Publications by authors named "Joung Soo Kim"

36 Publications

A Case of Verruciform Xanthoma of the Sole.

Ann Dermatol 2021 Feb 30;33(1):86-88. Epub 2020 Dec 30.

Department of Dermatology, Hanyang University Guri Hospital, Guri, Korea.

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http://dx.doi.org/10.5021/ad.2021.33.1.86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875220PMC
February 2021

A Case of Livedoid Vasculopathy Successfully Treated with Sulodexide.

Ann Dermatol 2020 Dec 11;32(6):508-511. Epub 2020 Nov 11.

Department of Dermatology, Hanyang University Guri Hospital, Guri, Korea.

We report a 29-year-old female with a one-month history of non-healing multiple erythematous to violaceous plaques with crusts over both legs and feet. Tender, scarring ulcers with surrounding erythema were present. The clinical manifestation, together with histopathologic findings of fibrinoid plugs within vascular lumens and walls, as well as red blood cell extravasation, led to diagnosis of livedoid vasculopathy. The patient experienced recurrent painful violaceous plaques with ulcerations during the two years of treatment with oral pentoxifylline 400 mg three times daily. The cutaneous lesions and symptoms dramatically improved after the treatment regimen changed to oral sulodexide (250 lipasemic units) three times daily. Sulodexide, a highly purified mixture of glycosaminoglycans including dermatan sulfate and low-molecular weight heparin, could be an effective therapy for recalcitrant livedoid vasculopathy. Herein, we report a case of livedoid vasculopathy treated with sulodexide, which has not previously been reported.
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http://dx.doi.org/10.5021/ad.2020.32.6.508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875231PMC
December 2020

Perceptions and Behavior Regarding Skin Health and Skin Care Products: Analysis of the Questionnaires for the Visitors of Skin Health Expo 2018.

Ann Dermatol 2020 Oct 29;32(5):375-382. Epub 2020 Sep 29.

Department of Dermatology, National Medical Center, Seoul, Korea.

Background: Social standards for skin health have changed and have led to a rise in the general population's interest to achieve flawless skin.

Objective: To survey the Korean public's perception of skin health and dermatologists and skin-health-related behaviors.

Methods: A total of 355 participants of the Skin Health Expo 2018, held by the Dermatological Research Foundation of the Korean Dermatological Association from September 14 to 16, 2018, completed a questionnaire that assessed demographics, status, and behaviors regarding skin health. The questionnaire also included lifestyle characteristics, satisfaction, behavioral factors, and perceptions regarding skin-care products.

Results: Participants were using various skin-care products including toners, lotions, hydrating or nutrition creams, sunscreens, essences, serums, facial masks and packs, body, hand, and foot moisturizers, eye creams, and hair products. The participants believed that the most reliable source of information on skin-care product recommendations was the dermatologist (41.55%). However, purchases were also being made at skin-care product stores (27.64%) based on the recommendation of a friend or acquaintance (40.11%). The results also revealed that 23.8% of participants experienced side effects from using skin-care and cosmetic products, and about 40% of participants could not yet distinguish hospitals run by dermatologists.

Conclusion: Demand for skin-care products has been increasing, and dermatologists should provide proper information about skin health to prevent adverse effects from skin-care products. Educational and informative activities, such as the expo planned by dermatologists, are necessary to improve skin health in the general population.
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http://dx.doi.org/10.5021/ad.2020.32.5.375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992584PMC
October 2020

Treatment of Recalcitrant Viral Warts with Combination Therapy of Systemic Acitretin and Diphenylcyclopropenone Immunotherapy.

Ann Dermatol 2020 Jun 24;32(3):243-246. Epub 2020 Apr 24.

Department of Dermatology, Hanyang University Guri Hospital, Guri, Korea.

Viral warts are benign proliferations of the epithelium caused by human papilloma virus (HPV) infection. Diverse therapeutic options are available for viral warts, depending on extension and severity of the disease. We report a case of a 19-year-old man who presented with multiple viral warts on hands and feet for 5 years. He was treated at other clinics before visiting our hospital, but there was no improvement. We treated the lesions with a combination therapy of systemic acitretin and diphenylcyclopropenone (DPCP) immunotherapy for 6 months. A significant improvement was observed during the 12th week of therapy. Herein, we report a case of recalcitrant viral warts showing complete regression when a combination therapy of oral acitretin and immunotherapy was administered.
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http://dx.doi.org/10.5021/ad.2020.32.3.243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992613PMC
June 2020

A Correlation between Serum Level of Alkaline Phosphatase and Acne Severity in Children and Adolescents: A Retrospective Cross-Sectional Study.

Ann Dermatol 2020 Jun 24;32(3):206-212. Epub 2020 Apr 24.

Department of Dermatology, Hanyang University Guri Hospital, Guri, Korea.

Background: Acne is a chronic inflammatory disease of the pilosebaceous unit and usually affects adolescents when the peak concentrations of growth hormone, insulin-like growth factor 1, and androgen are demonstrated. The activity of alkaline phosphatase (ALP), which increases physiologically in growing children and adolescents, in the pilosebaceous unit has been reported. However, the correlation between the serum level of ALP and the number of acne lesions has not been studied.

Objective: The present cross-sectional study was designed to evaluate the correlation between serum level of ALP and the numbers of non-inflammatory and inflammatory acne lesions in children and adolescents.

Methods: For this study, 202 pediatric and adolescent patients clinically diagnosed with acne vulgaris were included. Age, sex, serum level of ALP, number of non-inflammatory acne lesions, number of inflammatory acne lesions, and number of total acne lesions were evaluated. Additionally, the serum level of dehydroepiandrosterone sulfate was evaluated in 117 patients. Multiple regression analysis was performed. Multicollinearity was quantified using the variance inflation factor.

Results: In the 202 patients, serum level of ALP was the only independent factor that significantly affected both the number of non-inflammatory acne lesions and of total acne lesions (regression coefficient=0.089 and 0.086, respectively, <0.001).

Conclusion: There was a significant correlation between serum level of ALP and the extent of acne (non-inflammatory acne lesions and total acne lesions).
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http://dx.doi.org/10.5021/ad.2020.32.3.206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992616PMC
June 2020

Primary Cutaneous Solitary Fibrous Tumor on the Back.

Ann Dermatol 2020 Apr 11;32(2):155-158. Epub 2020 Mar 11.

Department of Dermatology, Hanyang University Guri Hospital, Guri, Korea.

Solitary fibrous tumors (SFT) are uncommon mesenchymal tumors. SFT have several synonyms including localized fibrous tumor, benign mesothelioma, localized fibrous mesothelioma, and submesothelial fibroma. SFT usually occur in the pleura or other serosal surfaces, but SFT can also develop in extrapleural areas including the nasal cavity, orbit, retroperitoneum, and pelvis. Cutaneous SFT is extremely rare, and more likely to occur in the head and neck region. Histologically, this tumor can mimic a variety of benign and malignant tumors such as dermatofibroma, dermatofibrosarcoma protuberans, spindle cell lipoma or other mesenchymal tumors. Most cases of SFT show non-aggressive clinical courses, with low recurrence rates. Herein, we describe a case of primary cutaneous SFT which presented with huge mass on the back.
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http://dx.doi.org/10.5021/ad.2020.32.2.155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992549PMC
April 2020

The KAAACI/KDA Evidence-Based Practice Guidelines for Chronic Spontaneous Urticaria in Korean Adults and Children: Part 2. Management of H1-Antihistamine-Refractory Chronic Urticaria.

Allergy Asthma Immunol Res 2020 Sep;12(5):750-770

Department of Dermatology, School of Medicine, Eulji University, Daejeon, Korea.

Quite a few patients with chronic spontaneous urticaria (CSU) are refractory to H₁-antihistamines, even though the dose of H₁-antihistamines is increased up to 4-fold. CSU that is not controlled with H₁-antihistamines results in increased disease burden. Several immunomodulators have been used to manage these patients. The guidelines reported herein are connected to Part 1 of the KAAACI/KDA Evidence-Based Practice Guidelines for Chronic Spontaneous Urticaria in Korean Adults and Children, and aimed to provide evidence-based recommendations for the management of H₁-antihistamine-refractory CSU. Part 2 focuses on the more commonly used additional treatment options for refractory CSU, including omalizumab, cyclosporine, leukotriene receptor antagonist, dapsone, methotrexate, and phototherapy. The evidence to support their efficacy, dosing, safety, and selection of these agents is systematically reviewed. To date, for patients with refractory CSU, the methodologically sound data to evaluate the use of omalizumab has been growing; however, the evidence of other immunomodulators and phototherapy is still insufficient. Therefore, an individualized stepwise approach with a goal of achieving complete symptom control and minimizing side effects can be recommended. Larger controlled studies are needed to elevate the level of evidence to select a rational therapeutic agent for patients with refractory CSU.
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http://dx.doi.org/10.4168/aair.2020.12.5.750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346997PMC
September 2020

The KAAACI/KDA Evidence-Based Practice Guidelines for Chronic Spontaneous Urticaria in Korean Adults and Children: Part 1. Definition, Methodology and First-line Management.

Allergy Asthma Immunol Res 2020 Jul;12(4):563-578

Department of Dermatology, Seoul St. Mary's Hospital, Brain Korea 21 PLUS Project for Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Chronic spontaneous urticaria (CSU) is defined as the occurrence of spontaneous wheals, angioedema, or both for >6 weeks in the absence of specific causes. It is a common condition associated with substantial disease burden both for affected individuals and societies in many countries, including Korea. CSU frequently persists for several years and requires high-intensity treatment; therefore, patients experience deteriorations in quality of life and medication-associated complications. During the last decade, there have been major advances in the pharmacological treatment of CSU and there is an outstanding need for evidence-based guidelines that reflect clinical practice in Korea. The guidelines reported here represent a joint initiative of the Korean Academy of Asthma, Allergy and Clinical Immunology and the Korean Dermatological Association, and aim to provide evidence-based guidance for the management of CSU in Korean adults and children. In Part 1, disease definition, guideline scope and development methodology as well as evidence-based recommendations on the use of antihistamines and corticosteroids are summarized.
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http://dx.doi.org/10.4168/aair.2020.12.4.563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224993PMC
July 2020

Markedly Reduced Risk of Internal Malignancies in Patients With Vitiligo: A Nationwide Population-Based Cohort Study.

J Clin Oncol 2019 04 20;37(11):903-911. Epub 2019 Feb 20.

11 Yeouido St Mary's Hospital College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Recent studies indicated that the autoimmunity of vitiligo exerts effects on cells other than melanocytes, which confer reduced risks of both melanoma and nonmelanoma skin cancers in patients with vitiligo. However, the risk of internal malignancy in patients with vitiligo has not been elucidated.

Patients And Methods: We conducted a population-based retrospective cohort study using data from the Korean National Health Insurance claims database obtained from January 2007 to December 2016. All patients age 20 years or older with vitiligo who had at least two contacts with a physician from 2009 to 2016, during which a principal diagnosis was made, were identified (vitiligo group). Controls were randomly selected (two per patient with vitiligo) after frequency matching with the vitiligo group for age and sex during the same period (control group).

Results: A total of 101,078 patients with vitiligo and 202,156 controls without vitiligo were included. The incidence rates of internal malignancies were 612.9 and 708.9 per 100,000 person-years in the vitiligo and control groups, respectively. Patients with vitiligo showed a significantly reduced risk of overall internal malignancies (hazard ratio [HR], 0.86; 95% CI, 0.82 to 0.89; P < .001) compared with controls without vitiligo after adjustments for age, sex, and comorbidities. With regard to organ-specific malignancies, patients with vitiligo showed a remarkably decreased risk of cancer in the colon and rectum (HR, 0.62; 95% CI, 0.55 to 0.69; P < .001), ovary (HR, 0.62; 95% CI, 0.46 to 0.83; P < .001), and lung (HR, 0.75; 95% CI, 0.65 to 0.86; P < .001).

Conclusion: Vitiligo was associated with a reduced risk of overall internal malignancies. These findings suggest that autoimmune diseases, including vitiligo, may provide immune surveillance for the development of cancer beyond the targeted organ.
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http://dx.doi.org/10.1200/JCO.18.01223DOI Listing
April 2019

What factors affect the duration of treatment with diphenylcyclopropenone immunotherapy for common warts?

Dermatol Ther 2018 11 8;31(6):e12740. Epub 2018 Oct 8.

Department of Dermatology, Hanyang University Guri Hospital, Gyeonggi-do, Republic of Korea.

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http://dx.doi.org/10.1111/dth.12740DOI Listing
November 2018

The risk of alopecia areata and other related autoimmune diseases in patients with sleep disorders: a Korean population-based retrospective cohort study.

Sleep 2018 09;41(9)

Department of Dermatology, Hanyang University Guri Hospital, Korea.

Study Objectives: The aim of our study was to investigate the risk of alopecia areata occurrence in patients with sleep disorders.

Methods: This study was a retrospective cohort study based on the National Health Insurance Service-National Sample Cohort database of patients with a sleep disorder, along with age- and sex-matched control subjects from 2003 to 2013. The hazard ratio (HR) of alopecia areata was compared between the patients with sleep disorders and control subjects adjusting comorbid diseases which could affect the incidence of alopecia areata. We also compared the prevalence of comorbid diseases in the patients with sleep disorders and control subjects.

Results: Among the 25,800 patients with sleep disorders and the 129,000 control subjects, patients with sleep disorders were at a significantly increased risk for alopecia areata when compared with control subjects (adjusted HR 1.651 [95% CI 1.382-1.974]), especially in younger age groups (0-24 and 25-44 years). In a multivariate logistic analysis, sleep disorders were not only associated with alopecia areata (OR 1.913 [95% CI 1.717-2.171]), but also with other comorbid diseases, including solid-organ cancers (OR 1.099 [95% CI 1.049-1.151]), Graves' disease (OR 1.717 [95% CI 1.562-1.886]), Hashimoto thyroiditis (OR 1.641 [95% CI 1.413-1.905]), vitiligo (OR 1.539 [95% CI 1.236-1.917]), and rheumatoid arthritis (OR 1.886 [95% CI 1.780-1.998]).

Conclusions: This study demonstrated that sleep disorder is an independent risk factor for alopecia areata, especially in individuals under the age of 45 years old.
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http://dx.doi.org/10.1093/sleep/zsy111DOI Listing
September 2018

Cancer risks among patients with alopecia areata: A population-based case-control study in Korea.

J Am Acad Dermatol 2018 01;78(1):209-211

Department of Dermatology, Hanyang University Guri Hospital, Guri-si, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2017.08.011DOI Listing
January 2018

Serum Zinc Status and Its Association with Allergic Sensitization: The Fifth Korea National Health and Nutrition Examination Survey.

Sci Rep 2017 10 3;7(1):12637. Epub 2017 Oct 3.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Zinc (Zn) is an essential trace element that plays important roles in the immune system. There is little known about the role of trace elements in allergic diseases, and previous reports have shown conflicting results. The aim of this study was to investigate the relationship between serum Zn levels and total or allergen-specific immunoglobulin E (IgE) levels. The initial candidates for this study were those who participated in the 5 Korean National Health and Nutrition Examination Survey 2010 (n = 8,958), and 1,867 adults who had serum total and allergen specific-IgE levels measured were included. Upon adjusting for covariates, mean total IgE, Dermatophagoides farinae and dog-specific IgE levels increased significantly as the Zn levels decrease from the highest to the lowest quartile (p = 0.009, 0.004, and < 0.001, respectively). The multiple logistic regression analyses showed significant negative linear correlations between serum Zn levels and total, D. farinae-, cockroach-, and dog-specific IgE levels (p-value for linear trend = 0.004, 0.006, 0.027, and < 0.001, respectively). This study demonstrated that total/allergen specific IgE and Zn levels are significantly inversely related.
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http://dx.doi.org/10.1038/s41598-017-13068-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626772PMC
October 2017

Knowledge and Behavior Regarding Cosmetics in Koreans Visiting Dermatology Clinics.

Ann Dermatol 2017 Apr 24;29(2):180-186. Epub 2017 Mar 24.

Arumdaun Nara Clinic, Seoul, Korea.

Background: Cosmetics can affect the skin condition profoundly, and yet no survey has been performed in Koreans visiting dermatology clinics.

Objective: To assess knowledge and consumer behavior regarding cosmetics in Koreans visiting dermatology clinics.

Methods: A questionnaire consisting of 43 questions concerning demographics and use/knowledge/selection/purchase of cosmetics was given to patients and accompanying persons who visited dermatologic clinics in university and private clinic settings.

Results: In total 1,015 subjects (73.2% females, mean age 32.5 years) completed the survey. Education level was college or higher in 72.8%. Thirty-one percent had been diagnosed with a skin disorder, atopic dermatitis and seborrheic dermatitis being the most frequent diagnoses (33.7% and 16.8%, respectively). The frequency of makeup/sunscreen/functional cosmetics use, amount of sunscreen use, recognition of functional cosmetics, and knowledge of shelf life were significantly correlated with level of education. Among "functional cosmetics," whitening products were used most frequently (29.2%). Regardless of education level, 79.2% purchased cosmetics without checking ingredients, and 85.7% were unaware of the all-ingredient-labelling regulations, and yet subjects considered ingredient the most important factor when purchasing a product.

Conclusion: Outpatient subjects in their twenties and thirties are the most knowledgeable about cosmetics in Korea.
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http://dx.doi.org/10.5021/ad.2017.29.2.180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383743PMC
April 2017

Transition from lichen sclerosus to squamous cell carcinoma in a single tissue section.

Cutis 2016 Apr;97(4):E6-8

Department of Dermatology, Hanyang University, Guri Hospital, South Korea.

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April 2016

Factors contributing to the treatment duration of diphenylcyclopropenone immunotherapy for periungual warts.

Dermatol Ther 2016 Mar-Apr;29(2):114-9. Epub 2015 Nov 11.

Department of Dermatology, Hanyang University Guri Hospital, Guri, Korea.

Diphenylcyclopropenone (DPCP) immunotherapy has been shown to be efficacious for the treatment of warts, especially periungual warts for which destructive techniques are limited. However, factors affecting the duration of treatment of periungual warts have not been studied. A total of 61 patients with periungual warts who were completely cured with DPCP immunotherapy were included in this study. Age, sex, disease duration, location (fingernail, toenail, or both), number of warts, diameter of the largest wart, application number for sensitization and two types of sensitization reactions, erythema and blister index (EBI), and pruritus index were evaluated. Multiple linear regression analysis was performed to find correlations of these variables with the treatment duration. Of the nine variables, application number for sensitization (regression coefficient = 3.251 and 2.428, respectively) and EBI (regression coefficient = -9.950 and -9.694, respectively) were independent factors significantly affecting both the total duration of treatment and the duration of treatment after sensitization (p < 0.05, respectively). The sample size was limited. A shorter sensitization period and more severe EBI of the sensitization reaction contribute to a shorter time required for a complete cure in the treatment of periungual warts with DPCP immunotherapy.
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http://dx.doi.org/10.1111/dth.12312DOI Listing
January 2017

Nodular extramammary Paget disease with fibroepitheliomatous hyperplasia.

Cutis 2014 Dec;94(6):276-8

Department of Dermatology, Hanyang University, Guri Hospital, 249-1, Gyomun-dong, Guri 471-701, South Korea.

Extramammary Paget disease (EMPD) is a rare skin condition usually found in the anogenital region. Histologically, EMPD may be associated with varying degrees of epidermal hyperplasia classified as squamous, papillomatous, or fibroepitheliomatous. We report a case of EMPD in a 90-year-old man who presented with well-demarcated plaques and a nodule in the pubic area with fibroepitheliomatous hyperplasia.
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December 2014

Anetoderma developing in generalized granuloma annulare in an infant.

Ann Dermatol 2014 Apr 30;26(2):283-5. Epub 2014 Apr 30.

Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.5021/ad.2014.26.2.283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037695PMC
April 2014

Comparison of cure rates and durations of treatment with diphenylcyclopropenone immunotherapy for warts in children/adolescents and adults.

Int J Dermatol 2014 Oct 2;53(10):1293-8. Epub 2014 Apr 2.

Department of Dermatology, Hanyang University Guri Hospital, Guri, Korea.

Background: Immunotherapy has been used for many years in the treatment of warts. Diphenylcyclopropenone is frequently used as an immunotherapeutic agent.

Methods: A total of 143 patients with 180 cases of warts were included in this study. We divided the patients into two groups: 72 children/adolescents and 71 adults aged 20 and over. We evaluated two types of sensitization reaction, using an erythema and blister index and a pruritus index.

Results: Of the 180 cases of warts, 159 (88.3%) were completely cured: 86 (92.5%) of the 93 cases in children/adolescents and 73 (83.9%) of the 87 cases in adults. The time required for complete cure was 17.72 ± 2.69 weeks in children/adolescents and 22.92 ± 2.59 weeks in adults (P < 0.05).

Conclusions: Diphenylcyclopropenone immunotherapy can be used effectively for both children/adolescents and adults. The time required for complete cure is shorter in children/adolescents than in adults.
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http://dx.doi.org/10.1111/ijd.12377DOI Listing
October 2014

Unusual manifestation of cutaneous cytomegalovirus infection: a nodular cutaneous lesion on the finger in a healthy adolescent girl.

Int J Dermatol 2013 Jul 24;52(7):846-8. Epub 2012 Sep 24.

Department of Dermatology, Hanyang University Guri Hospital, Guri, South Korea.

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http://dx.doi.org/10.1111/j.1365-4632.2011.05259.xDOI Listing
July 2013

Distinct variant of Sweet's syndrome: bortezomib-induced histiocytoid Sweet's syndrome in a patient with multiple myeloma.

Int J Dermatol 2012 Dec 24;51(12):1491-3. Epub 2012 Sep 24.

Department of Dermatology, Hanyang University Guri Hospital, Guri, Gyeonggi, South Korea.

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http://dx.doi.org/10.1111/j.1365-4632.2011.05141.xDOI Listing
December 2012

Merkel Cell Carcinoma Concurrent with Bowen's Disease.

Ann Dermatol 2012 Feb 2;24(1):77-80. Epub 2012 Feb 2.

Department of Dermatology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.

Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy of the elderly and immunocompromised patients. It is occasionally found coexisting with other diseases, such as squamous cell carcinoma, basal cell carcinoma, actinic keratosis, miscellaneous adnexal tumors, and rarely Bowen disease. A 75-year-old woman presented with a 6-month history of an irregularly shaped erythematous patch on the left mandibular angle. Three months later, a 1.5×1.0 cm sized painless and rapidly growing erythematous nodule developed on the patch. Microscopically, the patch lesion was consistent with that of Bowen disease. The nodular lesion showed a number of small uniform hyperchromatic cells with scanty cytoplasm. It showed dense small-cell like nodular infiltration in the dermis. Immunohistochemical staining for cytokeratin 20 showed a positive result with a dot-like perinuclear pattern. Additionally, the result for thyroid transcription factor-1 was negative, which is positive in small cell neuroendocrine carcinoma. From these findings, we diagnosed this lesion as MCC concurrent with Bowen disease.
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http://dx.doi.org/10.5021/ad.2012.24.1.77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283857PMC
February 2012

A case of dowling-degos disease on the vulva.

Ann Dermatol 2011 May 27;23(2):205-8. Epub 2011 May 27.

Department of Dermatology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.

Dowling-Degos disease (DDD) is an autosomal dominant genodermatosis and this disease is a genetically determined disturbance of epidermal proliferation. It is characterized by acquired, slowly progressive pigmented lesions that primarily involve the great skin folds and flexural areas such as the axilla, neck, limb flexures, the inframammary area and the inguinal folds. The vulva is an unusual location for DDD. A 41-year-old woman presented with a 10-year history of multiple, small, reticulated and brownish macules distributed symmetrically on the bilateral external genital regions. We found no other similarly pigmented skin lesions on her body, including the flexural areas. There was no known family history of similar eruptions or pigmentary changes. The histologic examination showed irregular rete ridge elongation with a filiform or antler-like pattern and basilar hyperpigmentation on the tips. Fontana-Masson staining showed increased pigmentation of the rete ridges and the S100 protein staining did not reveal an increased number of melanocytes in the epidermis. From these findings, we diagnosed this lesion as DDD.
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http://dx.doi.org/10.5021/ad.2011.23.2.205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130865PMC
May 2011

A case of myopericytoma on the lower leg.

Ann Dermatol 2011 May 27;23(2):201-4. Epub 2011 May 27.

Department of Dermatology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.

Myopericytoma (MP) is a benign tumor composed of cells that show apparent differentiation towards putative perivascular myoid cells called myopericytes. It arises most commonly in the dermis or subcutaneous tissue of the extremities in adults. The most common presentation is a well-circumscribed, slow-growing painless firm mass. A 45-year-old woman presented with a 2-year history of a painless, slowly growing 0.9×0.7 cm sized firm mass in the subcutaneous tissue of the posterior side of the right lower leg. We presumed this lesion to be an epidermal cyst, pilomatricoma or calcinosis cutis and performed an excisional biopsy. The histologic examination showed that it was composed of spindle-shaped myoid-appearing cells in a concentric arrangement, intimately associated with thin-walled vascular channels. Lesional spindle cells were diffusely positive for smooth muscle actin and were negative for CD34, desmin and S100 protein. From these findings, we diagnosed this lesion as a myopericytoma.
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http://dx.doi.org/10.5021/ad.2011.23.2.201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130864PMC
May 2011

Cure rate, duration required for complete cure and recurrence rate of onychomycosis according to clinical factors in Korean patients.

Mycoses 2011 Sep 19;54(5):e384-8. Epub 2010 Jul 19.

Department of Dermatology, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, Korea.

Many factors affect the cure rate (CR), duration required for complete cure (DC) and the recurrence rate (RR) of onychomycosis. The aim of this study was to evaluate the CR, DC and RR in onychomycosis according to various clinical factors. We retrospectively reviewed medical records of 637 Korean patients with onychomycosis between December 2000 and December 2006. We examined six clinical factors to evaluate the effects on the CR, DC and RR: age, sex, clinical type, treatment pattern, presence of diabetes mellitus (DM) and the extent of nail involvement. On the view of the clinical nail appearance and potassium hydroxide (KOH) preparation, we designated the CR, DC and RR. In addition, we examined the differences in the CR, DC and RR in terms of the above-mentioned clinical factors. A total of 207 eligible patients were finally analysed. The CR as a whole was 78.3%, the DC was 31.7 ± 18.4 weeks and the RR was 36.0%. There were significant differences in the CR, DC and RR according to the extent of nail involvement. Age affects the CR and DC, and DM also affects the DC and RR. We found that the extent of nail involvement, age and DM affect the CR, DC and RR of onychomycosis.
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http://dx.doi.org/10.1111/j.1439-0507.2010.01928.xDOI Listing
September 2011

A case of herpetiform appearance of digital mucous cysts.

Ann Dermatol 2010 May 18;22(2):194-5. Epub 2010 May 18.

Department of Dermatology, Guri Hospital, Hanyang University College of Medicine, Guri, Korea.

A digital mucous cyst (DMC) is clinically characterized by a round to oval, translucent, smooth nodule localized to the dorsal aspect of the distal digits near the distal interphalangeal joint. It usually presents as a solitary lesion, and multiple lesions are uncommon. An 88-year-old man presented with herpetiform translucent papules on the right thumb. We first diagnosed the lesion as molluscum contagiosum or herpetic whitlow. Histopathology showed a cystic space containing mucinous material and numerous fibroblasts surrounded by mucinous stroma in the upper dermis. The lining of the cyst wall was not apparent and mucinous material was stained with Alcian blue, indicating a diagnosis of DMC.
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http://dx.doi.org/10.5021/ad.2010.22.2.194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883424PMC
May 2010

An Unusual Clinical Presentation of Kimura's Disease Occurring on the Buttock of a Five-year-old Boy.

Ann Dermatol 2010 Feb 28;22(1):57-60. Epub 2010 Feb 28.

Department of Dermatology, College of Medicine, Hanyang University, Seoul, Korea.

Kimura's disease is a rare inflammatory disorder of unknown etiology primarily seen in young Asian males. It is characterized by painless subcutaneous masses, blood and tissue eosinophilia, and markedly elevated serum immunoglobulin E (IgE) levels. Clinically, the subcutaneous nodules occur predominantly in the head and neck. However, we report the case of a five-year-old boy presenting with an asymptomatic solitary brown pigmented nodule on the left buttock diagnosed with Kimura's disease. Here we describe the diagnosis and treatment of this unusual case.
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http://dx.doi.org/10.5021/ad.2010.22.1.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883399PMC
February 2010