Publications by authors named "Jualang Azlan Gansau"

4 Publications

  • Page 1 of 1

Review of and : A High Potential Supplement.

Molecules 2021 Nov 19;26(22). Epub 2021 Nov 19.

Faculty of Science and Natural Resources, Universiti Malaysia Sabah, UMS Road, Kota Kinabalu 88400, Sabah, Malaysia.

() and () are tropical fruits that gain popularity worldwide due to their tastiness. Currently, their potential to be used as pharmaceutical agents is underestimated. Chronic diseases such as cancer, diabetes and aging have high incidence rates in the modern world. Furthermore, pharmaceutical agents targeting pathogenic microorganisms have been hampered by the growing of antimicrobial resistance threats. The idea of food therapy leads to extensive nutraceuticals research on the potential of exotic fruits such as and to act as supplements. Phytochemicals such as phenolic compounds that present in the fruit act as potent antioxidants that contribute to the protective effects against diseases induced by oxidative stress. Fruit residuals such as the peel and seeds hold greater nutraceutical potential than the edible part. This review highlights the antioxidant and biological activities (anti-neoplastic, anti-microbial, hypoglycemic actions and anti-aging), and chemical contents of different parts of and . These fruits contain a diverse and important chemical profile that can alleviate or cure diseases.
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http://dx.doi.org/10.3390/molecules26227005DOI Listing
November 2021

A Review: Underutilized plant of Sabah and Its Potential Value.

Curr Pharm Biotechnol 2021 Feb 8. Epub 2021 Feb 8.

Faculty of Science and Natural Resources, University Malaysia Sabah, Jalan UMS, 88400, Kota Kinabalu, Sabah, . Malaysia.

Underutilized plants are referred to a plant species which their potential is not fully utilized yet and they are usually found abundantly in certain local area but globally rare. Sabah is known for a high biodiversity and contains many underutilized plants. To our knowledge, this is the first review is to provide an overview information of medicinal value and pharmacological properties of underutilized plant in Sabah. Extract and metabolites in different part of several underutilized plant contains multiple beneficial bioactive compounds and exploitation of these compounds was supported by additional data which plays various biological activities including anti-atherosclerotic, anti-cancer, antihypercholesterolemic and anti-ulcerogenic. A handful of pharmacological studies on the natural product these underutilized plants have conclusively outlined the mode of action in treatment of several diseases and in other health aspects. This paper limits its scope to reviewe and highlight the potential of using underutilized plants in Sabah only which could serve as reliable resource for health product development in pharmaceutical and nutraceutical through continuous discovering of more active and sustainable resources as well as ingredients for food and medicine.
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http://dx.doi.org/10.2174/1389201022666210208201212DOI Listing
February 2021

4-Thiazolidinone coumarin derivatives as two-component NS2B/NS3 DENV flavivirus serine protease inhibitors: synthesis, molecular docking, biological evaluation and structure-activity relationship studies.

Chem Cent J 2018 Jun 12;12(1):69. Epub 2018 Jun 12.

School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Penang, Malaysia.

A series of novel 4-thiazolidinone inhibitors SKYa-SKYg, containing coumarin as a core structure were synthesized via facile and efficient method. The structures of the synthesized compounds were established by extensive spectroscopic studies (FT IR, 1D NMR, 2D NMR, LC-MS) and elemental analysis. All the synthesized hybrids were further evaluated for their potential as anti-tubercular agents against Mycobacterium tuberculosis H37Rv ATCC 25618, and anti-bacterial agents against Escherichia coli, Enterobacter aerogenes, Salmonella typhi, Streptococcus pneumoniae and Staphylococcus aureus. Interestingly, the hybrids displayed potent bioactivity. However, compounds SKYc, SKYd, and SKYe appeared to be more effective against the tested bacterial strains, among which compound SKYb showed the highest inhibition against all the bacterial strains ranging from 41 to 165 μg/mL, as compared to the standards, streptomycin, kanamycin and vancomycin. Moreover, derivative SKYa was found to be the strongest against M. tuberculosis (83 μg/mL). Additionally, the anti-dengue potential of the coumarin hybrids as two-component NS2B/NS3 DENV flavivirus serine protease inhibitors was calculated using computational molecular docking approach, with reference to the standards 4-hydroxypanduratin, panduratin and ethyl 3-(4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy)propanoate with DS of - 3.379, - 3.189 and - 3.381, respectively. The docking results revealed that the synthesized hybrids exhibited potent anti-dengue activity among which compounds SKYf, SKYd, SKYc and SKYe were found to be the best ones with docking scores of - 4.014, - 3.964, - 3.905 and - 3.889. In summary, we discovered 4-thiazolidinone coumarin derivatives as a new scaffold that may eventually yield useful compounds in the treatment of bacterial and viral infections.
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http://dx.doi.org/10.1186/s13065-018-0435-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997609PMC
June 2018

Yeasts in sustainable bioethanol production: A review.

Biochem Biophys Rep 2017 Jul 6;10:52-61. Epub 2017 Mar 6.

Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, Malaysia.

Bioethanol has been identified as the mostly used biofuel worldwide since it significantly contributes to the reduction of crude oil consumption and environmental pollution. It can be produced from various types of feedstocks such as sucrose, starch, lignocellulosic and algal biomass through fermentation process by microorganisms. Compared to other types of microoganisms, yeasts especially is the common microbes employed in ethanol production due to its high ethanol productivity, high ethanol tolerance and ability of fermenting wide range of sugars. However, there are some challenges in yeast fermentation which inhibit ethanol production such as high temperature, high ethanol concentration and the ability to ferment pentose sugars. Various types of yeast strains have been used in fermentation for ethanol production including hybrid, recombinant and wild-type yeasts. Yeasts can directly ferment simple sugars into ethanol while other type of feedstocks must be converted to fermentable sugars before it can be fermented to ethanol. The common processes involves in ethanol production are pretreatment, hydrolysis and fermentation. Production of bioethanol during fermentation depends on several factors such as temperature, sugar concentration, pH, fermentation time, agitation rate, and inoculum size. The efficiency and productivity of ethanol can be enhanced by immobilizing the yeast cells. This review highlights the different types of yeast strains, fermentation process, factors affecting bioethanol production and immobilization of yeasts for better bioethanol production.
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http://dx.doi.org/10.1016/j.bbrep.2017.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637245PMC
July 2017
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