Jui-Hua Hsieh

Jui-Hua Hsieh

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Jui-Hua Hsieh

Jui-Hua Hsieh

Publications by authors named "Jui-Hua Hsieh"

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39Publications

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A scoping review of the health and toxicological activity of bisphenol A (BPA) structural analogues and functional alternatives.

Toxicology 2019 Aug 12;424:152235. Epub 2019 Jun 12.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, 530 Davis Drive, Research Triangle Park, NC, 27560, United States.

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http://dx.doi.org/10.1016/j.tox.2019.06.006DOI Listing
August 2019

Identifying Compounds with Genotoxicity Potential Using Tox21 High-Throughput Screening Assays.

Chem Res Toxicol 2019 Jul 18;32(7):1384-1401. Epub 2019 Jun 18.

Division of the National Toxicology Program , National Institute of Environmental Health Sciences , Research Triangle Park , North Carolina 27709 , United States.

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http://dx.doi.org/10.1021/acs.chemrestox.9b00053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740247PMC
July 2019

Using Tox21 High-Throughput Screening Assays for the Evaluation of Botanical and Dietary Supplements.

Appl In Vitro Toxicol 2019 Mar 9;5(1):10-25. Epub 2019 Mar 9.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1089/aivt.2018.0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442399PMC
March 2019

A high-throughput approach to identify specific neurotoxicants/ developmental toxicants in human neuronal cell function assays.

ALTEX 2018 21;35(2):235-253. Epub 2018 Jan 21.

In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.14573/altex.1712182DOI Listing
January 2019

Application of Benchmark Concentration (BMC) Analysis on Zebrafish Data: A New Perspective for Quantifying Toxicity in Alternative Animal Models.

Toxicol Sci 2019 01;167(1):92-104

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27709, USA.

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http://dx.doi.org/10.1093/toxsci/kfy258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317423PMC
January 2019

A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions.

Front Pharmacol 2018 4;9:1379. Epub 2018 Dec 4.

Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.3389/fphar.2018.01379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288363PMC
December 2018

Evaluation and Optimization of Pharmacokinetic Models for to Extrapolation of Estrogenic Activity for Environmental Chemicals.

Environ Health Perspect 2018 09;126(9):97001

National Toxicology Program Division, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/EHP1655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375436PMC
September 2018

In silico toxicology protocols.

Regul Toxicol Pharmacol 2018 Jul 17;96:1-17. Epub 2018 Apr 17.

Leadscope, Inc., 1393 Dublin Rd, Columbus, OH 43215, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S02732300183011
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http://dx.doi.org/10.1016/j.yrtph.2018.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026539PMC
July 2018

Tox21 Enricher: Web-based Chemical/Biological Functional Annotation Analysis Tool Based on Tox21 Toxicity Screening Platform.

Mol Inform 2018 05 29;37(5):e1700129. Epub 2018 Jan 29.

National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina, 27709, USA.

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http://dx.doi.org/10.1002/minf.201700129DOI Listing
May 2018

Accounting Artifacts in High-Throughput Toxicity Assays.

Authors:
Jui-Hua Hsieh

Methods Mol Biol 2016 ;1473:143-52

Kelly Government Solutions Supporting NTP, 530 Davis Dr., Morrisville, NC, 27560, USA.

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http://link.springer.com/10.1007/978-1-4939-6346-1_15
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http://dx.doi.org/10.1007/978-1-4939-6346-1_15DOI Listing
January 2018

Development of an in Vitro-Based Risk Assessment Framework for Predicting Ambient Particulate Matter-Bound Polycyclic Aromatic Hydrocarbon-Activated Toxicity Pathways.

Environ Sci Technol 2017 Dec 1;51(24):14262-14272. Epub 2017 Dec 1.

National Institute of Environmental Health Sciences, National Health Research Institutes , Zhunan, Taiwan 35053, ROC.

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http://dx.doi.org/10.1021/acs.est.7b02002DOI Listing
December 2017

Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage.

PLoS One 2017 22;12(5):e0177902. Epub 2017 May 22.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177902PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439695PMC
September 2017

An Intuitive Approach for Predicting Potential Human Health Risk with the Tox21 10k Library.

Environ Sci Technol 2017 Sep 6;51(18):10786-10796. Epub 2017 Sep 6.

National Toxicology Program, National Institute of Environmental Health Sciences , 111 T.W. Alexander Drive, Research Triangle Park, North Carolina 27709, United States.

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http://dx.doi.org/10.1021/acs.est.7b00650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657440PMC
September 2017

Assessment of the DNA damaging potential of environmental chemicals using a quantitative high-throughput screening approach to measure p53 activation.

Environ Mol Mutagen 2017 08 17;58(7):494-507. Epub 2017 Jul 17.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1002/em.22112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555817PMC
August 2017

Development of Novel Cell Lines for High-Throughput Screening to Detect Estrogen-Related Receptor Alpha Modulators.

SLAS Discov 2017 07 31;22(6):720-731. Epub 2017 Jan 31.

1 Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC, USA.

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http://dx.doi.org/10.1177/2472555216689772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486949PMC
July 2017

The Development of Target-Specific Pose Filter Ensembles To Boost Ligand Enrichment for Structure-Based Virtual Screening.

J Chem Inf Model 2017 06 1;57(6):1414-1425. Epub 2017 Jun 1.

Molecular Modeling and Drug Discovery Core Laboratory for District of Columbia Center for AIDS Research (DC CFAR), Department of Pharmaceutical Sciences, College of Pharmacy, Howard University , Washington, D.C. 20059, United States.

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http://dx.doi.org/10.1021/acs.jcim.6b00749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726860PMC
June 2017

Editor's Highlight: Comparative Toxicity of Organophosphate Flame Retardants and Polybrominated Diphenyl Ethers to Caenorhabditis elegans.

Toxicol Sci 2016 12 26;154(2):241-252. Epub 2016 Aug 26.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina

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http://dx.doi.org/10.1093/toxsci/kfw162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139065PMC
December 2016

Differential modulation of FXR activity by chlorophacinone and ivermectin analogs.

Toxicol Appl Pharmacol 2016 12 20;313:138-148. Epub 2016 Oct 20.

NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2016.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124510PMC
December 2016

Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity.

Neurotoxicol Teratol 2015 Nov-Dec;52(Pt B):181-93. Epub 2015 Sep 18.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1016/j.ntt.2015.09.003DOI Listing
October 2016

Gender differences in cancer susceptibility: role of oxidative stress.

Carcinogenesis 2016 Oct 31;37(10):985-992. Epub 2016 Jul 31.

Department of Theoretical and Applied Linguistics, University of Cambridge, Cambridge CB3 9DA, UK.

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http://dx.doi.org/10.1093/carcin/bgw076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276900PMC
October 2016

Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high-throughput screen for developmental neurotoxicity or neurotoxicity.

Neurotoxicology 2016 Mar 4;53:271-281. Epub 2016 Feb 4.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuro.2016.02.003DOI Listing
March 2016

Profiling animal toxicants by automatically mining public bioassay data: a big data approach for computational toxicology.

PLoS One 2014 20;9(6):e99863. Epub 2014 Jun 20.

Department of Chemistry, Rutgers University, Camden, New Jersey, United States of America; The Rutgers Center for Computational and Integrative Biology, Camden, New Jersey, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099863PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064997PMC
October 2015

A Data Analysis Pipeline Accounting for Artifacts in Tox21 Quantitative High-Throughput Screening Assays.

J Biomol Screen 2015 Aug 22;20(7):887-97. Epub 2015 Apr 22.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1177/1087057115581317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568956PMC
August 2015

Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor.

Sci Rep 2014 Sep 26;4:6437. Epub 2014 Sep 26.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1038/srep06437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894417PMC
September 2014

Do crystal structures obviate the need for theoretical models of GPCRs for structure-based virtual screening?

Proteins 2012 Jun 13;80(6):1503-21. Epub 2012 Mar 13.

Laboratory for Molecular Modeling, Division of Medicinal Chemistry and Natural Products and Carolina Exploratory Center for Cheminformatics Research, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA.

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http://doi.wiley.com/10.1002/prot.24035
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http://dx.doi.org/10.1002/prot.24035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133977PMC
June 2012

Cheminformatics meets molecular mechanics: a combined application of knowledge-based pose scoring and physical force field-based hit scoring functions improves the accuracy of structure-based virtual screening.

J Chem Inf Model 2012 Jan 14;52(1):16-28. Epub 2011 Dec 14.

Laboratory for Molecular Modeling, Division of Medicinal Chemistry and Natural Products, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1021/ci2002507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264743PMC
January 2012

Combined application of cheminformatics- and physical force field-based scoring functions improves binding affinity prediction for CSAR data sets.

J Chem Inf Model 2011 Sep 30;51(9):2027-35. Epub 2011 Aug 30.

Division of Medicinal Chemistry and Natural Products, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7360, United States.

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http://dx.doi.org/10.1021/ci200146eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183266PMC
September 2011

Differentiation of AmpC beta-lactamase binders vs. decoys using classification kNN QSAR modeling and application of the QSAR classifier to virtual screening.

J Comput Aided Mol Des 2008 Sep 13;22(9):593-609. Epub 2008 Mar 13.

Laboratory for Molecular Modeling, Division of Medicinal Chemistry and Natural Products, University of North Carolina at Chapel Hill, CB #7360, Beard Hall, Chapel Hill, NC, 27599-7360, USA.

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http://dx.doi.org/10.1007/s10822-008-9199-2DOI Listing
September 2008