Publications by authors named "Julia Keogh"

58Publications

Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities.

Sci Rep 2020 06 3;10(1):9028. Epub 2020 Jun 3.

University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

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June 2020

Leptin-Mediated Changes in the Human Metabolome.

J Clin Endocrinol Metab 2020 Aug;105(8)

University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

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August 2020

Neural networks associated with body composition in frontotemporal dementia.

Ann Clin Transl Neurol 2019 09 28;6(9):1707-1717. Epub 2019 Aug 28.

School of Psychology and Brain & Mind Centre, The University of Sydney, Sydney, Australia.

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September 2019

Genetic architecture of human thinness compared to severe obesity.

PLoS Genet 2019 01 24;15(1):e1007603. Epub 2019 Jan 24.

University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.

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January 2019

A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome.

Cell Rep 2018 03;22(13):3401-3408

University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. Electronic address:

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March 2018

Neural deletion of Sh2b1 results in brain growth retardation and reactive aggression.

FASEB J 2018 04 5;32(4):1830-1840. Epub 2018 Jan 5.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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April 2018

A Metabolomic Signature of Acute Caloric Restriction.

J Clin Endocrinol Metab 2017 12;102(12):4486-4495

University of Cambridge Metabolic Research Laboratories and National Institute for Health Research Cambridge Biomedical Research Centre, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, United Kingdom.

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December 2017

Oxytocin administration suppresses hypothalamic activation in response to visual food cues.

Sci Rep 2017 06 27;7(1):4266. Epub 2017 Jun 27.

University of Cambridge Metabolic Research Laboratories and the NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

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June 2017

Divergent effects of central melanocortin signalling on fat and sucrose preference in humans.

Nat Commun 2016 10 4;7:13055. Epub 2016 Oct 4.

Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Box 289, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.

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October 2016

Failure of sucrose replacement with the non-nutritive sweetener erythritol to alter GLP-1 or PYY release or test meal size in lean or obese people.

Appetite 2016 12 9;107:596-603. Epub 2016 Sep 9.

University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom. Electronic address:

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December 2016

The Sleep/Wake Cycle is Directly Modulated by Changes in Energy Balance.

Sleep 2016 Sep 1;39(9):1691-700. Epub 2016 Sep 1.

University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science and the NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, UK.

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September 2016

Role of melanocortin signalling in the preference for dietary macronutrients in human beings.

Lancet 2015 Feb;385 Suppl 1:S12

Metabolic Research Laboratories, Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

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February 2015

Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene.

J Clin Endocrinol Metab 2015 Sep 17;100(9):3227-30. Epub 2015 Jul 17.

Division of Pediatric Endocrinology and Diabetes (M.W., J.-B.F., J.v.S., F.D., C.D., A.M., P.F.-P.), and Department of Pediatrics and Adolescent Medicine (G.L., K.-M.D.), University Medical Center Ulm, 89075 Ulm, Germany; Clinical Genetics Department (I.M., M.E.), National Research Center, Cairo 12311, Egypt; Institute of Pharmacology and Toxicology (P.G., B.M.), University Medical Center Ulm, 89081 Ulm, Germany; and University of Cambridge Metabolic Research Laboratories (V.M., J.M.K., I.S.F.), Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

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September 2015

Obesity-associated melanocortin-4 receptor mutations are associated with changes in the brain response to food cues.

J Clin Endocrinol Metab 2014 Oct 25;99(10):E2101-6. Epub 2014 Jul 25.

University of Cambridge Metabolic Research Laboratories (A.A.v.d.K., J.M.K., E.H., S.O., I.S.F.), Wellcome Trust-Medical Research Council (MRC) Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; MRC Cognition and Brain Sciences Unit (E.A.H.v.d.H., A.D.L., A.J.C.), Cambridge CB2 7EF, United Kingdom; and School of Psychology (A.D.L.), Cardiff University, Cardiff CF10 3XQ, United Kingdom.

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October 2014

Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1.

Endocrinology 2014 Sep 27;155(9):3219-26. Epub 2014 Jun 27.

University of Cambridge Metabolic Research Laboratories and National Institute for Health Research Cambridge Biomedical Research Centre (L.R.P., J.M.K., E.H., E.G.B., S.G., S.Sa., S.O., I.B., I.S.F.), Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ United Kingdom; Graduate Program in Cellular and Molecular Biology (R.J., C.C.-S.), Department of Molecular and Integrative Physiology (M.E.D., H.-W.S., L.S.A., J.M.C., L.R., C.C.-S.), and Division of Metabolism, Endocrinology, and Diabetes (C.C.-S.), Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-5622; Joslin Diabetes Center and Department of Medicine (S.Sh.), Harvard University, Boston, Massachusetts 02115; and Wellcome Trust Sanger Institute (I.B.), Hinxton, CB10 1SA United Kingdom.

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September 2014

High protein intake stimulates postprandial GLP1 and PYY release.

Obesity (Silver Spring) 2013 Aug 13;21(8):1602-7. Epub 2013 May 13.

Department of Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

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August 2013

Postprandial total ghrelin suppression is modulated by melanocortin signaling in humans.

J Clin Endocrinol Metab 2013 Feb 11;98(2):E288-92. Epub 2013 Jan 11.

University of Cambridge, Metabolic Research Laboratories Box 289, Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom.

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February 2013

Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

J Clin Invest 2012 Dec 19;122(12):4732-6. Epub 2012 Nov 19.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109-5622, USA.

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December 2012

Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery.

J Clin Endocrinol Metab 2012 Jun 6;97(6):E1023-31. Epub 2012 Apr 6.

Massachusetts General Hospital, 149 13th Street, Room 8219, Charlestown, Massachusetts 02129, USA.

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June 2012

A mutation in the thyroid hormone receptor alpha gene.

N Engl J Med 2012 Jan 14;366(3):243-9. Epub 2011 Dec 14.

University of Cambridge Metabolic Research Laboratories and National Institute for Health Research Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.

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January 2012

Large, rare chromosomal deletions associated with severe early-onset obesity.

Nature 2010 Feb 6;463(7281):666-70. Epub 2009 Dec 6.

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

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February 2010

Modulation of blood pressure by central melanocortinergic pathways.

N Engl J Med 2009 Jan 17;360(1):44-52. Epub 2008 Dec 17.

University of Cambridge Metabolic Research Laboratories, Addenbrooke's Hospital, Cambridge, United Kingdom.

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January 2009

Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects.

Am J Clin Nutr 2009 Jan 3;89(1):106-113. Epub 2008 Dec 3.

Cambridge Institute for Medical Research and Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK (JRG, ISF, JMK, EH, AMH, AB, FR, FMG), and the Department of Medical Physiology, University of Copenhagen, The Panum Institute, Copenhagen N, Denmark (JJH).

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January 2009

Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.

Endocrinology 2009 Jan 18;150(1):114-25. Epub 2008 Sep 18.

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Box 289, Hills Road, Cambridge CB2 2QQ, United Kingdom.

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January 2009

Leptin regulates striatal regions and human eating behavior.

Science 2007 Sep 9;317(5843):1355. Epub 2007 Aug 9.

University Department of Medicine and Department of Clinical Biochemistry, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 2QQ, UK.

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September 2007

Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3.

J Clin Endocrinol Metab 2007 Sep 26;92(9):3369-73. Epub 2007 Jun 26.

University Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge CB2 2XY, United Kingdom.

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September 2007

Heterozygosity for a POMC-null mutation and increased obesity risk in humans.

Diabetes 2006 Sep;55(9):2549-53

University Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, CB2 2XY, UK.

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September 2006

A de novo mutation affecting human TrkB associated with severe obesity and developmental delay.

Nat Neurosci 2004 Nov 24;7(11):1187-9. Epub 2004 Oct 24.

University Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge CB2 2XY, UK.

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November 2004

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.

N Engl J Med 2003 Mar;348(12):1085-95

University Department of Medicine, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, United Kingdom.

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March 2003