Publications by authors named "Ju Hee Han"

50 Publications

The Risk of Psoriasis in Patients With Allergic Diseases: A Nationwide Population-based Cohort Study.

Allergy Asthma Immunol Res 2021 Jul;13(4):638-645

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

The spectrum of allergic diseases includes atopic dermatitis (AD), allergic rhinitis (AR), and asthma. To date, the association between allergic diseases and psoriasis has not yet been completely evaluated. This study was conducted to determine the risk of psoriasis in patients with allergic diseases. A health screening database, a sub-dataset of the Korean National Health Insurance Service database, was used. All 9,718,722 subjects who underwent health examination in 2009 at age over 20 were included. Subjects with allergic diseases including AD (n = 35,685), AR (n = 1,362,713), asthma (n = 279,451) and control subjects without all three allergic diseases (n = 8,210,042), without AD (n = 9,683,037), without AR (n = 8,356,009) and without asthma group (n = 9,439,271) were analyzed. The subjects were tracked using their medical records during the 8-year period from 2010 to 2017 to identify those who developed psoriasis. Multivariate Cox regression models were used to assess the risk of psoriasis. The incidence probability of psoriasis was analyzed through the Kaplan-Meier method. The incidence of psoriasis per 1,000 person-years was 9.57, 3.78, and 4.28 in the AD, AR, and asthma groups, respectively. The AD group exhibited a significantly increased risk of developing psoriasis compared to subjects without AD (hazard ratio [HR], 3.18; 95% confidence interval [95% CI], 3.05-3.31; < 0.001) after adjustment for confounding factors. The risk of psoriasis was significantly increased in the AR group compared to subjects without AR (HR, 1.32; 95% CI, 1.31-1.34; < 0.001) and asthma group compared to subjects without asthma (HR, 1.30; 95% CI, 1.27-1.33; < 0.001). Allergic diseases, particularly AD, may be a risk factor for psoriasis.
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http://dx.doi.org/10.4168/aair.2021.13.4.638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255348PMC
July 2021

Well-demarcated erythematous plaque on the arm.

Indian J Dermatol Venereol Leprol 2021 May 31:1-3. Epub 2021 May 31.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

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http://dx.doi.org/10.25259/IJDVL_608_19DOI Listing
May 2021

Association between metabolic syndrome and Behçet's disease: A nationwide population-based study.

J Dermatol 2021 Jul 7;48(7):1062-1066. Epub 2021 May 7.

Department of Dermatology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Metabolic syndrome (MetS) is characterized by insulin resistance, high blood pressure/sugar, dyslipidemia, and obesity. Whether MetS and its components affect the development of Behçet's disease (BD) remains unclear. This study was performed to investigate the associations between metabolic syndrome and risk of BD using nationwide population data. We conducted a retrospective cohort study of 10 505 818 Korean subjects who received health checkups in 2009-2012. Patients were classified into a MetS and its components group and were followed-up until 2016 for new-onset BD. A Cox proportional hazards model was used to assess the independent or synergistic effects of MetS and its components on the risk of incident BD. Compared to subjects without MetS components, the hazard ratio (HR) for development of BD in patients with MetS was 0.874 (95% confidence interval [CI]: 0.819-0.933) and this association was more prominent when all components of MetS were present (HR = 0.675, 95% CI = 0.571-0.798). Subjects with low high density lipoprotein (HDL) has a significantly increased risk of the development of BD (HR = 1.51, 95% CI = 1.4-1.594) compared to controls. This study showed that the incidence of Behçet's disease was reduced in subjects with MetS. Moreover, the presence of MetS components, with the exception of HDL, was negatively related to the development of BD.
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http://dx.doi.org/10.1111/1346-8138.15809DOI Listing
July 2021

Reconstruction Experience Using Logarithmic Spiral Flap on the Nasal Sidewall.

Ann Dermatol 2020 Jun 24;32(3):260-261. Epub 2020 Apr 24.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

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http://dx.doi.org/10.5021/ad.2020.32.3.260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992615PMC
June 2020

Automated severity scoring of atopic dermatitis patients by a deep neural network.

Sci Rep 2021 Mar 15;11(1):6049. Epub 2021 Mar 15.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 06591, Korea.

Scoring atopic dermatitis (AD) severity with the Eczema Area and Severity Index (EASI) in an objective and reproducible manner is challenging. Automated measurement of erythema, papulation, excoriation, and lichenification severity using images has not yet been investigated. Our aim was to determine whether convolutional neural networks (CNNs) could assess erythema, papulation, excoriation, and lichenification severity at a level of competence comparable to dermatologists. We created a standard dataset of 8,000 clinical images showing AD. Each component of the EASI was scored from 0 to 3 by three dermatologists. We trained four CNNs (ResNet V1, ResNet V2, GoogLeNet, and VGG-Net) with the image dataset and determined which CNN was the most suitable for erythema, papulation, excoriation, and lichenification scoring. The brightness of the images in each dataset was adjusted to - 80% to + 80% of the original brightness (i.e., 9 levels by 20%) to investigate if the CNNs accurately measured scores if image brightness levels were changed. Compared to the dermatologists' scoring, accuracy rates of the CNNs were 99.17% for erythema, 93.17% for papulation, 96.00% for excoriation, and 97.17% for lichenification. CNNs trained with brightness-adjusted images achieved a high accuracy without the need to standardize camera settings. These results suggested that CNNs perform at level of competence comparable to dermatologists for scoring erythema, papulation, excoriation, and lichenification severity.
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http://dx.doi.org/10.1038/s41598-021-85489-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961024PMC
March 2021

Highly Efficient 7,7-Dimethyl-9-(10-phenylanthracen-9-yl)-7H-Benzo[6,7]Indeno[1,2-f]Quinoline Derivatives for Blue Fluorescent Organic Light-Emitting Diodes.

J Nanosci Nanotechnol 2021 Aug;21(8):4341-4346

Department of Chemistry, Sungkyunkwan University, Suwon, Kyunggi-do, 440-746, South Korea.

Highly efficient blue fluorescent 7,7-dimethyl-9-(10-phenylanthracen-9-yl)-7H-benzo[6,7]indeno[1,2- f]quinoline derivatives, based on benzo-indeno-quinoline and phenylanthracene were designed and synthesized. To test their electroluminescent properties, organic light-emitting diodes (OLEDs) were fabricated with the configuration of indium-tin-oxide (ITO) (150 nm)/4,4',4″-Tris[2- naphthyl(phenyl)amino]triphenylamine (2-TNATA) (30 nm)/N,N'-di(1-naphthyl)-N,N'-diphenyl-1,1'- biphenyl)4,4'-diamine (NPB) (20 nm)/blue emitting materials (20 nm)/bathophenanthroline (Bphen) (30 nm)/Liq (2 nm)/Al (100 nm). The devices using these blue materials as emitters showed efficient blue emission. Particularly, a device employing 7,7-dimethyl-9-(10-phenylanthracen-9-yl)-7Hbenzo[ 6,7]indeno[1,2-f]quinoline as an emitting layer yielded the best performance with a luminous efficiency (LE), power efficiency (PE), and external quantum efficiency (EQE) and the Commission International de L'Eclairge (CIE) coordinates of 4.60 cd/A, 3.07 lm/W, 4.32% at 20 mA/cm², and (0.16, 0.12) at 8.0 V, respectively.
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http://dx.doi.org/10.1166/jnn.2021.19400DOI Listing
August 2021

Epigallocatechin-3-gallate Can Prevent Type 2 Human Papillomavirus from Suppressing Interferon-Stimulated Genes.

Int J Mol Sci 2021 Feb 28;22(5). Epub 2021 Feb 28.

Program of Immunology & Microbiology, Department of Biomedicine & Health Sciences, Graduate School, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Korea.

Human papillomavirus (HPV) in high-risk groups is known to suppress the type I interferon (IFN) signaling pathway leading to the transcription of interferon-stimulated genes (ISGs), which have many antiviral functions. However, the effects of HPV on the action of various ISGs in low-risk groups are not fully understood. We aimed to investigate whether antiviral ISGs are expressed in transfected keratinocytes with type 2 HPV (HPV-2) . The mRNA and protein expressions of ISGs and type I IFN signaling pathway components were evaluated by quantitative real-time polymerase chain reaction, western blot, immunofluorescence, and/or immunohistochemistry. Compared with normal skin, mRNA expression of all ISGs in HPV-2 positive cutaneous warts was significantly decreased ( < 0.05). In comparison with empty vector transfection, transfection significantly down-regulated the mRNA and protein expressions of ISGs and type I IFN signaling pathway components, which were significantly up-regulated by siRNA transfection ( < 0.05). Interestingly, epigallocatechin-3-gallate (EGCG) pretreatment up-regulated the mRNA and protein expressions of ISGs and type I IFN signaling pathway components, which were significantly down-regulated by transfection ( < 0.05). Our results demonstrate that EGCG is a potential candidate for cutaneous wart prevention.
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http://dx.doi.org/10.3390/ijms22052418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957673PMC
February 2021

Folliculotropic mycosis fungoides clinically resembling allergic contact dermatitis.

Contact Dermatitis 2021 Feb 17. Epub 2021 Feb 17.

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

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http://dx.doi.org/10.1111/cod.13816DOI Listing
February 2021

The long-term risk of lymphoma and skin cancer did not increase after topical calcineurin inhibitor use and phototherapy in a cohort of 25,694 patients with vitiligo.

J Am Acad Dermatol 2021 Jun 25;84(6):1619-1627. Epub 2021 Jan 25.

Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, South Korea. Electronic address:

Background: Topical calcineurin inhibitors have been used to treat vitiligo, either alone or in combination with phototherapy; however, the long-term safety of these agents remains controversial.

Objective: To investigate the risk of lymphoma and skin cancer in vitiligo patients who received topical calcineurin inhibitors or phototherapy.

Methods: A multicenter retrospective cohort study of 25,694 vitiligo patients who received topical calcineurin inhibitors or phototherapy for 6 weeks or more between 2001 and 2019 was performed. Cumulative doses of topical calcineurin inhibitors and total phototherapy sessions were determined. Outcomes were the development of lymphoma or skin cancer after enrollment, confirmed through chart review and pathology reports.

Results: During 95,203 person-years, 13 cases of lymphoma, 22 of actinic keratosis, 15 of nonmelanoma skin cancer, and 5 of melanoma were observed. The risk of lymphoma and skin cancer was not significantly increased by topical calcineurin inhibitor dose or phototherapy sessions. The interaction between the topical calcineurin inhibitors and phototherapy was not associated with an increased risk of skin cancer.

Limitations: Retrospective study, individual follow-up duration less than 4 years, and no adjustment for comorbidities and medication history. Not generalizable to other races.

Conclusion: The long-term risk of skin cancer or lymphoma was not associated with the use of topical calcineurin inhibitors, phototherapy, and both treatments in combination in patients with vitiligo.
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http://dx.doi.org/10.1016/j.jaad.2021.01.067DOI Listing
June 2021

In situ-forming collagen hydrogel crosslinked via multi-functional PEG as a matrix therapy for corneal defects.

Sci Rep 2020 10 7;10(1):16671. Epub 2020 Oct 7.

Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.

Visually significant corneal injuries and subsequent scarring collectively represent a major global human health challenge, affecting millions of people worldwide. Unfortunately, less than 2% of patients who could benefit from a sight-restoring corneal transplant have access to cadaveric donor corneal tissue. Thus, there is a critical need for new ways to repair corneal defects that drive proper epithelialization and stromal remodeling of the wounded area without the need for cadeveric donor corneas. Emerging therapies to replace the need for donor corneas include pre-formed biosynthetic buttons and in situ-forming matrices that strive to achieve the transparency, biocompatibility, patient comfort, and biointegration that is possible with native tissue. Herein, we report on the development of an in situ-forming hydrogel of collagen type I crosslinked via multi-functional polyethylene glycol (PEG)-N-hydroxysuccinimide (NHS) and characterize its biophysical properties and regenerative capacity both in vitro and in vivo. The hydrogels form under ambient conditions within minutes upon mixing without the need for an external catalyst or trigger such as light or heat, and their transparency, degradability, and stiffness are modulated as a function of number of PEG arms and concentration of PEG. In addition, in situ-forming PEG-collagen hydrogels support the migration and proliferation of corneal epithelial and stromal cells on their surface. In vivo studies in which the hydrogels were formed in situ over stromal keratectomy wounds without sutures showed that they supported multi-layered surface epithelialization. Overall, the in situ forming PEG-collagen hydrogels exhibited physical and biological properties desirable for a corneal stromal defect wound repair matrix that could be applied without the need for sutures or an external trigger such as a catalyst or light energy.
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http://dx.doi.org/10.1038/s41598-020-72978-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542443PMC
October 2020

Beyond the quality of life: A call for patients' own willingness to pay in chronic skin disease to assess psychosocial burden: A multi-center, cross-sectional prospective survey.

J Am Acad Dermatol 2020 Oct 3. Epub 2020 Oct 3.

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.09.088DOI Listing
October 2020

Platinum (II) Complexes Based on Tetradentate Pyridine-Containing Ligands for Phosphorescent Organic Light-Emitting Diodes.

J Nanosci Nanotechnol 2020 Nov;20(11):6683-6687

Department of Chemistry, Sungkyunkwan University, Suwon, Kyunggi-do 440-746, South Korea.

In this study, we designed and synthesized two phosphorescent emitting materials based on tetradentate pyridine-containing ligands. Their photophysical properties were examined for OLEDs and multilayer devices using these materials were fabricated in the following sequence; ITO (180 nm)/4,4',4″-Tris[2-naphthyl(phenyl)amino]triphenylamine (2-TNATA) (30 nm)/,'-di(1-naphthyl)-,'-diphenyl-1,1'-biphenyl)4,4'-diamine (NPB) (20 nm)/Tris(4-carbazoyl-9-ylphenyl)amine (TCTA) (10 nm)/4,4'-Bis(-carbazolyl)-1,1'-biphenyl(CBP): 5, 8, 15% Platinum (II) complexes (20 nm)/1,3,5-Tris(1-Phenyl-1-benzimidazol-2-yl)benzene) (TPBi) (40 nm)/Liq (2 nm)/Al (100 nm). In particularly, a device using Platinum (II) complex based on A/-(3,5-di-tert-butylphenyl)-6-phenyl--(6-phenylpyridin-2-yl)pyridin-2-amine ligand showed the efficient emission, with luminous efficiency, power efficiency, and external quantum efficiency, and the Commission International de LEclairge (CIE) coordinates of 29.29 cd/A, 9.37 lm/W, 8.66% at 20 mA/cm2, and (0.32, 0.62) at 8.0 V, respectively.
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http://dx.doi.org/10.1166/jnn.2020.18774DOI Listing
November 2020

Red Phosphorescent Platinum(II) Complexes with Tetradentate Pyridine-Containing Ligands for Organic Light Emitting Diodes.

J Nanosci Nanotechnol 2020 Nov;20(11):6669-6674

Department of Chemistry, Sungkyunkwan University, Suwon, 16419, Korea.

Here, red phosphorescent platinum(II) complexes based on tetradentate pyridine-containing lig-ands are studied. To investigate their electroluminescent properties, multilayer devices were fabricated in the following sequence; ITO (180 nm)/4,4',4″-Tris[2-naphthyl(phenyl)amino]triphenylamine (2-TNATA) (30 nm)/, '-di(1-naphthyl)-,'-diphenyl-1,1'-biphenyl)4,4'-diamine (NPB) (20 nm)/ Tris(4-carbazoyl-9-ylphenyl)amine (TCTA) (10 nm)/4,4'-Bis(-carbazolyl)-1,1'-biphenyl (CBP) (20 nm)/Platinum(II) complex (20 nm)/1,3,5-Tris(1-Phenyl-1H-benzimidazol-2-yl)benzene) (TPBi) (40 nm)/Liq (2 nm)/Al (100 nm). In particularly, a device using platinum(II) complex based on -(3,5-di-tert-butylphenyl)-3-(pyridin-2-yl)--(3-(pyridin-2-yl)phenyl)benzenamineligand showed the efficient red emission, with a luminous efficiency, power efficiency, and external quantum efficiency of, and the Commission International de LEclairge (CIE) coordinates of 27.26 cd/A, 10.54 lm/W, 8.50% at 20 mA/cm², and (0.65, 0.33) at 11.0 V, respectively.
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http://dx.doi.org/10.1166/jnn.2020.18758DOI Listing
November 2020

Red Phosphorescent Platinum(II) Complexes with Tetradentate Pyridine-Containing Ligands for Organic Light Emitting Diodes.

J Nanosci Nanotechnol 2020 Nov;20(11):6669-6674

Department of Chemistry, Sungkyunkwan University, Suwon, 16419, Korea.

Here, red phosphorescent platinum(II) complexes based on tetradentate pyridine-containing lig-ands are studied. To investigate their electroluminescent properties, multilayer devices were fabricated in the following sequence; ITO (180 nm)/4,4',4″-Tris[2-naphthyl(phenyl)amino]triphenylamine (2-TNATA) (30 nm)/, '-di(1-naphthyl)-,'-diphenyl-1,1'-biphenyl)4,4'-diamine (NPB) (20 nm)/ Tris(4-carbazoyl-9-ylphenyl)amine (TCTA) (10 nm)/4,4'-Bis(-carbazolyl)-1,1'-biphenyl (CBP) (20 nm)/Platinum(II) complex (20 nm)/1,3,5-Tris(1-Phenyl-1H-benzimidazol-2-yl)benzene) (TPBi) (40 nm)/Liq (2 nm)/Al (100 nm). In particularly, a device using platinum(II) complex based on -(3,5-di-tert-butylphenyl)-3-(pyridin-2-yl)--(3-(pyridin-2-yl)phenyl)benzenamineligand showed the efficient red emission, with a luminous efficiency, power efficiency, and external quantum efficiency of, and the Commission International de LEclairge (CIE) coordinates of 27.26 cd/A, 10.54 lm/W, 8.50% at 20 mA/cm², and (0.65, 0.33) at 11.0 V, respectively.
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http://dx.doi.org/10.1166/jnn.2020.18758DOI Listing
November 2020

Author Correction: Risk of End-Stage Renal Disease in Psoriatic Patients: Real-World Data from a Nationwide Population-Based Cohort Study.

Sci Rep 2020 Feb 5;10(1):2284. Epub 2020 Feb 5.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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http://dx.doi.org/10.1038/s41598-020-59024-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002528PMC
February 2020

Association between the AUDIT score and IgE in Korean adults: Results from the Korea National Health and Nutrition Examination Survey.

Allergol Int 2020 Apr 5;69(2):293-295. Epub 2019 Dec 5.

Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

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http://dx.doi.org/10.1016/j.alit.2019.10.010DOI Listing
April 2020

Risk of End-Stage Renal Disease in Psoriatic Patients: Real-World Data from a Nationwide Population-Based Cohort Study.

Sci Rep 2019 11 12;9(1):16581. Epub 2019 Nov 12.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Psoriasis is a chronic inflammatory skin disorder mediated by the T-cell-related immune response. Psoriatic patients may have a variety of comorbidities, but their risk of end-stage renal disease (ESRD), particularly according to the subtype of psoriasis, is unclear. We investigated the risk of ESRD in patients with psoriasis according to the subtype of psoriasis and history of systemic therapy for psoriasis. A total of 2,121,228 adults (1,590,921 in the control group and 530,307 in the psoriasis group) were enrolled in this nationwide population-based cohort study until 2015. During follow-up, 1,434 of the subjects in the psoriasis group developed ESRD. After adjusting for confounding factors, psoriasis was associated with the risk of ESRD (hazard ratio (HR) 1.58, 95% confidence interval [95% CI] 1.47-1.68). The psoriatic arthritis group (HR 7.60, 95% CI 1.90-30.41) had a higher risk of ESRD than the control group. Interestingly, no such association was detected in the systemically treated group (HR 1.07, 95% CI 0.80-1.41). Moreover, the acitretin-treated group had a lower risk of ESRD (HR 0.658, 95% CI, 0.494-0.875) than the non-systemically treated group. In conclusion, the risk of developing ESRD in patients with psoriasis differed according to the type of treatment and the presence of arthritis.
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http://dx.doi.org/10.1038/s41598-019-53017-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851155PMC
November 2019

Cutaneous Disorders Associated with Castleman's Disease.

Acta Derm Venereol 2019 Oct;99(11):984-989

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Castleman's disease is a rare disease of the lymph nodes and related tissues, presenting as angiofollicular or giant lymph node hyperplasia. Although various skin manifestations have been reported to occur in Castleman's disease, a comprehensive study of cutaneous disorders in Castleman's disease is lacking. Therefore, the aim of this study was to investigate Castleman's disease-associated cutaneous disorders. The medical records of 57 patients with Castleman's disease who visited our hospitals from January 2007 to May 2018 were analysed retrospectively. Patients were classified according to the presence of skin involvement. Plasma variant-type Castleman's disease and multicentric Castleman's disease were more commonly found in patients with Castleman's disease with a cutaneous disorder than in those without a cutaneous disorder. In addition, the skin disorders were classified according to pathomechanisms: immune complex-related (paraneoplastic pemphigus, xanthogranulomas), cytokine-related (vasculitis-like lesion, cherry angioma, hyperpigmentation), and non-specific (pruritus). This study builds on previous case reports of cutaneous disorders in Castleman's disease and proposes a new classification system.
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http://dx.doi.org/10.2340/00015555-3253DOI Listing
October 2019

Increased risk of psoriasis in subjects with abdominal obesity: A nationwide population-based study.

J Dermatol 2019 Aug 31;46(8):695-701. Epub 2019 May 31.

Department of Dermatology, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Psoriasis is a chronic inflammatory skin disease known to be associated with a variety of systemic comorbidities, such as metabolic syndrome and obesity. Obesity represents a major comorbidity and has been suggested to be related to psoriasis. This nationwide population-based prospective cohort study was performed to investigate the impacts of body mass index (BMI) and waist circumference (WC) on psoriasis. We used the health check-up database and the study population consisted of subjects who had undergone health screening between January 2009 and December 2012. This study investigated patients newly diagnosed with psoriasis (International Classification of Disease, Tenth Revision, code L40) by dermatologists during the follow-up period (5.32 years), based on claims data. The total population consisted of 22 633 536 subjects, among whom 399 461 had newly developed psoriasis. Subjects with BMI of more than 30 had a higher risk of psoriasis (hazards ratio [HR], 1.118; 95% confidence interval [CI], 1.100-1.137) compared with the BMI 18.5-23 group. WC showed a dose-dependent association with psoriatic risk. Subjects with WC over 105 cm showed the highest risk of psoriasis (HR, 1.305; 95% CI, 1.261-1.349) compared with subjects with WC lower than 80/75 after adjusting for confounding factors, including BMI. The risk of psoriasis was highest in males with normal BMI and abdominal obesity (HR, 1.175; 95% CI, 1.150-1.200). Our study indicates that WC is a specific factor affecting psoriatic risk and highlights the association between abdominal obesity and psoriasis, thus increasing awareness of the role of abdominal obesity in the pathogenesis and comorbidities of psoriasis.
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http://dx.doi.org/10.1111/1346-8138.14939DOI Listing
August 2019

Association of Psoriasis With Mental Health Disorders in South Korea.

JAMA Dermatol 2019 06;155(6):747-749

College of Medicine, Department of Dermatology, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.

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http://dx.doi.org/10.1001/jamadermatol.2019.0315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506891PMC
June 2019

Ceria Nanoparticles Synthesized With Aminocaproic Acid for the Treatment of Subarachnoid Hemorrhage.

Stroke 2018 12;49(12):3030-3038

From the Laboratory of Innovative Nanotechnology, Biomedical Research Institute and Department of Neurology, Seoul National University Hospital, Republic of Korea (H.-G.J., D.-W.K., D.Y.K., S.K.K., S.I.K., J.h.H., W.Y., C.K.K., S.-H.L.).

Background and Purpose- Despite early aneurysm repair and aggressive management for complications, subarachnoid hemorrhage (SAH) results in at least 25% mortality rate and 50% persistent neurological deficit. We investigated whether ceria nanoparticles which have potent antioxidative activities can protect against subarachnoid hemorrhage via attenuating fatal brain injuries. Methods- Uniform, 3 nm, water-dispersed ceria nanoparticles were prepared from short sol-gel reaction of cerium (III) ions with aminocaproic acid in aqueous phase. SAH was induced by endovascular perforation of middle cerebral artery of rats. A single dose of ceria nanoparticles (0.5 mg Ce/kg) or saline control was randomly administered intravenously at an hour post-SAH. Neuronal death, macrophage infiltration, SAH grade, and brain edema were evaluated at 72 hours. Mortality and neurological function were assessed for 14 days. Results- The obtained ceria nanoparticles with high Ce to Ce ratio demonstrated potent antioxidative, cytoprotective, and anti-inflammatory activities in vitro. In rodent SAH models, the severity of hemorrhage was comparable between the ceria nanoparticles- and saline-treated groups. However, ceria nanoparticles significantly reduced neuronal death, macrophage infiltration, and brain edema after SAH. Ceria nanoparticles successfully improved survival rates (88.2% in the ceria nanoparticles group versus 21.1% in the control group; P<0.001) and neurological outcomes (modified Garcia score: 12.1±0.5 in the ceria nanoparticles group versus 4.4±0.5 in the control group; P<0.001) of the animals with SAH. Conclusions- Ceria nanoparticles, totally synthesized in aqueous phase using aminocaproic acid, demonstrated promising results against SAH via potent antioxidative, neuroprotective and anti-inflammatory activities. Given the obvious limitations of current therapies for SAH, ceria nanoparticles can be a potential therapeutic agent which might result in a paradigm shift in SAH treatment.
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http://dx.doi.org/10.1161/STROKEAHA.118.022631DOI Listing
December 2018

Reciprocal relationship between herpes zoster and cardiovascular diseases: A nationwide population-based case-control study in Korea.

J Dermatol 2018 Nov 17;45(11):1312-1318. Epub 2018 Aug 17.

Department of Dermatology, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Recently, herpes zoster (HZ) has been identified as a risk factor for stroke, but there have been few studies on the relationship between HZ and other cardiovascular diseases (CVD), including myocardial infarction (MI) and heart failure (HF). The purpose of this study was to investigate the risk of HZ occurrence after CVD and the occurrence of CVD after HZ. This was a retrospective case-control study based on the National Health Insurance System claims database for 20 311 patients with HZ and 13 980 patients with CVD and 1:5 age- and sex-matched control subjects for each from January 2006 to December 2013. We evaluated the reciprocal relationship between HZ and CVD including MI, ischemic stroke and HF. Severe HZ requiring hospitalization independently increased the risk of subsequent MI (hazard ratio [HR], 1.831; 95% confidence interval [CI], 1.354-2.476)], ischemic stroke (HR, 1.523; 95% CI, 1.212-1.915) and HF (HR, 2.034; 95% CI, 1.615-2.562) during the study period. Likewise, patients with an episode of MI, ischemic stroke or HF were also at increased risk of HZ hospitalization (after MI: HR, 1.625; 95% CI, 1.144-2.308; after stroke: HR, 1.518; 95% CI, 1.177-1.957; and after HF: HR, 1.485, 95% CI 1.041-2.117). Our results suggest that there is a significant reciprocal relationship between severe HZ requiring hospitalization and CVD including MI, ischemic stroke and HF.
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http://dx.doi.org/10.1111/1346-8138.14597DOI Listing
November 2018

Psoriasis risk in patients with diabetic retinopathy: A nationwide population-based study.

Sci Rep 2018 06 14;8(1):9086. Epub 2018 Jun 14.

Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Psoriasis is a chronic cutaneous disease known to be related with systemic disease; however, the association between psoriasis and diabetic complications has not been previously reported. Diabetic microvascular complications include diabetic retinopathy (DR), nephropathy, and neuropathy, and overt diabetic nephropathy can lead to the end-stage renal disease (ESRD).The present study investigated the association between psoriasis and non-proliferative DR (NPDR) or proliferative DR (PDR) or ESRD. We analyzed the relationship between diabetic complication and psoriasis using data from the National Health Insurance Service between 2009 and 2015. During a mean follow-up of 5.18 years, 43,792 patients were newly diagnosed with psoriasis. In Cox proportional hazard models, patients with NPDR (hazard ratio [HR] 1.26) had a higher incidence of psoriasis and patients with PDR patients had a higher risk of psoriasis (HR 1.35). ESRD was defined by the ICD-10 code, including chronic kidney disease/renal failure, transplantation, and dialysis. The incidence of psoriasis increased in DR patients with ESRD (HR 2.99, 95% CI 2.49-3.59, p < 0.001) compared to non-DR patients without ESRD. This is the first association study between psoriasis and diabetic complications including DR and ESRD. DR and its severity were related to the onset of psoriasis. In addition, ESRD was related with an increased psoriasis in DR patients.
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http://dx.doi.org/10.1038/s41598-018-27147-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002525PMC
June 2018

P-Phenylenediamine Hair Dye Allergy and Its Clinical Characteristics.

Ann Dermatol 2018 Jun 23;30(3):316-321. Epub 2018 Apr 23.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: P-phenylenediamine (PPD) has been identified as the most frequent contact sensitizer of hair dye and the clinical characteristics of hair dye contact allergy (HDCA) are diverse.

Objective: The purpose of this study was to identify the clinical characteristics of HDCA and to assess the relationships between HDCA, exposure time to PPD and PPD positivity.

Methods: We analyzed 105 patients with patch test-confirmed hair dye allergy who presented between July 2009 and March 2015. Clinical symptoms, signs, associated skin diseases, involved ACD area, and patterns of hair dye use were obtained by reviewing medical records and by interview.

Results: HDCA was more common in women and in individuals aged more than 50 years. Pruritus was the most common symptom; erythematous macules and patches were the most frequently observed clinical signs. The most common site of HDCA was the face and non-specific eczema and urticaria were frequently observed with HDCA. Exposure time to hair dye, represented as frequency and duration, showed a positive correlation with the area affected by hair dye allergy (<0.001). Hair dye allergy was identified in most patients (80%) before diagnosis by patch test. However, only 28.6% of all patients stopped using hair dye, even after the diagnosis was confirmed.

Conclusion: The extent of hair dye allergy involvement was related to exposure time to hair dye. For effective treatment of HDCA, it is important to properly educate patients with HDCA about the clinical manifestations of HDCA and to keep away from allergens.
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http://dx.doi.org/10.5021/ad.2018.30.3.316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929949PMC
June 2018

Epidemiology and Medication Trends in Patients with Psoriasis: A Nationwide Population-based Cohort Study from Korea.

Acta Derm Venereol 2018 Apr;98(4):396-400

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 06591 Seoul, Korea.

This study investigated the prevalence of psoriasis and trends in prescription of medications for patients with psoriasis using the Korean National Health Insurance Claims Database from 2006 to 2015. The prevalence of psoriasis and psoriatic arthritis per 10,000 people increased from 47.4 to 61.5 and from 0.04 to 0.23 respectively. The prescription of topical agents was a mean of 73.3%. For systemic agents, prescription of acitretin decreased from 74.8 to 44.5%, methotrexate showed a fluctuation, with a mean of 14.9% and cyclosporine increased from 9.0 to 41.2%. The prescription of biological agents increased sharply from 18 to 1,127 patients. Use of ustekinumab increased from 4.1 to 82.4%; use of infliximab decreased from 20.7 to 6.7% and etanercept decreased from 100 to 6.1%. This study showed an increasing trend in the prevalence of psoriasis. We also reported a rapid increase in the use of biologics in recent years.
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http://dx.doi.org/10.2340/00015555-2877DOI Listing
April 2018

Therapeutic Effects of a Light Emitting Diode at a Variety of Wavelengths on Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice.

Ann Dermatol 2017 Dec 30;29(6):796-799. Epub 2017 Oct 30.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

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http://dx.doi.org/10.5021/ad.2017.29.6.796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705367PMC
December 2017

Primary extramedullary plasmacytoma mimicking oral lichen planus.

Eur J Dermatol 2017 10;27(5):533-534

Department of Dermatology, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, 180, Wangsan-ro, Dongdaemun-gu, Seoul 02559, Republic of Korea.

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http://dx.doi.org/10.1684/ejd.2017.3061DOI Listing
October 2017

Smoking and risk of psoriasis: A nationwide cohort study.

J Am Acad Dermatol 2017 09;77(3):573-575

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2017.04.015DOI Listing
September 2017

Attenuated Nuclear Factor Kappa B Activity by E7 Protein of Human Papillomavirus Type 2 in Human Epidermal Keratinocytes.

Ann Dermatol 2017 Jun 11;29(3):367-370. Epub 2017 May 11.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

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http://dx.doi.org/10.5021/ad.2017.29.3.367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438953PMC
June 2017

Decreased expression of Toll-like receptor 4 and 5 during progression of prostate transformation in transgenic adenocarcinoma of mouse prostate mice.

J Vet Sci 2015 20;16(3):281-7. Epub 2015 Mar 20.

Laboratory Animal Medicine, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.

Chronic inflammation has been considered an important risk factor for development of prostate cancer. Toll-like receptors (TLRs) recognize microbial moieties or endogenous molecules and play an important role in the triggering and promotion of inflammation. In this study, we examined whether expression of TLR4 and TLR5 was associated with progression of prostate transformation in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. The expression of TLR4 and TLR5 was evaluated by immunohistochemisty in formalin-fixed paraffin-embedded prostate tissue from wild-type (WT) and TRAMP mice. Normal prostate tissue from WT mice showed strong expression of TLR4 and TLR5. However, TLR4 expression in the prostate tissue from TRAMP mice gradually decreased as pathologic grade became more aggressive. TLR5 expression in the prostate tissue from TRAMP mice also decreased in low-grade prostate intraepithelial neoplasia (PIN), high-grade PIN and poorly differentiated adenocarcinoma. Overall, our results suggest that decreased expression of TLR4 and TLR5 may contribute to prostate tumorigenesis.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588013PMC
http://dx.doi.org/10.4142/jvs.2015.16.3.281DOI Listing
July 2016
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