Publications

Activation of sodium channel by a novel α-scorpion toxin, BmK NT2, stimulates ERK1/2 and CERB phosphorylation through a Ca(2+) dependent pathway in neocortical neurons.
Int J Biol Macromol 2017 Nov 4;104(Pt A):70-77. Epub 2017 Jun 4.
Jiangsu Provincial Key laboratory for TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China. Electronic address:

Modified carbon fiber/magnetic graphene/epoxy composites with synergistic effect for electromagnetic interference shielding over broad frequency band.
J Colloid Interface Sci 2017 Nov 6;506:217-226. Epub 2017 Jul 6.
Shandong Provincial Key Laboratory of Preparation and Measurement of Building Materials, University of Jinan, Jinan 250022, PR China; School of Material Science and Engineering, University of Jinan, Jinan 250022, PR China.


Critical Care Resources in Guangdong Province of China: Three Surveys from 2005 to 2015.
Crit Care Med 2017 Sep 8. Epub 2017 Sep 8.
1Department of Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China. 2Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong, China. 3Department of Critical Care Medicine, The Second People's Hospital of Shenzhen, Shenzhen, Guangdong, China. 4Department of Critical Care Medicine, Donghua Hospital, Dongguan, Guangdong, China. 5Department of Critical Care Medicine, The First People's Hospital of Foshan, Foshan, Guangdong, China. 6Department of Critical Care Medicine, People's Hospital of Maoming, Maoming, Guangdong, China. 7Department of Critical Care Medicine, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, Guangdong, China. 8Department of Critical Care Medicine, People's Hospital of Qingyuan, Qingyuan, Guangdong, China. 9Department of Critical Care Medicine,The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, China. 10Department of Critical Care Medicine, Central Hospital of Huizhou, Huizhou, Guangdong, China. 11Department of Critical Care Medicine, People's Hospital of Yuebei, Shaoguan, Guangdong, China. 12Department of Emergency and Critical Care Medicine, The Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China. 13Department of Critical Care Medicine, Central Hospital of Jiangmen, Jiangmen, Guangdong, China. 14Department of Emergency and Critical Care Medicine, The Second Affiliated Hospital of Shantou University, Shantou, Guangdong, China. 15Department of Critical Care Medicine, People's Hospital of Jieyang, Jieyang, Guangdong, China. 16Department of Critical Care Medicine, People's Hospital of Yangjiang, Yangjiang, Guangdong, China. 17Department of Critical Care Medicine, People's Hospital of Meizhou, Meizhou, Guangdong, China. 18Department of Critical Care Medicine, The People's Hospital of Zhuhai, Zhuhai, Guangdong, China. 19Department of Critical Care Medicine, People's Hospital of Yunfu, Yunfu, Guangdong, China. 20Department of Internal Medicine, Pengpai Memorial Hospital, Shanwei, Guangdong, China. 21Department of Internal Medicine, Central Hospital of Chaozhou, Chaozhou, Guangdong, China. 22Department of Critical Care Medicine, People's Hospital of Heyuan, Heyuan, Guangdong, China.

Tetrabromoethylcyclohexane affects gonadal differentiation and development in the frog Pelophylax nigromaculatus.
Aquat Toxicol 2017 Sep 9;192:40-47. Epub 2017 Sep 9.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

Corrigendum to "Magnetic graphene solid-phase extraction for the determination of carbamate pesticides in tomatoes coupled with high performance liquid chromatography [TAL 141 212-219]".
Talanta 2017 Aug;170:569
Key Laboratory of Chemistry of Northwestern Plant Resources of the CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, People's Republic of China.

Iritectol G, a novel iridal-type triterpenoid from Iris tectorum displays anti-epileptic activity in vitro through inhibition of sodium channels.
Fitoterapia 2017 Aug 12;122:20-25. Epub 2017 Aug 12.
State Key Laboratory of Natural Medicines & Jiangsu Provincial Key laboratory for TCM Evaluation and Translational Development, China Pharmaceutical University, Nanjing, Jiangsu 211198, China. Electronic address:

Genomic and transcriptomic analyses reveal differential regulation of diverse terpenoid and polyketides secondary metabolites in Hericium erinaceus.
Sci Rep 2017 Aug 31;7(1):10151. Epub 2017 Aug 31.
Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100193, P. R. China.

Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway.
J Ethnopharmacol 2017 Jul 24;206:160-169. Epub 2017 May 24.
Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China; Key Laboratory of New Drug Delivery System of Chinese Material Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing, Jiangsu, 210028, China. Electronic address:

N-Desmethyldauricine Induces Autophagic Cell Death in Apoptosis-Defective Cells via Ca(2+) Mobilization.
Front Pharmacol 2017 16;8:388. Epub 2017 Jun 16.
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and TechnologyMacau, China.

Efficacy and safety of SOX chemotherapy with or without surgery in AFP-producing advanced gastric cancer.
Oncol Lett 2017 Jul 24;14(1):579-586. Epub 2017 May 24.
Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated, Shandong University, Jinan, Shandong 250021, P.R. China.

A phase I study to investigate the metabolism, excretion, and pharmacokinetics of [(14)C]fruquintinib, a novel oral selective VEGFR inhibitor, in healthy Chinese male volunteers.
Cancer Chemother Pharmacol 2017 Jul 20. Epub 2017 Jul 20.
Phase I Clinical Trial Unit, The First Affiliated Hospital with Nanjing Medical University, #300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.

The ROS-mediated activation of IL-6/STAT3 signaling pathway is involved in the 27-hydroxycholesterol-induced cellular senescence in nerve cells.
Toxicol In Vitro 2017 Jul 22;45(Pt 1):10-18. Epub 2017 Jul 22.
Department of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University, Nanjing 211166, China. Electronic address:

iTRAQ and RNA-Seq Analyses Provide New Insights into Regulation Mechanism of Symbiotic Germination of Dendrobium officinale Seeds (Orchidaceae).
J Proteome Res 2017 Jun 17;16(6):2174-2187. Epub 2017 May 17.
Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100193, P. R. China.


A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury.
Sci Rep 2017 Jun 15;7(1):3575. Epub 2017 Jun 15.
Department of Physiology, Collaborative Innovation Center for Brain Science, School of Basic Medical Sciences, School of Medicine, Wuhan University, 185 Donghu Street, Wuhan, Hubei, 430071, China.

Berberine Ameliorates Diabetes-Associated Cognitive Decline through Modulation of Aberrant Inflammation Response and Insulin Signaling Pathway in DM Rats.
Front Pharmacol 2017 6;8:334. Epub 2017 Jun 6.
Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.

Pharmacokinetics of ginkgolides A, B and K after single and multiple intravenous infusions and their interactions with midazolam in healthy Chinese male subjects.
Eur J Clin Pharmacol 2017 May 20;73(5):537-546. Epub 2017 Jan 20.
State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Pharmaceutical CO. LTD, Lianyungang, Jiangsu, 222001, China.

Paeoniflorin ameliorates AGEs-induced mesangial cell injury through inhibiting RAGE/mTOR/autophagy pathway.
Biomed Pharmacother 2017 May 18;89:1362-1369. Epub 2017 Mar 18.
Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Jiangsu, Nanjing, 210028, PR China; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu, Nanjing, 210028, PR China.

All-trans retinoic acid and arsenic trioxide fail to derepress the monocytic differentiation driver Irf8 in acute promyelocytic leukemia cells.
Cell Death Dis 2017 May 11;8(5):e2782. Epub 2017 May 11.
State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

LncRNA-AF113014 promotes the expression of Egr2 by interaction with miR-20a to inhibit proliferation of hepatocellular carcinoma cells.
PLoS One 2017 19;12(5):e0177843. Epub 2017 May 19.
Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Bisperoxovandium (pyridin-2-squaramide) targets both PTEN and ERK1/2 to confer neuroprotection.
Br J Pharmacol 2017 Apr 27;174(8):641-656. Epub 2017 Feb 27.
Department of Physiology, Collaborative Innovation Center for Brain Science, School of Basic Medical Sciences, Wuhan University School of Medicine, Wuhan, China.

Deacetylation of Ku70 by SIRT6 attenuates Bax-mediated apoptosis in hepatocellular carcinoma.
Biochem Biophys Res Commun 2017 Apr 24;485(4):713-719. Epub 2017 Feb 24.
The Second Affiliated Hospital and the Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing, China. Electronic address:

27-Hydroxycholesterol induces invasion and migration of breast cancer cells by increasing MMP9 and generating EMT through activation of STAT-3.
Environ Toxicol Pharmacol 2017 Apr 10;51:1-8. Epub 2017 Feb 10.
Department of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University, Nanjing 211166, China; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China. Electronic address:

Alisol A 24-Acetate and Alisol B 23-Acetate Induced Autophagy Mediates Apoptosis and Nephrotoxicity in Human Renal Proximal Tubular Cells.
Front Pharmacol 2017 31;8:172. Epub 2017 Mar 31.
Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Province Academy of Traditional Chinese MedicineNanjing, China.

Regulation of different components from Ophiopogon japonicus on autophagy in human lung adenocarcinoma A549Cells through PI3K/Akt/mTOR signaling pathway.
Biomed Pharmacother 2017 Mar 31;87:118-126. Epub 2016 Dec 31.
Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing, Jiangsu 210028, China; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, China. Electronic address:

Screening of enzyme inhibitors from traditional Chinese medicine by magnetic immobilized α-glucosidase coupled with capillary electrophoresis.
Talanta 2017 Mar 13;164:548-555. Epub 2016 Dec 13.
Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, People's Republic of China. Electronic address:

Melatonin Mediates Protective Effects against Kainic Acid-Induced Neuronal Death through Safeguarding ER Stress and Mitochondrial Disturbance.
Front Mol Neurosci 2017 28;10:49. Epub 2017 Feb 28.
Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China; Institute for Brain Research, Huazhong University of Science and TechnologyWuhan, China.

Components of Goutengsan in Rat Plasma by Microdialysis Sampling and Its Protection on Aβ1-42-Induced PC12 Cells Injury.
Evid Based Complement Alternat Med 2017 2;2017:7593027. Epub 2017 Mar 2.
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Shi Zi Street No. 100, Hongshan Road, Jiangsu, Nanjing 210028, China; Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Shi Zi Street No. 100, Hongshan Road, Jiangsu, Nanjing 210028, China; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.

Getting a grip on reality: Grasping movements directed to real objects and images rely on dissociable neural representations.
Cortex 2017 Mar 18. Epub 2017 Mar 18.
The Brain and Mind Institute, University of Western Ontario, London, ON, Canada; Graduate Program in Neuroscience, University of Western Ontario, London ON Canada; Department of Psychology, University of Western Ontario, London ON, Canada. Electronic address:

Effects of Perfluorooctane sulfonate on immobilization, heartbeat, reproductive and biochemical performance of Daphnia magna.
Chemosphere 2017 Feb 7;168:1613-1618. Epub 2016 Dec 7.
State Key Laboratory of Urban and Regional Ecology, Research Centre for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; University of Chinese Academy of Sciences, Beijing, 100049, China.

Californium-252 neutron brachytherapy combined with external pelvic radiotherapy plus concurrent chemotherapy for cervical cancer: a retrospective clinical study.
Chin J Cancer 2017 Feb 28;36(1):24. Epub 2017 Feb 28.
Department of Oncology, Armed Police Hospital of Guangdong Affiliated with Guangzhou Medical University, No. 268 of Yanling Road, Tianhe District, Guangzhou, 510507, Guangdong, P. R. China.

Magnetic polyethyleneimine functionalized reduced graphene oxide as a novel magnetic solid-phase extraction adsorbent for the determination of polar acidic herbicides in rice.
Anal Chim Acta 2017 Jan 11;949:23-34. Epub 2016 Nov 11.
Key Laboratory of Chemistry of Northwestern Plant Resources of the CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, PR China. Electronic address:

Anti-inflammatory effect of miltirone on inflammatory bowel disease via TLR4/NF-κB/IQGAP2 signaling pathway.
Biomed Pharmacother 2017 Jan 27;85:531-540. Epub 2016 Nov 27.
Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Jiangsu, Nanjing 210028, PR China; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, PR China. Electronic address:

The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol-induced angiogenesis in human breast cancer cells.
Toxicol Lett 2016 Dec 14;264:79-86. Epub 2016 Nov 14.
Department of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. Electronic address:

A three-dimensional graphene oxide supramolecular hydrogel for infrared light-responsive cascade release of two anticancer drugs.
Chem Commun (Camb) 2016 Dec;52(100):14384-14387
Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. China.

Postnatal activation of TLR4 in astrocytes promotes excitatory synaptogenesis in hippocampal neurons.
J Cell Biol 2016 Dec 10;215(5):719-734. Epub 2016 Nov 10.
Department of Neurobiology, Institute of Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang University School of Medicine, Hangzhou, 310058, China


Antioxidative response of Kandelia obovata, a true mangrove species, to polybrominated diphenyl ethers (BDE-99 and BDE-209) during germination and early growth.
Mar Pollut Bull 2016 Dec 26. Epub 2016 Dec 26.
Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China; State Key Laboratory in Marine Pollution, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China. Electronic address:

Vertical distribution of dehalogenating bacteria in mangrove sediment and their potential to remove polybrominated diphenyl ether contamination.
Mar Pollut Bull 2016 Dec 26. Epub 2016 Dec 26.
Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China; State Key Laboratory in Marine Pollution, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China. Electronic address:

TGF-β1 along with other platelet contents augments Treg cells to suppress anti-FVIII immune responses in hemophilia A mice.
Blood Adv 2016 Dec;1(2):139-151
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI; Children's Research Institute, Children's Hospital of Wisconsin, Milwaukee, WI; Midwest Athletes Against Childhood Cancer Fund Research Center, Milwaukee, WI; Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI.

Glycine Potentiates AMPA Receptor Function through Metabotropic Activation of GluN2A-Containing NMDA Receptors.
Front Mol Neurosci 2016 19;9:102. Epub 2016 Oct 19.
Department of Physiology, Toronto Western Research Institute, School of Medicine, University of TorontoToronto, Canada; Department of Physiology and Cell Biology, University of Nevada School of MedicineReno, NV, USA; Department of Neurosurgery, Zhongnan Hospital, Wuhan University School of MedicineWuhan, China; Department of Physiology, School of Basic Medical Sciences, Wuhan University School of MedicineWuhan, China.

In Vitro Differentiation of Bone Marrow Mesenchymal Stem Cells into Neuron-Like Cells by Cerebrospinal Fluid Improves Motor Function of Middle Cerebral Artery Occlusion Rats.
Front Neurol 2016 27;7:183. Epub 2016 Oct 27.
Jiangsu Province Key Laboratory of Anesthesiology, Institute of Emergency Rescue Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, China; Emergency Center, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

Wnt5a Increases Properties of Lung Cancer Stem Cells and Resistance to Cisplatin through Activation of Wnt5a/PKC Signaling Pathway.
Stem Cells Int 2016 8;2016:1690896. Epub 2016 Nov 8.
College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, China; Human Stem Cell Institute of General Hospital, Ningxia Medical University, Yinchuan, Ningxia 750004, China.

Leaf miner-induced morphological, physiological and molecular changes in mangrove plant Avicennia marina (Forsk.) Vierh.
Tree Physiol 2017 01;37(1):82-97
Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of the Environment and Ecology, Xiamen University, Xiamen, Fujian, P.R. China.

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