Publications by authors named "Julia M Kroos"

3 Publications

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Clinical correlates of mathematical modeling of cortical spreading depression: Single-cases study.

Brain Behav 2019 10 10;9(10):e01387. Epub 2019 Sep 10.

Basque Center for Applied Mathematics, Bilbao, Spain.

Introduction: Considerable connections between migraine with aura and cortical spreading depression (CSD), a depolarization wave originating in the visual cortex and traveling toward the frontal lobe, lead to the hypothesis that CSD is underlying migraine aura. The highly individual and complex characteristics of the brain cortex suggest that the geometry might impact the propagation of cortical spreading depression.

Methods: In a single-case study, we simulated the CSD propagation for five migraine with aura patients, matching their symptoms during a migraine attack to the CSD wavefront propagation. This CSD wavefront was simulated on a patient-specific triangulated cortical mesh obtained from individual MRI imaging and personalized diffusivity tensors derived locally from diffusion tensor imaging data.

Results: The CSD wave propagation was simulated on both hemispheres, despite in all but one patient the symptoms were attributable to one hemisphere. The CSD wave diffused with a large wavefront toward somatosensory and prefrontal regions, devoted to pain processing.

Discussion: This case-control study suggests that the cortical geometry may contribute to the modality of CSD evolution and partly to clinical expression of aura symptoms. The simulated CSD is a large and diffuse phenomenon, possibly capable to activate trigeminal nociceptors and to involve cortical areas devoted to pain processing.
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http://dx.doi.org/10.1002/brb3.1387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790336PMC
October 2019

Patient-specific computational modeling of cortical spreading depression via diffusion tensor imaging.

Int J Numer Method Biomed Eng 2017 11 11;33(11). Epub 2017 Apr 11.

Basque Center for Applied Mathematics, Bilbao, Spain.

Cortical spreading depression, a depolarization wave originating in the visual cortex and traveling towards the frontal lobe, is commonly accepted as a correlate of migraine visual aura. As of today, little is known about the mechanisms that can trigger or stop such phenomenon. However, the complex and highly individual characteristics of the brain cortex suggest that the geometry might have a significant impact in supporting or contrasting the propagation of cortical spreading depression. Accurate patient-specific computational models are fundamental to cope with the high variability in cortical geometries among individuals, but also with the conduction anisotropy induced in a given cortex by the complex neuronal organisation in the grey matter. In this paper, we integrate a distributed model for extracellular potassium concentration with patient-specific diffusivity tensors derived locally from diffusion tensor imaging data.
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http://dx.doi.org/10.1002/cnm.2874DOI Listing
November 2017

Geometry Shapes Propagation: Assessing the Presence and Absence of Cortical Symmetries through a Computational Model of Cortical Spreading Depression.

Front Comput Neurosci 2016 2;10. Epub 2016 Feb 2.

BCAM - Basque Center for Applied Mathematics Bilbao, Spain.

Cortical spreading depression (CSD), a depolarization wave which originates in the visual cortex and travels toward the frontal lobe, has been suggested to be one neural correlate of aura migraine. To the date, little is known about the mechanisms which can trigger or stop aura migraine. Here, to shed some light on this problem and, under the hypothesis that CSD might mediate aura migraine, we aim to study different aspects favoring or disfavoring the propagation of CSD. In particular, by using a computational neuronal model distributed throughout a realistic cortical mesh, we study the role that the geometry has in shaping CSD. Our results are two-fold: first, we found significant differences in the propagation traveling patterns of CSD, both intra and inter-hemispherically, revealing important asymmetries in the propagation profile. Second, we developed methods able to identify brain regions featuring a peculiar behavior during CSD propagation. Our study reveals dynamical aspects of CSD, which, if applied to subject-specific cortical geometry, might shed some light on how to differentiate between healthy subjects and those suffering migraine.
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http://dx.doi.org/10.3389/fncom.2016.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735361PMC
February 2016