Juha Kere

Juha Kere

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Juha Kere

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Epigenome-wide meta-analysis of DNA methylation and childhood asthma.

J Allergy Clin Immunol 2019 Jun 21;143(6):2062-2074. Epub 2018 Dec 21.

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183278
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http://dx.doi.org/10.1016/j.jaci.2018.11.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556405PMC
June 2019

Gain-of-function CEBPE mutation causes non-canonical autoinflammatory inflammasomopathy.

J Allergy Clin Immunol 2019 Jun 12. Epub 2019 Jun 12.

Adult Immunodeficiency Unit, Infectious Diseases, Inflammation Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Rare Diseases Center and Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, P.O.Box 281, FI-00029 HUS, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.06.003DOI Listing
June 2019

Discovering heritable modes of MEG spectral power.

Hum Brain Mapp 2019 Apr 1;40(5):1391-1402. Epub 2019 Jan 1.

Department of Computer Science, Helsinki Institute for Information Technology HIIT, Aalto University, Helsinki, Finland.

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http://dx.doi.org/10.1002/hbm.24454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590382PMC
April 2019

A preliminary transcriptome analysis suggests a transitory effect of vitamin D on mitochondrial function in obese young Finnish subjects.

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

H Viljakainen, Folkhälsan Institute of Genetics, Folkhälsan Research Center, University of Helsinki, Finland.

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http://dx.doi.org/10.1530/EC-18-0537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499919PMC
April 2019

Delineating the healthy human skin UV response and early induction of interferon pathway in cutaneous lupus erythematosus.

J Invest Dermatol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermatology and Allergology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jid.2019.02.035DOI Listing
April 2019

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.

Authors:
Leanne K Küpers Claire Monnereau Gemma C Sharp Paul Yousefi Lucas A Salas Akram Ghantous Christian M Page Sarah E Reese Allen J Wilcox Darina Czamara Anne P Starling Alexei Novoloaca Samantha Lent Ritu Roy Cathrine Hoyo Carrie V Breton Catherine Allard Allan C Just Kelly M Bakulski John W Holloway Todd M Everson Cheng-Jian Xu Rae-Chi Huang Diana A van der Plaat Matthias Wielscher Simon Kebede Merid Vilhelmina Ullemar Faisal I Rezwan Jari Lahti Jenny van Dongen Sabine A S Langie Tom G Richardson Maria C Magnus Ellen A Nohr Zongli Xu Liesbeth Duijts Shanshan Zhao Weiming Zhang Michelle Plusquin Dawn L DeMeo Olivia Solomon Joosje H Heimovaara Dereje D Jima Lu Gao Mariona Bustamante Patrice Perron Robert O Wright Irva Hertz-Picciotto Hongmei Zhang Margaret R Karagas Ulrike Gehring Carmen J Marsit Lawrence J Beilin Judith M Vonk Marjo-Riitta Jarvelin Anna Bergström Anne K Örtqvist Susan Ewart Pia M Villa Sophie E Moore Gonneke Willemsen Arnout R L Standaert Siri E Håberg Thorkild I A Sørensen Jack A Taylor Katri Räikkönen Ivana V Yang Katerina Kechris Tim S Nawrot Matt J Silver Yun Yun Gong Lorenzo Richiardi Manolis Kogevinas Augusto A Litonjua Brenda Eskenazi Karen Huen Hamdi Mbarek Rachel L Maguire Terence Dwyer Martine Vrijheid Luigi Bouchard Andrea A Baccarelli Lisa A Croen Wilfried Karmaus Denise Anderson Maaike de Vries Sylvain Sebert Juha Kere Robert Karlsson Syed Hasan Arshad Esa Hämäläinen Michael N Routledge Dorret I Boomsma Andrew P Feinberg Craig J Newschaffer Eva Govarts Matthieu Moisse M Daniele Fallin Erik Melén Andrew M Prentice Eero Kajantie Catarina Almqvist Emily Oken Dana Dabelea H Marike Boezen Phillip E Melton Rosalind J Wright Gerard H Koppelman Letizia Trevisi Marie-France Hivert Jordi Sunyer Monica C Munthe-Kaas Susan K Murphy Eva Corpeleijn Joseph Wiemels Nina Holland Zdenko Herceg Elisabeth B Binder George Davey Smith Vincent W V Jaddoe Rolv T Lie Wenche Nystad Stephanie J London Debbie A Lawlor Caroline L Relton Harold Snieder Janine F Felix

Nat Commun 2019 04 23;10(1):1893. Epub 2019 Apr 23.

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41467-019-09671-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478731PMC
April 2019

Cationic gold nanoparticles elicit mitochondrial dysfunction: a multi-omics study.

Sci Rep 2019 Mar 13;9(1):4366. Epub 2019 Mar 13.

Nanosafety & Nanomedicine Laboratory, Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, 171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41598-019-40579-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416392PMC
March 2019

FUT2 Variants Confer Susceptibility to Familial Otitis Media.

Am J Hum Genet 2018 11 25;103(5):679-690. Epub 2018 Oct 25.

Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00029297183032
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http://dx.doi.org/10.1016/j.ajhg.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217759PMC
November 2018

MANF protects human pancreatic beta cells against stress-induced cell death.

Diabetologia 2018 10 21;61(10):2202-2214. Epub 2018 Jul 21.

Research Programs Unit, Molecular Neurology, Biomedicum Helsinki, University of Helsinki, PO Box 63, (Haartmaninkatu 8), 00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00125-018-4687-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133171PMC
October 2018

Human pluripotent reprogramming with CRISPR activators.

Nat Commun 2018 07 6;9(1):2643. Epub 2018 Jul 6.

Research Programs Unit, Molecular Neurology and Biomedicum Stem Cell Centre, Faculty of Medicine, University of Helsinki, Helsinki, 00014, Finland.

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http://dx.doi.org/10.1038/s41467-018-05067-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035213PMC
July 2018

DNA methylation in childhood asthma: an epigenome-wide meta-analysis.

Lancet Respir Med 2018 05 26;6(5):379-388. Epub 2018 Feb 26.

GRIAC research institute Groningen, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pediatric Pulmonology and Pediatric Allergy, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30052-3DOI Listing
May 2018

Reduced CDHR3 expression in children wheezing with rhinovirus.

Pediatr Allergy Immunol 2018 03;29(2):200-206

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/pai.12858DOI Listing
March 2018

Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium.

Authors:
Janine F Felix Bonnie R Joubert Andrea A Baccarelli Gemma C Sharp Catarina Almqvist Isabella Annesi-Maesano Hasan Arshad Nour Baïz Marian J Bakermans-Kranenburg Kelly M Bakulski Elisabeth B Binder Luigi Bouchard Carrie V Breton Bert Brunekreef Kelly J Brunst Esteban G Burchard Mariona Bustamante Leda Chatzi Monica Cheng Munthe-Kaas Eva Corpeleijn Darina Czamara Dana Dabelea George Davey Smith Patrick De Boever Liesbeth Duijts Terence Dwyer Celeste Eng Brenda Eskenazi Todd M Everson Fahimeh Falahi M Daniele Fallin Sara Farchi Mariana F Fernandez Lu Gao Tom R Gaunt Akram Ghantous Matthew W Gillman Semira Gonseth Veit Grote Olena Gruzieva Siri E Håberg Zdenko Herceg Marie-France Hivert Nina Holland John W Holloway Cathrine Hoyo Donglei Hu Rae-Chi Huang Karen Huen Marjo-Riitta Järvelin Dereje D Jima Allan C Just Margaret R Karagas Robert Karlsson Wilfried Karmaus Katerina J Kechris Juha Kere Manolis Kogevinas Berthold Koletzko Gerard H Koppelman Leanne K Küpers Christine Ladd-Acosta Jari Lahti Nathalie Lambrechts Sabine A S Langie Rolv T Lie Andrew H Liu Maria C Magnus Per Magnus Rachel L Maguire Carmen J Marsit Wendy McArdle Erik Melén Phillip Melton Susan K Murphy Tim S Nawrot Lorenza Nisticò Ellen A Nohr Björn Nordlund Wenche Nystad Sam S Oh Emily Oken Christian M Page Patrice Perron Göran Pershagen Costanza Pizzi Michelle Plusquin Katri Raikkonen Sarah E Reese Eva Reischl Lorenzo Richiardi Susan Ring Ritu P Roy Peter Rzehak Greet Schoeters David A Schwartz Sylvain Sebert Harold Snieder Thorkild I A Sørensen Anne P Starling Jordi Sunyer Jack A Taylor Henning Tiemeier Vilhelmina Ullemar Marina Vafeiadi Marinus H Van Ijzendoorn Judith M Vonk Annette Vriens Martine Vrijheid Pei Wang Joseph L Wiemels Allen J Wilcox Rosalind J Wright Cheng-Jian Xu Zongli Xu Ivana V Yang Paul Yousefi Hongmei Zhang Weiming Zhang Shanshan Zhao Golareh Agha Caroline L Relton Vincent W V Jaddoe Stephanie J London

Int J Epidemiol 2018 02;47(1):22-23u

National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, USA.

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http://dx.doi.org/10.1093/ije/dyx190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837319PMC
February 2018

Fetal Microsatellite in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia.

Hypertension 2018 01 4;71(1):95-102. Epub 2017 Dec 4.

From Medical and Clinical Genetics, Helsinki University Hospital (T.K., S.U., M.M.K., H.L.), Obstetrics and Gynaecology, Helsinki University Hospital (M.M.K., S.H.), Abdominal Center, Nephrology, Helsinki University Hospital (I.T.), Clinical Chemistry and Hematology, Helsinki University Hospital (P.L.), Children's Hospital, Helsinki University Central Hospital (E.K.), Molecular Neurology Research Program (J.K.), and Institute for Molecular Medicine Finland, HiLIFE Unit (H.L.), University of Helsinki, Finland; Department of Obstetrics and Gynecology, South-Karelia Central Hospital, Lappeenranta, Finland (M.M.K.); Bioinformatics Center, University of Eastern Finland, Kuopio (J.P.); Department of Clinical Chemistry, University of Turku (K.P.), and Saske Screening Center, Turku University Central Hospital (K.P.), Finland; Eastern Finland Laboratory Centre, Kuopio (K.P., J.R.); Minerva Foundation Institute for Medical Research, Helsinki, Finland (I.T., P.L.); Chronic Disease Prevention Unit (E.K.) and Department of Government Services (A.P.), National Institute for Health and Welfare, Helsinki, Finland; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Finland (E.K., A.P.); Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden (J.K.); Folkhälsan Institute of Genetics, Helsinki, Finland (J.K.); Department of Medical and Molecular Genetics, King's College London, United Kingdom (J.K.); Division of Cardiovascular Medicine, University of Cambridge, United Kingdom (K.K.); Faculty of Medicine and Life Sciences, University of Tampere, Finland (H.L.); and Department of Obstetrics and Gynecology, Tampere University Hospital, Finland (H.L.).

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.117.
Publisher Site
http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10425DOI Listing
January 2018

Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes.

J Allergy Clin Immunol 2017 Sep 21;140(3):782-796. Epub 2017 Jan 21.

Adult Immunodeficiency Unit, Infectious Diseases, Inflammation Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Rare Diseases Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jaci.2016.10.054DOI Listing
September 2017

Neuropeptide S (NPS) variants modify the signaling and risk effects of NPS Receptor 1 (NPSR1) variants in asthma.

PLoS One 2017 2;12(5):e0176568. Epub 2017 May 2.

Heart and Lung Center, Division of Pulmonary Medicine, University of Helsinki and Helsinki University Hospital, 00014 University of Helsinki, Helsinki, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176568PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413018PMC
September 2017

Optimizing bone morphogenic protein 4-mediated human embryonic stem cell differentiation into trophoblast-like cells using fibroblast growth factor 2 and transforming growth factor-β/activin/nodal signalling inhibition.

Reprod Biomed Online 2017 Sep 12;35(3):253-263. Epub 2017 Jun 12.

Competence Centre on Health Technologies, Tartu, Estonia; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Obstetrics and Gynaecology, University of Tartu, Tartu, Estonia; Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

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http://dx.doi.org/10.1016/j.rbmo.2017.06.003DOI Listing
September 2017

Unexpectedly High Prevalence of Common Variable Immunodeficiency in Finland.

Front Immunol 2017 28;8:1190. Epub 2017 Sep 28.

Adult Immunodeficiency Unit, Infectious Diseases, Inflammation Center, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.3389/fimmu.2017.01190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625003PMC
September 2017

Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population.

Hypertension 2017 08 26;70(2):365-371. Epub 2017 Jun 26.

From the Immunobiology, Research Programs Unit (A.I.L., S.M.), Molecular Neurology, Research Programs Unit (J.K.), and Institute for Molecular Medicine Finland/HiLIFE Unit (P.H., K.A., M.P., H.L.), University of Helsinki, Finland; Medical and Clinical Genetics (A.I.L., H.L.), Bacteriology and Immunology (A.I.L., S.M.), Obstetrics and Gynaecology (K.A., S.H., H.L.), and Children's Hospital (E.K), University of Helsinki and Helsinki University Hospital, Finland; Folkhälsan Institute of Genetics (J.K.), University of Helsinki, Finland; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA (E.D., M.I.K., M.D.); Department of Medicine, Division of Rheumatology (M.T., E.D.O.R., J.P.A.) and Department of Genetics (E.D.O.R.), Washington University School of Medicine, St. Louis, MO; Neurosurgery of Neuro Center, Kuopio University Hospital, Finland (M.I.K.); Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston (M.I.K.); Unit of Genetics and Biomarkers (K.A.), Department of Health (M.P., E.K.), Chronic Disease Prevention Unit, Department of Health (E.K.), and Department of Government Services (A.P.), National Institute for Health and Welfare, Helsinki, Finland; The Estonian Genome Center, University of Tartu, Estonia (M.P.); PEDEGO Research Unit, MRC Oulu, University of Oulu and Oulu University Hospital, Finland (E.K., A.P.); Department of Biosciences and Nutrition, Karolinska Institutet, Solna, Sweden (J.K.); Department of Medical and Molecular Genetics, King's College, London, United Kingdom (J.K.); Division of Cardiovascular Medicine, University of Cambridge, United Kingdom (K.K.); Department of Medicine, Hospital for Special Surgery-Weill Cornell Medicine, New York, NY (J.E.S.); and Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston (M.D.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535812PMC
August 2017

FANTOM5 CAGE profiles of human and mouse samples.

Authors:
Shuhei Noguchi Takahiro Arakawa Shiro Fukuda Masaaki Furuno Akira Hasegawa Fumi Hori Sachi Ishikawa-Kato Kaoru Kaida Ai Kaiho Mutsumi Kanamori-Katayama Tsugumi Kawashima Miki Kojima Atsutaka Kubosaki Ri-Ichiroh Manabe Mitsuyoshi Murata Sayaka Nagao-Sato Kenichi Nakazato Noriko Ninomiya Hiromi Nishiyori-Sueki Shohei Noma Eri Saijyo Akiko Saka Mizuho Sakai Christophe Simon Naoko Suzuki Michihira Tagami Shoko Watanabe Shigehiro Yoshida Peter Arner Richard A Axton Magda Babina J Kenneth Baillie Timothy C Barnett Anthony G Beckhouse Antje Blumenthal Beatrice Bodega Alessandro Bonetti James Briggs Frank Brombacher Ailsa J Carlisle Hans C Clevers Carrie A Davis Michael Detmar Taeko Dohi Albert S B Edge Matthias Edinger Anna Ehrlund Karl Ekwall Mitsuhiro Endoh Hideki Enomoto Afsaneh Eslami Michela Fagiolini Lynsey Fairbairn Mary C Farach-Carson Geoffrey J Faulkner Carmelo Ferrai Malcolm E Fisher Lesley M Forrester Rie Fujita Jun-Ichi Furusawa Teunis B Geijtenbeek Thomas Gingeras Daniel Goldowitz Sven Guhl Reto Guler Stefano Gustincich Thomas J Ha Masahide Hamaguchi Mitsuko Hara Yuki Hasegawa Meenhard Herlyn Peter Heutink Kelly J Hitchens David A Hume Tomokatsu Ikawa Yuri Ishizu Chieko Kai Hiroshi Kawamoto Yuki I Kawamura Judith S Kempfle Tony J Kenna Juha Kere Levon M Khachigian Toshio Kitamura Sarah Klein S Peter Klinken Alan J Knox Soichi Kojima Haruhiko Koseki Shigeo Koyasu Weonju Lee Andreas Lennartsson Alan Mackay-Sim Niklas Mejhert Yosuke Mizuno Hiromasa Morikawa Mitsuru Morimoto Kazuyo Moro Kelly J Morris Hozumi Motohashi Christine L Mummery Yutaka Nakachi Fumio Nakahara Toshiyuki Nakamura Yukio Nakamura Tadasuke Nozaki Soichi Ogishima Naganari Ohkura Hiroshi Ohno Mitsuhiro Ohshima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry A Ovchinnikov Robert Passier Margaret Patrikakis Ana Pombo Swati Pradhan-Bhatt Xian-Yang Qin Michael Rehli Patrizia Rizzu Sugata Roy Antti Sajantila Shimon Sakaguchi Hiroki Sato Hironori Satoh Suzana Savvi Alka Saxena Christian Schmidl Claudio Schneider Gundula G Schulze-Tanzil Anita Schwegmann Guojun Sheng Jay W Shin Daisuke Sugiyama Takaaki Sugiyama Kim M Summers Naoko Takahashi Jun Takai Hiroshi Tanaka Hideki Tatsukawa Andru Tomoiu Hiroo Toyoda Marc van de Wetering Linda M van den Berg Roberto Verardo Dipti Vijayan Christine A Wells Louise N Winteringham Ernst Wolvetang Yoko Yamaguchi Masayuki Yamamoto Chiyo Yanagi-Mizuochi Misako Yoneda Yohei Yonekura Peter G Zhang Silvia Zucchelli Imad Abugessaisa Erik Arner Jayson Harshbarger Atsushi Kondo Timo Lassmann Marina Lizio Serkan Sahin Thierry Sengstag Jessica Severin Hisashi Shimoji Masanori Suzuki Harukazu Suzuki Jun Kawai Naoto Kondo Masayoshi Itoh Carsten O Daub Takeya Kasukawa Hideya Kawaji Piero Carninci Alistair R R Forrest Yoshihide Hayashizaki

Sci Data 2017 08 29;4:170112. Epub 2017 Aug 29.

RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1038/sdata.2017.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574368PMC
August 2017

Identification of Novel Transcribed Regions in Zebrafish (Danio rerio) Using RNA-Sequencing.

PLoS One 2016 27;11(7):e0160197. Epub 2016 Jul 27.

Department of Biosciences and Nutrition, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160197PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962977PMC
July 2017

Combined immunodeficiency and hypoglycemia associated with mutations in hypoxia upregulated 1.

J Allergy Clin Immunol 2017 04 29;139(4):1391-1393.e11. Epub 2016 Nov 29.

Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland; Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland; Center for Innovative Medicine, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.1016/j.jaci.2016.09.050DOI Listing
April 2017

Human ROBO1 regulates white matter structure in corpus callosum.

Brain Struct Funct 2017 03 30;222(2):707-716. Epub 2016 May 30.

Research Programs Unit, Haartman Institute, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00429-016-1240-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334444PMC
March 2017

Cohort profile: the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC).

BMJ Open 2016 11 10;6(11):e013148. Epub 2016 Nov 10.

Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1136/bmjopen-2016-013148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129003PMC
November 2016

Whole-Exome Sequencing Suggests LAMB3 as a Susceptibility Gene for Morbid Obesity.

Diabetes 2016 10 18;65(10):2980-9. Epub 2016 Jul 18.

Lipid Laboratory, Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.2337/db16-0522DOI Listing
October 2016

The Hydroxysteroid (17β) Dehydrogenase Family Gene HSD17B12 Is Involved in the Prostaglandin Synthesis Pathway, the Ovarian Function, and Regulation of Fertility.

Endocrinology 2016 Oct 4;157(10):3719-3730. Epub 2016 Aug 4.

Department of Physiology and Turku Center for Disease Modeling (H.K., M.A., J.M.-J., T.D.L., L.S., M.P.), Institute of Biomedicine, University of Turku, FI-20540 Turku, Finland; Department of Clinical Science, Intervention and Technology (P.D., O.H.), Karolinska Institute, 141 52 Huddinge, Sweden; Swedish Toxicology Sciences Research Center (P.D.), Karolinska Institutet, 141 86 Stockholm, Sweden; Department of Biosciences and Nutrition (A.E.D., J.K.), Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Mathematics and Statistics (T.D.L., T.A.), University of Turku, FI-20014 Turku, Finland; Institute for Molecular Medicine Finland (T.A.), University of Helsinki, FI-00014 Helsinki, Finland; Experimental Genetics (J.A.), Center of Life and Food Sciences, Weihenstephan, 85354 Freising, Germany; Institute of experimental Genetics (J.A.), Helmholtz Zentrum, 81377 München, Germany; Genome Analysis Center (J.A.), German Research Center for Environmental Health, 85764 Neuherberg, Germany; Institute of Neuroscience and Physiology (H.R.), Sahlgrenska Academy, University of Gothenburg, SE-405 30 Gothenburg, Sweden; Institute of Medicine (C.O., M.P.), The Sahlgrenska Academy, University of Gothenburg, SE-413 46 Gothenburg, Sweden.

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http://dx.doi.org/10.1210/en.2016-1252DOI Listing
October 2016

The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation.

Development 2016 10 30;143(19):3459-3469. Epub 2016 Aug 30.

Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Huddinge 141 83, Sweden Science for Life Laboratory, Tomtebodavägen 23 A, Solna 171 21, Sweden Molecular Neurology Research Program, University of Helsinki and Folkhälsan Institute of Genetics, Biomedicum 1, Haartmaninkatu 8, Helsinki 00290, Finland

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http://dx.doi.org/10.1242/dev.134510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087614PMC
October 2016

Evidence for genetic regulation of the human parieto-occipital 10-Hz rhythmic activity.

Eur J Neurosci 2016 08 4;44(3):1963-71. Epub 2016 Jul 4.

Molecular Neurology Research Program, Research Programs Unit, University of Helsinki, PO Box 63, FI-00014, Helsinki, Finland.

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http://dx.doi.org/10.1111/ejn.13300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113795PMC
August 2016

The diagnosis of pre-eclampsia using two revised classifications in the Finnish Pre-eclampsia Consortium (FINNPEC) cohort.

BMC Pregnancy Childbirth 2016 08 12;16:221. Epub 2016 Aug 12.

Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1186/s12884-016-1010-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983019PMC
August 2016

An RGS2 3'UTR polymorphism is associated with preeclampsia in overweight women.

BMC Genet 2016 08 24;17(1):121. Epub 2016 Aug 24.

Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1186/s12863-016-0428-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997762PMC
August 2016

Exome sequencing in pooled DNA samples to identify maternal pre-eclampsia risk variants.

Sci Rep 2016 07 7;6:29085. Epub 2016 Jul 7.

Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1038/srep29085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935848PMC
July 2016

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis.

Authors:
Bonnie R Joubert Janine F Felix Paul Yousefi Kelly M Bakulski Allan C Just Carrie Breton Sarah E Reese Christina A Markunas Rebecca C Richmond Cheng-Jian Xu Leanne K Küpers Sam S Oh Cathrine Hoyo Olena Gruzieva Cilla Söderhäll Lucas A Salas Nour Baïz Hongmei Zhang Johanna Lepeule Carlos Ruiz Symen Ligthart Tianyuan Wang Jack A Taylor Liesbeth Duijts Gemma C Sharp Soesma A Jankipersadsing Roy M Nilsen Ahmad Vaez M Daniele Fallin Donglei Hu Augusto A Litonjua Bernard F Fuemmeler Karen Huen Juha Kere Inger Kull Monica Cheng Munthe-Kaas Ulrike Gehring Mariona Bustamante Marie José Saurel-Coubizolles Bilal M Quraishi Jie Ren Jörg Tost Juan R Gonzalez Marjolein J Peters Siri E Håberg Zongli Xu Joyce B van Meurs Tom R Gaunt Marjan Kerkhof Eva Corpeleijn Andrew P Feinberg Celeste Eng Andrea A Baccarelli Sara E Benjamin Neelon Asa Bradman Simon Kebede Merid Anna Bergström Zdenko Herceg Hector Hernandez-Vargas Bert Brunekreef Mariona Pinart Barbara Heude Susan Ewart Jin Yao Nathanaël Lemonnier Oscar H Franco Michael C Wu Albert Hofman Wendy McArdle Pieter Van der Vlies Fahimeh Falahi Matthew W Gillman Lisa F Barcellos Ashish Kumar Magnus Wickman Stefano Guerra Marie-Aline Charles John Holloway Charles Auffray Henning W Tiemeier George Davey Smith Dirkje Postma Marie-France Hivert Brenda Eskenazi Martine Vrijheid Hasan Arshad Josep M Antó Abbas Dehghan Wilfried Karmaus Isabella Annesi-Maesano Jordi Sunyer Akram Ghantous Göran Pershagen Nina Holland Susan K Murphy Dawn L DeMeo Esteban G Burchard Christine Ladd-Acosta Harold Snieder Wenche Nystad Gerard H Koppelman Caroline L Relton Vincent W V Jaddoe Allen Wilcox Erik Melén Stephanie J London

Am J Hum Genet 2016 Apr 31;98(4):680-96. Epub 2016 Mar 31.

National Institute of Environmental Health Sciences, NIH, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833289PMC
April 2016

Genomic sequencing of a dyslexia susceptibility haplotype encompassing ROBO1.

J Neurodev Disord 2016 27;8. Epub 2016 Jan 27.

Molecular Neurology Research Program, University of Helsinki, Helsinki, Finland ; Folkhälsan Institute of Genetics, Biomedicum Helsinki, Helsinki, Finland ; Department of Biosciences and Nutrition, and Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.

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http://link.springer.com/content/pdf/10.1186%2Fs11689-016-91
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http://dx.doi.org/10.1186/s11689-016-9136-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751651PMC
February 2016

Variant Profiling of Candidate Genes in Pancreatic Ductal Adenocarcinoma.

Clin Chem 2015 Nov 16;61(11):1408-16. Epub 2015 Sep 16.

Department of Medical Epidemiology and Biostatistics and

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http://dx.doi.org/10.1373/clinchem.2015.238543DOI Listing
November 2015

Mutation in CEP63 co-segregating with developmental dyslexia in a Swedish family.

Hum Genet 2015 Nov 23;134(11-12):1239-48. Epub 2015 Sep 23.

Department of Biosciences and Nutrition, and Center for Innovative Medicine, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.1007/s00439-015-1602-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628622PMC
November 2015

Candidate gene analysis and exome sequencing confirm LBX1 as a susceptibility gene for idiopathic scoliosis.

Spine J 2015 Oct 15;15(10):2239-46. Epub 2015 May 15.

Department of Orthopedics, Karolinska University Hospital, K54, SE-14186, Stockholm, Sweden; Department of Clinical Sciences, Intervention and Technology (CLINTEC) Karolinska Institutet, SE-14186, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.spinee.2015.05.013DOI Listing
October 2015

Transcriptome analysis of controlled and therapy-resistant childhood asthma reveals distinct gene expression profiles.

J Allergy Clin Immunol 2015 Sep 9;136(3):638-48. Epub 2015 Apr 9.

Department of Biosciences and Nutrition and Center for Innovative Medicine (CIMED), Karolinska Institutet, Stockholm, Sweden; Omics Science Center,§ RIKEN Yokohama Institute, Yokohama, Japan; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Japan.

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September 2015

Gene expression profiling of pre-eclamptic placentae by RNA sequencing.

Sci Rep 2015 09 21;5:14107. Epub 2015 Sep 21.

Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, FI-00014, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585671PMC
September 2015

Polymorphisms in DCDC2 and S100B associate with developmental dyslexia.

J Hum Genet 2015 Jul 16;60(7):399-401. Epub 2015 Apr 16.

1] Department of Biosciences and Nutrition, and Center for Innovative Medicine, Karolinska Institutet, Huddinge, Sweden [2] Science for Life Laboratory, Stockholm, Sweden [3] Molecular Neurology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland [4] Folkhälsan Institute of Genetics, Helsinki, Finland.

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http://dx.doi.org/10.1038/jhg.2015.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521290PMC
July 2015

Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes.

Clin Epigenetics 2015 26;7:34. Epub 2015 Mar 26.

Department of Biosciences and Nutrition, Center for Innovative Medicine, Karolinska Institutet, Stockholm, Sweden ; Folkhälsan Institute of Genetics, Helsinki, and Research Programs Unit, University of Helsinki, Helsinki, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396570PMC
April 2015

CTNND2-a candidate gene for reading problems and mild intellectual disability.

J Med Genet 2015 Feb 3;52(2):111-22. Epub 2014 Dec 3.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.

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February 2015