Knight

Julian C Knight

Publications by authors named "Julian C Knight"

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The association between endometriosis and autoimmune diseases: a systematic review and meta-analysis.

Hum Reprod Update 2019 Jul;25(4):486-503

Oxford Endometriosis CaRe Centre, Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/humupd/dmz014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601386PMC
July 2019

Transcriptomic Signatures in Sepsis and a Differential Response to Steroids. From the VANISH Randomized Trial.

Am J Respir Crit Care Med 2019 Apr;199(8):980-986

1 Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom.

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https://www.atsjournals.org/doi/10.1164/rccm.201807-1419OC
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http://dx.doi.org/10.1164/rccm.201807-1419OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467319PMC
April 2019

Translating GWAS in rheumatic disease: approaches to establishing mechanism and function for genetic associations with ankylosing spondylitis.

Brief Funct Genomics 2018 09;17(5):308-318

Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/bfgp/ely015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158798PMC
September 2018

Distinct HLA associations of LGI1 and CASPR2-antibody diseases.

Brain 2018 08;141(8):2263-2271

Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Level 3, West Wing, John Radcliffe Hospital, Oxford, OX3 9DS, UK.

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http://dx.doi.org/10.1093/brain/awy109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118231PMC
August 2018

AltHapAlignR: improved accuracy of RNA-seq analyses through the use of alternative haplotypes.

Bioinformatics 2018 07;34(14):2401-2408

Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/bioinformatics/bty125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041798PMC
July 2018

Genomic Response to Vitamin D Supplementation in the Setting of a Randomized, Placebo-Controlled Trial.

EBioMedicine 2018 May 10;31:133-142. Epub 2018 Apr 10.

Wellcome Centre for Human Genetics (WHG), Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013786PMC
May 2018

Microvesicle Subsets in Sepsis Due to Community Acquired Pneumonia Compared to Faecal Peritonitis.

Shock 2018 04;49(4):393-401

William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1097/SHK.0000000000000989DOI Listing
April 2018

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study.

Lancet Respir Med 2017 10 29;5(10):816-826. Epub 2017 Aug 29.

Center for Experimental Molecular Medicine, Academic Medical Center, Amsterdam, Netherlands; Division of Infectious Diseases, Academic Medical Center, Amsterdam, Netherlands.

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http://dx.doi.org/10.1016/S2213-2600(17)30294-1DOI Listing
October 2017

Insights from early experience of a Rare Disease Genomic Medicine Multidisciplinary Team: a qualitative study.

Eur J Hum Genet 2017 06 22;25(6):680-686. Epub 2017 Mar 22.

Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ejhg.2017.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427178PMC
June 2017

High resolution HLA haplotyping by imputation for a British population bioresource.

Hum Immunol 2017 Mar 19;78(3):242-251. Epub 2017 Jan 19.

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.humimm.2017.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367449PMC
March 2017

Enhanced understanding of the host-pathogen interaction in sepsis: new opportunities for omic approaches.

Lancet Respir Med 2017 03;5(3):212-223

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(17)30045-0DOI Listing
March 2017

HLA-C Level Is Regulated by a Polymorphic Oct1 Binding Site in the HLA-C Promoter Region.

Am J Hum Genet 2016 Dec 3;99(6):1353-1358. Epub 2016 Nov 3.

Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.09.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142108PMC
December 2016

XGR software for enhanced interpretation of genomic summary data, illustrated by application to immunological traits.

Genome Med 2016 12 13;8(1):129. Epub 2016 Dec 13.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1186/s13073-016-0384-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154134PMC
December 2016

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression.

Ann Rheum Dis 2016 08 9;75(8):1534-40. Epub 2015 Oct 9.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK National Institute for Health Research Oxford Musculoskeletal Biomedical Research Unit, Oxford, UK National Institute for Health Research Oxford Comprehensive Biomedical Research Centre, Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2015-20749
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http://dx.doi.org/10.1136/annrheumdis-2015-207490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975853PMC
August 2016

Characterisation of the global transcriptional response to heat shock and the impact of individual genetic variation.

Genome Med 2016 08 24;8(1):87. Epub 2016 Aug 24.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1186/s13073-016-0345-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995779PMC
August 2016

Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency disorders.

Clin Immunol 2015 Oct 26;160(2):301-14. Epub 2015 Jun 26.

Nuffield Department of Medicine, University of Oxford, Oxford, UK; Oxford NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2015.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601528PMC
October 2015

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

Authors:
Jenny C Taylor Hilary C Martin Stefano Lise John Broxholme Jean-Baptiste Cazier Andy Rimmer Alexander Kanapin Gerton Lunter Simon Fiddy Chris Allan A Radu Aricescu Moustafa Attar Christian Babbs Jennifer Becq David Beeson Celeste Bento Patricia Bignell Edward Blair Veronica J Buckle Katherine Bull Ondrej Cais Holger Cario Helen Chapel Richard R Copley Richard Cornall Jude Craft Karin Dahan Emma E Davenport Calliope Dendrou Olivier Devuyst Aimée L Fenwick Jonathan Flint Lars Fugger Rodney D Gilbert Anne Goriely Angie Green Ingo H Greger Russell Grocock Anja V Gruszczyk Robert Hastings Edouard Hatton Doug Higgs Adrian Hill Chris Holmes Malcolm Howard Linda Hughes Peter Humburg David Johnson Fredrik Karpe Zoya Kingsbury Usha Kini Julian C Knight Jonathan Krohn Sarah Lamble Craig Langman Lorne Lonie Joshua Luck Davis McCarthy Simon J McGowan Mary Frances McMullin Kerry A Miller Lisa Murray Andrea H Németh M Andrew Nesbit David Nutt Elizabeth Ormondroyd Annette Bang Oturai Alistair Pagnamenta Smita Y Patel Melanie Percy Nayia Petousi Paolo Piazza Sian E Piret Guadalupe Polanco-Echeverry Niko Popitsch Fiona Powrie Chris Pugh Lynn Quek Peter A Robbins Kathryn Robson Alexandra Russo Natasha Sahgal Pauline A van Schouwenburg Anna Schuh Earl Silverman Alison Simmons Per Soelberg Sørensen Elizabeth Sweeney John Taylor Rajesh V Thakker Ian Tomlinson Amy Trebes Stephen Rf Twigg Holm H Uhlig Paresh Vyas Tim Vyse Steven A Wall Hugh Watkins Michael P Whyte Lorna Witty Ben Wright Chris Yau David Buck Sean Humphray Peter J Ratcliffe John I Bell Andrew Om Wilkie David Bentley Peter Donnelly Gilean McVean

Nat Genet 2015 Jul 18;47(7):717-726. Epub 2015 May 18.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.3304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601524PMC
July 2015

Genomic modulators of gene expression in human neutrophils.

Nat Commun 2015 Jul 7;6:7545. Epub 2015 Jul 7.

Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1038/ncomms8545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507005PMC
July 2015

Preclinical target validation using patient-derived cells.

Nat Rev Drug Discov 2015 Mar 20;14(3):149-50. Epub 2015 Feb 20.

Structural Genomics Consortium, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1038/nrd4565DOI Listing
March 2015

Transcriptomic profiling facilitates classification of response to influenza challenge.

J Mol Med (Berl) 2015 Jan 28;93(1):105-14. Epub 2014 Oct 28.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1007/s00109-014-1212-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281383PMC
January 2015

Genetics of gene expression in immunity to infection.

Curr Opin Immunol 2014 Oct 31;30:63-71. Epub 2014 Jul 31.

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2014.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426291PMC
October 2014

An integrated approach to defining genetic and environmental determinants for major clinical outcomes involving vitamin D.

Mol Diagn Ther 2014 Jun;18(3):261-72

CGAT, MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.

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http://dx.doi.org/10.1007/s40291-014-0087-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031425PMC
June 2014

Fine mapping genetic determinants of the highly variably expressed MHC gene ZFP57.

Eur J Hum Genet 2014 Apr 6;22(4):568-71. Epub 2013 Nov 6.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ejhg.2013.244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953924PMC
April 2014

Major histocompatibility complex genomics and human disease.

Annu Rev Genomics Hum Genet 2013 15;14:301-23. Epub 2013 Jul 15.

Department of Pathology and Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 1QP, United Kingdom; email:

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http://dx.doi.org/10.1146/annurev-genom-091212-153455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426292PMC
December 2013

Genomic modulators of the immune response.

Authors:
Julian C Knight

Trends Genet 2013 Feb 1;29(2):74-83. Epub 2012 Nov 1.

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1016/j.tig.2012.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605582PMC
February 2013

Vitamin D receptor gene methylation is associated with ethnicity, tuberculosis, and TaqI polymorphism.

Hum Immunol 2011 Mar 16;72(3):262-8. Epub 2010 Dec 16.

Department of Biochemistry, University of Johannesburg, Auckland Park, South Africa.

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http://dx.doi.org/10.1016/j.humimm.2010.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955023PMC
March 2011

A common haplotype of the TNF receptor 2 gene modulates endotoxin tolerance.

J Immunol 2011 Mar 31;186(5):3058-65. Epub 2011 Jan 31.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1001791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3211060PMC
March 2011

Genetic determinants of HSP70 gene expression following heat shock.

Hum Mol Genet 2010 Dec 27;19(24):4939-47. Epub 2010 Sep 27.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/hmg/ddq418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989893PMC
December 2010

An allele-specific gene expression assay to test the functional basis of genetic associations.

J Vis Exp 2010 Nov 3(45). Epub 2010 Nov 3.

Wellcome Trust Centre for Human Genetics, University of Oxford, UK.

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http://dx.doi.org/10.3791/2279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157858PMC
November 2010

Understanding human genetic variation in the era of high-throughput sequencing.

Authors:
Julian C Knight

EMBO Rep 2010 Sep 20;11(9):650-2. Epub 2010 Aug 20.

Wellcome Trust Centre for Human Genetics at the University of Oxford, Oxford, UK.

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http://embor.embopress.org/cgi/doi/10.1038/embor.2010.126
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http://dx.doi.org/10.1038/embor.2010.126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933874PMC
September 2010

The human Major Histocompatibility Complex as a paradigm in genomics research.

Brief Funct Genomic Proteomic 2009 Sep 25;8(5):379-94. Epub 2009 May 25.

Wellcome Trust Centre for Human Genetics (WTCHG), University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/bfgp/elp010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987720PMC
September 2009

Insights into the nature and consequences of our variable genome.

Authors:
Julian C Knight

Brief Funct Genomic Proteomic 2009 Sep;8(5):343-4

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http://dx.doi.org/10.1093/bfgp/elp039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967738PMC
September 2009

Multiple sclerosis and the major histocompatibility complex.

Curr Opin Neurol 2009 Jun;22(3):219-25

Wellcome Trust Centre for Human Genetics, UK.

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http://dx.doi.org/10.1097/WCO.0b013e32832b5417DOI Listing
June 2009

Chromatin profiling across the human tumour necrosis factor gene locus reveals a complex, cell type-specific landscape with novel regulatory elements.

Nucleic Acids Res 2008 Sep 24;36(15):4845-62. Epub 2008 Jul 24.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1093/nar/gkn444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528168PMC
September 2008

Origins of magic: review of genetic and epigenetic effects.

BMJ 2007 Dec;335(7633):1299-301

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN.

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http://www.bmj.com/lookup/doi/10.1136/bmj.39414.582639.BE
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http://dx.doi.org/10.1136/bmj.39414.582639.BEDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151141PMC
December 2007

Analysis of allele-specific gene expression.

Authors:
Julian C Knight

Methods Mol Biol 2006 ;338:153-65

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1385/1-59745-097-9:153DOI Listing
September 2006

Regulatory polymorphisms underlying complex disease traits.

Authors:
Julian C Knight

J Mol Med (Berl) 2005 Feb 9;83(2):97-109. Epub 2004 Dec 9.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1007/s00109-004-0603-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132451PMC
February 2005

Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1.

Nat Genet 2004 Apr 28;36(4):394-9. Epub 2004 Mar 28.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

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http://www.nature.com/articles/ng1331
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http://dx.doi.org/10.1038/ng1331DOI Listing
April 2004

Functional implications of genetic variation in non-coding DNA for disease susceptibility and gene regulation.

Authors:
Julian C Knight

Clin Sci (Lond) 2003 May;104(5):493-501

Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford OX3 7BN, UK.

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http://clinsci.org/lookup/doi/10.1042/CS20020304
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http://dx.doi.org/10.1042/CS20020304DOI Listing
May 2003

In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading.

Nat Genet 2003 Apr 10;33(4):469-75. Epub 2003 Mar 10.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1038/ng1124DOI Listing
April 2003