Judith Hobrath

Judith Hobrath

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Judith Hobrath

Judith Hobrath

Publications by authors named "Judith Hobrath"

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Slow-Binding Inhibition of Mycobacterium tuberculosis Shikimate Kinase by Manzamine Alkaloids.

Biochemistry 2018 08 31;57(32):4923-4933. Epub 2018 Jul 31.

Department of Drug Discovery and Development, Harrison School of Pharmacy , Auburn University , 4306 Walker Building , Auburn , Alabama 36849 , United States.

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http://dx.doi.org/10.1021/acs.biochem.8b00231DOI Listing
August 2018

Mechanism of irreversible inhibition of Mycobacterium tuberculosis shikimate kinase by ilimaquinone.

Biochim Biophys Acta Proteins Proteom 2018 May - Jun;1866(5-6):731-739. Epub 2018 Apr 12.

Department of Drug Discovery and Development, Harrison School of Pharmacy, 3306 Walker Building, Auburn University, Auburn, AL 36849, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2018.04.007DOI Listing
July 2018

Oxazole and thiazole analogs of sulindac for cancer prevention.

Future Med Chem 2018 04 19;10(7):743-753. Epub 2018 Apr 19.

Division of Hematology & Oncology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

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http://dx.doi.org/10.4155/fmc-2017-0182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367724PMC
April 2018

A multifaceted approach to identify non-specific enzyme inhibition: Application to Mycobacterium tuberculosis shikimate kinase.

Bioorg Med Chem Lett 2018 02 5;28(4):802-808. Epub 2017 Dec 5.

Department of Drug Discovery and Development, Harrison School of Pharmacy, 4306 Walker Building, Auburn University, Auburn, AL 36849, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.12.002DOI Listing
February 2018

Amine Containing Analogs of Sulindac for Cancer Prevention.

Open Med Chem J 2018 31;12:1-12. Epub 2018 Jan 31.

Division of Hematology and Oncology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

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http://dx.doi.org/10.2174/1874104501812010001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817852PMC
January 2018

Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ.

J Steroid Biochem Mol Biol 2017 10 28;173:42-56. Epub 2016 Sep 28.

Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.1016/j.jsbmb.2016.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373926PMC
October 2017

Diverse amide analogs of sulindac for cancer treatment and prevention.

Bioorg Med Chem Lett 2017 10 13;27(20):4614-4621. Epub 2017 Sep 13.

Division of Hematology and Oncology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.09.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022754PMC
October 2017

Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens.

Med Chem Res 2017;26(11):3038-3045. Epub 2017 Aug 5.

Division of Hematology and Oncology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 USA.

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http://dx.doi.org/10.1007/s00044-017-2001-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656725PMC
August 2017

Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis.

PLoS One 2016 21;11(10):e0164100. Epub 2016 Oct 21.

Department of Chemistry, The University of Alabama at Birmingham, Birmingham, Alabama, 35294, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164100PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074515PMC
June 2017

Design and Synthesis of Nonpeptide Inhibitors of Hepatocyte Growth Factor Activation.

ACS Med Chem Lett 2016 Feb 22;7(2):177-81. Epub 2015 Dec 22.

Departments of Chemistry, Oncology and High Throughput Screening, Drug Discovery Division, and Toxicology and Pathology Services, Drug Development Division, Southern Research , 2000 Ninth Avenue S., Birmingham, Alabama 35205, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.5b00357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753539PMC
February 2016

Identification of shikimate kinase inhibitors among anti-Mycobacterium tuberculosis compounds by LC-MS.

Tuberculosis (Edinb) 2014 Mar 31;94(2):152-8. Epub 2013 Dec 31.

Department of Pharmacal Sciences, Harrison School of Pharmacy, 4306 Walker Building, Auburn University, Auburn, AL 36849, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tube.2013.12.004DOI Listing
March 2014

Combining computational methods for hit to lead optimization in Mycobacterium tuberculosis drug discovery.

Pharm Res 2014 Feb 17;31(2):414-35. Epub 2013 Oct 17.

Collaborative Drug Discovery, 1633 Bayshore Highway, Suite 342, Burlingame, California, 94010, USA,

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http://dx.doi.org/10.1007/s11095-013-1172-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946937PMC
February 2014

Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosis.

PLoS One 2012 29;7(3):e33886. Epub 2012 Mar 29.

School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033886PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315515PMC
November 2012

Identification of Rv0535 as methylthioadenosine phosphorylase from Mycobacterium tuberculosis.

Tuberculosis (Edinb) 2012 Mar 4;92(2):139-47. Epub 2012 Jan 4.

Department of Pharmacology and Toxicology, University of Alabama at Birmingham, 1530 Third Avenue South, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1016/j.tube.2011.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288397PMC
March 2012

Identification of novel small molecule activators of nuclear factor-κB with neuroprotective action via high-throughput screening.

J Neurosci Res 2011 Jan;89(1):58-72

Laboratory of Neuropharmacology, Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, Alabama 35205, USA.

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http://dx.doi.org/10.1002/jnr.22526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280078PMC
January 2011

Assay development and high-throughput antiviral drug screening against Bluetongue virus.

Antiviral Res 2009 Sep 24;83(3):267-73. Epub 2009 Jun 24.

Department of Biochemistry and Molecular Biology, Southern Research Institute, Birmingham, AL 35205, United States.

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http://dx.doi.org/10.1016/j.antiviral.2009.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727572PMC
September 2009

Recent advances in structure-based virtual screening of G-protein coupled receptors.

AAPS J 2009 Mar 17;11(1):178-85. Epub 2009 Mar 17.

Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35205, USA.

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http://link.springer.com/10.1208/s12248-009-9094-3
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http://dx.doi.org/10.1208/s12248-009-9094-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664893PMC
March 2009

Computational elucidation of the structural basis of ligand binding to the dopamine 3 receptor through docking and homology modeling.

J Med Chem 2006 Jul;49(15):4470-6

Department of Internal Medicine, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109-0934, USA.

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http://dx.doi.org/10.1021/jm0501634DOI Listing
July 2006