Publications by authors named "Jules A Hoffmann"

55Publications

The Kinase IKKβ Regulates a STING-and NF-κB-Dependent Antiviral Response Pathway in Drosophila.

Authors:
Akira Goto Kiyoshi Okado Nelson Martins Hua Cai Vincent Barbier Olivier Lamiable Laurent Troxler Estelle Santiago Lauriane Kuhn Donggi Paik Neal Silverman Andreas Holleufer Rune Hartmann Jiyong Liu Tao Peng Jules A Hoffmann Carine Meignin Laurent Daeffler Jean-Luc Imler

Immunity 2020 01;52(1):200

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January 2020

Pharmacological modulation of nucleic acid sensors - therapeutic potential and persisting obstacles.

Authors:
Claire Vanpouille-Box Jules A Hoffmann Lorenzo Galluzzi

Nat Rev Drug Discov 2019 11 25;18(11):845-867. Epub 2019 Sep 25.

Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.

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November 2019

The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila.

Authors:
Akira Goto Kiyoshi Okado Nelson Martins Hua Cai Vincent Barbier Olivier Lamiable Laurent Troxler Estelle Santiago Lauriane Kuhn Donggi Paik Neal Silverman Andreas Holleufer Rune Hartmann Jiyong Liu Tao Peng Jules A Hoffmann Carine Meignin Laurent Daeffler Jean-Luc Imler

Immunity 2018 08 14;49(2):225-234.e4. Epub 2018 Aug 14.

Université de Strasbourg, CNRS, Insect Models of Innate Immunity (M3I; UPR9022), 67084 Strasbourg, France; Sino-French Hoffmann Institute, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, China. Electronic address:

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August 2018

Analysis of the Contribution of Hemocytes and Autophagy to Drosophila Antiviral Immunity.

Authors:
Olivier Lamiable Johan Arnold Isaque Joao da Silva de Faria Roenick Proveti Olmo Francesco Bergami Carine Meignin Jules A Hoffmann Joao Trindade Marques Jean-Luc Imler

J Virol 2016 06 12;90(11):5415-5426. Epub 2016 May 12.

CNRS UPR9022, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France

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June 2016

Cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila.

Authors:
Olivier Lamiable Christine Kellenberger Cordula Kemp Laurent Troxler Nadège Pelte Michael Boutros Joao Trindade Marques Laurent Daeffler Jules A Hoffmann Alain Roussel Jean-Luc Imler

Proc Natl Acad Sci U S A 2016 Jan 6;113(3):698-703. Epub 2016 Jan 6.

Institut de Biologie Moleculaire et Cellulaire, CNRS-Unité Propre de Recherche 9022, 67084 Strasbourg, France; University of Strasbourg Institute for Advanced Studies, Université de Strasbourg, 67084 Strasbourg, France; Faculté des Sciences de la Vie, Université de Strasbourg, 67083 Strasbourg, France

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January 2016

RACK1 controls IRES-mediated translation of viruses.

Authors:
Karim Majzoub Mohamed Lamine Hafirassou Carine Meignin Akira Goto Stefano Marzi Antonina Fedorova Yann Verdier Joëlle Vinh Jules A Hoffmann Franck Martin Thomas F Baumert Catherine Schuster Jean-Luc Imler

Cell 2014 Nov;159(5):1086-1095

CNRS UPR9022, Institut de Biologie Moléculaire et Cellulaire, 67000 Strasbourg, France; Université de Strasbourg, 67000 Strasbourg, France. Electronic address:

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November 2014

Drosophila C virus systemic infection leads to intestinal obstruction.

Authors:
Stanislava Chtarbanova Olivier Lamiable Kwang-Zin Lee Delphine Galiana Laurent Troxler Carine Meignin Charles Hetru Jules A Hoffmann Laurent Daeffler Jean-Luc Imler

J Virol 2014 Dec 24;88(24):14057-69. Epub 2014 Sep 24.

CNRS UPR9022, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France Faculté des Sciences de la Vie, Université de Strasbourg, Strasbourg, France

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December 2014

Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex.

Authors:
Sarang Tartey Kazufumi Matsushita Alexis Vandenbon Daisuke Ori Tomoko Imamura Takashi Mino Daron M Standley Jules A Hoffmann Jean-Marc Reichhart Shizuo Akira Osamu Takeuchi

EMBO J 2014 Oct 8;33(20):2332-48. Epub 2014 Aug 8.

Laboratory of Infection and Prevention Institute for Virus Research Kyoto University, Sakyo-ku Kyoto, Japan CREST JST, Sakyo-ku Kyoto, Japan Laboratory of Host Defense WPI Immunology Frontier Research Center (IFReC), Osaka University Suita, Osaka, Japan

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October 2014

The chromatin regulator DMAP1 modulates activity of the nuclear factor B (NF-B) transcription factor Relish in the Drosophila innate immune response.

Authors:
Akira Goto Hidehiro Fukuyama Jean-Luc Imler Jules A Hoffmann

J Biol Chem 2014 Jul;289(30):20470-6

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July 2014

Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge.

Authors:
Hidehiro Fukuyama Yann Verdier Yongsheng Guan Chieko Makino-Okamura Victoria Shilova Xi Liu Elie Maksoud Jun Matsubayashi Iman Haddad Kerstin Spirohn Kenichiro Ono Charles Hetru Jean Rossier Trey Ideker Michael Boutros Joëlle Vinh Jules A Hoffmann

Proc Natl Acad Sci U S A 2013 Jun 7;110(26):10717-22. Epub 2013 Jun 7.

Institut National de la Santé et de la Recherche Médicale Equipe Avenir, 67084 Strasbourg, France.

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June 2013

big bang gene modulates gut immune tolerance in Drosophila.

Authors:
François Bonnay Eva Cohen-Berros Martine Hoffmann Sabrina Y Kim Gabrielle L Boulianne Jules A Hoffmann Nicolas Matt Jean-Marc Reichhart

Proc Natl Acad Sci U S A 2013 Feb 1;110(8):2957-62. Epub 2013 Feb 1.

Unité Propre de Recherche 9022 du Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 67084 Strasbourg, Cedex, France.

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February 2013

Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila.

Authors:
Cordula Kemp Stefanie Mueller Akira Goto Vincent Barbier Simona Paro François Bonnay Catherine Dostert Laurent Troxler Charles Hetru Carine Meignin Sébastien Pfeffer Jules A Hoffmann Jean-Luc Imler

J Immunol 2013 Jan 19;190(2):650-8. Epub 2012 Dec 19.

CNRS-UPR9022, Institut de Biologie Moléculaire et Cellulaire, 67084 Strasbourg Cedex, France.

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January 2013

Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif.

Authors:
Xi Liu Teruyuki Sano Yongsheng Guan Shigekazu Nagata Jules A Hoffmann Hidehiro Fukuyama

PLoS One 2012 15;7(8):e42725. Epub 2012 Aug 15.

INSERM Equipe Avenir, CNRS UPR9022, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.

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May 2013

Pillars article: the dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 1996. 86: 973-983.

Authors:
Bruno Lemaitre Emmanuelle Nicolas Lydia Michaut Jean-Marc Reichhart Jules A Hoffmann

J Immunol 2012 Jun;188(11):5210-20

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June 2012

ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections.

Authors:
Ioannis Eleftherianos Sungyong Won Stanislava Chtarbanova Barbara Squiban Karen Ocorr Rolf Bodmer Bruce Beutler Jules A Hoffmann Jean-Luc Imler

Proc Natl Acad Sci U S A 2011 Jul 30;108(29):12024-9. Epub 2011 Jun 30.

Centre National de la Recherche Scientifique, Unité Propre de Recherche 9022, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 67 084 Strasbourg Cedex, France.

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July 2011

RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila.

Authors:
Stefanie Mueller Valérie Gausson Nicolas Vodovar Safia Deddouche Laurent Troxler Jonathan Perot Sébastien Pfeffer Jules A Hoffmann Maria-Carla Saleh Jean-Luc Imler

Proc Natl Acad Sci U S A 2010 Nov 26;107(45):19390-5. Epub 2010 Oct 26.

Centre National de la Recherche Scientifique Unité Propre de Recherche 9022, Unité Propre de Recherche 9002, Institut de Biologie Moléculaire et Cellulaire du Centre National de la Recherche Scientifique UPR9002, 67084 Strasbourg, France.

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November 2010

NF-kappaB in the immune response of Drosophila.

Authors:
Charles Hetru Jules A Hoffmann

Cold Spring Harb Perspect Biol 2009 Dec 7;1(6):a000232. Epub 2009 Oct 7.

Centre National de la Recherche Scientifique, Institute of Molecular and Cellular Biology, 15 rue René Descartes, 67084 Strasbourg, France.

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December 2009

The N-terminal domain of Drosophila Gram-negative binding protein 3 (GNBP3) defines a novel family of fungal pattern recognition receptors.

Authors:
Yumiko Mishima Jessica Quintin Vishukumar Aimanianda Christine Kellenberger Franck Coste Cecile Clavaud Charles Hetru Jules A Hoffmann Jean-Paul Latgé Dominique Ferrandon Alain Roussel

J Biol Chem 2009 Oct 19;284(42):28687-97. Epub 2009 Aug 19.

Centre de Biophysique Moléculaire, UPR 4301 CNRS, 45071 Orléans Cedex 2, France.

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October 2009

Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium.

Authors:
Malou Fraiture Richard H G Baxter Stefanie Steinert Yogarany Chelliah Cécile Frolet Wilber Quispe-Tintaya Jules A Hoffmann Stéphanie A Blandin Elena A Levashina

Cell Host Microbe 2009 Mar;5(3):273-84

UPR 9022 CNRS, AVENIR group Inserm, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg, France.

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March 2009

The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila.

Authors:
Safia Deddouche Nicolas Matt Aidan Budd Stefanie Mueller Cordula Kemp Delphine Galiana-Arnoux Catherine Dostert Christophe Antoniewski Jules A Hoffmann Jean-Luc Imler

Nat Immunol 2008 Dec 26;9(12):1425-32. Epub 2008 Oct 26.

Unité Propre de Recherché 9022, Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire, 67084 Strasbourg, France.

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December 2008

Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.

Authors:
Akira Goto Kazufumi Matsushita Viola Gesellchen Laure El Chamy David Kuttenkeuler Osamu Takeuchi Jules A Hoffmann Shizuo Akira Michael Boutros Jean-Marc Reichhart

Nat Immunol 2008 Jan 9;9(1):97-104. Epub 2007 Dec 9.

Institut de Biologie Moléculaire et Cellulaire, CNRS UPR 9022, Université Louis Pasteur, 67084 Strasbourg Cedex, France.

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January 2008

A model of bacterial intestinal infections in Drosophila melanogaster.

Authors:
Nadine T Nehme Samuel Liégeois Beatrix Kele Philippe Giammarinaro Elizabeth Pradel Jules A Hoffmann Jonathan J Ewbank Dominique Ferrandon

PLoS Pathog 2007 Nov;3(11):e173

Equipe Fondation Recherche Médicale, UPR 9022 du CNRS, Institut de Biologie Moléculaire et Cellulaire du CNRS, Strasbourg, France.

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November 2007

The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections.

Authors:
Dominique Ferrandon Jean-Luc Imler Charles Hetru Jules A Hoffmann

Nat Rev Immunol 2007 Nov;7(11):862-74

UPR9022 CNRS, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg, France.

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November 2007

Genetic analysis of resistance to viral infection.

Authors:
Bruce Beutler Celine Eidenschenk Karine Crozat Jean-Luc Imler Osamu Takeuchi Jules A Hoffmann Shizuo Akira

Nat Rev Immunol 2007 Oct;7(10):753-66

Department of Genetics, The Scripps Research Institute, IMM-3-1, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA.

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October 2007

Fz2 and cdc42 mediate melanization and actin polymerization but are dispensable for Plasmodium killing in the mosquito midgut.

Authors:
Shin-Hong Shiao Miranda M A Whitten Daniel Zachary Jules A Hoffmann Elena A Levashina

PLoS Pathog 2006 Dec;2(12):e133

Institut de Biologie Moléculaire et Cellulaire, UPR9022 du CNRS, Equipe Avenir INSERM, Strasbourg, France.

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December 2006

Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors.

Authors:
Marie Gottar Vanessa Gobert Alexey A Matskevich Jean-Marc Reichhart Chengshu Wang Tariq M Butt Marcia Belvin Jules A Hoffmann Dominique Ferrandon

Cell 2006 Dec;127(7):1425-37

UPR 9022 du CNRS, Institut de Biologie Moléculaire et Cellulaire, F67084 Strasbourg Cedex, France.

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December 2006

Boosting NF-kappaB-dependent basal immunity of Anopheles gambiae aborts development of Plasmodium berghei.

Authors:
Cécile Frolet Martine Thoma Stéphanie Blandin Jules A Hoffmann Elena A Levashina

Immunity 2006 Oct;25(4):677-85

Institut de Biologie Moléculaire et Cellulaire, UPR9022 du CNRS, Equipe Avenir - Inserm, 15 rue R. Descartes, 67084 Strasbourg Cedex, France.

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October 2006

Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila.

Authors:
Delphine Galiana-Arnoux Catherine Dostert Anette Schneemann Jules A Hoffmann Jean-Luc Imler

Nat Immunol 2006 Jun 23;7(6):590-7. Epub 2006 Mar 23.

UPR9022 Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire Strasbourg 67000, France.

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June 2006

Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2.

Authors:
Vincent Bischoff Cécile Vignal Bernard Duvic Ivo G Boneca Jules A Hoffmann Julien Royet

PLoS Pathog 2006 Feb 24;2(2):e14. Epub 2006 Feb 24.

Institut de Biologie Moléculaire et Cellulaire, UPR 9022 du CNRS, Strasbourg, France.

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February 2006

Prophenoloxidase activation is not required for survival to microbial infections in Drosophila.

Authors:
Vincent Leclerc Nadège Pelte Laure El Chamy Cosimo Martinelli Petros Ligoxygakis Jules A Hoffmann Jean-Marc Reichhart

EMBO Rep 2006 Feb;7(2):231-5

UPR9022 du CNRS, IBMC, 15 rue Descartes, 67084 Strasbourg, France.

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February 2006

Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila.

Authors:
Christine Kocks Ju Hyun Cho Nadine Nehme Johanna Ulvila Alan M Pearson Marie Meister Charles Strom Stephanie L Conto Charles Hetru Lynda M Stuart Thilo Stehle Jules A Hoffmann Jean-Marc Reichhart Dominique Ferrandon Mika Rämet R Alan B Ezekowitz

Cell 2005 Oct;123(2):335-46

Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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October 2005

The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila.

Authors:
Catherine Dostert Emmanuelle Jouanguy Phil Irving Laurent Troxler Delphine Galiana-Arnoux Charles Hetru Jules A Hoffmann Jean-Luc Imler

Nat Immunol 2005 Sep 7;6(9):946-53. Epub 2005 Aug 7.

Centre National de la Recherche Scientifique UPR9022, Institut de Biologie Moléculaire et Cellulaire, 67000 Strasbourg, France.

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September 2005

New insights into Drosophila larval haemocyte functions through genome-wide analysis.

Authors:
Phil Irving Jean-Michel Ubeda Daniel Doucet Laurent Troxler Marie Lagueux Daniel Zachary Jules A Hoffmann Charles Hetru Marie Meister

Cell Microbiol 2005 Mar;7(3):335-50

UPR 9022 du CNRS, IBMC, 15 rue René Descartes, 67084 Strasbourg, France.

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March 2005

Sensing and signaling during infection in Drosophila.

Authors:
Julien Royet Jean-Marc Reichhart Jules A Hoffmann

Curr Opin Immunol 2005 Feb;17(1):11-7

UPR 9022 Centre national de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, Strasbourg, France.

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February 2005

Peptidomic and proteomic analyses of the systemic immune response of Drosophila.

Authors:
Francine Levy David Rabel Maurice Charlet Philippe Bulet Jules A Hoffmann Laurence Ehret-Sabatier

Biochimie 2004 Sep-Oct;86(9-10):607-16

Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg cedex, France.

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April 2005

Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria.

Authors:
Vincent Bischoff Cécile Vignal Ivo G Boneca Tatiana Michel Jules A Hoffmann Julien Royet

Nat Immunol 2004 Nov 26;5(11):1175-80. Epub 2004 Sep 26.

Institut de Biologie Moléculaire et Cellulaire, CNRS UPR 9022, 15 rue René Descartes, Université Louis Pasteur, 67084 Strasbourg Cedex, France.

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November 2004

Toll-dependent and Toll-independent immune responses in Drosophila.

Authors:
Jean-Luc Imler Dominique Ferrandon Julien Royet Jean-Marc Reichhart Charles Hetru Jules A Hoffmann

J Endotoxin Res 2004 ;10(4):241-6

UPR9022 du CNRS, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.

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February 2005

Sensing infection in Drosophila: Toll and beyond.

Authors:
Dominique Ferrandon Jean-Luc Imler Jules A Hoffmann

Semin Immunol 2004 Feb;16(1):43-53

UPR 9022 du CNRS, Institut de Biologie Moléculaire et Cellulaire, 15, rue R. Descartes, F67084 Strasbourg Cedex, France.

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February 2004

Dual activation of the Drosophila toll pathway by two pattern recognition receptors.

Authors:
Vanessa Gobert Marie Gottar Alexey A Matskevich Sophie Rutschmann Julien Royet Marcia Belvin Jules A Hoffmann Dominique Ferrandon

Science 2003 Dec;302(5653):2126-30

Unité Propre de Recherche 9022 du CNRS, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, F67084 Strasbourg Cedex, France.

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December 2003

The immune response of Drosophila.

Authors:
Jules A Hoffmann

Nature 2003 Nov;426(6962):33-8

Institut de Biologie Moléculaire et Cellulaire du CNRS, 67084 Strasbourg Cedex, France.

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November 2003

Spheniscins, avian beta-defensins in preserved stomach contents of the king penguin, Aptenodytes patagonicus.

Authors:
Cécile Thouzeau Yvon Le Maho Guillaume Froget Laurence Sabatier Céline Le Bohec Jules A Hoffmann Philippe Bulet

J Biol Chem 2003 Dec 2;278(51):51053-8. Epub 2003 Oct 2.

Centre National de la Recherche Scientifique, Centre d'Ecologie et Physiologie Energétiques, 23 rue Becquerel, F67087 Strasbourg Cedex 2, France.

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December 2003

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling.

Authors:
Alexander N R Weber Servane Tauszig-Delamasure Jules A Hoffmann Eric Lelièvre Hugues Gascan Keith P Ray Mary A Morse Jean-Luc Imler Nicholas J Gay

Nat Immunol 2003 Aug 20;4(8):794-800. Epub 2003 Jul 20.

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom.

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August 2003

Drosophila melanogaster antimicrobial defense.

Authors:
Charles Hetru Laurent Troxler Jules A Hoffmann

J Infect Dis 2003 Jun;187 Suppl 2:S327-34

Institut de Biologie Moléculaire et Cellulaire, UPR9022 du Centre National de la Recherche Scientifique, Strasbourg, France.

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June 2003

Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening.

Authors:
C Léopold Kurz Sophie Chauvet Emmanuel Andrès Marianne Aurouze Isabelle Vallet Gérard P F Michel Mitch Uh Jean Celli Alain Filloux Sophie De Bentzmann Ivo Steinmetz Jules A Hoffmann B Brett Finlay Jean-Pierre Gorvel Dominique Ferrandon Jonathan J Ewbank

EMBO J 2003 Apr;22(7):1451-60

Centre d'Immunologie de Marseille Luminy, INSERM/CNRS/Université de la Méditerranée, Case 906, 13288 Marseille cedex 9, France.

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April 2003

Tissue and stage-specific expression of the Tolls in Drosophila embryos.

Authors:
Zakaria Kambris Jules A Hoffmann Jean-Luc Imler Maria Capovilla

Gene Expr Patterns 2002 Dec;2(3-4):311-7

Institut de Biologie Moléculaire et Cellulaire, UPR 9022 du CNRS, 15, rue René Descartes, 67084 Strasbourg Cedex, France.

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December 2002

Toll signaling: the TIReless quest for specificity.

Authors:
Jean-Luc Imler Jules A Hoffmann

Nat Immunol 2003 Feb;4(2):105-6

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February 2003

A serpin mutant links Toll activation to melanization in the host defence of Drosophila.

Authors:
Petros Ligoxygakis Nadège Pelte Chuanyi Ji Vincent Leclerc Bernard Duvic Marcia Belvin Haobo Jiang Jules A Hoffmann Jean-Marc Reichhart

EMBO J 2002 Dec;21(23):6330-7

Institut de Biologie Moléculaire and Cellulaire, UPR 9022 du CNRS, 15, rue René Descartes, F-67084 Strasbourg Cedex, France.

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December 2002

PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae.

Authors:
Anne-Isabelle Munier Daniel Doucet Emmanuel Perrodou Daniel Zachary Marie Meister Jules A Hoffmann Charles A Janeway Marie Lagueux

EMBO Rep 2002 Dec 21;3(12):1195-200. Epub 2002 Nov 21.

Institut de Biologie Moléculaire et Cellulaire, CNRS UPR 9022, 15 rue Descartes, 67084 Strasbourg, France.

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December 2002

Notch signaling controls lineage specification during Drosophila larval hematopoiesis.

Authors:
Bernard Duvic Jules A Hoffmann Marie Meister Julien Royet

Curr Biol 2002 Nov;12(22):1923-7

Unité Propre de Recherche 9022, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084, Strasbourg, France.

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November 2002

The Drosophila immune defense against gram-negative infection requires the death protein dFADD.

Authors:
Silvia Naitza Carine Rossé Christine Kappler Philippe Georgel Marcia Belvin David Gubb Jacques Camonis Jules A Hoffmann Jean Marc Reichhart

Immunity 2002 Nov;17(5):575-81

Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 15 Rue René Descartes, 67084 Cedex, Strasbourg, France.

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November 2002

Immunity-related genes and gene families in Anopheles gambiae.

Authors:
George K Christophides Evgeny Zdobnov Carolina Barillas-Mury Ewan Birney Stephanie Blandin Claudia Blass Paul T Brey Frank H Collins Alberto Danielli George Dimopoulos Charles Hetru Ngo T Hoa Jules A Hoffmann Stefan M Kanzok Ivica Letunic Elena A Levashina Thanasis G Loukeris Gareth Lycett Stephan Meister Kristin Michel Luis F Moita Hans-Michael Müller Mike A Osta Susan M Paskewitz Jean-Marc Reichhart Andrey Rzhetsky Laurent Troxler Kenneth D Vernick Dina Vlachou Jennifer Volz Christian von Mering Jiannong Xu Liangbiao Zheng Peer Bork Fotis C Kafatos

Science 2002 Oct;298(5591):159-65

European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

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October 2002

Activation of Drosophila Toll during fungal infection by a blood serine protease.

Authors:
Petros Ligoxygakis Nadège Pelte Jules A Hoffmann Jean-Marc Reichhart

Science 2002 Jul;297(5578):114-6

Institut de Biologie Moléculaire et Cellulaire, UPR 9022 du CNRS, 15 rue R. Descartes, F67084 Strasbourg Cedex, France.

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July 2002

The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein.

Authors:
Marie Gottar Vanessa Gobert Tatiana Michel Marcia Belvin Geoffrey Duyk Jules A Hoffmann Dominique Ferrandon Julien Royet

Nature 2002 Apr 24;416(6881):640-4. Epub 2002 Mar 24.

UPR 9022 du Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, F67084 Strasbourg, Cedex, France.

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April 2002

Drosophila innate immunity: an evolutionary perspective.

Authors:
Jules A Hoffmann Jean-Marc Reichhart

Nat Immunol 2002 Feb;3(2):121-6

CNRS, Institute of Molecular and Cellular Biology, 15 rue Descartes, 67000 Strasbourg, France.

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February 2002

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections.

Authors:
Servane Tauszig-Delamasure Hana Bilak Maria Capovilla Jules A Hoffmann Jean-Luc Imler

Nat Immunol 2002 Jan 17;3(1):91-7. Epub 2001 Dec 17.

UPR9022 du Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire, 15, rue René Descartes, 67000 Strasbourg, France.

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January 2002