Publications by authors named "Juan Valcárcel"

87Publications

RNA-binding proteins in human genetic disease.

Nat Rev Genet 2020 Nov 24. Epub 2020 Nov 24.

European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41576-020-00302-yDOI Listing
November 2020

Mutations primarily alter the inclusion of alternatively spliced exons.

Elife 2020 10 28;9. Epub 2020 Oct 28.

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.

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http://dx.doi.org/10.7554/eLife.59959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673789PMC
October 2020

Roles and mechanisms of alternative splicing in cancer - implications for care.

Nat Rev Clin Oncol 2020 08 17;17(8):457-474. Epub 2020 Apr 17.

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41571-020-0350-xDOI Listing
August 2020

Splicing Calls Back.

Cell 2019 12;179(7):1446-1447

Centre de Regulació Genòmica and Barcelona Institute of Science and Technology, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.11.028DOI Listing
December 2019

Site-Specific mRNA Cleavage for Selective and Quantitative Profiling of Alternative Splicing with Label-Free Optical Biosensors.

Anal Chem 2019 12 15;91(23):15138-15146. Epub 2019 Nov 15.

Nanobiosensors and Bioanalytical Applications Group , Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, BIST and CIBER-BBN , 08193 Bellaterra, Barcelona , Spain.

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http://dx.doi.org/10.1021/acs.analchem.9b03898DOI Listing
December 2019

Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns.

Nat Commun 2019 08 13;10(1):3639. Epub 2019 Aug 13.

Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Göttingen, Germany.

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http://dx.doi.org/10.1038/s41467-019-11293-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692369PMC
August 2019

Functional Network Analysis Reveals the Relevance of SKIIP in the Regulation of Alternative Splicing by p38 SAPK.

Cell Rep 2019 04;27(3):847-859.e6

Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484779PMC
April 2019

Combinatorial Genetics Reveals a Scaling Law for the Effects of Mutations on Splicing.

Cell 2019 01 17;176(3):549-563.e23. Epub 2019 Jan 17.

Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr Aiguader 88, 08003 Barcelona, Spain; Gene Regulation, Stem Cells and Cancer Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr Aiguader 88, 08003 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg. Lluís Companys 23, 08010 Barcelona, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183162
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http://dx.doi.org/10.1016/j.cell.2018.12.010DOI Listing
January 2019

Elisa Izaurralde 1959-2018.

Nat Struct Mol Biol 2018 07;25(7):547

President of the RNA Society, Center for Genomic Regulation, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41594-018-0081-1DOI Listing
July 2018

Molecular basis of differential 3' splice site sensitivity to anti-tumor drugs targeting U2 snRNP.

Nat Commun 2017 12 13;8(1):2100. Epub 2017 Dec 13.

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr Aiguader 88, 08003, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41467-017-02007-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727392PMC
December 2017

Sudemycin K: A Synthetic Antitumor Splicing Inhibitor Variant with Improved Activity and Versatile Chemistry.

ACS Chem Biol 2017 01 1;12(1):163-173. Epub 2016 Dec 1.

Institute for Research in Biomedicine (IRB-Barcelona) , Baldiri i Reixac 10, 08028, Barcelona, Spain.

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http://pubs.acs.org/doi/10.1021/acschembio.6b00562
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http://dx.doi.org/10.1021/acschembio.6b00562DOI Listing
January 2017

Viral cell biology: Influenza raids the splicing store.

Nat Microbiol 2016 06 24;1(7):16100. Epub 2016 Jun 24.

Centro Nacional de Biotecnología (CNB), Darwin 3, 28049 Madrid, Spain and CIBER de Enfermedades Respiratorias (ISCIII), Madrid, Spain.

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http://dx.doi.org/10.1038/nmicrobiol.2016.100DOI Listing
June 2016

Correction to: The Spliceosome: The Ultimate RNA Chaperone and Sculptor: [Trends in Biochemical Sciences, January 2016, Vol 41, No. 1, 33-45].

Trends Biochem Sci 2016 04 20;41(4):386. Epub 2016 Jan 20.

Centre de Regulació Genòmica, The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu-Fabra, Dr. Aiguader 88, 08003 Barcelona, Spain; ICREA, Passeig Lluis Companys 23, 08010 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2015.12.010DOI Listing
April 2016

Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks.

Genome Res 2016 06 13;26(6):732-44. Epub 2016 Apr 13.

Universitat Pompeu Fabra, E08003 Barcelona, Spain; Catalan Institution for Research and Advanced Studies, E08010 Barcelona, Spain.

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http://dx.doi.org/10.1101/gr.199935.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889968PMC
June 2016

The complete local genotype-phenotype landscape for the alternative splicing of a human exon.

Nat Commun 2016 05 10;7:11558. Epub 2016 May 10.

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr Aiguader 88, Barcelona 08003, Spain.

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http://dx.doi.org/10.1038/ncomms11558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866304PMC
May 2016

Erratum to: Promoter-like epigenetic signatures in exons displaying cell type-specific splicing.

Genome Biol 2016 Mar 18;17:52. Epub 2016 Mar 18.

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader, 88, Barcelona, 08003, Catalonia, Spain.

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http://dx.doi.org/10.1186/s13059-016-0890-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799591PMC
March 2016

Tumor suppressor properties of the splicing regulatory factor RBM10.

RNA Biol 2016 ;13(4):466-72

a Centre de Regulació Genòmica, The Barcelona Institute of Science and Technology , Dr. Aiguader 88, 08003 Barcelona , Spain.

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http://www.tandfonline.com/doi/full/10.1080/15476286.2016.11
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http://dx.doi.org/10.1080/15476286.2016.1144004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841610PMC
December 2016

The Spliceosome: The Ultimate RNA Chaperone and Sculptor.

Trends Biochem Sci 2016 Jan 9;41(1):33-45. Epub 2015 Dec 9.

Centre de Regulació Genòmica, The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu-Fabra, Dr. Aiguader 88, 08003 Barcelona, Spain; ICREA, Passeig Lluis Companys 23, 08010 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2015.11.003DOI Listing
January 2016

The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches.

EMBO Rep 2015 Dec 13;16(12):1640-55. Epub 2015 Nov 13.

Centre de Regulació Genòmica (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain Universitat Pompeu-Fabra, Barcelona, Spain Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

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http://dx.doi.org/10.15252/embr.201541116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693517PMC
December 2015

Promoter-like epigenetic signatures in exons displaying cell type-specific splicing.

Genome Biol 2015 Oct 23;16:236. Epub 2015 Oct 23.

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader, 88, 08003, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1186/s13059-015-0797-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619081PMC
October 2015

Role of six single nucleotide polymorphisms, risk factors in coronary disease, in OLR1 alternative splicing.

RNA 2015 Jun 22;21(6):1187-202. Epub 2015 Apr 22.

Centre de Regulació Genòmica, 08003 Barcelona, Spain Universitat Pompeu Fabra, 08003 Barcelona, Spain Institució Catalana de Recerca i Estudis Avançats, 08020 Barcelona, Spain.

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http://dx.doi.org/10.1261/rna.049890.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436670PMC
June 2015

RNA. Prescribing splicing.

Science 2015 Jan;347(6218):124-5

Center for Genomic Regulation, 08003 Barcelona, Spain. Universitat Pompeu Fabra, 08003 Barcelona, Spain. Institució Catalana de Recerca i Estudis Avançats, 08010 Barcelona, Spain.

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http://dx.doi.org/10.1126/science.aaa4864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772402PMC
January 2015

Functional splicing network reveals extensive regulatory potential of the core spliceosomal machinery.

Mol Cell 2015 Jan 4;57(1):7-22. Epub 2014 Dec 4.

Centre de Regulació Genòmica, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra, Dr. Aiguader 88, 08003 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats, Passeig Lluis Companys 23, 08010 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.10.030DOI Listing
January 2015

Genome-wide identification of Fas/CD95 alternative splicing regulators reveals links with iron homeostasis.

Mol Cell 2015 Jan 4;57(1):23-38. Epub 2014 Dec 4.

Centre de Regulació Genòmica, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra, Dr. Aiguader 88, 08003 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats, Pg Lluis Companys, 23, 08003 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.10.029DOI Listing
January 2015

Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells.

Proc Natl Acad Sci U S A 2014 Nov 13;111(44):15622-9. Epub 2014 Oct 13.

Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología, Biología Molecular y Celular, Instituto de Fisiología, Biología Molecular y Neurociencias-Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina;

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http://dx.doi.org/10.1073/pnas.1416858111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226100PMC
November 2014

Splicing together sister chromatids.

EMBO J 2014 Nov 29;33(22):2601-3. Epub 2014 Sep 29.

Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.15252/embj.201489988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282569PMC
November 2014

Co-option of the piRNA pathway for germline-specific alternative splicing of C. elegans TOR.

Cell Rep 2014 Sep 15;8(6):1609-1616. Epub 2014 Sep 15.

Gene Regulation, Stem Cells and Cancer Program, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra, Dr. Aiguader 88, 08003 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluis Companys 23, 08010 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.08.016DOI Listing
September 2014

Molecular biology. A splicing magic bullet.

Science 2014 Aug;345(6197):624-5

Centre de Regulació Genòmica, Dr. Aiguader 88, 08003 Barcelona, Spain. Universitat Pompeu Fabra, Dr. Aiguader 88, 08003 Barcelona, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg Lluis Companys 23, 08010, Barcelona, Spain.

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http://dx.doi.org/10.1126/science.1258444DOI Listing
August 2014

Regulation of FAS exon definition and apoptosis by the Ewing sarcoma protein.

Cell Rep 2014 May 10;7(4):1211-26. Epub 2014 May 10.

Centre for Genomic Regulation, carrer Doctor Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra, carrer Doctor Aiguader 88, 08003 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats, Pg Lluis Companys 23, 08010 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.03.077DOI Listing
May 2014

Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1.

Nucleic Acids Res 2014 May 25;42(9):5949-66. Epub 2014 Mar 25.

Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany Center for Integrated Protein Science Munich and Biomolecular NMR, Department Chemie Technische Universität München, Lichtenbergstraße 4, 85747 Garching, Germany

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http://dx.doi.org/10.1093/nar/gku193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027183PMC
May 2014

Synonymous mutations frequently act as driver mutations in human cancers.

Cell 2014 Mar;156(6):1324-1335

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation, Dr. Aiguader 88, 08003 Barcelona, Spain; Centre for Genomic Regulation, Universitat Pompeu Fabra, Barcelona 08003, Spain; Institució Catalana de Recerca i Estudis Avançats, Passeig Lluis Companys 23, 08010 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.01.051DOI Listing
March 2014

RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.

Mol Cell 2013 Dec;52(5):720-33

Centre de Regulació Genòmica, Dr. Aiguader, 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra, Dr. Aiguader, 88, 08003 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Dr. Aiguader, 88, 08003 Barcelona, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765130083
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http://dx.doi.org/10.1016/j.molcel.2013.11.010DOI Listing
December 2013

RNAtomy of the Spliceosome's heart.

EMBO J 2013 Oct 24;32(21):2785-7. Epub 2013 Sep 24.

1] Centre de Regulació Genòmica, Barcelona, Spain [2] Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1038/emboj.2013.213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817464PMC
October 2013

Competition by the masses.

Mol Cell 2013 Aug;51(3):279-80

Centre de Regulació Genòmica, Dr. Aiguader 88, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.molcel.2013.07.018DOI Listing
August 2013

Chromatin's thread to alternative splicing regulation.

Chromosoma 2013 Dec 3;122(6):465-74. Epub 2013 Aug 3.

Centre de Regulació Genòmica (CRG), Barcelona, Spain.

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http://dx.doi.org/10.1007/s00412-013-0425-xDOI Listing
December 2013

In vitro correction of a pseudoexon-generating deep intronic mutation in LGMD2A by antisense oligonucleotides and modified small nuclear RNAs.

Hum Mutat 2013 Oct 7;34(10):1387-95. Epub 2013 Aug 7.

Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain; Neuroscience Area, Health Research Institute Biodonostia, San Sebastian, Spain.

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http://dx.doi.org/10.1002/humu.22379DOI Listing
October 2013

Isolated pseudo-RNA-recognition motifs of SR proteins can regulate splicing using a noncanonical mode of RNA recognition.

Proc Natl Acad Sci U S A 2013 Jul 8;110(30):E2802-11. Epub 2013 Jul 8.

Institute for Molecular Biology and Biophysics, Swiss Federal Institute of Technology, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1073/pnas.1303445110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725064PMC
July 2013

CPEB1 coordinates alternative 3'-UTR formation with translational regulation.

Nature 2013 Mar 24;495(7439):121-5. Epub 2013 Feb 24.

Institute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1038/nature11901DOI Listing
March 2013

Evolution. Splicing in 4D.

Science 2012 Dec;338(6114):1547-8

Centre de Regulació Genòmica, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1126/science.1233219DOI Listing
December 2012

The spliceosome as a target of novel antitumour drugs.

Nat Rev Drug Discov 2012 Nov;11(11):847-59

Centre de Regulació Genòmica, Dr. Aiguader 88, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1038/nrd3823DOI Listing
November 2012

Alternative splicing and cancer.

J Nucleic Acids 2012 20;2012:363809. Epub 2012 May 20.

Inserm U1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Université de Lyon, 69008 Lyon, France.

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http://dx.doi.org/10.1155/2012/363809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364008PMC
August 2012

hnRNP A1 proofreads 3' splice site recognition by U2AF.

Mol Cell 2012 Feb;45(3):314-29

Centre de Regulació Genòmica, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra, Dr. Aiguader 88, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.molcel.2011.11.033DOI Listing
February 2012

Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF.

Nature 2011 Jul 13;475(7356):408-11. Epub 2011 Jul 13.

Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1038/nature10171DOI Listing
July 2011

A splicing mastermind for EMT.

EMBO J 2010 Oct;29(19):3217-8

Centre de Regulació Genòmica, Barcelona, Spain.

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http://dx.doi.org/10.1038/emboj.2010.234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957219PMC
October 2010

RNA processing: Redrawing the map of charted territory.

Mol Cell 2009 Dec;36(6):918-9

Centre de Regulació Genòmica, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.molcel.2009.12.004DOI Listing
December 2009

Nucleosome positioning as a determinant of exon recognition.

Nat Struct Mol Biol 2009 Sep;16(9):996-1001

Center for Genomic Regulation, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1038/nsmb.1658DOI Listing
September 2009

Decrypting the genome's alternative messages.

Curr Opin Cell Biol 2009 Jun 21;21(3):377-86. Epub 2009 Mar 21.

Centre de Regulació Genómica, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra, Dr. Aiguader 88, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.ceb.2009.02.006DOI Listing
June 2009

Global analysis of alternative splicing regulation by insulin and wingless signaling in Drosophila cells.

Genome Biol 2009 29;10(1):R11. Epub 2009 Jan 29.

Centre de Regulació Genòmica, Parc de Recerca Biomèdica de Barcelona, Dr Aiguader 88, Barcelona, Spain.

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http://genomebiology.biomedcentral.com/articles/10.1186/gb-2
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http://dx.doi.org/10.1186/gb-2009-10-1-r11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687788PMC
September 2009

Molecular biology: spliceosome meets telomerase.

Nature 2008 Dec;456(7224):879-80

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http://www.nature.com/doifinder/10.1038/456879a
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http://dx.doi.org/10.1038/456879aDOI Listing
December 2008

RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition.

Mol Cell 2008 Oct;32(1):81-95

Centre de Regulació Genòmica, Dr. Aigüader, 88 08003 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.molcel.2008.08.008DOI Listing
October 2008

Genome-wide analysis of alternative pre-mRNA splicing.

J Biol Chem 2008 Jan 16;283(3):1229-33. Epub 2007 Nov 16.

Centre de Regulació Genòmica, Dr. Aiguader 88, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1074/jbc.R700033200DOI Listing
January 2008

Powering a two-stroke RNA engine.

Nat Struct Mol Biol 2007 Jul;14(7):574-6

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http://www.nature.com/articles/nsmb0707-574
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http://dx.doi.org/10.1038/nsmb0707-574DOI Listing
July 2007

U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.

Nat Struct Mol Biol 2007 Jul 24;14(7):620-9. Epub 2007 Jun 24.

European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, D-69117 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nsmb1260DOI Listing
July 2007

Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein.

J Biol Chem 2007 Jul 8;282(27):19410-7. Epub 2007 May 8.

Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M700688200
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http://dx.doi.org/10.1074/jbc.M700688200DOI Listing
July 2007

Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing.

J Biol Chem 2007 Jan 29;282(3):1539-43. Epub 2006 Nov 29.

Centro de Biología Molecular "Severo Ochoa"-Universidad Autónoma de Madrid (CBMSO-UAM), Cantoblanco 28049 Madrid, Spain.

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http://www.jbc.org/lookup/doi/10.1074/jbc.C600198200
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http://dx.doi.org/10.1074/jbc.C600198200DOI Listing
January 2007

Unweaving the meanings of messenger RNA sequences.

Mol Cell 2006 Jul;23(2):150-1

Centre de Regulació Genòmica, Passeig Marítim 37-49, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.molcel.2006.07.003DOI Listing
July 2006

A simple principle to explain the evolution of pre-mRNA splicing.

Genes Dev 2006 Jul;20(13):1679-84

Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid, Cantoblanco 28049 Madrid, Spain.

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http://dx.doi.org/10.1101/gad.1449106DOI Listing
July 2006

Intron removal requires proofreading of U2AF/3' splice site recognition by DEK.

Science 2006 Jun;312(5782):1961-5

Centre de Regulació Genòmica, Passeig Marítim 37-49, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1126/science.1128659DOI Listing
June 2006

The expanding transcriptome: the genome as the 'Book of Sand'.

EMBO J 2006 Mar 2;25(5):923-31. Epub 2006 Mar 2.

Centre de Regulació Genòmica, Barcelona, Spain.

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http://dx.doi.org/10.1038/sj.emboj.7601023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1409726PMC
March 2006

Building specificity with nonspecific RNA-binding proteins.

Nat Struct Mol Biol 2005 Aug;12(8):645-53

Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado 80309, USA.

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http://dx.doi.org/10.1038/nsmb961DOI Listing
August 2005

Alternative splicing microarrays reveal functional expression of neuron-specific regulators in Hodgkin lymphoma cells.

J Biol Chem 2005 Feb 16;280(6):4779-84. Epub 2004 Nov 16.

European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

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http://dx.doi.org/10.1074/jbc.M411976200DOI Listing
February 2005

Regulation of alternative pre-mRNA splicing.

Brief Funct Genomic Proteomic 2002 Oct;1(3):266-77

European Molecular Biology Laboratory, Heidelberg, Germany.

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http://dx.doi.org/10.1093/bfgp/1.3.266DOI Listing
October 2002

Diversity of vertebrate splicing factor U2AF35: identification of alternatively spliced U2AF1 mRNAS.

J Biol Chem 2004 Jun 19;279(26):27039-49. Epub 2004 Apr 19.

Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, 1649-028 Lisbon, Portugal.

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http://dx.doi.org/10.1074/jbc.M402136200DOI Listing
June 2004

The conserved RNA recognition motif 3 of U2 snRNA auxiliary factor (U2AF 65) is essential in vivo but dispensable for activity in vitro.

RNA 2004 Feb;10(2):240-53

Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado 80309, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370536PMC
http://dx.doi.org/10.1261/rna.5153204DOI Listing
February 2004

U2 small nuclear ribonucleoprotein particle (snRNP) auxiliary factor of 65 kDa, U2AF65, can promote U1 snRNP recruitment to 5' splice sites.

Biochem J 2003 May;372(Pt 1):235-40

Gene Expression Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

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http://dx.doi.org/10.1042/BJ20021202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223361PMC
May 2003

Getting to the heart of a splicing enhancer.

Nat Struct Biol 2003 Jan;10(1):6-7

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http://www.nature.com/doifinder/10.1038/nsb0103-6
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January 2003

The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites.

EMBO J 2002 Dec;21(24):6882-92

Gene Expression Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC139089PMC
http://dx.doi.org/10.1093/emboj/cdf668DOI Listing
December 2002

Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1-associated proteins in alternative pre-mRNA splicing.

J Biol Chem 2003 Jan 19;278(5):3040-7. Epub 2002 Nov 19.

Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany.

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http://dx.doi.org/10.1074/jbc.M210737200DOI Listing
January 2003

Optimization of oligonucleotide-based DNA microarrays.

Nucleic Acids Res 2002 Jun;30(11):e51

Gene Expression Programme and Functional Genomics Technology and Instrumentation Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC117213PMC
http://dx.doi.org/10.1093/nar/30.11.e51DOI Listing
June 2002

Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45.

Cell 2002 May;109(3):285-96

Gene Expression Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117, Heidelberg, Germany.

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http://dx.doi.org/10.1016/s0092-8674(02)00730-4DOI Listing
May 2002

Alternative splicing and genome complexity.

Nat Genet 2002 Jan 17;30(1):29-30. Epub 2001 Dec 17.

Max Delbrück Center for Molecular Medicine, Robert-Rössle Strasse 10, Berlin-Buch, 13125 Germany.

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http://www.nature.com/doifinder/10.1038/ng803
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January 2002