Juergen Debus

Juergen Debus

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Juergen Debus

Publications by authors named "Juergen Debus"

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Overcoming radioresistance in WiDr cells with heavy ion irradiation and radiosensitization by 2-deoxyglucose with photon irradiation.

Clin Transl Radiat Oncol 2019 Nov 20;19:52-58. Epub 2019 Aug 20.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ctro.2019.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733777PMC
November 2019

Fostering efficacy of anti-PD-1-treatment: Nivolumab plus radiotherapy in advanced non-small cell lung cancer - study protocol of the FORCE trial.

BMC Cancer 2019 Nov 8;19(1):1074. Epub 2019 Nov 8.

Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s12885-019-6205-0DOI Listing
November 2019

The impact of vaginal dilator use on vaginal stenosis and sexual quality of life in women treated with adjuvant radiotherapy for endometrial cancer.

Strahlenther Onkol 2019 Oct 17;195(10):902-912. Epub 2019 Apr 17.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00066-019-01466-1DOI Listing
October 2019

The impact of age on the outcome of patients treated with radiotherapy for mucoepidermoid carcinoma (MEC) of the salivary glands in the head and neck: A 15-year single-center experience.

Oral Oncol 2019 Oct 5;97:115-123. Epub 2019 Sep 5.

Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; National Center for Tumor Diseases (NCT), Heidelberg, Germany; Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2019.08.018DOI Listing
October 2019

Re-irradiation with protons or heavy ions with focus on head and neck, skull base and brain malignancies.

Br J Radiol 2019 Oct 24:20190516. Epub 2019 Oct 24.

Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1259/bjr.20190516DOI Listing
October 2019

Offline imaging of positron emitters induced by therapeutic helium, carbon and oxygen ion beams with a full-ring PET/CT scanner: experiments in reference targets.

Phys Med Biol 2019 Sep 27. Epub 2019 Sep 27.

Experimental Physics Medical Physics, Ludwig-Maximilians-Universitaet Muenchen, Am Coulombwall 1, 85748 Garching b Munchen, Munich, GERMANY.

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http://dx.doi.org/10.1088/1361-6560/ab48b4DOI Listing
September 2019

The role of organ- and function-preserving radiotherapy in the treatment of adenoid cystic carcinoma of the larynx.

Head Neck 2019 Jul 5;41(7):2208-2214. Epub 2019 Feb 5.

Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/hed.25678DOI Listing
July 2019

Chemoradiation in female patients with anal cancer: Patient-reported outcome of acute and chronic side effects.

Tumori 2019 Apr 28;105(2):174-180. Epub 2018 Nov 28.

1 Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1177/0300891618811273DOI Listing
April 2019

Results of a combination treatment with intensity modulated radiotherapy and active raster-scanning carbon ion boost for adenoid cystic carcinoma of the minor salivary glands of the nasopharynx.

Oral Oncol 2019 Apr 27;91:39-46. Epub 2019 Feb 27.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120 Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13688375193006
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http://dx.doi.org/10.1016/j.oraloncology.2019.02.019DOI Listing
April 2019

Helical tomotherapy in patients with leptomeningeal metastases.

Cancer Manag Res 2019 31;11:401-409. Epub 2018 Dec 31.

Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.2147/CMAR.S185414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317467PMC
December 2018

Persistence of radiation-induced aberrations in patients after radiotherapy with C-ions and IMRT.

Clin Transl Radiat Oncol 2018 Nov 10;13:57-63. Epub 2018 Oct 10.

GSI Helmholtzzentrum fuer Schwerionenforschung, Biophysics Department, Darmstadt, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S24056308183006
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http://dx.doi.org/10.1016/j.ctro.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198102PMC
November 2018

Linear accelerator-based stereotactic fractionated photon radiotherapy as an eye-conserving treatment for uveal melanoma.

Radiat Oncol 2018 Aug 2;13(1):140. Epub 2018 Aug 2.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s13014-018-1088-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090919PMC
August 2018

Improving the modelling of irradiation-induced brain activation for in vivo PET verification of proton therapy.

Radiother Oncol 2018 07 24;128(1):101-108. Epub 2018 Apr 24.

Department of Medical Physics, Ludwig Maximillians University Munich, Germany.

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http://dx.doi.org/10.1016/j.radonc.2018.01.016DOI Listing
July 2018

Neoadjuvant versus definitive chemoradiotherapy for locally advanced esophageal cancer : Outcomes and patterns of failure.

Strahlenther Onkol 2018 02 15;194(2):116-124. Epub 2017 Sep 15.

Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00066-017-1211-0DOI Listing
February 2018

Sequential proton boost after standard chemoradiation for high-grade glioma.

Radiother Oncol 2017 11 16;125(2):266-272. Epub 2017 Oct 16.

University Hospital of Heidelberg, Department of Radiation Oncology, Germany; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Heidelberg Ion-Beam Therapy Center (HIT), Germany; Heidelberg Institute for Radiation Oncology (HIRO), Germany.

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http://dx.doi.org/10.1016/j.radonc.2017.09.040DOI Listing
November 2017

Quantitative assessment of radiation dose and fractionation effects on normal tissue by utilizing a novel lung fibrosis index model.

Radiat Oncol 2017 Nov 7;12(1):172. Epub 2017 Nov 7.

German Cancer Consortium (DKTK), Translational Radiation Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), INF 460, 69120, Heidelberg, Germany.

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https://ro-journal.biomedcentral.com/articles/10.1186/s13014
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http://dx.doi.org/10.1186/s13014-017-0912-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678815PMC
November 2017

Intensity-modulated versus 3-dimensional conformal radiotherapy in the definitive treatment of esophageal cancer: comparison of outcomes and acute toxicity.

Radiat Oncol 2017 Aug 15;12(1):131. Epub 2017 Aug 15.

National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://ro-journal.biomedcentral.com/articles/10.1186/s13014-
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http://dx.doi.org/10.1186/s13014-017-0863-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558777PMC
August 2017

Malignant pleural mesothelioma - Pleural cavity irradiation after decortication with helical tomotherapy.

Rep Pract Oncol Radiother 2017 Sep-Oct;22(5):402-407. Epub 2017 Aug 11.

Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.rpor.2017.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554964PMC
August 2017

Craniospinal irradiation using helical tomotherapy for central nervous system tumors.

J Radiat Res 2017 Mar;58(2):238-246

Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, Heidelberg 69120, Germany.

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http://dx.doi.org/10.1093/jrr/rrw095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439401PMC
March 2017

The influence of hyperglycemia during radiotherapy on survival in patients with primary glioblastoma.

Acta Oncol 2016 20;55(2):201-7. Epub 2015 May 20.

a University Hospital of Heidelberg, Department of Radiation Oncology , Heidelberg , Germany.

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http://dx.doi.org/10.3109/0284186X.2015.1043397DOI Listing
January 2017

Prognostic factors for long-term quality of life after adjuvant radiotherapy in women with endometrial cancer.

Strahlenther Onkol 2016 Dec 7;192(12):895-904. Epub 2016 Sep 7.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00066-016-1037-1DOI Listing
December 2016

Do Increased Doses to Stem-Cell Niches during Radiation Therapy Improve Glioblastoma Survival?

Stem Cells Int 2016 27;2016:8793462. Epub 2016 Jun 27.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120 Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1155/2016/8793462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939331PMC
July 2016

Radiotherapy plus concomitant temozolomide in primary gliosarcoma.

J Neurooncol 2016 06 30;128(2):341-8. Epub 2016 Mar 30.

Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11060-016-2117-xDOI Listing
June 2016

Intensity modulated radiation therapy (IMRT) for sinonasal tumors: a single center long-term clinical analysis.

Radiat Oncol 2016 Feb 4;11:17. Epub 2016 Feb 4.

CCU Mol&Radiation Oncology, German Cancer Research Center (DKFZ), 280 INF, Heidelberg, 69120, Germany.

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http://dx.doi.org/10.1186/s13014-016-0595-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743109PMC
February 2016

For the next trick: new discoveries in radiobiology applied to glioblastoma.

Am Soc Clin Oncol Educ Book 2014 :e95-9

From the German Cancer Consortium (DKTK), Heidelberg, Germany; Department of Radiation Oncology, Heidelberg Ion Therapy Center (HIT), Heidelberg Institute of Radiation Oncology (HIRO), University of Heidelberg Medical School; Molecular and Translational Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.14694/EdBook_AM.2014.34.e95DOI Listing
December 2015

Metformin influences progression in diabetic glioblastoma patients.

Strahlenther Onkol 2015 Dec 2;191(12):928-35. Epub 2015 Sep 2.

Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00066-015-0884-5DOI Listing
December 2015

A randomized phase II study of radiation induced immune boost in operable non-small cell lung cancer (RadImmune trial).

BMC Cancer 2015 Dec 19;15:988. Epub 2015 Dec 19.

Departments of Molecular and Radiation Oncology, Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s12885-015-2006-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684916PMC
December 2015

Loss of SOX2 expression induces cell motility via vimentin up-regulation and is an unfavorable risk factor for survival of head and neck squamous cell carcinoma.

Mol Oncol 2015 Oct 20;9(8):1704-19. Epub 2015 May 20.

Department of Otolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Heidelberg, D-69120, Germany; Research Group Molecular Mechanisms of Head and Neck Tumors, German Cancer Research Center (DKFZ), Heidelberg, D-69120, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528792PMC
October 2015

Mesenchymal stem cells – A new hope for radiotherapy-induced tissue damage?

Cancer Lett 2015 Oct 9;366(2):133-40. Epub 2015 Jul 9.

Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Department of Molecular and Radiation Oncology, German Cancer Research Center (dkfz), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.canlet.2015.06.012DOI Listing
October 2015

Prognostic factors, patterns of recurrence and toxicity for patients with esophageal cancer undergoing definitive radiotherapy or chemo-radiotherapy.

J Radiat Res 2015 Jul 23;56(4):742-9. Epub 2015 Apr 23.

Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, Heidelberg 69120, Germany Heidelberg Institute of Radiation Oncology (HIRO), Im Neuenheimer Feld 400, Heidelberg 69120, Germany German Cancer Research Center (DKFZ), Clinical Cooperation Unit Radiation Oncology, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.

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http://dx.doi.org/10.1093/jrr/rrv022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497395PMC
July 2015

Prognostic factors for survival of women with unstable spinal bone metastases from breast cancer.

Radiat Oncol 2015 Jul 15;10:144. Epub 2015 Jul 15.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s13014-015-0458-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501125PMC
July 2015

Lymphadenectomy in women with endometrial cancer: aspiration and reality from a radiation oncologist's point of view.

Radiat Oncol 2015 Jul 16;10:147. Epub 2015 Jul 16.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s13014-015-0460-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504041PMC
July 2015

Bone density as a marker for local response to radiotherapy of spinal bone metastases in women with breast cancer: a retrospective analysis.

Radiat Oncol 2015 Mar 7;10:62. Epub 2015 Mar 7.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s13014-015-0368-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355128PMC
March 2015

Accelerated tomotherapy delivery with TomoEdge technique.

J Appl Clin Med Phys 2015 Mar 8;16(2):4964. Epub 2015 Mar 8.

Department of Radiation Oncology, University Hospital Heidelberg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690089PMC
http://dx.doi.org/10.1120/jacmp.v16i2.4964DOI Listing
March 2015

Influence of human papillomavirus and p16(INK4a) on treatment outcome of patients with anal cancer.

Radiother Oncol 2014 Dec 22;113(3):331-6. Epub 2014 Nov 22.

Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2014.11.013DOI Listing
December 2014

Hypofractionated IMRT of the prostate bed after radical prostatectomy: acute toxicity in the PRIAMOS-1 trial.

Int J Radiat Oncol Biol Phys 2014 Nov 9;90(4):926-33. Epub 2014 Sep 9.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ijrobp.2014.07.015DOI Listing
November 2014

Helical tomotherapy of the complete scalp and the ipsilateral lymph nodes in a case of scalp angiosarcoma.

Ear Nose Throat J 2014 Jun;93(6):E24-8

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.

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June 2014

Survival of women with clear cell and papillary serous endometrial cancer after adjuvant radiotherapy.

Radiat Oncol 2014 Jun 18;9:141. Epub 2014 Jun 18.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1186/1748-717X-9-141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078392PMC
June 2014

Re-irradiation in the treatment of patients with cerebral metastases of solid tumors: retrospective analysis.

Radiat Oncol 2014 Jan 3;9. Epub 2014 Jan 3.

Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany.

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http://dx.doi.org/10.1186/1748-717X-9-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904456PMC
January 2014

Helical intensity-modulated radiotherapy of the pelvic lymph nodes with integrated boost to the prostate bed - initial results of the PLATIN 3 Trial.

BMC Cancer 2014 Jan 14;14:20. Epub 2014 Jan 14.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1186/1471-2407-14-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893457PMC
January 2014

Intraoperative electron radiation therapy (IOERT) in patients with locally recurrent renal cell carcinoma.

Radiat Oncol 2013 Dec 2;8:282. Epub 2013 Dec 2.

Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400 Heidelberg 69120, Germany.

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http://dx.doi.org/10.1186/1748-717X-8-282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922867PMC
December 2013

Primary radiotherapy with endobronchial high-dose-rate brachytherapy boost for inoperable lung cancer: long-term results.

Tumori 2013 Mar-Apr;99(2):183-90

Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1700/1283.14190DOI Listing
August 2013

Treatment of squamous cell carcinoma of the mobile tongue or tongue margins: an interdisciplinary challenge.

Acta Oncol 2013 Jun 15;52(5):1017-21. Epub 2012 Sep 15.

Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.3109/0284186X.2012.722678DOI Listing
June 2013

Posterior reversible leukoencephalopathy syndrome associated with pazopanib.

Case Rep Oncol 2013 Jan 6;6(1):204-8. Epub 2013 Apr 6.

Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1159/000350742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636956PMC
January 2013

Intraoperative Electron Radiation Therapy (IOERT) in the management of locally recurrent rectal cancer.

BMC Cancer 2012 Dec 11;12:592. Epub 2012 Dec 11.

Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany.

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http://dx.doi.org/10.1186/1471-2407-12-592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557137PMC
December 2012

Accelerated large volume irradiation with dynamic Jaw/Dynamic Couch Helical Tomotherapy.

Radiat Oncol 2012 Nov 12;7:191. Epub 2012 Nov 12.

Department of Radiation Oncology, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/1748-717X-7-191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544594PMC
November 2012

Hypofractionated helical intensity-modulated radiotherapy of the prostate bed after prostatectomy with or without the pelvic lymph nodes - the PRIAMOS trial.

BMC Cancer 2012 Oct 31;12:504. Epub 2012 Oct 31.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/1471-2407-12-504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495015PMC
October 2012

Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma.

Cancer Res 2011 Dec 17;71(23):7155-67. Epub 2011 Oct 17.

Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1212DOI Listing
December 2011