Publications by authors named "Juanjuan Cheng"

10 Publications

  • Page 1 of 1

Cleavage of the N≡N Triple Bond and Unpredicted Formation of the Cyclic 1,3-Diaza-2,4-Diborete (FB) N from N and Fluoroborylene BF.

Angew Chem Int Ed Engl 2021 Jul 26;60(31):17205-17210. Epub 2021 Jun 26.

Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Fabeckstrasse 34-36, 14195, Berlin, Germany.

A complete cleavage of the triple bond of N by fluoroborylene (:BF) was achieved in a low-temperature N matrix by the formation of the four-membered heterocycle FB(μ-N) BF, which lacks a trans-annular N-N bond. Additionally, the linear complex FB=N-N=BF and cyclic FB(η -N ) were formed. These novel species were characterized by their matrix infrared spectra and quantum-chemical calculations. The puckered four-membered-ring B N complex shows a delocalized aromatic two-electron π-system in conjugation with the exo-cyclic fluorine π lone pairs. This work may contribute to a rational design of catalysts based on borylene for artificial dinitrogen activation.
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http://dx.doi.org/10.1002/anie.202106984DOI Listing
July 2021

Anti-Hyperuricemic and Nephroprotective Effects of Dihydroberberine in Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice.

Front Pharmacol 2021 20;12:645879. Epub 2021 Apr 20.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.

Phellodendri Chinese Cortex has long been used to treat hyperuricemia and gout. Berberine (BBR), its characteristic ingredient, has also been shown to be effective in alleviating monosodium urate crystals-triggered gout inflammation and . Dihydroberberine (DHB) is a hydrogenated derivative of BBR that showed improved efficacy on many metabolic disorders. However, its anti-hyperuricemia effect remains underexplored. In the present work, the hypouricemic and renoprotective effects of DHB on hyperuricemic mice were investigated. The hyperuricemic mice model was induced by intraperitoneal injection of potassium oxonate (PO, 300 mg/kg) combined with intragastric administration of hypoxanthine (HX, 300 mg/kg) for 7 days. Different dosages of DHB (25, 50 mg/kg), BBR (50 mg/kg) or febuxostat (Feb, 5 mg/kg) were orally given to mice 1 h after modeling. The molecular docking results showed that DHB effectively inhibited xanthine oxidase (XOD) by binding with its active site. , DHB exhibited significant XOD inhibitory activity (IC value, 34.37 μM). The results showed that DHB had obvious hypouricemic and renoprotective effects in hyperuricemic mice. It could not only lower the uric acid and XOD levels in serum, but also suppress the activities of XOD and adenosine deaminase (ADA) in the liver. Furthermore, DHB noticeably down-regulated the renal mRNA and protein expression of XOD. Besides, DHB remarkably and dose-dependently ameliorated renal damage, as evidenced by considerably reducing serum creatinine and blood urea nitrogen (BUN) levels, inflammatory cytokine (TNF-α, IL-1β, IL-6 and IL-18) levels and restoring kidney histological deteriorations. Further mechanistic investigation showed that DHB distinctly down-regulated renal mRNA and protein levels of URAT1, GLUT9, NOD-like receptor 3 (NLRP3), apoptosis-associated speck-like (ASC), caspase-1 and IL-1β. Our study revealed that DHB had outstanding hypouricemic and renoprotective effects via suppressing XOD, URAT1, GLUT9 and NLRP3 inflammasome activation in the kidney.
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http://dx.doi.org/10.3389/fphar.2021.645879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093860PMC
April 2021

Gut Microbiota-Mediated Transformation of Coptisine Into a Novel Metabolite 8-Oxocoptisine: Insight Into Its Superior Anti-Colitis Effect.

Front Pharmacol 2021 30;12:639020. Epub 2021 Mar 30.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.

Coptisine (COP) is a bioactive isoquinoline alkaloid derived from Franch, which is traditionally applied for the management of colitis. However, the blood concentration of COP was extremely low, and its gut microbiota-mediated metabolites were thought to contribute to its prominent bioactivities. To comparatively elucidate the protective effect and underlying mechanism of COP and its novel gut microbiota metabolite (8-oxocoptisine, OCOP) against colitis, we used dextran sulfate sodium (DSS) to induce colitis in mice. Clinical symptoms, microscopic alternation, immune-inflammatory parameters for colitis were estimated. The results indicated that OCOP dramatically ameliorated disease activity index (DAI), the shortening of colon length and colonic histopathological deteriorations. OCOP treatment also suppressed the mRNA expression and release of inflammatory mediators (TGF-β, TNF-α, IL-6, IL-18, IL-1β and IFN-γ) and elevated the transcriptional and translational levels of anti-inflammatory cytokine (IL-10) as well as the mRNA expression levels of adhesion molecules ( and ). Besides, the activation of NF-κB pathway and NLRP3 inflammasome was markedly inhibited by OCOP. Furthermore, OCOP displayed superior anti-colitis effect to COP, and was similar to MSZ with much smaller dosage. Taken together, the protective effect of OCOP against DSS-induced colitis might be intimately related to inhibition of NF-κB pathway and NLRP3 inflammasome. And the findings indicated that OCOP might have greater potential than COP to be further exploited as a promising candidate in the treatment of colitis.
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http://dx.doi.org/10.3389/fphar.2021.639020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042337PMC
March 2021

CO activation by ligand-free manganese hydrides in a parahydrogen matrix.

Chem Commun (Camb) 2021 Mar 3;57(18):2301-2304. Epub 2021 Feb 3.

Shanghai Key Lab of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China.

Manganese formate complexes, HMn(η-OCH) and Mn(η-OCH), are formed through MnH and MnH reactions with CO in solid parahydrogen and identified by matrix infrared spectroscopy with the basis of isotopic substitutions and theoretical frequency calculations. The reaction mechanism has been proposed that the reaction proceeds by concerted hydride ion transfer.
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http://dx.doi.org/10.1039/d0cc08256bDOI Listing
March 2021

Isolated IgG4-related sclerosing cholangitis with normal serum IgG4 levels-A case report.

Clin Case Rep 2020 Nov 3;8(11):2186-2190. Epub 2020 Jul 3.

Division of Gastroenterology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China.

The isolated IgG4-SC that absent from AIP is quite rare and difficult to diagnose. We presented a case of isolated IgG4-SC with the normal serum IgG4 which was hard to differentiate with cholangiocarcinoma. Under such circumstances, liver pathology has a pivotal role in the diagnosis.
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http://dx.doi.org/10.1002/ccr3.3083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669420PMC
November 2020

FBMF (M = V, Nb, and Ta) and FBMF (M = Nb and Ta): A Combined Matrix Isolation Infrared Spectroscopic and Quantum Chemical Investigation.

J Phys Chem A 2020 Oct 24;124(40):8192-8200. Epub 2020 Sep 24.

School of Chemical Science and Engineering, Shanghai Key Lab of Chemical Assessment and Sustainability, Tongji University, Shanghai 200092, China.

Through matrix isolation infrared spectrometry and quantum chemical calculations, the reactions of laser ablated V, Nb, and Ta with boron trifluoride were investigated in excess solid neon at 4 K. The possible reaction products FBMF, FBMF, and BMF (M = V, Nb, and Ta) were calculated at the B3LYP, BPW91, and CCSD(T) levels of theory. The B-M bond strength in FBMF molecules is confirmed by energy decomposition analysis-natural orbitals for chemical valence calculations, CASSCF calculation, and natural bond orbital analysis, which favors one σ bond and two half π bonds.
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http://dx.doi.org/10.1021/acs.jpca.0c05132DOI Listing
October 2020

Matrix infrared spectroscopy of FBMF and FB[triple bond, length as m-dash]WF (M = Cr, Mo and W) complexes and quantum chemistry calculations.

Phys Chem Chem Phys 2019 Nov;21(46):25577-25583

School of Chemical Science and Engineering, Shanghai Key Lab of Chemical Assessment and Sustainability, Tongji University, Shanghai, 200092, China.

Laser-ablated group 6 transition metal atoms react with BF3 to yield typical transition metal inserted complexes F2B-MF (M = Cr, Mo, and W) and terminal borylene complex FB[triple bond, length as m-dash]WF2. These products are investigated by using infrared spectroscopy, isotopic substitution and theoretical frequency calculations. The inserted complexes F2B-MF (M = Cr, Mo, and W) were identified by antisymmetric and symmetric stretching modes of F-B-F. The FB[triple bond, length as m-dash]WF2 molecule has a 11B-F (10B-F) stretching frequency at 1453.2 (1505.0) cm-1 and the triple bond between boron and tungsten is confirmed by EDA-NOCV calculations, CASSCF calculation and NBO analysis. Furthermore, the bonding for tungsten complexes is compared with that of molybdenum and chromium complexes, which reveals interesting differences in their chemistries.
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http://dx.doi.org/10.1039/c9cp04888jDOI Listing
November 2019

Boron-Transition-Metal Triple-Bond FB≡MF Complexes.

Inorg Chem 2019 Oct 24;58(19):13418-13425. Epub 2019 Sep 24.

Department of Chemistry , University of Virginia , Charlottesville , Virginia 22904 , United States.

The boron-transition-metal triple-bond complexes FB≡MF (M= Ir, Os, Re, W, Ta) were trapped in excess solid neon and argon through metal atom reactions with boron trifluoride and identified by matrix isolation infrared spectroscopy and quantum chemical calculations. The FB≡MF molecule features very high B-F stretching frequencies at 1586.6 cm (Ir), 1526.6 cm (Os), 1505.5 cm (Re), and 1453.2 cm (W), respectively. The very high strength of B≡M bonds with triple-bonding character is confirmed by EDA-NOCV calculations and the active molecular orbital and NBO analysis. The experimental observation of FB stabilization by heavy transition-metal atoms with triple bonds opens the door to design new boron-transition-metal complexes.
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http://dx.doi.org/10.1021/acs.inorgchem.9b02318DOI Listing
October 2019

In in vivo evaluation of the anti-inflammatory and analgesic activities of compound Muniziqi granule in experimental animal models.

BMC Complement Altern Med 2016 Jan 22;16:20. Epub 2016 Jan 22.

Institute of Chinese Materia Medica, The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai,, 201203, China.

Background: Compound Muniziqi granule (MNZQ), a traditional Uighur medicinal preparation, comprises 13 species of medicinal plants. MNZQ is traditionally used for regulating body immunity, modulating inflammation and pain, detoxification, and inhibiting tumor growth. This study aims to scientifically evaluate the anti-inflammatory and analgesic activities of MNZQ, support its clinical use and further research with scientific evidence.

Methods: The analgesic activity of MNZQ was evaluated using hot plate test and acetic acid-induced abdominal writhing test. Acute inflammation was evaluated using xylene-induced ear edema and carrageenan-induced paw edema models, while chronic inflammation was evaluated using cotton pellet-induced granuloma model.

Results: MNZQ exerted analgesic activities with a significant dose-dependent increase in latency in the hot plate test. The percentage inhibition suggested that MNZQ exhibited analgesic activities in the central nervous system. Meanwhile, MNZQ at 0.8, 2.4, and 7.2 g/kg strongly inhibited the acetic acid-induced writhing response by 25.22% (p < 0.01), 44.60% (p < 0.001), and 49.41% (p < 0.001), respectively. MNZQ also exerted analgesic activities in the peripheral nervous system. Moreover, MNZQ was demonstrated a significant anti-inflammatory effect against xylene-induced edema in a dose-dependent manner. The percentage inhibition was 22.24% (p < 0.01) at the highest dosage of 7.2 g/kg. MNZQ at 1.62 and 4.86 g/kg significantly reduced carrageenan-induced rat hind paw edema by 82.43% and 84.32% (p < 0.001), respectively, 1 h after injecting carrageenan, and the inhibitory effect lasted for 5 h. MNZQ also exerted a significant anti-inflammatory effect against cotton pellet-induced granuloma formation. MNZQ at 1.62 and 4.86 g/kg could inhibit granuloma formation by 17.07% and 17.60%, respectively, whereas the percentage inhibition of diclofenac was 33.12%.

Conclusions: The results obtained suggest that MNZQ possesses potential anti-inflammatory and analgesic activities. This study provides a scientific basis for the use of MNZQ in alleviating pain and treating inflammatory disorders.
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http://dx.doi.org/10.1186/s12906-016-0999-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722770PMC
January 2016

Characterization of acute respiratory infections among 340 infants in Wuxi, Jiangsu Province.

Ann Transl Med 2015 Oct;3(18):264

1 Department of Pediatrics, 2 Department of Laboratory Medicine, Wuxi Second People's Hospital of Nanjing Medical University, Wuxi 214002, China ; 3 Department of Pediatrics, Wuxi People's Hospital of Nanjing Medical University, Wuxi 214002, China.

Background: To investigate the etiological and epidemiological features of acute respiratory infections among children in Wuxi, Jiangsu Province.

Methods: Nasopharyngeal swab specimens were collected from 340 pediatric patients from Wuxi Second People's Hospital from June 2012 to May 2014. Seven respiratory viruses including influenza virus A (FA), influenza virus B (FB), parainfluenza virus I (PIVI), parainfluenza virus II (PIVII), parainfluenza virus III (PIVIII), adenovirus (ADV), and respiratory syncytial virus (RSV) were detected using direct immunofluorescence method. Epidemiological analysis was performed in terms of gender, age, and seasonal distribution.

Results: Among these 340 patients, viral pathogens were detected in 116 cases (34.12%), with the leading three viruses being RSV (16.18%; 55/340), FB (5.29%; 18/340), and FA (5.00%; 17/340). The positive rate was not significantly different between male (36.32%; 73/201) and female (31.65%; 44/139) patients (P>0.05). The positive rate was highest in the 0-1-year-old group (48.48%; 32/66) and in winter (42.72%; 44/103).

Conclusions: RSV is the most commonly detected respiratory virus in Wuxi. Infants aged 0-1 year should be a priority population during disease prevention and control. Respiratory infections among children are more common in winter.
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http://dx.doi.org/10.3978/j.issn.2305-5839.2015.10.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630556PMC
October 2015
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