Judith A Clements

Judith A Clements

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Judith A Clements

Judith A Clements

Publications by authors named "Judith A Clements"

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100Publications

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Manfred Schmitt (1947-2018).

Biol Chem 2018 Sep;399(9):923-924

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

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September 2018

Mining human cancer datasets for kallikrein expression in cancer: the 'KLK-CANMAP' Shiny web tool.

Biol Chem 2018 Sep;399(9):983-995

Australian Prostate Cancer Research Centre - Queensland, Translational Research Institute, 37 Kent St, Brisbane, Queensland, 4102, Australia.

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September 2018

Kallikrein-related peptidases represent attractive therapeutic targets for ovarian cancer.

Expert Opin Ther Targets 2018 Sep 6;22(9):745-763. Epub 2018 Sep 6.

d Department of Obstetrics and Gynecology , Technical University of Munich , Munich , Germany.

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September 2018

A Plasma Biomarker Panel of Four MicroRNAs for the Diagnosis of Prostate Cancer.

Sci Rep 2018 Apr 27;8(1):6653. Epub 2018 Apr 27.

Australian Prostate Cancer Research Centre- Queensland, Translational Research Institute, Brisbane, QLD 4102, Australia.

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April 2018

Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases.

Am J Cancer Res 2017 1;7(11):2257-2274. Epub 2017 Nov 1.

Mater Research Institute-University of Queensland, Translational Research InstituteWoolloongabba, Queensland 4102, Australia.

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November 2017

Kallikrein-related peptidase 4 induces cancer-associated fibroblast features in prostate-derived stromal cells.

Mol Oncol 2017 10 10;11(10):1307-1329. Epub 2017 Aug 10.

Australian Prostate Cancer Research Centre - Queensland, Translational Research Institute, Queensland University of Technology (QUT), Woolloongabba, Australia.

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October 2017

Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7) Shed Light on KLK Proteolytic Activity in the Stratum Corneum.

J Invest Dermatol 2017 02 30;137(2):430-439. Epub 2016 Sep 30.

Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia. Electronic address:

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February 2017

Single nucleotide polymorphisms in clinics: Fantasy or reality for cancer?

Crit Rev Clin Lab Sci 2016 23;53(1):29-39. Epub 2015 Sep 23.

a Cancer and Molecular Medicine Program, Institute of Health and Biomedical Innovation, Queensland University of Technology , Brisbane , Australia and.

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October 2016

MicroRNA Theranostics in Prostate Cancer Precision Medicine.

Clin Chem 2016 Oct 18;62(10):1318-33. Epub 2016 Aug 18.

School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Australian Prostate Cancer Research Centre-Queensland (APCRC-Q), Australia; Translational Research Institute, Queensland University of Technology, Brisbane, Australia;

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October 2016

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.

Authors:
Siddhartha P Kar Jonathan Beesley Ali Amin Al Olama Kyriaki Michailidou Jonathan Tyrer ZSofia Kote-Jarai Kate Lawrenson Sara Lindstrom Susan J Ramus Deborah J Thompson Adam S Kibel Agnieszka Dansonka-Mieszkowska Agnieszka Michael Aida K Dieffenbach Aleksandra Gentry-Maharaj Alice S Whittemore Alicja Wolk Alvaro Monteiro Ana Peixoto Andrzej Kierzek Angela Cox Anja Rudolph Anna Gonzalez-Neira Anna H Wu Annika Lindblom Anthony Swerdlow Argyrios Ziogas Arif B Ekici Barbara Burwinkel Beth Y Karlan Børge G Nordestgaard Carl Blomqvist Catherine Phelan Catriona McLean Celeste Leigh Pearce Celine Vachon Cezary Cybulski Chavdar Slavov Christa Stegmaier Christiane Maier Christine B Ambrosone Claus K Høgdall Craig C Teerlink Daehee Kang Daniel C Tessier Daniel J Schaid Daniel O Stram Daniel W Cramer David E Neal Diana Eccles Dieter Flesch-Janys Digna R Velez Edwards Dominika Wokozorczyk Douglas A Levine Drakoulis Yannoukakos Elinor J Sawyer Elisa V Bandera Elizabeth M Poole Ellen L Goode Elza Khusnutdinova Estrid Høgdall Fengju Song Fiona Bruinsma Florian Heitz Francesmary Modugno Freddie C Hamdy Fredrik Wiklund Graham G Giles Håkan Olsson Hans Wildiers Hans-Ulrich Ulmer Hardev Pandha Harvey A Risch Hatef Darabi Helga B Salvesen Heli Nevanlinna Henrik Gronberg Hermann Brenner Hiltrud Brauch Hoda Anton-Culver Honglin Song Hui-Yi Lim Iain McNeish Ian Campbell Ignace Vergote Jacek Gronwald Jan Lubiński Janet L Stanford Javier Benítez Jennifer A Doherty Jennifer B Permuth Jenny Chang-Claude Jenny L Donovan Joe Dennis Joellen M Schildkraut Johanna Schleutker John L Hopper Jolanta Kupryjanczyk Jong Y Park Jonine Figueroa Judith A Clements Julia A Knight Julian Peto Julie M Cunningham Julio Pow-Sang Jyotsna Batra Kamila Czene Karen H Lu Kathleen Herkommer Kay-Tee Khaw Keitaro Matsuo Kenneth Muir Kenneth Offitt Kexin Chen Kirsten B Moysich Kristiina Aittomäki Kunle Odunsi Lambertus A Kiemeney Leon F A G Massuger Liesel M Fitzgerald Linda S Cook Lisa Cannon-Albright Maartje J Hooning Malcolm C Pike Manjeet K Bolla Manuel Luedeke Manuel R Teixeira Marc T Goodman Marjanka K Schmidt Marjorie Riggan Markus Aly Mary Anne Rossing Matthias W Beckmann Matthieu Moisse Maureen Sanderson Melissa C Southey Michael Jones Michael Lush Michelle A T Hildebrandt Ming-Feng Hou Minouk J Schoemaker Montserrat Garcia-Closas Natalia Bogdanova Nazneen Rahman Nhu D Le Nick Orr Nicolas Wentzensen Nora Pashayan Paolo Peterlongo Pascal Guénel Paul Brennan Paula Paulo Penelope M Webb Per Broberg Peter A Fasching Peter Devilee Qin Wang Qiuyin Cai Qiyuan Li Radka Kaneva Ralf Butzow Reidun Kristin Kopperud Rita K Schmutzler Robert A Stephenson Robert J MacInnis Robert N Hoover Robert Winqvist Roberta Ness Roger L Milne Ruth C Travis Sara Benlloch Sara H Olson Shannon K McDonnell Shelley S Tworoger Sofia Maia Sonja Berndt Soo Chin Lee Soo-Hwang Teo Stephen N Thibodeau Stig E Bojesen Susan M Gapstur Susanne Krüger Kjær Tanja Pejovic Teuvo L J Tammela Thilo Dörk Thomas Brüning Tiina Wahlfors Tim J Key Todd L Edwards Usha Menon Ute Hamann Vanio Mitev Veli-Matti Kosma Veronica Wendy Setiawan Vessela Kristensen Volker Arndt Walther Vogel Wei Zheng Weiva Sieh William J Blot Wojciech Kluzniak Xiao-Ou Shu Yu-Tang Gao Fredrick Schumacher Matthew L Freedman Andrew Berchuck Alison M Dunning Jacques Simard Christopher A Haiman Amanda Spurdle Thomas A Sellers David J Hunter Brian E Henderson Peter Kraft Stephen J Chanock Fergus J Couch Per Hall Simon A Gayther Douglas F Easton Georgia Chenevix-Trench Rosalind Eeles Paul D P Pharoah Diether Lambrechts

Cancer Discov 2016 09 17;6(9):1052-67. Epub 2016 Jul 17.

VIB Vesalius Research Center, KU Leuven, Leuven, Belgium.

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September 2016

Prostate Cancer-Associated Kallikrein-Related Peptidase 4 Activates Matrix Metalloproteinase-1 and Thrombospondin-1.

J Proteome Res 2016 08 27;15(8):2466-78. Epub 2016 Jul 27.

Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology at the Translational Research Institute , 37 Kent Street, Woolloongabba, Queensland 4102, Australia.

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August 2016

Erratum to: Fusion transcript loci share many genomic features with non-fusion loci.

BMC Genomics 2016 Jun 3;17(1):424. Epub 2016 Jun 3.

Australian Prostate Cancer Research Centre - Queensland, Translational Research Institute, Brisbane, Australia.

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June 2016

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.

Authors:
Alexander Gusev Huwenbo Shi Gleb Kichaev Mark Pomerantz Fugen Li Henry W Long Sue A Ingles Rick A Kittles Sara S Strom Benjamin A Rybicki Barbara Nemesure William B Isaacs Wei Zheng Curtis A Pettaway Edward D Yeboah Yao Tettey Richard B Biritwum Andrew A Adjei Evelyn Tay Ann Truelove Shelley Niwa Anand P Chokkalingam Esther M John Adam B Murphy Lisa B Signorello John Carpten M Cristina Leske Suh-Yuh Wu Anslem J M Hennis Christine Neslund-Dudas Ann W Hsing Lisa Chu Phyllis J Goodman Eric A Klein John S Witte Graham Casey Sam Kaggwa Michael B Cook Daniel O Stram William J Blot Rosalind A Eeles Douglas Easton Zsofia Kote-Jarai Ali Amin Al Olama Sara Benlloch Kenneth Muir Graham G Giles Melissa C Southey Liesel M Fitzgerald Henrik Gronberg Fredrik Wiklund Markus Aly Brian E Henderson Johanna Schleutker Tiina Wahlfors Teuvo L J Tammela Børge G Nordestgaard Tim J Key Ruth C Travis David E Neal Jenny L Donovan Freddie C Hamdy Paul Pharoah Nora Pashayan Kay-Tee Khaw Janet L Stanford Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Christiane Maier Walther Vogel Manuel Luedeke Kathleen Herkommer Adam S Kibel Cezary Cybulski Dominika Wokolorczyk Wojciech Kluzniak Lisa Cannon-Albright Craig Teerlink Hermann Brenner Aida K Dieffenbach Volker Arndt Jong Y Park Thomas A Sellers Hui-Yi Lin Chavdar Slavov Radka Kaneva Vanio Mitev Jyotsna Batra Amanda Spurdle Judith A Clements Manuel R Teixeira Hardev Pandha Agnieszka Michael Paula Paulo Sofia Maia Andrzej Kierzek David V Conti Demetrius Albanes Christine Berg Sonja I Berndt Daniele Campa E David Crawford W Ryan Diver Susan M Gapstur J Michael Gaziano Edward Giovannucci Robert Hoover David J Hunter Mattias Johansson Peter Kraft Loic Le Marchand Sara Lindström Carmen Navarro Kim Overvad Elio Riboli Afshan Siddiq Victoria L Stevens Dimitrios Trichopoulos Paolo Vineis Meredith Yeager Gosia Trynka Soumya Raychaudhuri Frederick R Schumacher Alkes L Price Matthew L Freedman Christopher A Haiman Bogdan Pasaniuc

Nat Commun 2016 Apr 7;7:10979. Epub 2016 Apr 7.

Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, California 90095, USA.

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April 2016

Tie-2 regulates the stemness and metastatic properties of prostate cancer cells.

Oncotarget 2016 Jan;7(3):2572-84

Australian Prostate Cancer Research Centre-Queensland and Institute of Health and Biomedical Innovation, Queensland University of Technology and Translational Research Institute, Woolloongabba, QLD, Australia.

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January 2016

Adipocytes promote prostate cancer stem cell self-renewal through amplification of the cholecystokinin autocrine loop.

Oncotarget 2016 Jan;7(4):4939-48

Australian Prostate Cancer Research Centre-Queensland & Institute of Health and Biomedical Innovation, Queensland University of Technology and Translational Research Institute, Woolloongabba, QLD, Australia.

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January 2016

Fusion transcript loci share many genomic features with non-fusion loci.

BMC Genomics 2015 Dec 1;16:1021. Epub 2015 Dec 1.

Australian Prostate Cancer Research Centre - Queensland, Translational Research Institute, Brisbane, Australia.

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December 2015

Genome-wide association study of prostate cancer-specific survival.

Cancer Epidemiol Biomarkers Prev 2015 Nov 25;24(11):1796-800. Epub 2015 Aug 25.

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

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November 2015

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans.

Hum Mol Genet 2015 Oct 29;24(19):5589-602. Epub 2015 May 29.

Division of Genetics and Epidemiology, The Institute of Cancer Research & Royal Marsden NHS Foundation Trust, London, UK,

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October 2015

Association between single-nucleotide polymorphisms in growth factor genes and quality of life in men with prostate cancer and the general population.

Qual Life Res 2015 Sep 28;24(9):2183-93. Epub 2015 Feb 28.

Institute of Health and Biomedical Innovation (IHBI), School of Nursing, Queensland University of Technology (QUT), Kelvin Grove, Brisbane, QLD, 4059, Australia,

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September 2015

Tissue engineered humanized bone supports human hematopoiesis in vivo.

Biomaterials 2015 Aug 19;61:103-14. Epub 2015 May 19.

Stem Cell Biology Group and Stem Cells and Cancer Group - Blood and Bone Diseases Program, Mater Research Institute - The University of Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, QLD 4102, Brisbane, Australia; School of Medicine, The University of Queensland, 288 Herston Road, Herston, QLD 4006, Brisbane, Australia. Electronic address:

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August 2015

3D Cultures of prostate cancer cells cultured in a novel high-throughput culture platform are more resistant to chemotherapeutics compared to cells cultured in monolayer.

PLoS One 2014 7;9(11):e111029. Epub 2014 Nov 7.

Stem Cell Therapies Laboratory, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia; Australian Prostate Cancer Research Centre, Translational Research Institute, Brisbane, Queensland, Australia; Mater Research Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.

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July 2015

Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci.

Cancer Epidemiol Biomarkers Prev 2015 Jul 2;24(7):1121-9. Epub 2015 Apr 2.

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom.

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July 2015

A genetic variant of MDM4 influences regulation by multiple microRNAs in prostate cancer.

Endocr Relat Cancer 2015 Apr 10;22(2):265-76. Epub 2015 Feb 10.

School of Biomedical SciencesInstitute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre - Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, AustraliaDame Roma Mitchell Cancer Research LaboratoriesSchool of Medicine, Adelaide Prostate Cancer Research CentreSchool of MedicineFreemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, AustraliaMolecular Cancer Epidemiology LaboratoryGenetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia

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April 2015

Kallikrein-Related Peptidases in Prostate Cancer: From Molecular Function to Clinical Application.

EJIFCC 2014 Oct 24;25(3):269-81. Epub 2014 Oct 24.

Cancer Program, Institute of Health and Biomedical Innovation, Queensland University of Technology , Brisbane, Australia.

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October 2014

Paracrine interactions between LNCaP prostate cancer cells and bioengineered bone in 3D in vitro culture reflect molecular changes during bone metastasis.

Bone 2014 Jun 12;63:121-31. Epub 2014 Feb 12.

Regenerative Medicine and Cancer Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia; Australian Prostate Cancer Research Centre-Queensland, Queensland University of Technology and Translational Research Institute, Brisbane, Queensland, Australia. Electronic address:

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June 2014

Breast cancer cells induce osteolytic bone lesions in vivo through a reduction in osteoblast activity in mice.

PLoS One 2013 12;8(9):e68103. Epub 2013 Sep 12.

Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia ; Skeletal Biology and Forensic Anatomy Research Program, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.

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April 2014

A humanized tissue-engineered in vivo model to dissect interactions between human prostate cancer cells and human bone.

Clin Exp Metastasis 2014 Apr 8;31(4):435-46. Epub 2014 Feb 8.

Australian Prostate Cancer Research Centre, Translational Research Institute, Queensland University of Technology, 37 Kent Street, Woolloongabba, QLD, 4102, Australia.

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April 2014

Species-specific homing mechanisms of human prostate cancer metastasis in tissue engineered bone.

Biomaterials 2014 Apr 16;35(13):4108-15. Epub 2014 Feb 16.

Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD 4049, Australia; George W Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive Northwest, Atlanta, GA 30332, USA; Institute for Advanced Study, Technical University Munich, Lichtenbergstr. 2a, 85748 Garching, Munich, Germany. Electronic address:

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April 2014

Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells.

Mol Oncol 2014 Feb 1;8(1):68-82. Epub 2013 Oct 1.

Institute of Molecular Medicine and Cell Research, University of Freiburg, D-79104 Freiburg, Germany; BIOSS Centre for Biological Signaling Studies, University of Freiburg, D-79104 Freiburg, Germany. Electronic address:

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February 2014

Metastasis of ovarian cancer is mediated by kallikrein related peptidases.

Clin Exp Metastasis 2014 Jan 17;31(1):135-47. Epub 2013 Sep 17.

Cancer Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD, 4059, Australia,

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January 2014

A bioengineered 3D ovarian cancer model for the assessment of peptidase-mediated enhancement of spheroid growth and intraperitoneal spread.

Biomaterials 2013 Oct 1;34(30):7389-400. Epub 2013 Jul 1.

Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland 4059, Australia.

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October 2013

Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment.

PLoS One 2013 25;8(2):e57056. Epub 2013 Feb 25.

Cancer Program, Institute of Health and Biomedical Innovation and Faculty of Sciences and Technology, Queensland University of Technology, Kelvin Grove, Queensland, Australia.

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September 2013

Hydrogel Microwell Arrays Allow the Assessment of Protease-Associated Enhancement of Cancer Cell Aggregation and Survival.

Microarrays (Basel) 2013 Aug 22;2(3):208-27. Epub 2013 Aug 22.

Faculty of Science and Engineering, IHBI, QUT, 60 Musk Avenue, Kelvin Grove 4059, Brisbane, Australia.

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August 2013

Delineating breast cancer cell interactions with engineered bone microenvironments.

J Bone Miner Res 2013 Jun;28(6):1399-411

Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Australia.

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June 2013

Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression.

Hum Mol Genet 2013 Jun 27;22(12):2520-8. Epub 2013 Mar 27.

The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.

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June 2013

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.

Authors:
Rosalind A Eeles Ali Amin Al Olama Sara Benlloch Edward J Saunders Daniel A Leongamornlert Malgorzata Tymrakiewicz Maya Ghoussaini Craig Luccarini Joe Dennis Sarah Jugurnauth-Little Tokhir Dadaev David E Neal Freddie C Hamdy Jenny L Donovan Ken Muir Graham G Giles Gianluca Severi Fredrik Wiklund Henrik Gronberg Christopher A Haiman Fredrick Schumacher Brian E Henderson Loic Le Marchand Sara Lindstrom Peter Kraft David J Hunter Susan Gapstur Stephen J Chanock Sonja I Berndt Demetrius Albanes Gerald Andriole Johanna Schleutker Maren Weischer Federico Canzian Elio Riboli Tim J Key Ruth C Travis Daniele Campa Sue A Ingles Esther M John Richard B Hayes Paul D P Pharoah Nora Pashayan Kay-Tee Khaw Janet L Stanford Elaine A Ostrander Lisa B Signorello Stephen N Thibodeau Dan Schaid Christiane Maier Walther Vogel Adam S Kibel Cezary Cybulski Jan Lubinski Lisa Cannon-Albright Hermann Brenner Jong Y Park Radka Kaneva Jyotsna Batra Amanda B Spurdle Judith A Clements Manuel R Teixeira Ed Dicks Andrew Lee Alison M Dunning Caroline Baynes Don Conroy Melanie J Maranian Shahana Ahmed Koveela Govindasami Michelle Guy Rosemary A Wilkinson Emma J Sawyer Angela Morgan David P Dearnaley Alan Horwich Robert A Huddart Vincent S Khoo Christopher C Parker Nicholas J Van As Christopher J Woodhouse Alan Thompson Tim Dudderidge Chris Ogden Colin S Cooper Artitaya Lophatananon Angela Cox Melissa C Southey John L Hopper Dallas R English Markus Aly Jan Adolfsson Jiangfeng Xu Siqun L Zheng Meredith Yeager Rudolf Kaaks W Ryan Diver Mia M Gaudet Mariana C Stern Roman Corral Amit D Joshi Ahva Shahabi Tiina Wahlfors Teuvo L J Tammela Anssi Auvinen Jarmo Virtamo Peter Klarskov Børge G Nordestgaard M Andreas Røder Sune F Nielsen Stig E Bojesen Afshan Siddiq Liesel M Fitzgerald Suzanne Kolb Erika M Kwon Danielle M Karyadi William J Blot Wei Zheng Qiuyin Cai Shannon K McDonnell Antje E Rinckleb Bettina Drake Graham Colditz Dominika Wokolorczyk Robert A Stephenson Craig Teerlink Heiko Muller Dietrich Rothenbacher Thomas A Sellers Hui-Yi Lin Chavdar Slavov Vanio Mitev Felicity Lose Srilakshmi Srinivasan Sofia Maia Paula Paulo Ethan Lange Kathleen A Cooney Antonis C Antoniou Daniel Vincent François Bacot Daniel C Tessier Zsofia Kote-Jarai Douglas F Easton

Nat Genet 2013 Apr;45(4):385-91, 391e1-2

The Institute of Cancer Research, Sutton, UK.

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April 2013

Genetic association of the KLK4 locus with risk of prostate cancer.

PLoS One 2012 6;7(9):e44520. Epub 2012 Sep 6.

Molecular Cancer Epidemiology Group, Genetics and Population Health Division, Queensland Institute of Medical Research, 300 Herston Rd, Herston, Brisbane, Queensland, Australia.

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March 2013

Phenotypic characterization of prostate cancer LNCaP cells cultured within a bioengineered microenvironment.

PLoS One 2012 5;7(9):e40217. Epub 2012 Sep 5.

Regenerative Medicine and Cancer Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.

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February 2013

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease.

Authors:
Ali Amin Al Olama Zsofia Kote-Jarai Fredrick R Schumacher Fredrik Wiklund Sonja I Berndt Sara Benlloch Graham G Giles Gianluca Severi David E Neal Freddie C Hamdy Jenny L Donovan David J Hunter Brian E Henderson Michael J Thun Michael Gaziano Edward L Giovannucci Afshan Siddiq Ruth C Travis David G Cox Federico Canzian Elio Riboli Timothy J Key Gerald Andriole Demetrius Albanes Richard B Hayes Johanna Schleutker Anssi Auvinen Teuvo L J Tammela Maren Weischer Janet L Stanford Elaine A Ostrander Cezary Cybulski Jan Lubinski Stephen N Thibodeau Daniel J Schaid Karina D Sorensen Jyotsna Batra Judith A Clements Suzanne Chambers Joanne Aitken Robert A Gardiner Christiane Maier Walther Vogel Thilo Dörk Hermann Brenner Tomonori Habuchi Sue Ingles Esther M John Joanne L Dickinson Lisa Cannon-Albright Manuel R Teixeira Radka Kaneva Hong-Wei Zhang Yong-Jie Lu Jong Y Park Kathleen A Cooney Kenneth R Muir Daniel A Leongamornlert Edward Saunders Malgorzata Tymrakiewicz Nadiya Mahmud Michelle Guy Koveela Govindasami Lynne T O'Brien Rosemary A Wilkinson Amanda L Hall Emma J Sawyer Tokhir Dadaev Jonathan Morrison David P Dearnaley Alan Horwich Robert A Huddart Vincent S Khoo Christopher C Parker Nicholas Van As Christopher J Woodhouse Alan Thompson Tim Dudderidge Chris Ogden Colin S Cooper Artitaya Lophatonanon Melissa C Southey John L Hopper Dallas English Jarmo Virtamo Loic Le Marchand Daniele Campa Rudolf Kaaks Sara Lindstrom W Ryan Diver Susan Gapstur Meredith Yeager Angela Cox Mariana C Stern Roman Corral Markus Aly William Isaacs Jan Adolfsson Jianfeng Xu S Lilly Zheng Tiina Wahlfors Kimmo Taari Paula Kujala Peter Klarskov Børge G Nordestgaard M Andreas Røder Ruth Frikke-Schmidt Stig E Bojesen Liesel M FitzGerald Suzanne Kolb Erika M Kwon Danielle M Karyadi Torben Falck Orntoft Michael Borre Antje Rinckleb Manuel Luedeke Kathleen Herkommer Andreas Meyer Jürgen Serth James R Marthick Briony Patterson Dominika Wokolorczyk Amanda Spurdle Felicity Lose Shannon K McDonnell Amit D Joshi Ahva Shahabi Pedro Pinto Joana Santos Ana Ray Thomas A Sellers Hui-Yi Lin Robert A Stephenson Craig Teerlink Heiko Muller Dietrich Rothenbacher Norihiko Tsuchiya Shintaro Narita Guang-Wen Cao Chavdar Slavov Vanio Mitev Stephen Chanock Henrik Gronberg Christopher A Haiman Peter Kraft Douglas F Easton Rosalind A Eeles

Hum Mol Genet 2013 Jan 12;22(2):408-15. Epub 2012 Oct 12.

Strangeways Laboratory, Centre for Cancer Genetic Epidemiology, Worts Causeway, Cambridge CB1 8RN, UK.

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January 2013

Combined expression of KLK4, KLK5, KLK6, and KLK7 by ovarian cancer cells leads to decreased adhesion and paclitaxel-induced chemoresistance.

Gynecol Oncol 2012 Dec 8;127(3):569-78. Epub 2012 Sep 8.

Cancer Program, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia.

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December 2012

Genetic polymorphisms in the human tissue kallikrein (KLK) locus and their implication in various malignant and non-malignant diseases.

Biol Chem 2012 Dec;393(12):1365-90

Australian Prostate Cancer Research Centre-Queensland and Institute of Health and Biomedical Innovation, QueenslandUniversity of Technology, Brisbane, Queensland, Australia.

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December 2012

Selective cleavage of human sex hormone-binding globulin by kallikrein-related peptidases and effects on androgen action in LNCaP prostate cancer cells.

Endocrinology 2012 Jul 30;153(7):3179-89. Epub 2012 Apr 30.

Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia.

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July 2012

Long terminal repeats act as androgen-responsive enhancers for the PSA-kallikrein locus.

Endocrinology 2012 Jul 17;153(7):3199-210. Epub 2012 May 17.

Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Queensland 4059, Australia.

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July 2012

The cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) contributes to epidermal growth factor receptor-mediated cell migration.

J Biol Chem 2012 Mar 7;287(13):9792-803. Epub 2012 Feb 7.

Cancer Research Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia.

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March 2012

Human kallikrein 4 signal peptide induces cytotoxic T cell responses in healthy donors and prostate cancer patients.

Cancer Immunol Immunother 2012 Feb 27;61(2):169-179. Epub 2011 Aug 27.

Dendritic Cell Program, Mater Medical Research Institute, Level 3 Aubigny Place, South Brisbane, QLD, 4101, Australia.

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February 2012

Expression of PTRF in PC-3 Cells modulates cholesterol dynamics and the actin cytoskeleton impacting secretion pathways.

Mol Cell Proteomics 2012 Feb 26;11(2):M111.012245. Epub 2011 Oct 26.

The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Queensland 4102, Australia.

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February 2012

A replication study examining novel common single nucleotide polymorphisms identified through a prostate cancer genome-wide association study in a Japanese population.

Am J Epidemiol 2011 Dec 15;174(12):1391-5. Epub 2011 Nov 15.

Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland 4059, Australia.

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December 2011

Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells.

Prostate 2011 Aug 12;71(11):1198-209. Epub 2011 Jan 12.

Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.

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August 2011

Kallikrein-related peptidase 3 (KLK3/PSA) single nucleotide polymorphisms and ovarian cancer survival.

Twin Res Hum Genet 2011 Aug;14(4):323-7

Hormone Dependent Cancer Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia.

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August 2011

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.

Authors:
Zsofia Kote-Jarai Ali Amin Al Olama Graham G Giles Gianluca Severi Johanna Schleutker Maren Weischer Daniele Campa Elio Riboli Tim Key Henrik Gronberg David J Hunter Peter Kraft Michael J Thun Sue Ingles Stephen Chanock Demetrius Albanes Richard B Hayes David E Neal Freddie C Hamdy Jenny L Donovan Paul Pharoah Fredrick Schumacher Brian E Henderson Janet L Stanford Elaine A Ostrander Karina Dalsgaard Sorensen Thilo Dörk Gerald Andriole Joanne L Dickinson Cezary Cybulski Jan Lubinski Amanda Spurdle Judith A Clements Suzanne Chambers Joanne Aitken R A Frank Gardiner Stephen N Thibodeau Dan Schaid Esther M John Christiane Maier Walther Vogel Kathleen A Cooney Jong Y Park Lisa Cannon-Albright Hermann Brenner Tomonori Habuchi Hong-Wei Zhang Yong-Jie Lu Radka Kaneva Ken Muir Sara Benlloch Daniel A Leongamornlert Edward J Saunders Malgorzata Tymrakiewicz Nadiya Mahmud Michelle Guy Lynne T O'Brien Rosemary A Wilkinson Amanda L Hall Emma J Sawyer Tokhir Dadaev Jonathan Morrison David P Dearnaley Alan Horwich Robert A Huddart Vincent S Khoo Christopher C Parker Nicholas Van As Christopher J Woodhouse Alan Thompson Tim Christmas Chris Ogden Colin S Cooper Aritaya Lophatonanon Melissa C Southey John L Hopper Dallas R English Tiina Wahlfors Teuvo L J Tammela Peter Klarskov Børge G Nordestgaard M Andreas Røder Anne Tybjærg-Hansen Stig E Bojesen Ruth Travis Federico Canzian Rudolf Kaaks Fredrik Wiklund Markus Aly Sara Lindstrom W Ryan Diver Susan Gapstur Mariana C Stern Roman Corral Jarmo Virtamo Angela Cox Christopher A Haiman Loic Le Marchand Liesel Fitzgerald Suzanne Kolb Erika M Kwon Danielle M Karyadi Torben Falck Orntoft Michael Borre Andreas Meyer Jürgen Serth Meredith Yeager Sonja I Berndt James R Marthick Briony Patterson Dominika Wokolorczyk Jyotsna Batra Felicity Lose Shannon K McDonnell Amit D Joshi Ahva Shahabi Antje E Rinckleb Ana Ray Thomas A Sellers Hui-Yi Lin Robert A Stephenson James Farnham Heiko Muller Dietrich Rothenbacher Norihiko Tsuchiya Shintaro Narita Guang-Wen Cao Chavdar Slavov Vanio Mitev Douglas F Easton Rosalind A Eeles

Nat Genet 2011 Jul 10;43(8):785-91. Epub 2011 Jul 10.

The Institute of Cancer Research, Sutton, Surrey, UK.

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July 2011

Interactions between human osteoblasts and prostate cancer cells in a novel 3D in vitro model.

Organogenesis 2010 Jul-Sep;6(3):181-8

Institute of Health and Biomedical Innovation, Queensland University of Technology, QLD, Australia.

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A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival.

BMC Cancer 2011 Apr 1;11:119. Epub 2011 Apr 1.

Australian Prostate Cancer Research centre-Queensland and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland 4059, Australia.

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April 2011

Mineralized human primary osteoblast matrices as a model system to analyse interactions of prostate cancer cells with the bone microenvironment.

Biomaterials 2010 Nov 5;31(31):7928-36. Epub 2010 Aug 5.

Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia.

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Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells.

Biomaterials 2010 Nov 14;31(32):8494-506. Epub 2010 Aug 14.

Hormone Dependent Cancer Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia.

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November 2010

Kallikreins on steroids: structure, function, and hormonal regulation of prostate-specific antigen and the extended kallikrein locus.

Endocr Rev 2010 Aug 26;31(4):407-46. Epub 2010 Jan 26.

Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.

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August 2010

A variant of the KLK4 gene is expressed as a cis sense-antisense chimeric transcript in prostate cancer cells.

RNA 2010 Jun 20;16(6):1156-66. Epub 2010 Apr 20.

Australian Prostate Cancer Research Centre-Queensland, Queensland University of Technology and Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia.

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June 2010

Kallikrein-related peptidase 10 (KLK10) expression and single nucleotide polymorphisms in ovarian cancer survival.

Int J Gynecol Cancer 2010 May;20(4):529-36

School of Life Sciences, Hormone-Dependent Cancer Research Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia.

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May 2010

Kallikrein-related peptidase 7 promotes multicellular aggregation via the alpha(5)beta(1) integrin pathway and paclitaxel chemoresistance in serous epithelial ovarian carcinoma.

Cancer Res 2010 Apr 23;70(7):2624-33. Epub 2010 Mar 23.

Hormone Dependent Cancer Program, Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Kelvin Grove, Queensland, Australia.

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April 2010

Can tissue engineering concepts advance tumor biology research?

Trends Biotechnol 2010 Mar 6;28(3):125-33. Epub 2010 Jan 6.

Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia.

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March 2010

The use of predictive or prognostic genetic biomarkers in endometrial and other hormone-related cancers: justification for extensive candidate gene single nucleotide polymorphism studies of the matrix metalloproteinase family and their inhibitors.

Cancer Epidemiol Biomarkers Prev 2009 Sep 1;18(9):2352-65. Epub 2009 Sep 1.

Institute of Health and Biomedical Innovation, School of Life Sciences, Queensland University of Technology, Kelvin Grove, Queensland, Australia.

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September 2009

Translating tissue engineering technology platforms into cancer research.

J Cell Mol Med 2009 Aug 20;13(8A):1417-27. Epub 2009 Jul 20.

Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia.

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August 2009

Direct progesterone receptor and indirect androgen receptor interactions with the kallikrein-related peptidase 4 gene promoter in breast and prostate cancer.

Mol Cancer Res 2009 Jan;7(1):129-41

Hormone Dependent Cancer Program, School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Cnr Blamey Street and Musk Avenue, Kelvin Grove, QLD 4059, Australia.

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January 2009

Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades?

Biol Chem 2008 Dec;389(12):1447-54

Hormone Dependent Cancer Program, Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Brisbane 4059, QLD, Australia.

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December 2008

Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs).

Biol Chem 2008 Jun;389(6):653-68

Institute of Health and Biomedical Innovation, Queensland University of Technology, 6 Musk Avenue, Kelvin Grove, Queensland 4059, Australia.

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June 2008

Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression.

J Biol Chem 2008 May 28;283(18):12293-304. Epub 2008 Feb 28.

Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Corner Musk Ave. and Blamey St., Kelvin Grove, Queensland 4059, Australia.

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May 2008

Tissue-specific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic function.

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Hormone Dependent Cancer Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.

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February 2008

Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression.

J Cell Physiol 2007 Nov;213(2):374-83

Embryology Laboratory, Murdoch Children's Research Institute, The Royal Children's Hospital, Victoria, Australia.

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November 2007

Epithelial-mesenchymal transition in prostate cancer and the potential role of kallikrein serine proteases.

Cells Tissues Organs 2007 ;185(1-3):111-5

Hormone-Dependent Cancer Program, School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.

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July 2007

PSA/KLK3 AREI promoter polymorphism alters androgen receptor binding and is associated with prostate cancer susceptibility.

Carcinogenesis 2007 May 6;28(5):1032-9. Epub 2006 Dec 6.

Cluster for Molecular Biotechnology, School of Life Sciences and Science Research Centre, Queensland University of Technology, Victoria Park Road, Kelvin Grove, Brisbane, QLD 4059, Australia

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May 2007

Bone and prostate cancer cell interactions in metastatic prostate cancer.

BJU Int 2007 Apr 13;99(4):735-42. Epub 2006 Dec 13.

School of Medicine, University of Queensland, Brisbane, Queensland, Australia.

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April 2007

Kallikrein 4 is a potential mediator of cellular interactions between cancer cells and osteoblasts in metastatic prostate cancer.

Prostate 2007 Mar;67(4):348-60

Prostate Cancer Research Program, School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.

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March 2007

Seminal fluid characterization for male fertility and prostate cancer: kallikrein-related serine proteases and whole proteome approaches.

Semin Thromb Hemost 2007 Feb;33(1):87-99

School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.

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February 2007

Kallikrein-related peptidase (KLK) family mRNA variants and protein isoforms in hormone-related cancers: do they have a function?

Biol Chem 2006 Jun;387(6):697-705

Hormone-Dependent Cancer Research Program, School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane 4001, QLD, Australia.

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June 2006

The role of kallikrein-related peptidases in prostate cancer: potential involvement in an epithelial to mesenchymal transition.

Biol Chem 2006 Jun;387(6):707-14

Hormone-Dependent Cancer Program, School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, and Department of Urology, Princess Alexandria Hospital, Brisbane 4000, QLD, Australia.

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June 2006

The tissue kallikrein family of serine proteases: functional roles in human disease and potential as clinical biomarkers.

Crit Rev Clin Lab Sci 2004 ;41(3):265-312

Hormone Dependent Cancer Program, Cluster for Molecular Biotechnology, School of Life Sciences & Science Research Centre, Queensland University of Technology, Brisbane, Australia.

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November 2004

Realizing the potential of ejaculate/seminal fluid in detecting and predicting natural history.

Methods Mol Med 2003 ;81:199-217

Department of Surgery at Royal Brisbane Hospital, University of Queensland, Herston, Australia.

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Production and characterization of antipeptide kallikrein 4 antibodies. Use of computer modeling to design peptides specific to Kallikrein 4.

Methods Mol Med 2003 ;81:241-54

Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Australia.

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Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers.

Clin Cancer Res 2003 May;9(5):1710-20

The Center of Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Australia.

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