Publications by authors named "Judith Voynow"

51Publications

Polysulfated Hyaluronan GM-1111 Inhibits Elastase and Improves Rheology in CF Sputum.

Am J Respir Cell Mol Biol 2020 Dec 2. Epub 2020 Dec 2.

Children's Hospital of Richmond at Virginia Commonwealth University, 480853, Division of Pediatric Pulmonology, Richmond, Virginia, United States;

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http://dx.doi.org/10.1165/rcmb.2020-0157OCDOI Listing
December 2020

Glycosaminoglycans as Multifunctional Anti-Elastase and Anti-Inflammatory Drugs in Cystic Fibrosis Lung Disease.

Front Pharmacol 2020 8;11:1011. Epub 2020 Jul 8.

Department of Pediatric Pulmonology, Children's Hospital of Richmond at VCU, Richmond, VA, United States.

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http://dx.doi.org/10.3389/fphar.2020.01011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360816PMC
July 2020

Airway Surface Liquid and Impaired Antiviral Defense in Cystic Fibrosis.

Am J Respir Cell Mol Biol 2020 01;62(1):12-13

Division of Pediatric Pulmonary MedicineChildren's Hospital of Richmond at Virginia Commonwealth UniversityRichmond, Virginia.

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http://dx.doi.org/10.1165/rcmb.2019-0239EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938140PMC
January 2020

On the Process of Discovering Leads That Target the Heparin-Binding Site of Neutrophil Elastase in the Sputum of Cystic Fibrosis Patients.

J Med Chem 2019 06 28;62(11):5501-5511. Epub 2019 May 28.

Department of Medicinal Chemistry , Virginia Commonwealth University , Richmond , Virginia 23298 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818412PMC
June 2019

The Gut-Lung Axis and Pulmonary Responses to Ozone.

Am J Respir Cell Mol Biol 2018 09;59(3):281-282

2 Division of Neonatal Medicine Children's Hospital of Richmond at Virginia Commonwealth University Richmond, Virginia.

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http://dx.doi.org/10.1165/rcmb.2018-0140EDDOI Listing
September 2018

Tracheal aspirate VEGF and sphingolipid metabolites in the preterm infant with later development of bronchopulmonary dysplasia.

Pediatr Pulmonol 2018 08 23;53(8):1046-1052. Epub 2018 Apr 23.

Division of Pulmonary Medicine, Department of Pediatrics, Children's Hospital of Richmond at VCU and School of Medicine, Virginia Commonwealth University, Richmond, Virginia.

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http://dx.doi.org/10.1002/ppul.24022DOI Listing
August 2018

Neutrophil elastase correlates with increased sphingolipid content in cystic fibrosis sputum.

Pediatr Pulmonol 2018 07 6;53(7):872-880. Epub 2018 Apr 6.

Division of Pediatric Pulmonology, Children's Hospital of Richmond at VCU, Richmond, Virginia.

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http://dx.doi.org/10.1002/ppul.24001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566867PMC
July 2018

Cystic Fibrosis Sputum Rheology Correlates With Both Acute and Longitudinal Changes in Lung Function.

Chest 2018 08 17;154(2):370-377. Epub 2018 Mar 17.

Department of Pediatrics, Children's Hospital of Richmond at VCU, Richmond, VA. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2018.03.005DOI Listing
August 2018

High-Mobility Group Box 1 Upregulates MUC5AC and MUC5B Expression in Primary Airway Epithelial Cells.

Am J Respir Cell Mol Biol 2018 01;58(1):126-128

1 Children's Hospital of Richmond at Virginia Commonwealth University Richmond, Virginia.

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http://dx.doi.org/10.1165/rcmb.2017-0250LEDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946841PMC
January 2018

Mucins, Mucus, and Goblet Cells.

Chest 2018 07 21;154(1):169-176. Epub 2017 Nov 21.

Division of Pediatric Pulmonology, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, VA. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2017.11.008DOI Listing
July 2018

Neutrophil elastase increases airway ceramide levels via upregulation of serine palmitoyltransferase.

Am J Physiol Lung Cell Mol Physiol 2018 01 12;314(1):L206-L214. Epub 2017 Oct 12.

Division of Pediatric Pulmonary Medicine, Children's Hospital of Richmond at Virginia Commonwealth University , Richmond, Virginia.

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http://dx.doi.org/10.1152/ajplung.00322.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866429PMC
January 2018

"New" bronchopulmonary dysplasia and chronic lung disease.

Authors:
Judith A Voynow

Paediatr Respir Rev 2017 Sep 12;24:17-18. Epub 2017 Jun 12.

Division of Pediatric Pulmonology, Children's Hospital of Richmond at VCU, Box 980315, Richmond, VA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.prrv.2017.06.006DOI Listing
September 2017

COPD: balancing oxidants and antioxidants.

Int J Chron Obstruct Pulmon Dis 2015 2;10:261-76. Epub 2015 Feb 2.

National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Chapel Hill, NC, USA.

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http://www.dovepress.com/copd-balancing-oxidants-and-antioxi
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http://dx.doi.org/10.2147/COPD.S42414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321570PMC
September 2015

Nasal NO as a biomarker: don't say NO to the many challenges of translational medicine.

Pediatr Pulmonol 2015 Jan 13;50(1):100-2. Epub 2014 Oct 13.

Department of Pediatrics, Box 980315, Virginia Commonwealth University, Richmond, Virginia.

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http://dx.doi.org/10.1002/ppul.23111DOI Listing
January 2015

Human neutrophil elastase-mediated goblet cell metaplasia is attenuated in TACE-deficient mice.

Am J Physiol Lung Cell Mol Physiol 2013 May 5;304(10):L701-7. Epub 2013 Apr 5.

Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.

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http://ajplung.physiology.org/content/ajplung/304/10/L701.fu
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http://ajplung.physiology.org/cgi/doi/10.1152/ajplung.00259.
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http://dx.doi.org/10.1152/ajplung.00259.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652059PMC
May 2013

Deficiency of α-1-antitrypsin influences systemic iron homeostasis.

Int J Chron Obstruct Pulmon Dis 2013 22;8:45-51. Epub 2013 Jan 22.

Human Studies Facility, US Environmental Protection Agency, 104 Mason Farm Rd., Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.2147/COPD.S37897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556862PMC
June 2013

Increased expression of senescence markers in cystic fibrosis airways.

Am J Physiol Lung Cell Mol Physiol 2013 Mar 11;304(6):L394-400. Epub 2013 Jan 11.

Division of Pediatric Pulmonary and Sleep Medicine, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1152/ajplung.00091.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602742PMC
March 2013

NADPH:quinone oxidoreductase 1 regulates host susceptibility to ozone via isoprostane generation.

J Biol Chem 2013 Feb 28;288(7):4681-91. Epub 2012 Dec 28.

Division of Pediatric Pulmonary and Sleep Medicine, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.438440
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http://dx.doi.org/10.1074/jbc.M112.438440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576073PMC
February 2013

NAD(P)H quinone oxidoreductase 1 regulates neutrophil elastase-induced mucous cell metaplasia.

Am J Physiol Lung Cell Mol Physiol 2012 Aug 1;303(3):L181-8. Epub 2012 Jun 1.

Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1152/ajplung.00084.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423858PMC
August 2012

Pathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammation.

Int J Chron Obstruct Pulmon Dis 2011 5;6:413-21. Epub 2011 Aug 5.

Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.2147/COPD.S10770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157944PMC
January 2012

Isoprostanes and asthma.

Biochim Biophys Acta 2011 Nov 8;1810(11):1091-5. Epub 2011 May 8.

Division of Pediatric Pulmonary and Sleep Medicine, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.bbagen.2011.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192308PMC
November 2011

MARCKS-related peptide modulates in vivo the secretion of airway Muc5ac.

Am J Physiol Lung Cell Mol Physiol 2010 Sep 11;299(3):L345-52. Epub 2010 Jun 11.

Division of Pulmonary, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1152/ajplung.00067.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951072PMC
September 2010

Mucins, mucus, and sputum.

Chest 2009 Feb;135(2):505-512

Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC.

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http://dx.doi.org/10.1378/chest.08-0412DOI Listing
February 2009

NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans.

Am J Respir Cell Mol Biol 2009 Jul 4;41(1):107-13. Epub 2008 Dec 4.

Division of Pediatric Pulmonary Medicine, Department of Pediatrics, Duke University Medical Center, Box 2994, Durham, NC 27710, USA.

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http://dx.doi.org/10.1165/rcmb.2008-0381OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701957PMC
July 2009

Airway epithelial cells: current concepts and challenges.

Proc Am Thorac Soc 2008 Sep;5(7):772-7

Weill Cornell Medical College, Cornell University, 1300 York Ave, New York, NY 10065, USA.

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http://pats.atsjournals.org/cgi/doi/10.1513/pats.200805-041H
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http://dx.doi.org/10.1513/pats.200805-041HRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820806PMC
September 2008

Proteases and cystic fibrosis.

Int J Biochem Cell Biol 2008 14;40(6-7):1238-45. Epub 2008 Mar 14.

Department of Pediatrics, Duke University Medical Center, Box 2994, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.biocel.2008.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2431113PMC
August 2008

Neutrophil elastase inhibition of cell cycle progression in airway epithelial cells in vitro is mediated by p27kip1.

Am J Physiol Lung Cell Mol Physiol 2007 Sep 22;293(3):L762-8. Epub 2007 Jun 22.

Division of Pediatric Pulmonary Medicine, Duke Univ. Medical Center, Box 2994, Durham, NC 27710, USA.

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http://dx.doi.org/10.1152/ajplung.00067.2007DOI Listing
September 2007

Regulation of MUC5AC expression by NAD(P)H:quinone oxidoreductase 1.

Free Radic Biol Med 2007 May 31;42(9):1398-408. Epub 2007 Jan 31.

Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2007.01.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913945PMC
May 2007

Regulation of mucin genes in chronic inflammatory airway diseases.

Am J Respir Cell Mol Biol 2006 Jun 2;34(6):661-5. Epub 2006 Feb 2.

Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1165/rcmb.2006-0035SFDOI Listing
June 2006

Respiratory tract mucin genes and mucin glycoproteins in health and disease.

Physiol Rev 2006 Jan;86(1):245-78

Research Center for Genetic Medicine, Room 5700, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA.

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http://dx.doi.org/10.1152/physrev.00010.2005DOI Listing
January 2006

Basal-like cells constitute the proliferating cell population in cystic fibrosis airways.

Am J Respir Crit Care Med 2005 Oct 14;172(8):1013-8. Epub 2005 Jul 14.

Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1164/rccm.200410-1398OCDOI Listing
October 2005

ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposure.

FASEB J 2005 Aug 27;19(10):1374-6. Epub 2005 May 27.

Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1096/fj.04-2675fjeDOI Listing
August 2005

Neutrophil elastase induces mucus cell metaplasia in mouse lung.

Am J Physiol Lung Cell Mol Physiol 2004 Dec 23;287(6):L1293-302. Epub 2004 Jul 23.

Department of Pediatrics, Duke University Medical Center, Box 2994, Durham, NC 27710, USA.

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http://dx.doi.org/10.1152/ajplung.00140.2004DOI Listing
December 2004

Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro: oxidant-mediated pathways and transcription factors.

Free Radic Biol Med 2003 Nov;35(9):1158-67

Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.

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http://dx.doi.org/10.1016/s0891-5849(03)00498-2DOI Listing
November 2003

Neutrophil elastase increases MUC4 expression in normal human bronchial epithelial cells.

Am J Physiol Lung Cell Mol Physiol 2003 Apr 20;284(4):L671-9. Epub 2002 Dec 20.

Division of Pediatric Pulmonary Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1152/ajplung.00220.2002DOI Listing
April 2003

What does mucin have to do with lung disease?

Authors:
Judith A Voynow

Paediatr Respir Rev 2002 Jun;3(2):98-103

Division of Pediatric Pulmonary Diseases, Box 2994, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/s1526-0550(02)00007-0DOI Listing
June 2002

Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species.

Am J Respir Cell Mol Biol 2002 Apr;26(4):447-52

Division of Pediatric Pulmonary Diseases, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1165/ajrcmb.26.4.4473DOI Listing
April 2002