Publications by authors named "Juhyung Kim"

17 Publications

  • Page 1 of 1

Keeping a balance in chronic lymphocytic leukemia (CLL) patients taking ibrutinib: ibrutinib-associated adverse events and their management based on drug interactions.

Expert Rev Hematol 2021 09 22;14(9):819-830. Epub 2021 Aug 22.

Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea.

Introduction: Ibrutinib is a highly effective drug for patients with chronic lymphocytic leukemia (CLL), and is well tolerated even by older patients and those unfit to receive conventional immuno-chemotherapy.

Areas Covered: The occurrence of adverse events was revealed as a major cause of ibrutinib failure in the real-world. Ibrutinib-induced lymphocytosis carries the risk of an untimely interruption of therapy because it may be misinterpreted as disease progression. In addition, drug interactions can worsen ibrutinib-associated toxicities by increasing the plasma concentration of ibrutinib. In this review, we present a case of major hemorrhage and atrial fibrillation (AF) during ibrutinib use and summarize the adverse events associated with ibrutinib. Furthermore, the practical management of ibrutinib-associated toxicities was covered with reference to a drug interaction mechanism.

Expert Opinion: Clinicians should examine the prescribed drugs prior to ibrutinib initiation and carefully monitor toxicities while taking ibrutinib. A reduced dose of ibrutinib with the concurrent use of CYP3A inhibitors such as antifungal agents could be an attractive strategy to reduce toxicities and may confer financial benefits. Reducing unexpected toxicities is as significant as achieving treatment response in the era of life-long therapy with ibrutinib in patients with CLL.
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http://dx.doi.org/10.1080/17474086.2021.1967139DOI Listing
September 2021

Therapeutic strategies, including allogeneic stem cell transplantation, to overcome relapsed/refractory adult T-cell acute lymphoblastic leukemia.

Expert Rev Hematol 2021 Aug 9;14(8):765-775. Epub 2021 Aug 9.

Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea.

Introduction: The long-term survival of relapsed/refractory (R/R) adult T-cell acute lymphoblastic leukemia (T-ALL) is quite poor, and early T-cell precursor (ETP) ALL has recently been described as a high-risk T-ALL subgroup. However, the optimal therapeutic approach to R/R adult T-ALL remains poorly established.

Areas Covered: At present, cytoreductive therapy followed by allogeneic stem cell transplantation (allo-SCT) is considered to be the most clinically relevant and curative modality for R/R T-ALL. Above all, achieving minimal residual disease (MRD) is a key factor for successful allo-SCT and maintaining long-term remission for R/R patients. As a salvage regimen, nelarabine is the only therapy that was specifically approved for use in patients with R/R T-ALL. A combination of conventional chemotherapeutic agents and novel agents, such as venetoclax, can be used as alternatives for cytoreduction and bridging to transplantation. Relevant literatures published in the last 30 years were searched from PubMed to review the topic of T-ALL, and allo-SCT.

Expert Opinion: An effective salvage regimen, to achieve negative MRD, followed by allo-SCT is currently the best way to improve the clinical outcomes of adult R/R T-ALL. Moreover, posttransplant therapies, such as prophylactic or preemptive donor leukocyte infusion and hypomethylating agents, need to be considered as sequential therapy.
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http://dx.doi.org/10.1080/17474086.2021.1960817DOI Listing
August 2021

Clinical Impact of Postoperative Vitamin D Deficiency on the Recurrence of Colon Cancer After Curative Surgical Resection.

Anticancer Res 2021 Jul;41(7):3683-3688

Department of Oncology/Hematology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Kyungpook National University Cancer Research Institute, Daegu, Republic of Korea;

Background/aim: There are no clinically significant cutoff values of serum vitamin D levels and time points to predict the prognosis of colon cancer, particularly in patients who underwent curative surgical resection.

Patients And Methods: We retrospectively analyzed serum vitamin D levels in 795 patients with stages I to III colon cancer who underwent curative surgical resection.

Results: Patients with vitamin D levels below 12 ng/ml at one year after surgical resection demonstrated a significantly reduced disease-free survival (DFS) than those who did not have vitamin D deficiency (p=0.01). In the multivariate analysis, an age of 70 years or older [hazard ratio (HR)=1.992; p=0.001], pathologic stage (HR=3.739; p<0.001), and vitamin D deficiency (less than 12 ng/ml) at one year after surgery (HR=0.563; p=0.020) were factors unfavorably influencing DFS.

Conclusion: In patients with stages I to III of colon cancer, vitamin D deficiency at one year after surgical resection was associated with increased disease relapse.
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http://dx.doi.org/10.21873/anticanres.15159DOI Listing
July 2021

Clinical impact of cell-free serum Epstein-Barr virus status in patients with newly diagnosed malignant lymphoma.

Blood Res 2021 Jun;56(2):65-71

Department of Hematology/Oncology, Chonnam National University Hwasun Hospital, School of Medicine, Chonnam National University, Hwasun, Korea.

Background: We analyzed cell-free serum Epstein‒Barr virus (EBV) DNA to identify its prognostic role in patients with newly diagnosed lymphoma.

Methods: We retrospectively reviewed patients diagnosed with lymphoma between January 2014 and July 2020. Patients were enrolled according to the following criteria: i) pathologically confirmed lymphomas according to the World Health Organization criteria, ii) age over 18 years, iii) serum EBV DNA measurement using polymerase chain reaction prior to first-line therapy, and iv) receipt of curative standard chemotherapy. In total, 263 patients met these criteria and were included in this study.

Results: Serum EBV DNA was detected in 79 patients (30.0%). Patients with positive serum EBV tended to be older ( =0.090), and the proportion of T-cell lineage lymphomas was higher than that of B-cell lymphomas ( =0.003). EBV positivity was significantly associated with more advanced disease based on the Ann Arbor staging system ( =0.008) and the International Prognostic Index ( =0.009). EBV positivity was also associated with higher disease relapse ( =0.038) and death rates ( =0.005). EBV-positive lymphomas further showed inferior long-term survival outcomes in terms of progression-free survival (PFS) (=0.053) and overall survival (OS) (=0.014). In the subgroup analyses, serum EBV positivity was a significant prognostic factor for patients with B-cell lineage lymphomas in terms of PFS ( =0.003) and OS (=0.033).

Conclusion: We demonstrated that cell-free serum EBV DNA status at the time of diagnosis has potential as a prognostic biomarker for patients with newly diagnosed malignant lymphomas.
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http://dx.doi.org/10.5045/br.2021.2021028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246039PMC
June 2021

Virus-like Particle (VLP) Mediated Antigen Delivery as a Sensitization Tool of Experimental Allergy Mouse Models.

Immune Netw 2020 Aug 15;20(4):e35. Epub 2020 Jul 15.

Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.

Antigen delivery systems play critical roles in determining the quality and quantity of Ab responses . Induction of protective antibodies by B cells is essential in the development of vaccines against infectious pathogens, whereas production of IgE antibodies is prerequisite for investigation of allergic responses, or type 1 hypersensitivity reactions. Virus-like particles (VLPs) are efficient platforms for expression of proteins of interest in highly repetitive manners, which grants strong Ab responses to target antigens. Here, we report that delivery of hen egg lysozyme (HEL), a model allergen, through VLP could provoke strong HEL specific IgE Ab responses in mice. Moreover, acute allergic responses were robustly induced in the mice sensitized with VLPs that express HEL, when challenged with recombinant HEL protein. Our data show that antigen delivery in the context of VLPs could function as a platform for sensitization of mice and for subsequent examination of allergic reactions to molecules of interest.
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http://dx.doi.org/10.4110/in.2020.20.e35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458801PMC
August 2020

Hypomethylating agent-based post-transplant strategies to maximize the outcome of high-risk acute myeloid leukemia after allogeneic stem cell transplantation.

Expert Rev Hematol 2020 09 14;13(9):959-969. Epub 2020 Aug 14.

Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University , Daegu, South Korea.

Introduction: Clinical outcomes of patients diagnosed with high-risk acute myeloid leukemia (AML) are poor, and relapse or refractoriness is main cause of treatment failure, even in those who underwent standard allogeneic stem cell transplantation (allo-SCT). Therefore, innovative or additional approaches are necessary to overcome refractoriness to the graft-versus-leukemia (GVL) effect immediately after allo-SCT.

Areas Covered: Hypomethylating agents (HMA) present a feasible option that can be adopted during the post-transplant phase. Moreover, combination strategies based on HMA may induce a synergistic effect by promoting anti-leukemic effects that overcome residual leukemic burden, and it is a well-tolerated therapeutic option for high-risk disease. Relevant literatures published in the last 30 years were searched from PubMed to review the topic of AML, allo-SCT, and HMAs.

Expert Opinion: Post-transplant therapy is strongly needed to improve the outcomes of allogeneic transplantation for certain AML patients classified with high-risk disease. In that sense, prophylactic and preemptive HMAs are a promising additive therapy for allogeneic recipients.
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http://dx.doi.org/10.1080/17474086.2020.1804355DOI Listing
September 2020

A Case of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging of Eosinophilic Granulomatosis With Polyangiitis Combined With Non-tuberculous Mycobacterium.

Eur J Case Rep Intern Med 2019 22;6(12):001299. Epub 2019 Nov 22.

Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.

Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18FDG-PET/CT) has been used to diagnose vasculitis, tuberculosis and malignancy. As PET/CT scans show hotspots during an activation of clinically suspected lesions, they are widely used for diagnosis. However, there are rare cases of PET/CT images for vasculitis combined with tuberculosis. Here, we report a case of eosinophilic granulomatosis with polyangiitis in a patient with disseminated non-tuberculous mycobacterial infection in multiple sites mimicking metastatic malignancy and describe the associated PET/CT scan findings before and after treatment.

Learning Points: PET/CT can better inform accurate diagnosis for detecting biopsy sites and differentiating diseases.Eosinophilic granulomatosis with polyangiitis and non-tuberculous mycobacterial infection have been diagnosed simultaneously in this case.The therapeutic response can be assessed with PET/CT in patients with eosinophilic granulomatosis with polyangiitis.
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http://dx.doi.org/10.12890/2019_001299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936917PMC
November 2019

Optimal Target Assignment with Seamless Handovers for Networked Radars.

Sensors (Basel) 2019 Oct 19;19(20). Epub 2019 Oct 19.

Department of Aerospace Engineering & KI for Robotics, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.

This paper proposes a binary linear programming formulation for multiple target assignment of a radar network and demonstrates its applicability to obtain optimal solutions using an off-the-shelf mixed-integer linear programming solver. The goal of radar resource scheduling in this paper is to assign the maximum number of targets by handing over targets between networked radar systems to overcome physical limitations such as the detection range and simultaneous tracking capability of each radar. To achieve this, time windows are generated considering the relation between each radar and target considering incoming target information. Numerical experiments using a local-scale simulation were performed to verify the functionality of the formulation and a sensitivity analysis was conducted to identify the trend of the results with respect to several parameters. Additional experiments performed for a large-scale (battlefield) scenario confirmed that the proposed formulation is valid and applicable for hundreds of targets and corresponding radar network systems composed of five distributed radars. The performance of the scheduling solutions using the proposed formulation was better than that of the general greedy algorithm as a heuristic approach in terms of objective value as well as the number of handovers.
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http://dx.doi.org/10.3390/s19204555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832481PMC
October 2019

Improving Charge-Imbalanced Problem of Quantum Dot Light-Emitting Diodes with TPBi/ZnO Electron Transport Layer.

J Nanosci Nanotechnol 2019 Oct;19(10):6152-6157

Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon 16419, South Korea.

To solve charge-imbalanced problem caused by excessive electron injection into the emitting layer (EML) of quantum dot light emitting diodes (QLEDs) with ZnO electron transport layer (ETL), we proposed QLEDs with TPBi((2,2',2''-(1,3,5-Benzinetriyl)-tris(1-phenyl-1-H-benzimidazole)))/ZnO ETL layered design. Spin coated TPBi demonstrated lower value of the lowest unoccupied molecular orbital (LUMO) than conduction band maximum (CBM) of ZnO, resulting in effective prevention of excessive injection of electrons into the EML even under excessive stress conditions. Experimental results demonstrated that QLEDs with TPBi/ZnO ETL not only could minimize charge imbalanced problem under high current density operation, but also could increase the maximum luminance of QLEDs by up to 156% (i.e., from 10,320 to 16,081 cd/m²). In addition, the new design with TPBi resulted in low roll-off phenomenon in external quantum efficiency (EQE)-current density characteristics.
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http://dx.doi.org/10.1166/jnn.2019.17020DOI Listing
October 2019

A financing model to solve financial barriers for implementing green building projects.

ScientificWorldJournal 2013 24;2013:240394. Epub 2013 Nov 24.

Department of Sustainable Architectural Engineering, Hanyang University, 17 Haengdang-dong, Seongdong-gu, Seoul 426-791, Republic of Korea.

Along with the growing interest in greenhouse gas reduction, the effect of greenhouse gas energy reduction from implementing green buildings is gaining attention. The government of the Republic of Korea has set green growth as its paradigm for national development, and there is a growing interest in energy saving for green buildings. However, green buildings may have financial barriers that have high initial construction costs and uncertainties about future project value. Under the circumstances, governmental support to attract private funding is necessary to implement green building projects. The objective of this study is to suggest a financing model for facilitating green building projects with a governmental guarantee based on Certified Emission Reduction (CER). In this model, the government provides a guarantee for the increased costs of a green building project in return for CER. And this study presents the validation of the model as well as feasibility for implementing green building project. In addition, the suggested model assumed governmental guarantees for the increased cost, but private guarantees seem to be feasible as well because of the promising value of the guarantee from CER. To do this, certification of Clean Development Mechanisms (CDMs) for green buildings must be obtained.
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http://dx.doi.org/10.1155/2013/240394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859162PMC
June 2014

Assessment of trabecular bone mineral density using quantitative computed tomography in normal cats.

J Vet Med Sci 2012 Nov 6;74(11):1461-7. Epub 2012 Jul 6.

Laboratory of Medical Imaging, College of Veterinary Medicine, Chungbuk National University, Chungbuk, Republic of Korea.

The aim of this study was to assess age-related changes and anatomic variation in trabecular bone mineral density (tBMD) using quantitative computed tomography (QCT) in normal cats. Seventeen normal cats were included in this study and divided into the following 3 age groups:<6 months (n=4), 2-5 years (n=10) and >6 years (n=3). A computed tomographic scan of each vertebra from the 12th thoracic to the 7th lumbar spine and the pelvis was performed with a bone-density phantom (50, 100 and 150 mg/cm(3), calcium hydroxyapatite, CIRS phantom(®)). On the central transverse section, the elliptical region of interest (ROI) was drawn to measure the mean Hounsfield unit (HU) value. Those values were converted to equivalent tBMD (mg/cm(3)) by use of the bone-density phantom and linear regression analysis (r(2) >0.95). The mean tBMD value of the thoracic vertebrae (369.4 ± 31.8 mg/cm(3)) was significantly higher than that of the lumbar vertebrae (285 ± 58.1 mg/cm(3)). The maximum tBMD occurred at the T12, T13 and L1 levels in all age groups. There was a statistically significant difference in the mean tBMD value among the 3 age groups at the T12 (P<0.001), T13 (P<0.001) and L4 levels (P=0.013), respectively. The present study suggests that age-related changes and anatomic variation in tBMD values should be considered when assessing tBMD using QCT in cats with bone disorders.
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http://dx.doi.org/10.1292/jvms.11-0579DOI Listing
November 2012

Pseudomelanosis ilei associated with ingestion of charcoal: case report and review of literature.

Dig Endosc 2010 Jan;22(1):56-8

Department of Gastroenterology, Korea University Guro Hospital, Seoul, Korea.

Melanosis or pseudomelanosis of the gastrointestinal tract refers to an accumulation of pigment deposits in the gastrointestinal mucosa. Pigmentation can affect the entire gastrointestinal tract. Melanosis of the colon is not uncommon, but black pigmentation of the small intestine is extremely rare. We report a case of pseudomelanosis of the terminal ileum in a 52-year-old woman who had ingested a tablespoon of charcoal powder daily for 2 years. Numerous small and medium-sized irregular grayish black pigmentations mostly on the background of geographic light grayish discolored mucosa and some on the normal-looking mucosa were seen on the terminal ileum. The finding was similar to a cut surface of a dragon fruit and we named the lesion 'dragon fruit ileum'. Follow up endoscopy 10 months later revealed no significant change in the pigmentation. We could not search any English literature on this lesion. However, we could find three cases from two papers from Korea describing similar lesions after chronic charcoal ingestion and the papers were reviewed with a report of our case.
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http://dx.doi.org/10.1111/j.1443-1661.2009.00919.xDOI Listing
January 2010

Determination of optimal dosage and delay time for computed tomographic lymphography after percutaneous injection of Iohexol into popliteal lymph nodes in dogs.

J Vet Med Sci 2009 Jul;71(7):873-8

Veterinary Medical Center , College of Veterinary Medicine, Chungbuk National University, Chungbuk, Republic of Korea.

The purposes of this study were to determine the optimal dose and delay time for lymphography by injection of Iohexol into popliteal lymph nodes and to assess images of computed tomography by the established protocol. Three different doses (30, 60 and 90 mgI/kg) of water-soluble iodinated contrast medium were injected into 15 popliteal lymph nodes of 10 adult beagles, and fluoroscopy was performed. Filling and duration of contrast media and the number of visible ducts from popliteal lymph nodes to the thoracic duct and its branches were recorded. CT lymphography was performed, and the number of visible thoracic ducts was compared with that found by radiographic lymphography. Radiographs obtained between 130 and 800 seconds after injection of contrast medium provided a detailed view of the thoracic duct. The dose of 60 mgI/kg was determined to enable quality diagnostic imaging without extranodal leakage in radiographic lymphography. There was no significant difference in the number of thoracic ducts between the two modalities at each anatomic location. However, CT lymphography provided images of the thoracic duct with better spatial resolution and without superimposition of surrounding tissue. The present study provides an adequate delay time and injection for identification of the canine thoracic duct, and therefore, this technique could be applied to diagnosis of disease associated with chest lymphatic drainage.
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http://dx.doi.org/10.1292/jvms.71.873DOI Listing
July 2009

[A prospective multicenter study on the prevalence and symptoms of erosive reflux esophagitis in secondary and tertiary hospitals in Korea].

Korean J Gastroenterol 2009 May;53(5):283-91

Department of Internal Medicine, Korea University College of Medicine, Guro-gu, Seoul, Korea.

Background/aims: Recent studies suggest that the prevalence of erosive esophagitis (EE) is increasing in Asia. The aims of this study were to determine the prevalence of EE among outpatients visiting gastroenterology clinics of secondary and tertiary hospitals in Korea, and to analyze their symptoms.

Methods: From May to July 2003, outpatients undergoing their first upper gastrointestinal endoscopies after visiting gastroenterology clinics in secondary and tertiary hospitals in Korea were enrolled. Prevalence of EE was calculated from their endoscopic findings, and symptoms were analyzed from the validated symptom questionnaire.

Results: Among 4,275 cases from 24 hospitals, 506 (11.8%) had EE. Among 836 cases with predominantly typical GERD symptoms, EE was diagnosed in 140 (16.7%). Among 530 cases having predominantly typical GERD symptoms with a frequency of at least twice a week or with a significant impact on their daily lives, EE was found in 104 (19.6%). The prevalence of EE was positively associated with males irrespective of age, old aged (> or =65 years) females, predominantly typical GERD symptoms at least twice a week, and the numbers of typical GERD symptoms. The severity of GERD symptoms did not affect the prevalence of EE. The most common typical and atypical GERD symptoms in cases with EE were regurgitation and epigastric soreness, respectively.

Conclusions: The prevalence of EE among outpatients visiting gastroenterology clinics in Korea was 11.8%. Independent factors associated with increased prevalence of EE were males irrespective of age, old aged (> or =65 years) females, number of typical GERD symptoms, and frequent typical GERD symptoms.
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http://dx.doi.org/10.4166/kjg.2009.53.5.283DOI Listing
May 2009

Evaluation of partial cranial cruciate ligament rupture with positive contrast computed tomographic arthrography in dogs.

J Vet Sci 2008 Dec;9(4):395-400

Veterinary Medical Center, College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Korea.

Computed tomographic arthrography (CTA) of four cadaveric canine stifles was performed before and after partial cranial cruciate ligament rupture in order to verify the usefulness of CTA examination for the diagnosis of partial cranial cruciate ligament rupture. To obtain the sequential true transverse image of a cranial cruciate ligament, the computed tomography gantry was angled such that the scanning plane was parallel to the fibula. True transverse images of cranial cruciate ligaments were identified on every sequential image, beginning just proximal to the origin of the cranial cruciate ligament distal to the tibial attachment, after the administration of iodinated contrast medium. A significant decrease in the area of the cranial cruciate ligament was identified on CTA imaging after partial surgical rupture of the cranial cruciate ligament. This finding implies that CTA can be used for assessing partial cranial cruciate ligament ruptures in dogs.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811781PMC
http://dx.doi.org/10.4142/jvs.2008.9.4.395DOI Listing
December 2008

Pneumoretroperitoneum following acupuncture.

J Altern Complement Med 2008 Dec;14(10):1299-301

Department of Gastroenterology, Korea University Guro Hospital, Seoul, Korea.

Pneumoretroperitoneum is a rare event. It can be associated with infection, trauma, and medical interventions such as endoscopic procedures. Acupuncture is generally regarded as a safe procedure, yet cases of iatrogenic complications related with acupuncture have been reported. This report describes a case of pneumoretroperitoneum that developed after acupuncture. A 25-year-old female patient had been treated with acupuncture for her low back pain. Fever and right flank pain developed thereafter. Abdominal plain radiography and computed tomography (CT) disclosed retroperitoneal air along the right psoas muscle. After treatment with antibiotics and analgesics for a week, she was transferred to our hospital. The pneumoretroperitoneum disappeared on the follow-up abdominal CT. This is the first report of pneumoretroperitoneum following acupuncture.
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http://dx.doi.org/10.1089/acm.2008.0261DOI Listing
December 2008

Endoscopic findings around the gastroesophageal junction: an experience from a tertiary hospital in Korea.

Korean J Intern Med 2008 Sep;23(3):127-33

Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea.

Background/aims: Important lesions related to gastroesophageal reflux disease (GERD) are located around the gastroesophageal junction (GEJ). This study examined the distribution of endoscopic findings around the GEJ and elucidated their relationship to each other and esophageal manometric features.

Methods: Endoscopic data were collected prospectively from 2,450 consecutive diagnostic upper gastrointestinal endoscopies. The presence and degree of hiatal hernia (HH), columnar-lined esophagus (CLE), and reflux esophagitis (RE) were recorded. Esophageal manometric data were collected from 181 patients.

Results: The prevalence of HH, CLE, and RE was 9.8, 18.8, and 9.9%, respectively. Of all HH and CLE cases, 62.8 and 98.9%, respectively, were of the short-segment variety. Of all RE cases, 95.0% were mild. Younger age, male gender, the presence of HH, and a higher gastroesophageal flap valve (GEFV) grades were associated with the presence of RE. Increased ZAP grades were associated with increased prevalence and grades of HH, CLE, and RE. Higher GEFV grades were associated with increased prevalence and grades of HH, CLE, and RE. Lower esophageal sphincter pressure (LESP) decreased in patients with HH or RE compared to those without HH or RE.

Conclusions: Endoscopic findings around the GEJ revealed that a substantial proportion of our patients showed features potentially related to GERD. In combination with other recent reports, our study implies that Korea is no longer a very-low-prevalence area of GERD, although it may predominate in silent or milder forms.
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http://dx.doi.org/10.3904/kjim.2008.23.3.127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686963PMC
September 2008
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