Publications by authors named "Judith Bellemare"

13Publications

Dual roles for splice variants of the glucuronidation pathway as regulators of cellular metabolism.

Mol Pharmacol 2014 Jan 18;85(1):29-36. Epub 2013 Oct 18.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center, Faculty of Pharmacy, Laval University, Québec City, Québec, Canada.

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.113.08
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http://dx.doi.org/10.1124/mol.113.089227DOI Listing
January 2014

Overexpression of uridine diphospho glucuronosyltransferase 2B17 in high-risk chronic lymphocytic leukemia.

Blood 2013 Feb 20;121(7):1175-83. Epub 2012 Nov 20.

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1182/blood-2012-08-447359DOI Listing
February 2013

Protein-protein interactions between the bilirubin-conjugating UDP-glucuronosyltransferase UGT1A1 and its shorter isoform 2 regulatory partner derived from alternative splicing.

Biochem J 2013 Feb;450(1):107-14

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec (CHUQ) Research Center, 2705 Boul. Laurier, Québec, Canada, G1V 4G2, and Faculty of Pharmacy, Laval University, Pavillon Ferdinand-Vandry, Université Laval, Québec, Canada, G1V 0A6.

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http://dx.doi.org/10.1042/BJ20121594DOI Listing
February 2013

The impact of germline genetic variations in hydroxysteroid (17-beta) dehydrogenases on prostate cancer outcomes after prostatectomy.

Eur Urol 2012 Jul 21;62(1):88-96. Epub 2011 Dec 21.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec (CHUQ) Research Center and Faculty of Pharmacy, Laval University, Québec, Canada.

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http://dx.doi.org/10.1016/j.eururo.2011.12.021DOI Listing
July 2012

Deletions of the androgen-metabolizing UGT2B genes have an effect on circulating steroid levels and biochemical recurrence after radical prostatectomy in localized prostate cancer.

J Clin Endocrinol Metab 2011 Sep 6;96(9):E1550-7. Epub 2011 Jul 6.

Pharmacogenomics Laboratory, Centre Hospitalier de l'Université Laval CHUQ Research Center, and Faculty of Pharmacy, and L'Hôtel-Dieu de Quebec, CHUQ Research Center and Faculty of Medicine, Laval University, Québec, Canada.

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http://dx.doi.org/10.1210/jc.2011-1049DOI Listing
September 2011

SRD5A polymorphisms and biochemical failure after radical prostatectomy.

Eur Urol 2011 Dec 29;60(6):1226-34. Epub 2011 Jun 29.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec (CHUQ) Research Centre and Faculty of Pharmacy, Laval University, Québec, Canada.

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http://dx.doi.org/10.1016/j.eururo.2011.06.020DOI Listing
December 2011

Immunohistochemical expression of conjugating UGT1A-derived isoforms in normal and tumoral drug-metabolizing tissues in humans.

J Pathol 2011 Feb 29;223(3):425-35. Epub 2010 Oct 29.

Pharmacogenomics Laboratory, CHUQ Research Center and Faculty of Pharmacy, Laval University, G1V 4G2 Québec, Canada.

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http://dx.doi.org/10.1002/path.2805DOI Listing
February 2011

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro.

Drug Metab Dispos 2010 Oct 7;38(10):1785-9. Epub 2010 Jul 7.

Pharmacogenomics Laboratory, Centre Hospitalier de l'Université Laval Research Center and Faculty of Pharmacy, Laval University, Boulevard Laurier, Québec, QC, Canada.

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http://dx.doi.org/10.1124/dmd.110.034835DOI Listing
October 2010

Extensive splicing of transcripts encoding the bile acid-conjugating enzyme UGT2B4 modulates glucuronidation.

Pharmacogenet Genomics 2010 Mar;20(3):195-210

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec (CHUQ), Canada.

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http://dx.doi.org/10.1097/FPC.0b013e328336ef1cDOI Listing
March 2010

Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions.

J Biol Chem 2010 Feb 8;285(6):3600-7. Epub 2009 Dec 8.

Pharmacogenomics Laboratory, Centre Hospitalier de l'Université Laval Research Center and Faculty of Pharmacy, Laval University, Québec G1V 4G2, Canada.

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http://dx.doi.org/10.1074/jbc.M109.083139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823500PMC
February 2010

UGT genomic diversity: beyond gene duplication.

Drug Metab Rev 2010 Feb;42(1):24-44

Pharmacogenomics Laboratory, CHUQ Research Center and Faculty of Pharmacy, Laval University, Quebec City, Quebec, Canada.

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http://dx.doi.org/10.3109/03602530903210682DOI Listing
February 2010

Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity.

Pharmacogenet Genomics 2007 Dec;17(12):1077-89

Laboratory of Pharmacogenomics, Oncology and Molecular Endocrinology Research Center, CHUL Research Center and Faculty of Pharmacy, Laval University, Québec, Canada.

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http://dx.doi.org/10.1097/FPC.0b013e3282f1f118DOI Listing
December 2007

Epidermis promotes dermal fibrosis: role in the pathogenesis of hypertrophic scars.

J Pathol 2005 May;206(1):1-8

Laboratoires des grands brûlés/LOEX, Hôpital du Saint-Sacrement du Centre Hospitalier Affilié Université de Québec, Québec, Canada.

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http://dx.doi.org/10.1002/path.1737DOI Listing
May 2005