Jukka Westermarck

Jukka Westermarck

UNVERIFIED PROFILE

Are you Jukka Westermarck?   Register this Author

Register author
Jukka Westermarck

Jukka Westermarck

Publications by authors named "Jukka Westermarck"

Are you Jukka Westermarck?   Register this Author

62Publications

1084Reads

33Profile Views

Genistein Decreases APP/tau Phosphorylation and Ameliorates Aβ Over- production Through Inhibiting CIP2A.

Curr Alzheimer Res 2019 Aug 30. Epub 2019 Aug 30.

Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan. China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1567205016666190830113420DOI Listing
August 2019

CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits.

Neurobiol Aging 2019 03 6;75:198-208. Epub 2018 Dec 6.

Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; The Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01974580183043
Publisher Site
http://dx.doi.org/10.1016/j.neurobiolaging.2018.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405315PMC
March 2019

Targeted therapies don't work for a reason; the neglected tumor suppressor phosphatase PP2A strikes back.

FEBS J 2018 11 17;285(22):4139-4145. Epub 2018 Aug 17.

Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/febs.14617DOI Listing
November 2018

CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.

Cell Rep 2018 07;24(3):713-723

Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; The Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095478PMC
July 2018

Enhanced expression of MycN/CIP2A drives neural crest toward a neural stem cell-like fate: Implications for priming of neuroblastoma.

Proc Natl Acad Sci U S A 2018 07 18;115(31):E7351-E7360. Epub 2018 Jul 18.

Department of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1800039115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077707PMC
July 2018

Phosphatases catching up with the level of knowledge: Finally druggable?

Int J Biochem Cell Biol 2018 03 11;96:96-97. Epub 2018 Jan 11.

Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland; Institute of Biomedicine, University of Turku, Turku, Finland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biocel.2018.01.007DOI Listing
March 2018

Non-genomic mechanisms of protein phosphatase 2A (PP2A) regulation in cancer.

Int J Biochem Cell Biol 2018 03 31;96:157-164. Epub 2018 Jan 31.

Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland; Institute of Biomedicine, Research Center for Cancer, Infections, and Immunity, University of Turku, Turku, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biocel.2018.01.005DOI Listing
March 2018

PP2A Inactivation Mediated by Haploinsufficiency Promotes Cancer Development.

Cancer Res 2017 12 18;77(24):6825-6837. Epub 2017 Oct 18.

Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-16-2911DOI Listing
December 2017

PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression.

Dev Cell 2017 10;43(2):240-252.e5

Department of Biosciences, University of Helsinki, 00790 Helsinki, Finland; Institute of Biotechnology, University of Helsinki, 00790 Helsinki, Finland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.devcel.2017.09.022DOI Listing
October 2017

PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells.

Cancer Res 2016 12 26;76(23):7001-7011. Epub 2016 Sep 26.

Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-16-1134DOI Listing
December 2016

Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1.

Biochem Soc Trans 2016 12;44(6):1683-1693

Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, PO Box 123, Tykistökatu 6, 20520 Turku, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BST20160161DOI Listing
December 2016

Copy number increase of oncoprotein CIP2A is associated with poor patient survival in human head and neck squamous cell carcinoma.

J Oral Pathol Med 2016 May 5;45(5):329-37. Epub 2015 Oct 5.

Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jop.12372DOI Listing
May 2016

MYC is not detected in highly proliferating normal spermatogonia but is coupled with CIP2A in testicular cancers.

Matters (Zur) 2016 Mar 3;2016. Epub 2016 Mar 3.

Department of Physiology, University of Turku; Department of Molecular and Medical Genetics and Knight Cancer Institute, Oregon Health and Science University; Centre for Biotechnology and Department of Pathology, University of Turku.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843371PMC
http://dx.doi.org/10.19185/matters.201602000040DOI Listing
March 2016

Potential role for inhibition of protein phosphatase 2A tumor suppressor in salivary gland malignancies.

Genes Chromosomes Cancer 2016 Jan 23;55(1):69-81. Epub 2015 Sep 23.

The Centre for Biotechnology, University of Turku and Åbo Akademi University, Tykistökatu, BioCity, Turku, FI-20521, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/gcc.22312DOI Listing
January 2016

Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data.

Mol Cell Proteomics 2015 Dec 23;14(12):3274-83. Epub 2015 Oct 23.

From the ‡Institute for Molecular Medicine Finland FIMM, University of Helsinki, PO Box 20, FIN-00014 Helsinki, Finland; §Centre for Biotechnology, ¶Department of Pathology,University of Turku and Åbo Akademi, Turku, Finland, PO Box 123, FIN-20521 Turku, Finland.;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.M115.050773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762622PMC
December 2015

CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations.

Oncotarget 2015 Aug;6(23):19661-70

Prostate Cancer Research Center (PCRC), Institute of Biosciences and Medical Technology (BioMediTech), University of Tampere and Tampere University Hospital, Tampere, Finland.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637312PMC
http://dx.doi.org/10.18632/oncotarget.3875DOI Listing
August 2015

Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation.

Cell Rep 2015 Aug 30;12(6):1019-31. Epub 2015 Jul 30.

Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, 20520 Turku, Finland; Department of Pathology, University of Turku, 20520 Turku, Finland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2015.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535171PMC
August 2015

Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling.

Sci Rep 2015 Aug 17;5:13099. Epub 2015 Aug 17.

1] Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Tykistokatu 6, FI-20520 Turku, Finland [2] Faculty of Pharmacy, Meijo University, Yagotoyama 150, Tempaku, Nagoya 468-8503, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep13099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642524PMC
August 2015

CIP2A is an Oct4 target gene involved in head and neck squamous cell cancer oncogenicity and radioresistance.

Oncotarget 2015 Jan;6(1):144-58

Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland. Department of Pathology, University of Turku, Finland.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381584PMC
http://dx.doi.org/10.18632/oncotarget.2670DOI Listing
January 2015

ColonyArea: an ImageJ plugin to automatically quantify colony formation in clonogenic assays.

PLoS One 2014 19;9(3):e92444. Epub 2014 Mar 19.

Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092444PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960247PMC
November 2014

Molecular pathways: harnessing E2F1 regulation for prosenescence therapy in p53-defective cancer cells.

Clin Cancer Res 2014 Jul 1;20(14):3644-50. Epub 2014 May 1.

Authors' Affiliations: Turku Centre for Biotechnology, University of Turku and Åbo Akademi University; and Department of Pathology, University of Turku, Turku, Finland

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-13-1942DOI Listing
July 2014

Mesoporous silica nanoparticles with redox-responsive surface linkers for charge-reversible loading and release of short oligonucleotides.

Dalton Trans 2014 Mar;43(10):4115-26

Centre for Functional Materials, Laboratory for Physical Chemistry, Department of Natural Sciences, Åbo Akademi University, Porthansgatan 3-5, Turku 20500, Finland.

View Article

Download full-text PDF

Source
http://xlink.rsc.org/?DOI=c3dt53071j
Publisher Site
http://dx.doi.org/10.1039/c3dt53071jDOI Listing
March 2014

Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells.

Cancer Res 2013 Nov 26;73(22):6757-69. Epub 2013 Sep 26.

Authors' Affiliations: Institute of Biomedical Technology and BioMediTech, University of Tampere and Tampere University Hospital; Tampere Graduate Program in Biomedicine and Biotechnology (TGPBB), University of Tampere, Tampere; Turku Centre for Biotechnology, University of Turku and Åbo Akademi University; Department of Pathology, University of Turku; Turku Doctoral Program of Biomedical Sciences (TuBS), Turku; Department of Pathology, HUSLAB and Haartman Institute, Helsinki University, Central Hospital and University of Helsinki; University of Helsinki Institute of Biomedicine and Genome-Scale Biology Research Program; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Karlsruhe Institute of Technology, Campus North, Institute of Toxicology and Genetics, Karlsruhe, Germany; Adult Cancer Program, Lowy Cancer Centre and Prince of Wales Hospital, UNSW Medicine, University of New South Wales, Sydney, Australia; Department of Medical Biology and Genetics, Faculty of Medicine, Akdeniz University, Antalya, Turkey; Division of Oncology, Children's Hospital of Philadelphia; and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-1002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870284PMC
November 2013

Cancerous inhibitor of protein phosphatase 2A, an emerging human oncoprotein and a potential cancer therapy target.

Cancer Res 2013 Nov 7;73(22):6548-53. Epub 2013 Nov 7.

Authors' Affiliations: Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Hospital, University of New South Wales (UNSW) Medicine; Translational Cancer Research Network, University of New South Wales (UNSW), Sydney, Australia; Turku Centre for Biotechnology, University of Turku and Åbo Akademi University; and Department of Pathology, University of Turku, Turku, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-1994DOI Listing
November 2013

Identification of protein interactions involved in cellular signaling.

Mol Cell Proteomics 2013 Jul 12;12(7):1752-63. Epub 2013 Mar 12.

Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland.

View Article

Download full-text PDF

Source
http://www.mcponline.org/content/early/2013/03/12/mcp.R113.0
Web Search
http://www.mcponline.org/cgi/doi/10.1074/mcp.R113.027771
Publisher Site
http://dx.doi.org/10.1074/mcp.R113.027771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708163PMC
July 2013

Nucleolar AATF regulates c-Jun-mediated apoptosis.

Mol Biol Cell 2012 Nov 29;23(21):4323-32. Epub 2012 Aug 29.

Department of Biosciences, Åbo Akademi University, FIN-20521 Turku, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.E12-05-0419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484108PMC
November 2012

Identification and regulation of a stage-specific stem cell niche enriched by Nanog-positive spermatogonial stem cells in the mouse testis.

Stem Cells 2012 May;30(5):1008-20

Department of Physiology,University of Turku, Kiinamyllynkatu, Turku, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/stem.1077DOI Listing
May 2012

Regulation of transcription factor function by targeted protein degradation: an overview focusing on p53, c-Myc, and c-Jun.

Methods Mol Biol 2010 ;647:31-6

Institute of Medical Technology, University of Tampere, Tampere, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-60761-738-9_2DOI Listing
December 2010

Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme.

Genome Med 2010 Sep 7;2(9):65. Epub 2010 Sep 7.

Computational Systems Biology Laboratory, Institute of Biomedicine and Genome-Scale Biology Research Program, University of Helsinki, Haartmaninkatu 8, Helsinki, FIN-00014, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/gm186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092116PMC
September 2010

CIP2A increases self-renewal and is linked to Myc in neural progenitor cells.

Differentiation 2010 Jul 5;80(1):68-77. Epub 2010 May 5.

Medical Biochemistry and Developmental Biology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.diff.2010.04.003DOI Listing
July 2010

CIP2A is associated with human breast cancer aggressivity.

Clin Cancer Res 2009 Aug 11;15(16):5092-100. Epub 2009 Aug 11.

Centre for Biotechnology, University of Turku, Turku, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-08-3283DOI Listing
August 2009

PRELI is a mitochondrial regulator of human primary T-helper cell apoptosis, STAT6, and Th2-cell differentiation.

Blood 2009 Feb 22;113(6):1268-77. Epub 2008 Oct 22.

Turku Centre for Biotechnology, University of Turku and Abo Akademi, Turku, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2008-07-166553DOI Listing
February 2009

Integrated network analysis platform for protein-protein interactions.

Nat Methods 2009 Jan 14;6(1):75-7. Epub 2008 Dec 14.

Genome-Scale Biology Program, Institute of Biomedicine, University of Helsinki, Haartmaninkatu 8, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.1282DOI Listing
January 2009

Identification of nucleolar effects in JNK-deficient cells.

FEBS Lett 2008 Sep 12;582(20):3145-51. Epub 2008 Aug 12.

Center for Biotechnology, University of Turku and Abo Akademi University, Artillerigatan 6, 20520 Turku, Finland.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1016/j.febslet.2008.08.004
Publisher Site
http://dx.doi.org/10.1016/j.febslet.2008.08.004DOI Listing
September 2008

Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival.

FASEB J 2008 Apr 26;22(4):954-65. Epub 2007 Nov 26.

Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland.

View Article

Download full-text PDF

Source
http://www.fasebj.org/doi/10.1096/fj.06-7859rev
Publisher Site
http://dx.doi.org/10.1096/fj.06-7859revDOI Listing
April 2008

Multiple pathways regulated by the tumor suppressor PP2A in transformation.

Trends Mol Med 2008 Apr 10;14(4):152-60. Epub 2008 Mar 10.

Institute of Medical Technology, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmed.2008.02.001DOI Listing
April 2008

Mechanisms of MYC stabilization in human malignancies.

Cell Cycle 2008 Mar 29;7(5):592-6. Epub 2007 Dec 29.

Department of Pathology, University of California Comprehensive Cancer Center, San Francisco, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cc.7.5.5492DOI Listing
March 2008

IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration.

J Cell Sci 2008 Mar 26;121(Pt 6):854-64. Epub 2008 Feb 26.

Apoptosis Department and Center for Genotoxic Stress, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.013722DOI Listing
March 2008

Single-step Strep-tag purification for the isolation and identification of protein complexes from mammalian cells.

Proteomics 2005 Apr;5(5):1199-203

Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.200400991DOI Listing
April 2005