Julia M Keogh

Julia M Keogh

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Julia M Keogh

Julia M Keogh

Publications by authors named "Julia M Keogh"

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42Publications

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Neural networks associated with body composition in frontotemporal dementia.

Ann Clin Transl Neurol 2019 Sep 28;6(9):1707-1717. Epub 2019 Aug 28.

School of Psychology and Brain & Mind Centre, The University of Sydney, Sydney, Australia.

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http://dx.doi.org/10.1002/acn3.50869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764740PMC
September 2019

Genetic architecture of human thinness compared to severe obesity.

PLoS Genet 2019 01 24;15(1):e1007603. Epub 2019 Jan 24.

University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1007603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345421PMC
January 2019

Neural deletion of Sh2b1 results in brain growth retardation and reactive aggression.

FASEB J 2018 04 5;32(4):1830-1840. Epub 2018 Jan 5.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1096/fj.201700831RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893167PMC
April 2018

A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome.

Cell Rep 2018 03;22(13):3401-3408

University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896230PMC
March 2018

A Metabolomic Signature of Acute Caloric Restriction.

J Clin Endocrinol Metab 2017 12;102(12):4486-4495

University of Cambridge Metabolic Research Laboratories and National Institute for Health Research Cambridge Biomedical Research Centre, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, United Kingdom.

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http://academic.oup.com/jcem/article/102/12/4486/4209888
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http://dx.doi.org/10.1210/jc.2017-01020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718701PMC
December 2017

Oxytocin administration suppresses hypothalamic activation in response to visual food cues.

Sci Rep 2017 06 27;7(1):4266. Epub 2017 Jun 27.

University of Cambridge Metabolic Research Laboratories and the NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1038/s41598-017-04600-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487325PMC
June 2017

Failure of sucrose replacement with the non-nutritive sweetener erythritol to alter GLP-1 or PYY release or test meal size in lean or obese people.

Appetite 2016 12 9;107:596-603. Epub 2016 Sep 9.

University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.appet.2016.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119236PMC
December 2016

Divergent effects of central melanocortin signalling on fat and sucrose preference in humans.

Nat Commun 2016 10 4;7:13055. Epub 2016 Oct 4.

Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Box 289, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1038/ncomms13055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059464PMC
October 2016

The Sleep/Wake Cycle is Directly Modulated by Changes in Energy Balance.

Sleep 2016 Sep 1;39(9):1691-700. Epub 2016 Sep 1.

University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science and the NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.5665/sleep.6094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989258PMC
September 2016

Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene.

J Clin Endocrinol Metab 2015 Sep 17;100(9):3227-30. Epub 2015 Jul 17.

Division of Pediatric Endocrinology and Diabetes (M.W., J.-B.F., J.v.S., F.D., C.D., A.M., P.F.-P.), and Department of Pediatrics and Adolescent Medicine (G.L., K.-M.D.), University Medical Center Ulm, 89075 Ulm, Germany; Clinical Genetics Department (I.M., M.E.), National Research Center, Cairo 12311, Egypt; Institute of Pharmacology and Toxicology (P.G., B.M.), University Medical Center Ulm, 89081 Ulm, Germany; and University of Cambridge Metabolic Research Laboratories (V.M., J.M.K., I.S.F.), Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2015-2263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570156PMC
September 2015

Obesity-associated melanocortin-4 receptor mutations are associated with changes in the brain response to food cues.

J Clin Endocrinol Metab 2014 Oct 25;99(10):E2101-6. Epub 2014 Jul 25.

University of Cambridge Metabolic Research Laboratories (A.A.v.d.K., J.M.K., E.H., S.O., I.S.F.), Wellcome Trust-Medical Research Council (MRC) Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; MRC Cognition and Brain Sciences Unit (E.A.H.v.d.H., A.D.L., A.J.C.), Cambridge CB2 7EF, United Kingdom; and School of Psychology (A.D.L.), Cardiff University, Cardiff CF10 3XQ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2014-1651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258603PMC
October 2014

Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1.

Endocrinology 2014 Sep 27;155(9):3219-26. Epub 2014 Jun 27.

University of Cambridge Metabolic Research Laboratories and National Institute for Health Research Cambridge Biomedical Research Centre (L.R.P., J.M.K., E.H., E.G.B., S.G., S.Sa., S.O., I.B., I.S.F.), Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ United Kingdom; Graduate Program in Cellular and Molecular Biology (R.J., C.C.-S.), Department of Molecular and Integrative Physiology (M.E.D., H.-W.S., L.S.A., J.M.C., L.R., C.C.-S.), and Division of Metabolism, Endocrinology, and Diabetes (C.C.-S.), Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-5622; Joslin Diabetes Center and Department of Medicine (S.Sh.), Harvard University, Boston, Massachusetts 02115; and Wellcome Trust Sanger Institute (I.B.), Hinxton, CB10 1SA United Kingdom.

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http://dx.doi.org/10.1210/en.2014-1264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138566PMC
September 2014

High protein intake stimulates postprandial GLP1 and PYY release.

Obesity (Silver Spring) 2013 Aug 13;21(8):1602-7. Epub 2013 May 13.

Department of Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1002/oby.20154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548554PMC
August 2013

Postprandial total ghrelin suppression is modulated by melanocortin signaling in humans.

J Clin Endocrinol Metab 2013 Feb 11;98(2):E288-92. Epub 2013 Jan 11.

University of Cambridge, Metabolic Research Laboratories Box 289, Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2012-2553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565120PMC
February 2013

Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

J Clin Invest 2012 Dec 19;122(12):4732-6. Epub 2012 Nov 19.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109-5622, USA.

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http://dx.doi.org/10.1172/JCI62696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533535PMC
December 2012

Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery.

J Clin Endocrinol Metab 2012 Jun 6;97(6):E1023-31. Epub 2012 Apr 6.

Massachusetts General Hospital, 149 13th Street, Room 8219, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1210/jc.2011-3432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387412PMC
June 2012

A mutation in the thyroid hormone receptor alpha gene.

N Engl J Med 2012 Jan 14;366(3):243-9. Epub 2011 Dec 14.

University of Cambridge Metabolic Research Laboratories and National Institute for Health Research Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1056/NEJMoa1110296DOI Listing
January 2012

Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.

Endocrinology 2009 Jan 18;150(1):114-25. Epub 2008 Sep 18.

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Box 289, Hills Road, Cambridge CB2 2QQ, United Kingdom.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2008-0721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732289PMC
January 2009

Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects.

Am J Clin Nutr 2009 Jan 3;89(1):106-113. Epub 2008 Dec 3.

Cambridge Institute for Medical Research and Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK (JRG, ISF, JMK, EH, AMH, AB, FR, FMG), and the Department of Medical Physiology, University of Copenhagen, The Panum Institute, Copenhagen N, Denmark (JJH).

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https://academic.oup.com/ajcn/article/89/1/106/4598228
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http://dx.doi.org/10.3945/ajcn.2008.26362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340573PMC
January 2009

Modulation of blood pressure by central melanocortinergic pathways.

N Engl J Med 2009 Jan 17;360(1):44-52. Epub 2008 Dec 17.

University of Cambridge Metabolic Research Laboratories, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1056/NEJMoa0803085DOI Listing
January 2009

Heterozygosity for a POMC-null mutation and increased obesity risk in humans.

Diabetes 2006 Sep;55(9):2549-53

University Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, CB2 2XY, UK.

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http://dx.doi.org/10.2337/db06-0214DOI Listing
September 2006

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.

N Engl J Med 2003 Mar;348(12):1085-95

University Department of Medicine, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1056/NEJMoa022050DOI Listing
March 2003