Publications by authors named "Jules A Hoffmann"

55Publications

Pharmacological modulation of nucleic acid sensors - therapeutic potential and persisting obstacles.

Nat Rev Drug Discov 2019 11 25;18(11):845-867. Epub 2019 Sep 25.

Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.

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November 2019

The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila.

Immunity 2018 08 14;49(2):225-234.e4. Epub 2018 Aug 14.

Université de Strasbourg, CNRS, Insect Models of Innate Immunity (M3I; UPR9022), 67084 Strasbourg, France; Sino-French Hoffmann Institute, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, China. Electronic address:

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August 2018

Cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila.

Proc Natl Acad Sci U S A 2016 Jan 6;113(3):698-703. Epub 2016 Jan 6.

Institut de Biologie Moleculaire et Cellulaire, CNRS-Unité Propre de Recherche 9022, 67084 Strasbourg, France; University of Strasbourg Institute for Advanced Studies, Université de Strasbourg, 67084 Strasbourg, France; Faculté des Sciences de la Vie, Université de Strasbourg, 67083 Strasbourg, France

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January 2016

RACK1 controls IRES-mediated translation of viruses.

Cell 2014 Nov;159(5):1086-1095

CNRS UPR9022, Institut de Biologie Moléculaire et Cellulaire, 67000 Strasbourg, France; Université de Strasbourg, 67000 Strasbourg, France. Electronic address:

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November 2014

Drosophila C virus systemic infection leads to intestinal obstruction.

J Virol 2014 Dec 24;88(24):14057-69. Epub 2014 Sep 24.

CNRS UPR9022, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France Faculté des Sciences de la Vie, Université de Strasbourg, Strasbourg, France

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December 2014

Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex.

EMBO J 2014 Oct 8;33(20):2332-48. Epub 2014 Aug 8.

Laboratory of Infection and Prevention Institute for Virus Research Kyoto University, Sakyo-ku Kyoto, Japan CREST JST, Sakyo-ku Kyoto, Japan Laboratory of Host Defense WPI Immunology Frontier Research Center (IFReC), Osaka University Suita, Osaka, Japan

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October 2014

big bang gene modulates gut immune tolerance in Drosophila.

Proc Natl Acad Sci U S A 2013 Feb 1;110(8):2957-62. Epub 2013 Feb 1.

Unité Propre de Recherche 9022 du Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 67084 Strasbourg, Cedex, France.

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February 2013

Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif.

PLoS One 2012 15;7(8):e42725. Epub 2012 Aug 15.

INSERM Equipe Avenir, CNRS UPR9022, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.

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May 2013

ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections.

Proc Natl Acad Sci U S A 2011 Jul 30;108(29):12024-9. Epub 2011 Jun 30.

Centre National de la Recherche Scientifique, Unité Propre de Recherche 9022, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 67 084 Strasbourg Cedex, France.

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July 2011

RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila.

Proc Natl Acad Sci U S A 2010 Nov 26;107(45):19390-5. Epub 2010 Oct 26.

Centre National de la Recherche Scientifique Unité Propre de Recherche 9022, Unité Propre de Recherche 9002, Institut de Biologie Moléculaire et Cellulaire du Centre National de la Recherche Scientifique UPR9002, 67084 Strasbourg, France.

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November 2010

NF-kappaB in the immune response of Drosophila.

Cold Spring Harb Perspect Biol 2009 Dec 7;1(6):a000232. Epub 2009 Oct 7.

Centre National de la Recherche Scientifique, Institute of Molecular and Cellular Biology, 15 rue René Descartes, 67084 Strasbourg, France.

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December 2009

Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium.

Cell Host Microbe 2009 Mar;5(3):273-84

UPR 9022 CNRS, AVENIR group Inserm, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg, France.

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March 2009

The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila.

Nat Immunol 2008 Dec 26;9(12):1425-32. Epub 2008 Oct 26.

Unité Propre de Recherché 9022, Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire, 67084 Strasbourg, France.

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December 2008

Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.

Nat Immunol 2008 Jan 9;9(1):97-104. Epub 2007 Dec 9.

Institut de Biologie Moléculaire et Cellulaire, CNRS UPR 9022, Université Louis Pasteur, 67084 Strasbourg Cedex, France.

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January 2008

A model of bacterial intestinal infections in Drosophila melanogaster.

PLoS Pathog 2007 Nov;3(11):e173

Equipe Fondation Recherche Médicale, UPR 9022 du CNRS, Institut de Biologie Moléculaire et Cellulaire du CNRS, Strasbourg, France.

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November 2007

The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections.

Nat Rev Immunol 2007 Nov;7(11):862-74

UPR9022 CNRS, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg, France.

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November 2007

Genetic analysis of resistance to viral infection.

Nat Rev Immunol 2007 Oct;7(10):753-66

Department of Genetics, The Scripps Research Institute, IMM-3-1, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA.

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October 2007

Fz2 and cdc42 mediate melanization and actin polymerization but are dispensable for Plasmodium killing in the mosquito midgut.

PLoS Pathog 2006 Dec;2(12):e133

Institut de Biologie Moléculaire et Cellulaire, UPR9022 du CNRS, Equipe Avenir INSERM, Strasbourg, France.

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December 2006

Boosting NF-kappaB-dependent basal immunity of Anopheles gambiae aborts development of Plasmodium berghei.

Immunity 2006 Oct;25(4):677-85

Institut de Biologie Moléculaire et Cellulaire, UPR9022 du CNRS, Equipe Avenir - Inserm, 15 rue R. Descartes, 67084 Strasbourg Cedex, France.

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October 2006

Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila.

Nat Immunol 2006 Jun 23;7(6):590-7. Epub 2006 Mar 23.

UPR9022 Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire Strasbourg 67000, France.

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June 2006

Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2.

PLoS Pathog 2006 Feb 24;2(2):e14. Epub 2006 Feb 24.

Institut de Biologie Moléculaire et Cellulaire, UPR 9022 du CNRS, Strasbourg, France.

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February 2006

The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila.

Nat Immunol 2005 Sep 7;6(9):946-53. Epub 2005 Aug 7.

Centre National de la Recherche Scientifique UPR9022, Institut de Biologie Moléculaire et Cellulaire, 67000 Strasbourg, France.

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September 2005

Sensing and signaling during infection in Drosophila.

Curr Opin Immunol 2005 Feb;17(1):11-7

UPR 9022 Centre national de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, Strasbourg, France.

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February 2005

Peptidomic and proteomic analyses of the systemic immune response of Drosophila.

Biochimie 2004 Sep-Oct;86(9-10):607-16

Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg cedex, France.

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April 2005

Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria.

Nat Immunol 2004 Nov 26;5(11):1175-80. Epub 2004 Sep 26.

Institut de Biologie Moléculaire et Cellulaire, CNRS UPR 9022, 15 rue René Descartes, Université Louis Pasteur, 67084 Strasbourg Cedex, France.

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November 2004

Toll-dependent and Toll-independent immune responses in Drosophila.

J Endotoxin Res 2004 ;10(4):241-6

UPR9022 du CNRS, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.

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February 2005

Sensing infection in Drosophila: Toll and beyond.

Semin Immunol 2004 Feb;16(1):43-53

UPR 9022 du CNRS, Institut de Biologie Moléculaire et Cellulaire, 15, rue R. Descartes, F67084 Strasbourg Cedex, France.

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February 2004

Dual activation of the Drosophila toll pathway by two pattern recognition receptors.

Science 2003 Dec;302(5653):2126-30

Unité Propre de Recherche 9022 du CNRS, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, F67084 Strasbourg Cedex, France.

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December 2003

The immune response of Drosophila.

Authors:
Jules A Hoffmann

Nature 2003 Nov;426(6962):33-8

Institut de Biologie Moléculaire et Cellulaire du CNRS, 67084 Strasbourg Cedex, France.

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November 2003

Spheniscins, avian beta-defensins in preserved stomach contents of the king penguin, Aptenodytes patagonicus.

J Biol Chem 2003 Dec 2;278(51):51053-8. Epub 2003 Oct 2.

Centre National de la Recherche Scientifique, Centre d'Ecologie et Physiologie Energétiques, 23 rue Becquerel, F67087 Strasbourg Cedex 2, France.

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December 2003

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling.

Nat Immunol 2003 Aug 20;4(8):794-800. Epub 2003 Jul 20.

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom.

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August 2003

Drosophila melanogaster antimicrobial defense.

J Infect Dis 2003 Jun;187 Suppl 2:S327-34

Institut de Biologie Moléculaire et Cellulaire, UPR9022 du Centre National de la Recherche Scientifique, Strasbourg, France.

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June 2003

Tissue and stage-specific expression of the Tolls in Drosophila embryos.

Gene Expr Patterns 2002 Dec;2(3-4):311-7

Institut de Biologie Moléculaire et Cellulaire, UPR 9022 du CNRS, 15, rue René Descartes, 67084 Strasbourg Cedex, France.

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December 2002

A serpin mutant links Toll activation to melanization in the host defence of Drosophila.

EMBO J 2002 Dec;21(23):6330-7

Institut de Biologie Moléculaire and Cellulaire, UPR 9022 du CNRS, 15, rue René Descartes, F-67084 Strasbourg Cedex, France.

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December 2002

PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae.

EMBO Rep 2002 Dec 21;3(12):1195-200. Epub 2002 Nov 21.

Institut de Biologie Moléculaire et Cellulaire, CNRS UPR 9022, 15 rue Descartes, 67084 Strasbourg, France.

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December 2002

Notch signaling controls lineage specification during Drosophila larval hematopoiesis.

Curr Biol 2002 Nov;12(22):1923-7

Unité Propre de Recherche 9022, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084, Strasbourg, France.

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November 2002

The Drosophila immune defense against gram-negative infection requires the death protein dFADD.

Immunity 2002 Nov;17(5):575-81

Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 15 Rue René Descartes, 67084 Cedex, Strasbourg, France.

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November 2002

Activation of Drosophila Toll during fungal infection by a blood serine protease.

Science 2002 Jul;297(5578):114-6

Institut de Biologie Moléculaire et Cellulaire, UPR 9022 du CNRS, 15 rue R. Descartes, F67084 Strasbourg Cedex, France.

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July 2002

The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein.

Nature 2002 Apr 24;416(6881):640-4. Epub 2002 Mar 24.

UPR 9022 du Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, F67084 Strasbourg, Cedex, France.

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April 2002

Drosophila innate immunity: an evolutionary perspective.

Nat Immunol 2002 Feb;3(2):121-6

CNRS, Institute of Molecular and Cellular Biology, 15 rue Descartes, 67000 Strasbourg, France.

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February 2002

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections.

Nat Immunol 2002 Jan 17;3(1):91-7. Epub 2001 Dec 17.

UPR9022 du Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire, 15, rue René Descartes, 67000 Strasbourg, France.

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January 2002