Publications by authors named "Judith A Clements"

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Kallikrein-related peptidase 4 induces cancer-associated fibroblast features in prostate-derived stromal cells.
Mol Oncol 2017 Oct 10;11(10):1307-1329. Epub 2017 Aug 10.
Australian Prostate Cancer Research Centre - Queensland, Translational Research Institute, Queensland University of Technology (QUT), Woolloongabba, Australia.


Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7) Shed Light on KLK Proteolytic Activity in the Stratum Corneum.
J Invest Dermatol 2017 Feb 30;137(2):430-439. Epub 2016 Sep 30.
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia. Electronic address:

MicroRNA Theranostics in Prostate Cancer Precision Medicine.
Clin Chem 2016 Oct 18;62(10):1318-33. Epub 2016 Aug 18.
School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Australian Prostate Cancer Research Centre-Queensland (APCRC-Q), Australia; Translational Research Institute, Queensland University of Technology, Brisbane, Australia;

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.
Nat Commun 2016 Apr 7;7:10979. Epub 2016 Apr 7.
Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, California 90095, USA.

Tie-2 regulates the stemness and metastatic properties of prostate cancer cells.
Oncotarget 2016 Jan;7(3):2572-84
Australian Prostate Cancer Research Centre-Queensland and Institute of Health and Biomedical Innovation, Queensland University of Technology and Translational Research Institute, Woolloongabba, QLD, Australia.

Adipocytes promote prostate cancer stem cell self-renewal through amplification of the cholecystokinin autocrine loop.
Oncotarget 2016 Jan;7(4):4939-48
Australian Prostate Cancer Research Centre-Queensland & Institute of Health and Biomedical Innovation, Queensland University of Technology and Translational Research Institute, Woolloongabba, QLD, Australia.

Genome-wide association study of prostate cancer-specific survival.
Cancer Epidemiol Biomarkers Prev 2015 Nov 25;24(11):1796-800. Epub 2015 Aug 25.
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans.
Hum Mol Genet 2015 Oct 29;24(19):5589-602. Epub 2015 May 29.
Division of Genetics and Epidemiology, The Institute of Cancer Research & Royal Marsden NHS Foundation Trust, London, UK,

Association between single-nucleotide polymorphisms in growth factor genes and quality of life in men with prostate cancer and the general population.
Qual Life Res 2015 Sep 28;24(9):2183-93. Epub 2015 Feb 28.
Institute of Health and Biomedical Innovation (IHBI), School of Nursing, Queensland University of Technology (QUT), Kelvin Grove, Brisbane, QLD, 4059, Australia,


Tissue engineered humanized bone supports human hematopoiesis in vivo.
Biomaterials 2015 Aug 19;61:103-14. Epub 2015 May 19.
Stem Cell Biology Group and Stem Cells and Cancer Group - Blood and Bone Diseases Program, Mater Research Institute - The University of Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, QLD 4102, Brisbane, Australia; School of Medicine, The University of Queensland, 288 Herston Road, Herston, QLD 4006, Brisbane, Australia. Electronic address:

Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci.
Cancer Epidemiol Biomarkers Prev 2015 Jul 2;24(7):1121-9. Epub 2015 Apr 2.
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom.

A genetic variant of MDM4 influences regulation by multiple microRNAs in prostate cancer.
Endocr Relat Cancer 2015 Apr 10;22(2):265-76. Epub 2015 Feb 10.
School of Biomedical SciencesInstitute of Health and Biomedical Innovation, Translational Research Institute Pty Ltd, Australian Prostate Cancer Research Centre - Queensland, Queensland University of Technology, 37 Kent Street, Woolloongabba, Brisbane, Queensland 4102, AustraliaDame Roma Mitchell Cancer Research LaboratoriesSchool of Medicine, Adelaide Prostate Cancer Research CentreSchool of MedicineFreemasons Foundation Centre for Men's Health, The University of Adelaide, Adelaide, South Australia 5005, AustraliaMolecular Cancer Epidemiology LaboratoryGenetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia


Paracrine interactions between LNCaP prostate cancer cells and bioengineered bone in 3D in vitro culture reflect molecular changes during bone metastasis.
Bone 2014 Jun 12;63:121-31. Epub 2014 Feb 12.
Regenerative Medicine and Cancer Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia; Australian Prostate Cancer Research Centre-Queensland, Queensland University of Technology and Translational Research Institute, Brisbane, Queensland, Australia. Electronic address:

A humanized tissue-engineered in vivo model to dissect interactions between human prostate cancer cells and human bone.
Clin Exp Metastasis 2014 Apr 8;31(4):435-46. Epub 2014 Feb 8.
Australian Prostate Cancer Research Centre, Translational Research Institute, Queensland University of Technology, 37 Kent Street, Woolloongabba, QLD, 4102, Australia.

Species-specific homing mechanisms of human prostate cancer metastasis in tissue engineered bone.
Biomaterials 2014 Apr 16;35(13):4108-15. Epub 2014 Feb 16.
Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD 4049, Australia; George W Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive Northwest, Atlanta, GA 30332, USA; Institute for Advanced Study, Technical University Munich, Lichtenbergstr. 2a, 85748 Garching, Munich, Germany. Electronic address:

Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells.
Mol Oncol 2014 Feb 1;8(1):68-82. Epub 2013 Oct 1.
Institute of Molecular Medicine and Cell Research, University of Freiburg, D-79104 Freiburg, Germany; BIOSS Centre for Biological Signaling Studies, University of Freiburg, D-79104 Freiburg, Germany. Electronic address:


A bioengineered 3D ovarian cancer model for the assessment of peptidase-mediated enhancement of spheroid growth and intraperitoneal spread.
Biomaterials 2013 Oct 1;34(30):7389-400. Epub 2013 Jul 1.
Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland 4059, Australia.


Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression.
Hum Mol Genet 2013 Jun 27;22(12):2520-8. Epub 2013 Mar 27.
The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
Nat Genet 2013 Apr;45(4):385-91, 391e1-2
The Institute of Cancer Research, Sutton, UK.

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease.
Hum Mol Genet 2013 Jan 12;22(2):408-15. Epub 2012 Oct 12.
Strangeways Laboratory, Centre for Cancer Genetic Epidemiology, Worts Causeway, Cambridge CB1 8RN, UK.

Combined expression of KLK4, KLK5, KLK6, and KLK7 by ovarian cancer cells leads to decreased adhesion and paclitaxel-induced chemoresistance.
Gynecol Oncol 2012 Dec 8;127(3):569-78. Epub 2012 Sep 8.
Cancer Program, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia.

Selective cleavage of human sex hormone-binding globulin by kallikrein-related peptidases and effects on androgen action in LNCaP prostate cancer cells.
Endocrinology 2012 Jul 30;153(7):3179-89. Epub 2012 Apr 30.
Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia.


Human kallikrein 4 signal peptide induces cytotoxic T cell responses in healthy donors and prostate cancer patients.
Cancer Immunol Immunother 2012 Feb 27;61(2):169-179. Epub 2011 Aug 27.
Dendritic Cell Program, Mater Medical Research Institute, Level 3 Aubigny Place, South Brisbane, QLD, 4101, Australia.

Expression of PTRF in PC-3 Cells modulates cholesterol dynamics and the actin cytoskeleton impacting secretion pathways.
Mol Cell Proteomics 2012 Feb 26;11(2):M111.012245. Epub 2011 Oct 26.
The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Queensland 4102, Australia.

A replication study examining novel common single nucleotide polymorphisms identified through a prostate cancer genome-wide association study in a Japanese population.
Am J Epidemiol 2011 Dec 15;174(12):1391-5. Epub 2011 Nov 15.
Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland 4059, Australia.

Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells.
Prostate 2011 Aug 12;71(11):1198-209. Epub 2011 Jan 12.
Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
Nat Genet 2011 Jul 10;43(8):785-91. Epub 2011 Jul 10.
The Institute of Cancer Research, Sutton, Surrey, UK.

A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival.
BMC Cancer 2011 Apr 1;11:119. Epub 2011 Apr 1.
Australian Prostate Cancer Research centre-Queensland and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland 4059, Australia.

Mineralized human primary osteoblast matrices as a model system to analyse interactions of prostate cancer cells with the bone microenvironment.
Biomaterials 2010 Nov 5;31(31):7928-36. Epub 2010 Aug 5.
Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia.



A variant of the KLK4 gene is expressed as a cis sense-antisense chimeric transcript in prostate cancer cells.
RNA 2010 Jun 20;16(6):1156-66. Epub 2010 Apr 20.
Australian Prostate Cancer Research Centre-Queensland, Queensland University of Technology and Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia.

Kallikrein-related peptidase 10 (KLK10) expression and single nucleotide polymorphisms in ovarian cancer survival.
Int J Gynecol Cancer 2010 May;20(4):529-36
School of Life Sciences, Hormone-Dependent Cancer Research Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia.


Kallikrein-related peptidase 7 promotes multicellular aggregation via the alpha(5)beta(1) integrin pathway and paclitaxel chemoresistance in serous epithelial ovarian carcinoma.
Cancer Res 2010 Apr 23;70(7):2624-33. Epub 2010 Mar 23.
Hormone Dependent Cancer Program, Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Kelvin Grove, Queensland, Australia.

The use of predictive or prognostic genetic biomarkers in endometrial and other hormone-related cancers: justification for extensive candidate gene single nucleotide polymorphism studies of the matrix metalloproteinase family and their inhibitors.
Cancer Epidemiol Biomarkers Prev 2009 Sep 1;18(9):2352-65. Epub 2009 Sep 1.
Institute of Health and Biomedical Innovation, School of Life Sciences, Queensland University of Technology, Kelvin Grove, Queensland, Australia.


Direct progesterone receptor and indirect androgen receptor interactions with the kallikrein-related peptidase 4 gene promoter in breast and prostate cancer.
Mol Cancer Res 2009 Jan;7(1):129-41
Hormone Dependent Cancer Program, School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Cnr Blamey Street and Musk Avenue, Kelvin Grove, QLD 4059, Australia.

Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs).
Biol Chem 2008 Jun;389(6):653-68
Institute of Health and Biomedical Innovation, Queensland University of Technology, 6 Musk Avenue, Kelvin Grove, Queensland 4059, Australia.

Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression.
J Biol Chem 2008 May 28;283(18):12293-304. Epub 2008 Feb 28.
Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Corner Musk Ave. and Blamey St., Kelvin Grove, Queensland 4059, Australia.


Tissue-specific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic function.
Biol Chem 2008 Feb;389(2):99-109
Hormone Dependent Cancer Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.

PSA/KLK3 AREI promoter polymorphism alters androgen receptor binding and is associated with prostate cancer susceptibility.
Carcinogenesis 2007 May 6;28(5):1032-9. Epub 2006 Dec 6.
Cluster for Molecular Biotechnology, School of Life Sciences and Science Research Centre, Queensland University of Technology, Victoria Park Road, Kelvin Grove, Brisbane, QLD 4059, Australia


The role of kallikrein-related peptidases in prostate cancer: potential involvement in an epithelial to mesenchymal transition.
Biol Chem 2006 Jun;387(6):707-14
Hormone-Dependent Cancer Program, School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, and Department of Urology, Princess Alexandria Hospital, Brisbane 4000, QLD, Australia.


Phenotypic characterization of prostate cancer LNCaP cells cultured within a bioengineered microenvironment.
PLoS One 2012 5;7(9):e40217. Epub 2012 Sep 5.
Regenerative Medicine and Cancer Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.

Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment.
PLoS One 2013 25;8(2):e57056. Epub 2013 Feb 25.
Cancer Program, Institute of Health and Biomedical Innovation and Faculty of Sciences and Technology, Queensland University of Technology, Kelvin Grove, Queensland, Australia.

Breast cancer cells induce osteolytic bone lesions in vivo through a reduction in osteoblast activity in mice.
PLoS One 2013 12;8(9):e68103. Epub 2013 Sep 12.
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia ; Skeletal Biology and Forensic Anatomy Research Program, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.

3D Cultures of prostate cancer cells cultured in a novel high-throughput culture platform are more resistant to chemotherapeutics compared to cells cultured in monolayer.
PLoS One 2014 7;9(11):e111029. Epub 2014 Nov 7.
Stem Cell Therapies Laboratory, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia; Australian Prostate Cancer Research Centre, Translational Research Institute, Brisbane, Queensland, Australia; Mater Research Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.

Prostate Cancer-Associated Kallikrein-Related Peptidase 4 Activates Matrix Metalloproteinase-1 and Thrombospondin-1.
J Proteome Res 2016 08 27;15(8):2466-78. Epub 2016 Jul 27.
Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology at the Translational Research Institute , 37 Kent Street, Woolloongabba, Queensland 4102, Australia.

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.
Cancer Discov 2016 09 17;6(9):1052-67. Epub 2016 Jul 17.
VIB Vesalius Research Center, KU Leuven, Leuven, Belgium.

Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases.
Am J Cancer Res 2017 1;7(11):2257-2274. Epub 2017 Nov 1.
Mater Research Institute-University of Queensland, Translational Research InstituteWoolloongabba, Queensland 4102, Australia.


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