Publications by authors named "Juan David Roa"

3 Publications

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Worldwide epidemiology of neuro-coronavirus disease in children: lessons for the next pandemic.

Curr Opin Pediatr 2021 12;33(6):580-590

Division of Pediatric Critical Care Medicine, UPMC Children's Hospital of Pittsburgh.

Purpose Of Review: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has overwhelmed the global community, negatively impacting patient health and research efforts; associated neurological manifestations are a significant cause of morbidity. This review outlines the worldwide epidemiology of neurologic manifestations of different SARS-CoV-2 clinical pediatric phenotypes, including acute coronavirus disease 2019 (COVID-19), multisystem inflammatory syndrome in children (MIS-C) and postacute sequelae of COVID-19 (PASC). We discuss strategies to develop adaptive global research platforms for future investigation into emerging pediatric neurologic conditions.

Recent Findings: Multicenter, multinational studies show that neurological manifestations of acute COVID-19, such as smell/taste disorders, headache, and stroke, are common in hospitalized adults (82%) and children (22%), associated with increased mortality in adults. Neurological manifestations of MIS-C are reported in up to 20% of children, including headache, irritability, and encephalopathy. Data on PASC are emerging and include fatigue, cognitive changes, and headache. Reports of neurological manifestations in each phenotype are limited by lack of pediatric-informed case definitions, common data elements, and resources.

Summary: Coordinated, well resourced, multinational investigation into SARS-CoV-2-related neurological manifestations in children is critical to rapid identification of global and region-specific risk factors, and developing treatment and mitigation strategies for the current pandemic and future health neurologic emergencies.
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http://dx.doi.org/10.1097/MOP.0000000000001069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571058PMC
December 2021

COVID-19 and the Pediatric Nervous System: Global Collaboration to Meet a Global Need.

Neurocrit Care 2021 10 28;35(2):283-290. Epub 2021 Jun 28.

Division of Pediatric Critical Care Medicine, Department of Pediatric Neurology and Critical Care, and Safar Center for Resuscitation Research, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

The coronavirus disease 2019 (COVID-19) pandemic has affected mortality and morbidity across all ages, including children. It is now known that neurological manifestations of COVID-19, ranging from headaches to stroke, may involve the central and/or peripheral nervous system at any age. Neurologic involvement is also noted in the multisystem inflammatory syndrome in children, a pediatric condition that occurs weeks after infection with the causative virus of COVID-19, severe acute respiratory syndrome coronavirus 2. Knowledge about mechanisms of neurologic disease is scarce but rapidly growing. COVID-19 neurologic manifestations may have particularly adverse impacts on the developing brain. Emerging data suggest a cohort of patients with COVID-19 will have longitudinal illness affecting their cognitive, physical, and emotional health, but little is known about the long-term impact on affected children and their families. Pediatric collaboratives have begun to provide important initial information on neuroimaging manifestations and the incidence of ischemic stroke in children with COVID 19. The Global Consortium Study of Neurologic Dysfunction in COVID-19-Pediatrics, a multinational collaborative, is working to improve understanding of the epidemiology, mechanisms of neurological manifestations, and the long-term implications of COVID-19 in children and their families.
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http://dx.doi.org/10.1007/s12028-021-01269-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238033PMC
October 2021

[The Moral Deliberation: The Clinical Ethics Method. Presentation of a Paediatric Case].

Rev Colomb Psiquiatr 2016 Jul-Sep;45(3):224-7. Epub 2015 Oct 23.

Trabajadora Social, Hospital de San José, Bogotá, Colombia.

Decision-making is one of the most difficult tasks of medical judgment, especially when cases involve paediatric patients with different cultural characteristics. It is the obligation of clinical ethics, taking the interdisciplinary approach as a tool to comprehensively analyse the clinical, social, cultural and legal aspects, among other topics, when choosing the treatment options that will be more beneficial for the patient. A clinical case, should enable this process of analysis and teamwork to be understood in practical way in order to address difficult medical problems.
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http://dx.doi.org/10.1016/j.rcp.2015.09.004DOI Listing
April 2017
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