Jukka-Pekka Mecklin

Jukka-Pekka Mecklin

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Jukka-Pekka Mecklin

Jukka-Pekka Mecklin

Publications by authors named "Jukka-Pekka Mecklin"

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Epidemiological, clinical and molecular characterization of Lynch-like syndrome: A population-based study.

Int J Cancer 2019 Jul 7;145(1):87-98. Epub 2019 Jan 7.

Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/ijc.32085DOI Listing
July 2019

Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

Nat Commun 2019 05 14;10(1):2154. Epub 2019 May 14.

Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.

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http://www.nature.com/articles/s41467-019-09775-w
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http://dx.doi.org/10.1038/s41467-019-09775-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517433PMC
May 2019

Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report.

Hered Cancer Clin Pract 2019 28;17. Epub 2019 Feb 28.

4Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway.

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https://hccpjournal.biomedcentral.com/articles/10.1186/s1305
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http://dx.doi.org/10.1186/s13053-019-0106-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394091PMC
February 2019

Appendiceal neoplasm risk associated with complicated acute appendicitis-a population based study.

Int J Colorectal Dis 2019 Jan 22;34(1):39-46. Epub 2018 Sep 22.

Division of Digestive Surgery and Urology, Department of Digestive Surgery, Turku University Hospital, Kiinanmyllynkatu 4-8, 20520, Turku, Finland.

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http://dx.doi.org/10.1007/s00384-018-3156-xDOI Listing
January 2019

Molecular changes preceding endometrial and ovarian cancer: a study of consecutive endometrial specimens from Lynch syndrome surveillance.

Mod Pathol 2018 08 27;31(8):1291-1301. Epub 2018 Mar 27.

Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/s41379-018-0044-4DOI Listing
August 2018

Converging endometrial and ovarian tumorigenesis in Lynch syndrome: Shared origin of synchronous carcinomas.

Gynecol Oncol 2018 07 30;150(1):92-98. Epub 2018 Apr 30.

Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ygyno.2018.04.566DOI Listing
July 2018

High immune cell score predicts improved survival in pancreatic cancer.

Virchows Arch 2018 Apr 22;472(4):653-665. Epub 2018 Jan 22.

Department of Surgery, Central Finland Central Hospital, Keskussairaalantie 19, 40620, Jyväskylä, Finland.

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http://dx.doi.org/10.1007/s00428-018-2297-1DOI Listing
April 2018

Cancer costs and outcomes in the Finnish population 2004-2014.

Acta Oncol 2018 Feb 11;57(2):297-303. Epub 2017 Jul 11.

c Cancer Society of Finland , Helsinki , Finland.

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http://dx.doi.org/10.1080/0284186X.2017.1343495DOI Listing
February 2018

Uptake of genetic testing by the children of Lynch syndrome variant carriers across three generations.

Eur J Hum Genet 2017 11 23;25(11):1237-1245. Epub 2017 Aug 23.

Department of Education and Science, Central Finland Health Care District, Jyväskylä, Finland.

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http://dx.doi.org/10.1038/ejhg.2017.132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643966PMC
November 2017

Subtotal Colectomy for Colon Cancer Reduces the Need for Subsequent Surgery in Lynch Syndrome.

Dis Colon Rectum 2017 Aug;60(8):792-799

1 Department of Gastrointestinal Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland 2 Research Programs Unit, Genome-Scale Biology, University of Helsinki, Helsinki, Finland 3 Department of Education and Science, Central Finland Health Care District, Jyväskylä Finland and University of Eastern Finland, Finland.

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http://dx.doi.org/10.1097/DCR.0000000000000802DOI Listing
August 2017

Immunoscore in mismatch repair-proficient and -deficient colon cancer.

J Pathol Clin Res 2017 Jul 19;3(3):203-213. Epub 2017 Jul 19.

Department of PathologyCentral Finland Central HospitalJyväskyläFinland.

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http://dx.doi.org/10.1002/cjp2.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527320PMC
July 2017

Reliability and Validity Study of the Finnish Adaptation of Scoliosis Research Society Questionnaire Version SRS-30.

Spine (Phila Pa 1976) 2017 Jun;42(12):943-949

*Department of Orthopaedics and Traumatology, Central Hospital of Central Finland, Jyväskylä, Finland †Department of Physical Medicine and Rehabilitation, Central Hospital of Central Finland, Jyväskylä, Finland ‡Department of Education and Science, Central Finland Health Care District, Jyväskylä, Finland §University of Eastern Finland, Jyväskylä, Finland ¶Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.

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http://dx.doi.org/10.1097/BRS.0000000000001938DOI Listing
June 2017

Is preoperative distinction between complicated and uncomplicated acute appendicitis feasible without imaging?

Surgery 2016 09 3;160(3):789-95. Epub 2016 Jun 3.

Division of Digestive Surgery and Urology, Department of Acute and Digestive Surgery, Turku University Hospital, Turku, Finland; Department of Surgery, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1016/j.surg.2016.04.021DOI Listing
September 2016

Endometrial cancer risk factors among Lynch syndrome women: a retrospective cohort study.

Br J Cancer 2016 07 23;115(3):375-81. Epub 2016 Jun 23.

Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1038/bjc.2016.193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973157PMC
July 2016

Obesity, Aspirin, and Risk of Colorectal Cancer in Carriers of Hereditary Colorectal Cancer: A Prospective Investigation in the CAPP2 Study.

J Clin Oncol 2015 Nov 17;33(31):3591-7. Epub 2015 Aug 17.

Mohammad Movahedi, Beheshti University of Medical Sciences, Tehran, Iran; Mohammad Movahedi and D. Timothy Bishop, University of Leeds, Leeds; Diana Eccles, University of Southampton, Southampton; D. Gareth Evans, St Mary's Hospital, Manchester; Eamonn R. Maher, University of Birmingham, Birmingham; Malcolm G. Dunlop, Western General Hospital, Edinburgh; Shirley V. Hodgson, St George's Hospital; Lucy Side, University College London; Huw J.W. Thomas, St Mark's Hospital, Imperial College, London; Patrick J. Morrison, Queens University Belfast, Belfast City Hospital Health and Social Care Trust, Belfast; Victoria Murday, Yorkhill Hospital, Glasgow; John Burn and John C. Mathers, Newcastle University, Newcastle upon Tyne, United Kingdom; Finlay Macrae, Royal Melbourne Hospital, Melbourne, Victoria; Rodney J. Scott, John Hunter Hospital, New Lambton, New South Wales, Australia; Jukka-Pekka Mecklin, Jyväskylä Central Hospital, Jyväskylä, Finland; Gabriela Moeslein, HELIOS St Josefs Hospital, Bochum-Linden, Germany; Sylviane Olschwang, Institut Paoli Calmettes, Marseille, France; Lucio Bertario, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy; Marie-Luise Bisgaard, University of Copenhagen, Hvidovre, Denmark; Judy W.C. Ho, Queen Mary Hospital, Hong Kong, Special Administrative Region, People's Republic of China; Annika Lindblom, Karolinska Institutet, Stockholm, Sweden; Jan Lubinski, International Hereditary Cancer Centre, Szczecin, Poland; Raj S. Ramesar, University of Cape Town, South Africa; and Hans F. Vasen, Netherlands Foundation of the Detection of Hereditary Tumours and Leiden University, Leiden, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2014.58.9952DOI Listing
November 2015

CTCF/cohesin-binding sites are frequently mutated in cancer.

Nat Genet 2015 Jul 8;47(7):818-21. Epub 2015 Jun 8.

1] Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland. [2] Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/ng.3335DOI Listing
July 2015

Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.

JAMA 2015 Jun;313(23):2340-8

Division of Digestive Surgery and Urology, Departments of Acute and Digestive Surgery, Turku University Hospital, Turku, Finland2Department of Surgery, Turku University, Turku, Finland.

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http://dx.doi.org/10.1001/jama.2015.6154DOI Listing
June 2015

Systematic search for rare variants in Finnish early-onset colorectal cancer patients.

Cancer Genet 2015 Jan-Feb;208(1-2):35-40. Epub 2014 Dec 31.

Department of Medical Genetics, Genome-Scale Biology Program, University of Helsinki, Biomedicum, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2014.12.004DOI Listing
May 2015

Reply: To PMID 24941021.

Gastroenterology 2015 Jan 22;148(1):259. Epub 2014 Nov 22.

Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1053/j.gastro.2014.11.028DOI Listing
January 2015

Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas.

Hum Mutat 2014 Sep 21;35(9):1136-41. Epub 2014 Jul 21.

Department of Medical Genetics, Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/humu.22612DOI Listing
September 2014

Quantitative analysis of γ-H2AX and p53 nuclear expression levels in ovarian and fallopian tube epithelium from risk-reducing salpingo-oophorectomies in BRCA1 and BRCA2 mutation carriers.

Int J Gynecol Pathol 2014 May;33(3):309-16

Laboratory of Cancer Biology (S.S., J.I.), Institute of Biomedical Technology, BioMediTech Medical School (J.M.), University of Tampere Department of Obstetrics and Gynecology (S.S., J.M.) Fimlab Laboratories (T.T.) Genetics Outpatient Clinic and Department of Dermatology (S.-L.S.), Tampere University Hospital, Tampere Department of Surgery (J.-P.M.), Jyväskylä Central Hospital, Jyväskylä School of Medicine, University of Eastern Finland (J.-P.M.), Kuopio, Finland.

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http://dx.doi.org/10.1097/PGP.0b013e31829c673bDOI Listing
May 2014

Psychosocial consequences of predictive genetic testing for Lynch syndrome and associations to surveillance behaviour in a 7-year follow-up study.

Fam Cancer 2013 Dec;12(4):639-46

Department of Medical Genetics, Haartman Institute Biomedicum, University of Helsinki, PO Box 63, FIN-00014, Helsinki, Finland,

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http://link.springer.com/10.1007/s10689-013-9628-9
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http://dx.doi.org/10.1007/s10689-013-9628-9DOI Listing
December 2013

Distinct molecular profiles in Lynch syndrome-associated and sporadic ovarian carcinomas.

Int J Cancer 2013 Dec 21;133(11):2596-608. Epub 2013 Jun 21.

Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/ijc.28287DOI Listing
December 2013

BRAF mutation in sporadic colorectal cancer and Lynch syndrome.

Virchows Arch 2013 Nov 21;463(5):613-21. Epub 2013 Aug 21.

Division of Pathology and Genetics, HUSLAB, and Haartman Institute, Helsinki University Central Hospital and University of Helsinki, P.O. Box 400, Helsinki, FIN-00029 HUS, Finland.

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http://link.springer.com/content/pdf/10.1007/s00428-013-1470
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http://link.springer.com/10.1007/s00428-013-1470-9
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http://dx.doi.org/10.1007/s00428-013-1470-9DOI Listing
November 2013

Exome sequencing in diagnostic evaluation of colorectal cancer predisposition in young patients.

Scand J Gastroenterol 2013 Jun 2;48(6):672-8. Epub 2013 Apr 2.

Department of Medical Genetics, Genome-Scale Biology Program, University of Helsinki, Biomedicum, P.O. Box 63, FIN-00014 University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.3109/00365521.2013.783102DOI Listing
June 2013

Uroepithelial and kidney carcinoma in Lynch syndrome.

Fam Cancer 2012 Sep;11(3):395-401

Department of Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland.

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http://link.springer.com/10.1007/s10689-012-9526-6
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http://dx.doi.org/10.1007/s10689-012-9526-6DOI Listing
September 2012

Causes of death of mutation carriers in Finnish Lynch syndrome families.

Fam Cancer 2012 Sep;11(3):467-71

Department of Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland.

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http://dx.doi.org/10.1007/s10689-012-9537-3DOI Listing
September 2012

Sharing genetic risk with next generation: mutation-positive parents' communication with their offspring in Lynch Syndrome.

Fam Cancer 2011 Mar;10(1):43-50

Department of Medical Genetics, Haartman Institute Biomedicum, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1007/s10689-010-9386-xDOI Listing
March 2011

Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.

BMC Med Genet 2011 Feb 14;12:23. Epub 2011 Feb 14.

Department of Medical Genetics, Genome-Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1186/1471-2350-12-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045878PMC
February 2011

Somatic mutations and germline sequence variants in patients with familial colorectal cancer.

Int J Cancer 2010 Dec;127(12):2974-80

Department of Medical Genetics, Genome-Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Finland.

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http://dx.doi.org/10.1002/ijc.25529DOI Listing
December 2010

Low-penetrance susceptibility variants in familial colorectal cancer.

Cancer Epidemiol Biomarkers Prev 2010 Jun 25;19(6):1478-83. Epub 2010 May 25.

Department of Medical Genetics, Genome-Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/1055-9965.EPI-09-1320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883738PMC
June 2010

Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members.

J Clin Oncol 2009 Oct 31;27(28):4793-7. Epub 2009 Aug 31.

Department of Surgery, University of Helsinki, FI-00029 HUS, Helsinki, Finland.

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http://dx.doi.org/10.1200/JCO.2009.23.7784DOI Listing
October 2009

Unregulated smooth-muscle myosin in human intestinal neoplasia.

Proc Natl Acad Sci U S A 2008 Apr 7;105(14):5513-8. Epub 2008 Apr 7.

Department of Medical Genetics and Division of Pathology, HUSLAB and Haartman Institute, Helsinki University Central Hospital and Genome Scale Biology Program, Biomedicum Helsinki, University of Helsinki, 00014, Helsinki, Finland.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0801213105
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http://dx.doi.org/10.1073/pnas.0801213105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291082PMC
April 2008

Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution.

Cancer Res 2008 Jan;68(1):14-7

Department of Medical Genetics, Genome-Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, P.O. Box 63, FIN-00014 Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-5766DOI Listing
January 2008

Development of colorectal tumors in colonoscopic surveillance in Lynch syndrome.

Gastroenterology 2007 Oct 14;133(4):1093-8. Epub 2007 Aug 14.

Department of Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland.

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http://dx.doi.org/10.1053/j.gastro.2007.08.019DOI Listing
October 2007

No evidence for association of NOD2 R702W and G908R with colorectal cancer.

Int J Cancer 2007 Jul;121(1):76-9

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/ijc.22651DOI Listing
July 2007

Background mutation frequency in microsatellite-unstable colorectal cancer.

Cancer Res 2007 Jun;67(12):5691-8

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4314DOI Listing
June 2007

Surveillance for endometrial cancer in hereditary nonpolyposis colorectal cancer syndrome.

Int J Cancer 2007 Feb;120(4):821-4

Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1002/ijc.22446DOI Listing
February 2007

Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors.

Clin Cancer Res 2007 Jan;13(1):356-61

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Finland.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-1256DOI Listing
January 2007

Compliance and Satisfaction with Long-Term Surveillance in Finnish HNPCC Families.

Fam Cancer 2006 ;5(2):175-8

Department of Surgery, Jyväskylä Central Hospital, Keskussairaalantie 19, FIN-40620, Jyväskylä, Finland.

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http://dx.doi.org/10.1007/s10689-005-5442-3DOI Listing
August 2006

The genetics of HNPCC: application to diagnosis and screening.

Crit Rev Oncol Hematol 2006 Jun 23;58(3):208-20. Epub 2006 Jan 23.

Department of Medical Genetics, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.critrevonc.2005.11.001DOI Listing
June 2006

EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis.

BMC Cancer 2006 Jun 1;6:145. Epub 2006 Jun 1.

Department of Medical Genetics, Molecular and Cancer Biology Research Program, P,O, BOX 63, 00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1186/1471-2407-6-145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513590PMC
June 2006

Surveillance in Lynch syndrome.

Fam Cancer 2005 ;4(3):267-71

Department of Surgery, Jyväskylä Central Hospital, 40620, Jyväskylä, Finland.

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http://dx.doi.org/10.1007/s10689-005-1475-xDOI Listing
December 2005

Numbers of mutations to different types of colorectal cancer.

BMC Cancer 2005 Oct 3;5:126. Epub 2005 Oct 3.

Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1186/1471-2407-5-126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266026PMC
October 2005

p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome.

Clin Cancer Res 2005 Oct;11(19 Pt 1):6840-4

Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-1139DOI Listing
October 2005

SMAD4 levels and response to 5-fluorouracil in colorectal cancer.

Clin Cancer Res 2005 Sep;11(17):6311-6

Department of Medical Genetics, Biomedicum Helsinki, Haartman Institute, University of Helsinki, Finland.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-0244DOI Listing
September 2005