Juleen R Zierath

Juleen R Zierath

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Major Advances and Discoveries in Diabetes - 2019 in Review.

Authors:
Juleen R Zierath

Curr Diab Rep 2019 Nov 4;19(11):118. Epub 2019 Nov 4.

Section of Integrative Physiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Biomedicum, Solnavägen 9, 171 65, Stockholm, SE, Sweden.

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http://dx.doi.org/10.1007/s11892-019-1255-xDOI Listing
November 2019

Influence of Obesity, Weight Loss, and Free Fatty Acids on Skeletal Muscle Clock Gene Expression.

Am J Physiol Endocrinol Metab 2019 Oct 15. Epub 2019 Oct 15.

Integrative Physiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Integrative Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1152/ajpendo.00289.2019DOI Listing
October 2019

Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis.

Trends Endocrinol Metab 2019 Sep 19;30(9):603-617. Epub 2019 Jul 19.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2019.06.003DOI Listing
September 2019

Identification of two microRNA nodes as potential cooperative modulators of liver metabolism.

Hepatol Res 2019 Aug 13. Epub 2019 Aug 13.

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/hepr.13419DOI Listing
August 2019

Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis.

Cell Metab 2019 Jul 18;30(1):92-110.e4. Epub 2019 Apr 18.

Center for Epigenetics and Metabolism, INSERM U1233, Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.03.013DOI Listing
July 2019

Paternal high-fat diet transgenerationally impacts hepatic immunometabolism.

FASEB J 2019 May 15;33(5):6269-6280. Epub 2019 Feb 15.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1096/fj.201801879RRDOI Listing
May 2019

Circadian rhythms and exercise - re-setting the clock in metabolic disease.

Nat Rev Endocrinol 2019 04;15(4):197-206

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://www.nature.com/articles/s41574-018-0150-x
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http://dx.doi.org/10.1038/s41574-018-0150-xDOI Listing
April 2019

Voluntary wheel running in the late dark phase ameliorates diet-induced obesity in mice without altering insulin action.

J Appl Physiol (1985) 2019 Apr 7;126(4):993-1005. Epub 2019 Feb 7.

Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen , Copenhagen , Denmark.

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http://dx.doi.org/10.1152/japplphysiol.00737.2018DOI Listing
April 2019

Circulating Exosomal miR-20b-5p Is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle.

Diabetes 2019 03 14;68(3):515-526. Epub 2018 Dec 14.

Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden

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http://dx.doi.org/10.2337/db18-0470DOI Listing
March 2019

Interplay between diet, exercise and the molecular circadian clock in orchestrating metabolic adaptations of adipose tissue.

J Physiol 2019 Mar 28;597(6):1439-1450. Epub 2019 Jan 28.

Department of Physiology and Pharmacology, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1113/JP276488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418759PMC
March 2019

Short-term low-calorie diet remodels skeletal muscle lipid profile and metabolic gene expression in obese adults.

Am J Physiol Endocrinol Metab 2019 02 27;316(2):E178-E185. Epub 2018 Nov 27.

Division of Surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet , Stockholm , Sweden.

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http://dx.doi.org/10.1152/ajpendo.00253.2018DOI Listing
February 2019

Regulation of glucose uptake and inflammation markers by FOXO1 and FOXO3 in skeletal muscle.

Mol Metab 2019 02 16;20:79-88. Epub 2018 Nov 16.

Department of Physiology and Pharmacology, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358548PMC
February 2019

AMPK activation negatively regulates GDAP1, which influences metabolic processes and circadian gene expression in skeletal muscle.

Mol Metab 2018 10 25;16:12-23. Epub 2018 Jul 25.

Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden; Department of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden; Section of Integrative Physiology, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157647PMC
October 2018

Skeletal Muscle Insulin Sensitivity Show Circadian Rhythmicity Which Is Independent of Exercise Training Status.

Front Physiol 2018 28;9:1198. Epub 2018 Aug 28.

Section of Integrative Physiology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.

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https://www.frontiersin.org/article/10.3389/fphys.2018.01198
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http://dx.doi.org/10.3389/fphys.2018.01198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121032PMC
August 2018

Effects of high-fat diet and AMP-activated protein kinase modulation on the regulation of whole-body lipid metabolism.

J Lipid Res 2018 07 8;59(7):1276-1282. Epub 2018 May 8.

Department of Molecular Medicine and Surgery Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.1194/jlr.D082370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027908PMC
July 2018

Proteomics Analysis of Skeletal Muscle from Leptin-Deficient ob/ob Mice Reveals Adaptive Remodeling of Metabolic Characteristics and Fiber Type Composition.

Proteomics 2018 03 20;18(5-6):e1700375. Epub 2018 Feb 20.

Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Martinsried, Germany.

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http://dx.doi.org/10.1002/pmic.201700375DOI Listing
March 2018

FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle.

Diabetologia 2018 02 11;61(2):424-432. Epub 2017 Oct 11.

Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, von Eulers väg 4a, IV, SE-171 65, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00125-017-4451-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449061PMC
February 2018

Diacylglycerol kinase α deficiency alters inflammation markers in adipose tissue in response to a high-fat diet.

J Lipid Res 2018 02 12;59(2):273-282. Epub 2017 Dec 12.

Department of Physiology and Pharmacology Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.1194/jlr.M079517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794422PMC
February 2018

The ZBED6-IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals.

Proc Natl Acad Sci U S A 2018 02 12;115(9):E2048-E2057. Epub 2018 Feb 12.

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden;

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http://dx.doi.org/10.1073/pnas.1719278115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834713PMC
February 2018

DGKζ deficiency protects against peripheral insulin resistance and improves energy metabolism.

J Lipid Res 2017 12 24;58(12):2324-2333. Epub 2017 Oct 24.

Department of Physiology and Pharmacology Karolinska Institutet, 171 77 Stockholm, Sweden

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http://dx.doi.org/10.1194/jlr.M079723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711495PMC
December 2017

Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle.

Am J Physiol Endocrinol Metab 2017 10 18;313(4):E483-E491. Epub 2017 Jul 18.

Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.1152/ajpendo.00147.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668594PMC
October 2017

Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle.

Diabetes 2017 07 12;66(7):1807-1818. Epub 2017 Apr 12.

Department of Physiology and Pharmacology, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.2337/db17-0141DOI Listing
July 2017

Early vertebrate origin and diversification of small transmembrane regulators of cellular ion transport.

J Physiol 2017 07 29;595(14):4611-4630. Epub 2017 May 29.

Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1113/JP274254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509871PMC
July 2017

Grandpaternal-induced transgenerational dietary reprogramming of the unfolded protein response in skeletal muscle.

Mol Metab 2017 07 22;6(7):621-630. Epub 2017 May 22.

Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.molmet.2017.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485306PMC
July 2017

Diacylglycerol kinase ε deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice.

J Lipid Res 2017 05 28;58(5):907-915. Epub 2017 Feb 28.

Section of Integrative Physiology, Department of Molecular Medicine and Surgery and Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.1194/jlr.M074443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408609PMC
May 2017

The Limits of Exercise Physiology: From Performance to Health.

Cell Metab 2017 May;25(5):1000-1011

Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Molecular Medicine and Surgery, Section of Integrative Physiology, Karolinska Institutet, 171 76 Stockholm, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.04.018DOI Listing
May 2017

Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK.

Diabetes 2017 03 26;66(3):598-612. Epub 2016 Oct 26.

Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark

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http://diabetes.diabetesjournals.org/content/diabetes/early/
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http://dx.doi.org/10.2337/db16-0530DOI Listing
March 2017

Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle.

Diabetes 2017 03 23;66(3):651-662. Epub 2016 Dec 23.

Integrative Physiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.2337/db16-0882DOI Listing
March 2017

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance.

Cell Rep 2017 01;18(3):636-646

Section for Integrative Physiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, 17177 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.12.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5276805PMC
January 2017

Building Bridges through Scientific Conferences.

Authors:
Juleen R Zierath

Cell 2016 Nov;167(5):1155-1158

Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, 171 77 Stockholm, Sweden; Section of Integrative Physiology, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.11.006DOI Listing
November 2016

Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes.

Diabetes Metab Res Rev 2016 10 1;32(7):754-761. Epub 2016 May 1.

Department of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/dmrr.2798DOI Listing
October 2016

The role of diet and exercise in the transgenerational epigenetic landscape of T2DM.

Nat Rev Endocrinol 2016 08 17;12(8):441-51. Epub 2016 Jun 17.

The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Integrative Physiology, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen 2200, Denmark.

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http://dx.doi.org/10.1038/nrendo.2016.87DOI Listing
August 2016

SnapShot: Exercise Metabolism.

Cell Metab 2016 08;24(2):342-342.e1

Department of Molecular Medicine and Surgery and Department of Physiology and Pharmacology, Section of Integrative Physiology, Karolinska Institutet, 17177 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.cmet.2016.07.013DOI Listing
August 2016

Exercise Promotes Healthy Aging of Skeletal Muscle.

Cell Metab 2016 06;23(6):1034-1047

Section of Integrative Physiology, Department of Molecular Medicine and Surgery and Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Solna, Sweden; Section of Integrative Physiology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, 2200 Copenhagen, Denmark; Faculty of Health and Medical Science, University of Copenhagen, 1165 Copenhagen, Denmark. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045036PMC
http://dx.doi.org/10.1016/j.cmet.2016.05.007DOI Listing
June 2016

AMPKγ3 is dispensable for skeletal muscle hypertrophy induced by functional overload.

Am J Physiol Endocrinol Metab 2016 Mar 12;310(6):E461-72. Epub 2016 Jan 12.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; and

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http://dx.doi.org/10.1152/ajpendo.00387.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796264PMC
March 2016

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring.

Mol Metab 2016 Mar 25;5(3):184-197. Epub 2015 Dec 25.

The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2015.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770269PMC
March 2016

Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients.

Mol Metab 2016 Mar 2;5(3):171-183. Epub 2016 Jan 2.

Section of Integrative Physiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Section of Integrative Physiology, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark; Section of Integrative Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2015.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770265PMC
March 2016

Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans.

Cell Metab 2016 Feb 6;23(2):369-78. Epub 2015 Dec 6.

The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.11.004DOI Listing
February 2016

Diacylglycerol kinase-δ regulates AMPK signaling, lipid metabolism, and skeletal muscle energetics.

Am J Physiol Endocrinol Metab 2016 Jan 3;310(1):E51-60. Epub 2015 Nov 3.

Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden; Department of Physiology and Pharmacology, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.1152/ajpendo.00209.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675797PMC
January 2016

Turning the page.

Authors:
Juleen R Zierath

Diabetologia 2015 Dec;58(12):2685-7

Department of Molecular Medicine and Surgery, Karolinska Institutet, Von Eulers Väg 4a, 4 Tr., 171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00125-015-3764-8DOI Listing
December 2015

Erratum to: Turning the page.

Authors:
Juleen R Zierath

Diabetologia 2015 Dec;58(12):2899

Department of Molecular Medicine and Surgery, Karolinska Institutet, Von Eulers Väg 4a, 4 Tr., 171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00125-015-3782-6DOI Listing
December 2015

MicroRNA-208b progressively declines after spinal cord injury in humans and is inversely related to myostatin expression.

Physiol Rep 2015 Nov 24;3(11). Epub 2015 Nov 24.

Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.14814/phy2.12622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673649PMC
November 2015

Skeletal muscle AMP-activated protein kinase γ1(H151R) overexpression enhances whole body energy homeostasis and insulin sensitivity.

Am J Physiol Endocrinol Metab 2015 Oct 25;309(7):E679-90. Epub 2015 Aug 25.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden;

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http://dx.doi.org/10.1152/ajpendo.00195.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593773PMC
October 2015

Influence of physical activity and gender on arterial function in type 2 diabetes, normal and impaired glucose tolerance.

Diab Vasc Dis Res 2015 Sep 19;12(5):315-24. Epub 2015 Jun 19.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden Department of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.

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http://dx.doi.org/10.1177/1479164115588548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527971PMC
September 2015

Effects of sleeping with reduced carbohydrate availability on acute training responses.

J Appl Physiol (1985) 2015 Sep 25;119(6):643-55. Epub 2015 Jun 25.

Centre for Exercise and Nutrition, Mary MacKillop Health Research Institute, Australian Catholic University, Melbourne, Australia; Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom

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http://dx.doi.org/10.1152/japplphysiol.00857.2014DOI Listing
September 2015

Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men.

J Clin Endocrinol Metab 2015 Sep 13;100(9):E1255-61. Epub 2015 Jul 13.

Department of Neuroscience (J.C., S.V., J.E.B., H.B.S., C.B.), Uppsala University, 751 24 Uppsala, Sweden; Department of Molecular Medicine and Surgery (M.E.O., J.R.Z.), Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Experimental Diabetology (H.V.), German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany; and Department of Physiology, Institute of Neuroscience and Physiology (H.V., S.L.D.), The Sahlgrenska Academy at the University of Gothenburg, 411 37 Gothenburg, Sweden.

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https://thehubedu-production.s3.amazonaws.com/uploads/3/b64d
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http://press.endocrine.org/doi/10.1210/JC.2015-2284
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http://dx.doi.org/10.1210/JC.2015-2284DOI Listing
September 2015

Diabetologia at 50: celebrating half a century of progress in diabetes research and care.

Authors:
Juleen R Zierath

Diabetologia 2015 Aug;58(8):1685-7

Department of Molecular Medicine and Surgery, Karolinska Institutet, Von Eulers Väg 4a, 4 Tr., 171 77, Stockholm, Sweden,

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http://dx.doi.org/10.1007/s00125-015-3640-6DOI Listing
August 2015

Looking Ahead Perspective: Where Will the Future of Exercise Biology Take Us?

Cell Metab 2015 Jul;22(1):25-30

Department of Molecular Medicine and Surgery, Section of Integrative Physiology, Karolinska Institute, von Eulers väg 4a, 4 Tr. SE 171 77, Stockholm, Sweden; Department of Physiology and Pharmacology, Section of Integrative Physiology, Karolinska Institute, von Eulers väg 4a, 4 Tr. SE 171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.cmet.2015.06.015DOI Listing
July 2015

Prior AICAR stimulation increases insulin sensitivity in mouse skeletal muscle in an AMPK-dependent manner.

Diabetes 2015 Jun 31;64(6):2042-55. Epub 2014 Dec 31.

Section of Molecular Physiology, August Krogh Centre, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark

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http://dx.doi.org/10.2337/db14-1402DOI Listing
June 2015

Changes in gene expression in responders and nonresponders to a low-intensity walking intervention.

Diabetes Care 2015 Jun 20;38(6):1154-60. Epub 2015 Mar 20.

Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden Department of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.

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http://care.diabetesjournals.org/content/early/2015/03/19/dc
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http://care.diabetesjournals.org/lookup/doi/10.2337/dc14-260
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http://dx.doi.org/10.2337/dc14-2606DOI Listing
June 2015

Altered promoter methylation of PDK4, IL1 B, IL6, and TNF after Roux-en Y gastric bypass.

Surg Obes Relat Dis 2014 Jul-Aug;10(4):671-8. Epub 2014 Jan 28.

Division of Surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.soard.2013.12.019DOI Listing
May 2015

Metabolism. Exercise remodels subcutaneous fat tissue and improves metabolism.

Nat Rev Endocrinol 2015 Apr 24;11(4):198-200. Epub 2015 Feb 24.

Department of Molecular Medicine and Surgery, Section of Integrative Physiology, Karolinska Institutet, von Eulers väg 4a, SE 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1038/nrendo.2015.24DOI Listing
April 2015

mRNA expression of diacylglycerol kinase isoforms in insulin-sensitive tissues: effects of obesity and insulin resistance.

Physiol Rep 2015 Apr;3(4)

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.14814/phy2.12372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425976PMC
April 2015

Association of the ACTN3 R577X polymorphism with glucose tolerance and gene expression of sarcomeric proteins in human skeletal muscle.

Physiol Rep 2015 Mar;3(3)

Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden Department of Physiology and Pharmacology, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.14814/phy2.12314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393151PMC
March 2015

Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation.

Diabetes 2015 Feb 22;64(2):360-9. Epub 2014 Oct 22.

Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.2337/db14-0508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703413PMC
February 2015

Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes.

Cell Metab 2015 Jan;21(1):138-49

Department of Medicine, Johns Hopkins University School of Medicine, 855 North Wolfe Street, Baltimore, MD 21205, USA; Center for Epigenetics, Johns Hopkins University School of Medicine, 855 North Wolfe Street, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340475PMC
January 2015

Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes.

Am J Physiol Cell Physiol 2014 Nov 20;307(9):C774-87. Epub 2014 Aug 20.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden;

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http://dx.doi.org/10.1152/ajpcell.00110.2014DOI Listing
November 2014

Integrative biology of exercise.

Cell 2014 Nov;159(4):738-49

Department of Molecular Medicine, Karolinska Institutet, von Eulers väg 4a, 171 77 Stockholm, Sweden; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674140131
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http://dx.doi.org/10.1016/j.cell.2014.10.029DOI Listing
November 2014

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes.

Nature 2014 Aug 18;512(7513):190-3. Epub 2014 Jun 18.

1] The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark [2] Faculty of Health Sciences, University of Southern Denmark, 5000 Odense, Denmark.

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http://dx.doi.org/10.1038/nature13425DOI Listing
August 2014

Dynamic epigenetic responses to muscle contraction.

Drug Discov Today 2014 Jul 12;19(7):1010-4. Epub 2014 Mar 12.

The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2014.03.003DOI Listing
July 2014

A simple and rapid method to characterize lipid fate in skeletal muscle.

BMC Res Notes 2014 Jun 24;7:391. Epub 2014 Jun 24.

Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1186/1756-0500-7-391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089939PMC
June 2014

Time course analysis reveals gene-specific transcript and protein kinetics of adaptation to short-term aerobic exercise training in human skeletal muscle.

PLoS One 2013 12;8(9):e74098. Epub 2013 Sep 12.

Institute for Sport and Health, School of Public Health, Physiotherapy, and Population Sciences, University College Dublin, Dublin, Ireland ; Department of Molecular Medicine and Surgery, Section of Integrative Physiology, Karolinska Institute, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074098PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771935PMC
May 2014

Effects of AMPK activation on insulin sensitivity and metabolism in leptin-deficient ob/ob mice.

Diabetes 2014 May 31;63(5):1560-71. Epub 2014 Jan 31.

Integrative Physiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.2337/db13-0670DOI Listing
May 2014

Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7.

Am J Physiol Endocrinol Metab 2013 Dec 8;305(11):E1359-66. Epub 2013 Oct 8.

Department of Physiology and Pharmacology, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden;

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http://ajpendo.physiology.org/content/ajpendo/305/11/E1359.f
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http://ajpendo.physiology.org/cgi/doi/10.1152/ajpendo.00236.
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http://dx.doi.org/10.1152/ajpendo.00236.2013DOI Listing
December 2013

Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle.

Am J Physiol Endocrinol Metab 2013 Dec 15;305(11):E1408-14. Epub 2013 Oct 15.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; and.

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http://dx.doi.org/10.1152/ajpendo.00212.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882372PMC
December 2013

Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle.

Endocrinology 2013 Oct 26;154(10):3502-14. Epub 2013 Jul 26.

Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at the Heinrich-Heine-University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1210/en.2012-2147DOI Listing
October 2013

Effect of leptin treatment on mitochondrial function in obese leptin-deficient ob/ob mice.

Metabolism 2013 Sep 8;62(9):1258-67. Epub 2013 May 8.

Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.metabol.2013.04.001DOI Listing
September 2013

Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet.

FASEB J 2013 Sep 31;27(9):3660-71. Epub 2013 May 31.

The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Blå stråket 5, SE-41345 Gothenburg, Sweden.

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http://www.fasebj.org/cgi/doi/10.1096/fj.13-228494
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http://dx.doi.org/10.1096/fj.13-228494DOI Listing
September 2013

Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training.

J Physiol 2013 Sep 24;591(18):4637-53. Epub 2013 Jun 24.

A. P. Russell: Centre for Physical Activity and Nutrition Research (C-PAN), School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway 3125, Burwood, Australia.

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http://doi.wiley.com/10.1113/jphysiol.2013.255695
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http://dx.doi.org/10.1113/jphysiol.2013.255695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784204PMC
September 2013

Epigenetic flexibility in metabolic regulation: disease cause and prevention?

Trends Cell Biol 2013 May 29;23(5):203-9. Epub 2012 Dec 29.

Integrative Physiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, von Eulers väg 4, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.tcb.2012.11.008DOI Listing
May 2013

Weight loss after gastric bypass surgery in human obesity remodels promoter methylation.

Cell Rep 2013 Apr 11;3(4):1020-7. Epub 2013 Apr 11.

Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.celrep.2013.03.018DOI Listing
April 2013

Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes.

Diabetes 2013 Feb 5;62(2):457-65. Epub 2012 Oct 5.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.2337/db12-0337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554355PMC
February 2013

Altered response of skeletal muscle to IL-6 in type 2 diabetic patients.

Diabetes 2013 Feb 18;62(2):355-61. Epub 2012 Oct 18.

Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.2337/db11-1790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554367PMC
February 2013

Exercise metabolism and the molecular regulation of skeletal muscle adaptation.

Cell Metab 2013 Feb;17(2):162-84

Institute for Sport and Health, School of Public Health, Physiotherapy and Population Science, University College Dublin, Belfield, Dublin 4, Ireland.

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http://dx.doi.org/10.1016/j.cmet.2012.12.012DOI Listing
February 2013

L-Arginine enhances glucose and lipid metabolism in rat L6 myotubes via the NO/ c-GMP pathway.

Metabolism 2013 Jan 11;62(1):79-89. Epub 2012 Aug 11.

Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.

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http://dx.doi.org/10.1016/j.metabol.2012.06.011DOI Listing
January 2013

The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism.

Am J Physiol Endocrinol Metab 2012 Aug 12;303(4):E524-33. Epub 2012 Jun 12.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1152/ajpendo.00605.2011DOI Listing
August 2012

Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells.

J Biol Chem 2012 Jul 18;287(28):23451-63. Epub 2012 May 18.

Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M111.331926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390622PMC
July 2012

Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes.

Am J Physiol Endocrinol Metab 2012 Mar 17;302(6):E731-9. Epub 2012 Jan 17.

Karolinska Institutet, Section of Integrative Physiology, Stockholm, Sweden.

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http://dx.doi.org/10.1152/ajpendo.00159.2011DOI Listing
March 2012

Acute exercise remodels promoter methylation in human skeletal muscle.

Cell Metab 2012 Mar;15(3):405-11

Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.cmet.2012.01.001DOI Listing
March 2012

Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus.

Metabolism 2012 Feb 3;61(2):175-85. Epub 2011 Aug 3.

Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.metabol.2011.06.014DOI Listing
February 2012

Evidence for non-CpG methylation in mammals.

Exp Cell Res 2011 Nov 7;317(18):2555-61. Epub 2011 Sep 7.

Section of Integrative Physiology, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.yexcr.2011.08.019DOI Listing
November 2011

Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle.

J Biol Chem 2011 Oct 26;286(40):34567-74. Epub 2011 Aug 26.

Department of Molecular Medicine and Surgery and Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M111.268292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186409PMC
October 2011

Nutritional status affects the epigenomic profile of peripheral blood cells.

Epigenomics 2011 Jun;3(3):259-60

The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.2217/epi.11.24DOI Listing
June 2011

DNA methylation in metabolic disorders.

Am J Clin Nutr 2011 Apr 2;93(4):897S-900. Epub 2011 Feb 2.

School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.3945/ajcn.110.001933DOI Listing
April 2011

[Molecular mechanisms underlying insulin resistance in skeletal muscle].

Lakartidningen 2010 Nov 10-16;107(45):2802-5

Institutionen för molekylär medicin och kirurgi, Karolinska institutet, Stockholm.

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January 2011