Publications by authors named "Juan Lafaille"

66Publications

Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy.

Cell 2020 Aug 1;182(3):641-654.e20. Epub 2020 Jul 1.

The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA; Howard Hughes Medical Institute, New York, NY, USA; Department of Pathology, New York University School of Medicine, New York, NY, USA. Electronic address:

View Article and Find Full Text PDF
August 2020

Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression.

Circ Res 2020 Jul 27;127(3):335-353. Epub 2020 Apr 27.

From the Leon H. Charney Division of Cardiology, Department of Medicine (M. Sharma, M.P.S., M.S.A., E.J.B., K.R., A.W., E.M.C., C.v.S., G.J.K., L.C.S., L.B., D.P., E.A.F., K.J.M.), New York University Grossman School of Medicine.

View Article and Find Full Text PDF
July 2020

P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice.

Nat Commun 2020 04 14;11(1):1784. Epub 2020 Apr 14.

Department of Anesthesiology, Columbia University Medical Center, New York, NY, 10032, USA.

View Article and Find Full Text PDF
April 2020

Route of Antigen Presentation Can Determine the Selection of Foxp3-Dependent or Foxp3-Independent Dominant Immune Tolerance.

J Immunol 2018 01 22;200(1):101-109. Epub 2017 Nov 22.

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal;

View Article and Find Full Text PDF
January 2018

CX3CR1 monocytes modulate learning and learning-dependent dendritic spine remodeling via TNF-α.

Nat Med 2017 Jun 15;23(6):714-722. Epub 2017 May 15.

Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University (NYU) School of Medicine, New York, New York, USA.

View Article and Find Full Text PDF
June 2017

Increased generation of Foxp3(+) regulatory T cells by manipulating antigen presentation in the thymus.

Nat Commun 2016 Feb 29;7:10562. Epub 2016 Feb 29.

Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA.

View Article and Find Full Text PDF
February 2016

Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination.

Nature 2015 Oct 30;526(7573):448-52. Epub 2015 Sep 30.

New York University Neuroscience Institute, Department of Neuroscience and Physiology, New York University School of Medicine, New York, New York 10016, USA.

View Article and Find Full Text PDF
October 2015

Reaginic antibodies.

Curr Top Microbiol Immunol 2015 ;388:v-vii

View Article and Find Full Text PDF
April 2015

Biology of IgE production: IgE cell differentiation and the memory of IgE responses.

Curr Top Microbiol Immunol 2015 ;388:1-19

Singapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.

View Article and Find Full Text PDF
April 2015

PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner.

Sci Rep 2014 Nov 12;4:7023. Epub 2014 Nov 12.

1] Department of Orthopaedic Surgery, New York University Medical Center, New York, NY, 10003 [2] Department of Cell Biology, New York University School of Medicine, New York, NY 10016.

View Article and Find Full Text PDF
November 2014

Focused specificity of intestinal TH17 cells towards commensal bacterial antigens.

Nature 2014 Jun 13;510(7503):152-6. Epub 2014 Apr 13.

1] The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA [2] Howard Hughes Medical Institute, New York University School of Medicine, New York, New York 10016, USA.

View Article and Find Full Text PDF
June 2014

Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells.

PLoS One 2013 27;8(12):e84841. Epub 2013 Dec 27.

Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, New York, United States of America ; Department of Pathology, New York University School of Medicine, New York, New York, United States of America.

View Article and Find Full Text PDF
February 2015

Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.

Cell 2013 Dec;155(7):1596-609

Molecular Neurobiology Program, The Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA. Electronic address:

View Article and Find Full Text PDF
December 2013

Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10.

Blood 2013 May 26;121(19):3936-45, S1. Epub 2013 Mar 26.

Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.

View Article and Find Full Text PDF
May 2013

The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate.

Cell Rep 2012 Nov 25;2(5):1104-10. Epub 2012 Oct 25.

Program in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.

View Article and Find Full Text PDF
November 2012

What is unique about the IgE response?

Adv Immunol 2012 ;116:113-41

Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, USA.

View Article and Find Full Text PDF
January 2013

On the differentiation of mouse IgE⁺ cells.

Nat Immunol 2012 Jun 19;13(7):623; author reply 623-4. Epub 2012 Jun 19.

View Article and Find Full Text PDF
June 2012

Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function.

Proc Natl Acad Sci U S A 2012 Jan 17;109(5):1625-30. Epub 2012 Jan 17.

Molecular Pathogenesis Program, Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.

View Article and Find Full Text PDF
January 2012

Sequential class switching is required for the generation of high affinity IgE antibodies.

J Exp Med 2012 Feb 16;209(2):353-64. Epub 2012 Jan 16.

Skirball Institute of Biomolecular Medicine, The Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, NY 10016, USA.

View Article and Find Full Text PDF
February 2012

Induced CD4+Foxp3+ regulatory T cells in immune tolerance.

Annu Rev Immunol 2012 6;30:733-58. Epub 2012 Jan 6.

Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

View Article and Find Full Text PDF
July 2012

It takes two to tango.

Immunity 2011 Jul;35(1):6-8

Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

View Article and Find Full Text PDF
July 2011

Lipid phosphate phosphatase 3 enables efficient thymic egress.

J Exp Med 2011 Jun 16;208(6):1267-78. Epub 2011 May 16.

Program in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.

View Article and Find Full Text PDF
June 2011

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity.

Nature 2011 Apr 27;472(7344):486-90. Epub 2011 Mar 27.

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA.

View Article and Find Full Text PDF
April 2011

Can TNF-α boost regulatory T cells?

J Clin Invest 2010 Dec 22;120(12):4190-2. Epub 2010 Nov 22.

Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Pathology, New York University School of Medicine, New York, New York, USA.

View Article and Find Full Text PDF
December 2010

Mechanisms of tolerance and allergic sensitization in the airways and the lungs.

Curr Opin Immunol 2010 Oct 29;22(5):616-22. Epub 2010 Sep 29.

Singapore Immunology Network (SIgN), 8A Biomedical Grove, #4-06 Immunos, Singapore 138648, Singapore.

View Article and Find Full Text PDF
October 2010

Protein kinase C-theta mediates negative feedback on regulatory T cell function.

Science 2010 Apr 25;328(5976):372-6. Epub 2010 Mar 25.

Molecular Pathogenesis Program, Helen and Martin Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.

View Article and Find Full Text PDF
April 2010

Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites.

J Immunol Methods 2010 Jan 2;352(1-2):89-100. Epub 2009 Oct 2.

Helen L. and Martin S. Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.

View Article and Find Full Text PDF
January 2010

TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes.

J Exp Med 2009 Sep 8;206(10):2121-30. Epub 2009 Sep 8.

Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.

View Article and Find Full Text PDF
September 2009

Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?

Immunity 2009 May;30(5):626-35

Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, and Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.

View Article and Find Full Text PDF
May 2009

Swift entry of myelin-specific T lymphocytes into the central nervous system in spontaneous autoimmune encephalomyelitis.

J Immunol 2008 Oct;181(7):4648-55

Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

View Article and Find Full Text PDF
October 2008

Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation.

Immunity 2008 Jul;29(1):114-26

Program of Molecular Pathogenesis, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

View Article and Find Full Text PDF
July 2008

Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells.

Nat Med 2008 Feb 3;14(2):162-9. Epub 2008 Feb 3.

Molecular Pathogenesis Program and Skirball Institute for Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA.

View Article and Find Full Text PDF
February 2008

Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells.

Blood 2007 Nov 12;110(9):3218-25. Epub 2007 Jul 12.

Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 1st Avenue, New York, NY 10016, USA.

View Article and Find Full Text PDF
November 2007

Unique maturation program of the IgE response in vivo.

Immunity 2007 Feb 8;26(2):191-203. Epub 2007 Feb 8.

Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.

View Article and Find Full Text PDF
February 2007

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.

Cell 2006 Sep;126(6):1121-33

Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.

View Article and Find Full Text PDF
September 2006

Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo.

J Exp Med 2006 Mar 13;203(3):505-11. Epub 2006 Mar 13.

Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.

View Article and Find Full Text PDF
March 2006

Control of homeostatic proliferation by regulatory T cells.

J Clin Invest 2005 Dec 17;115(12):3517-26. Epub 2005 Nov 17.

Molecular Pathogenesis Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.

View Article and Find Full Text PDF
December 2005

Latent TGF-beta1-transduced CD4+ T cells suppress the progression of allergic encephalomyelitis.

J Leukoc Biol 2006 Jan 21;79(1):140-6. Epub 2005 Oct 21.

Department of Pathology, NYU Cancer Institute, School of Medicine, New York, NY, USA.

View Article and Find Full Text PDF
January 2006

Do regulatory T cells play a role in the control of homeostatic proliferation?

Int Rev Immunol 2005 May-Aug;24(3-4):269-84

Molecular Pathogenesis Progam, Skirball Institute of Biomolecular Medicine, and Department of Pathology, New York University School of Medicine, New York 10016, USA.

View Article and Find Full Text PDF
October 2005

Oral tolerance in the absence of naturally occurring Tregs.

J Clin Invest 2005 Jul 2;115(7):1923-33. Epub 2005 Jun 2.

Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.

View Article and Find Full Text PDF
July 2005

Immune regulatory mechanisms influence early pathology in spinal cord injury and in spontaneous autoimmune encephalomyelitis.

Am J Pathol 2005 Jun;166(6):1749-60

Program of Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, USA.

View Article and Find Full Text PDF
June 2005

IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis.

J Immunol 2005 Feb;174(3):1416-23

Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA.

View Article and Find Full Text PDF
February 2005

CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion.

J Immunol 2004 Dec;173(12):7259-68

Molecular Pathogenesis Program, Skirball Institute, and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.

View Article and Find Full Text PDF
December 2004

The role of regulatory T cells in allergy.

Springer Semin Immunopathol 2004 Feb 22;25(3-4):295-310. Epub 2003 Oct 22.

Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University School of Medicine, NY 10016, USA.

View Article and Find Full Text PDF
February 2004

T-cell receptor transgenic mice in the study of autoimmune diseases.

Authors:
Juan J Lafaille

J Autoimmun 2004 Mar;22(2):95-106

Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.

View Article and Find Full Text PDF
March 2004

Early self-regulatory mechanisms control the magnitude of CD8+ T cell responses against liver stages of murine malaria.

J Immunol 2003 Jul;171(2):964-70

Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY 10010, USA.

View Article and Find Full Text PDF
July 2003

CD4(+) regulatory T cells in autoimmunity and allergy.

Curr Opin Immunol 2002 Dec;14(6):771-8

Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, and Department of Pathology New York University School of Medicine, New York, NY 10016, USA.

View Article and Find Full Text PDF
December 2002

A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions.

Nat Genet 2002 Nov 30;32(3):411-4. Epub 2002 Sep 30.

Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

View Article and Find Full Text PDF
November 2002

Interleukin 2 signaling is required for CD4(+) regulatory T cell function.

J Exp Med 2002 Sep;196(6):851-7

Program of Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.

View Article and Find Full Text PDF
September 2002