Jost Klawitter

Jost Klawitter

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Jost Klawitter

Jost Klawitter

Publications by authors named "Jost Klawitter"

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Temsirolimus metabolic pathways revisited.

Xenobiotica 2020 Jun 23;50(6):640-653. Epub 2019 Oct 23.

iC42 Clinical Research and Development, Department of Anesthesiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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http://dx.doi.org/10.1080/00498254.2019.1678793DOI Listing
June 2020

Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy.

Clin Toxicol (Phila) 2020 Feb 21;58(2):124-128. Epub 2019 May 21.

Section of Emergency Medicine and Medical Toxicology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora, CO, USA.

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http://dx.doi.org/10.1080/15563650.2019.1616093DOI Listing
February 2020

Disposition of Oral Cannabidiol-Rich Cannabis Extracts in Children with Epilepsy.

Clin Pharmacokinet 2020 Feb 12. Epub 2020 Feb 12.

Section of Emergency Medicine and Medical Toxicology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, 13123 E 16th Ave B251, Aurora, CO, 8004, USA.

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http://dx.doi.org/10.1007/s40262-020-00869-zDOI Listing
February 2020

Depressed prostaglandins and leukotrienes in veterans with Gulf War illness.

J Environ Sci Health B 2019 29;54(8):623-639. Epub 2019 Apr 29.

Department of Medicine, University of Colorado , Aurora , CO , USA.

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http://dx.doi.org/10.1080/03601234.2019.1596001DOI Listing
November 2019

Prospective evaluation of oral cannabis extracts in children with epilepsy.

Seizure 2019 Nov 16;72:23-27. Epub 2019 Sep 16.

Department of Pediatrics and Neurology, University of Colorado, Anschutz Medical Campus, Aurora CO 80045, United States.

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http://dx.doi.org/10.1016/j.seizure.2019.09.007DOI Listing
November 2019

Cyclophilin D knockout protects the mouse kidney against cyclosporin A-induced oxidative stress.

Am J Physiol Renal Physiol 2019 09 12;317(3):F683-F694. Epub 2019 Jun 12.

Clinical Research and Development, Department of Anesthesiology, University of Colorado Denver, Aurora, Colorado.

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http://dx.doi.org/10.1152/ajprenal.00417.2018DOI Listing
September 2019

Assessment of tacrolimus intrapatient variability in stable adherent transplant recipients: Establishing baseline values.

Am J Transplant 2019 05 26;19(5):1410-1420. Epub 2018 Dec 26.

Division of Hematology and Oncology, Children's Hospital of Richmond, Richmond, Virginia.

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http://doi.wiley.com/10.1111/ajt.15199
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http://dx.doi.org/10.1111/ajt.15199DOI Listing
May 2019

Bone marrow-derived cPLA2α contributes to renal fibrosis progression.

J Lipid Res 2018 02 11;59(2):380-390. Epub 2017 Dec 11.

Department of Medicine, Renal Division, University of Colorado Anschutz Medical Campus, Aurora, CO.

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http://dx.doi.org/10.1194/jlr.M082362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794431PMC
February 2018

An Atmospheric Pressure Chemical Ionization MS/MS Assay Using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine.

Ther Drug Monit 2017 10;39(5):556-564

*Department of Anesthesiology, University of Colorado, Aurora; †Division of Substance Dependence, Department of Psychiatry, University of Colorado, Aurora; ‡Department of Neurology, University of Colorado, Aurora; §Department of Pediatrics, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora; ¶Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora; and ‖Division of Pulmonary Medicine, National Jewish Health, Denver, Colorado.

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http://dx.doi.org/10.1097/FTD.0000000000000427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600652PMC
October 2017

Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart.

J Cell Biochem 2017 09 12;118(9):2933-2940. Epub 2017 Apr 12.

Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.

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http://dx.doi.org/10.1002/jcb.25947DOI Listing
September 2017

Identifying biomarkers for asthma diagnosis using targeted metabolomics approaches.

Respir Med 2016 12 21;121:59-66. Epub 2016 Oct 21.

Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, USA.

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http://dx.doi.org/10.1016/j.rmed.2016.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516646PMC
December 2016

Amino acids in a targeted versus a non-targeted metabolomics LC-MS/MS assay. Are the results consistent?

Clin Biochem 2016 Sep 8;49(13-14):955-61. Epub 2016 Jun 8.

iC42 Clinical Research and Development, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

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http://dx.doi.org/10.1016/j.clinbiochem.2016.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047903PMC
September 2016

Biomarkers in Transplantation--Proteomics and Metabolomics.

Ther Drug Monit 2016 Apr;38 Suppl 1:S70-4

iC42 Clinical Research and Development, University of Colorado, Aurora.

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http://dx.doi.org/10.1097/FTD.0000000000000243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769975PMC
April 2016

Pravastatin Therapy and Biomarker Changes in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease.

Clin J Am Soc Nephrol 2015 Sep 29;10(9):1534-41. Epub 2015 Jul 29.

Division of Renal Diseases and Hypertension, Department of Pediatrics, University of Colorado, Aurora, Colorado.

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http://dx.doi.org/10.2215/CJN.11331114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559520PMC
September 2015

Everolimus and sirolimus in transplantation-related but different.

Expert Opin Drug Saf 2015 Jul 26;14(7):1055-70. Epub 2015 Apr 26.

University of Colorado, iC42 Clinical Research and Development , Anschutz Medical Campus, 1999 North Fitzsimons Parkway, Suite 100, Aurora, CO 80045-7503 , USA +1 303 724 5665 ; +1 303 724 5662 ;

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http://dx.doi.org/10.1517/14740338.2015.1040388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053318PMC
July 2015

A high-performance liquid chromatography-tandem mass spectrometry-based targeted metabolomics kidney dysfunction marker panel in human urine.

Clin Chim Acta 2015 Jun 11;446:43-53. Epub 2015 Apr 11.

iC42 Clinical Research and Development, Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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http://dx.doi.org/10.1016/j.cca.2015.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028022PMC
June 2015

Fatty acid desaturation index in human plasma: comparison of different analytical methodologies for the evaluation of diet effects.

Anal Bioanal Chem 2014 Oct 13;406(25):6399-408. Epub 2014 Aug 13.

iC42 Integrated Solutions in Systems Biology, University of Colorado, Aurora, CO, 80045-7503, USA,

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http://dx.doi.org/10.1007/s00216-014-8020-4DOI Listing
October 2014

Proteomics and metabolomics in renal transplantation-quo vadis?

Transpl Int 2013 Mar 21;26(3):225-41. Epub 2012 Nov 21.

iC42 Clinical Research & Development, Department of Anesthesiology, University of Colorado Denver, Aurora, CO, USA.

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http://dx.doi.org/10.1111/tri.12003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006577PMC
March 2013

Association of DJ-1/PTEN/AKT- and ASK1/p38-mediated cell signalling with ischaemic cardiomyopathy.

Cardiovasc Res 2013 Jan 26;97(1):66-76. Epub 2012 Sep 26.

Clinical Research and Development, Department of Anesthesiology, University of Colorado Denver, 1999 N. Fitzsimons Parkway Bioscience East, Suite 100, Aurora, CO 80045-7503, USA.

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http://dx.doi.org/10.1093/cvr/cvs302DOI Listing
January 2013

Mass Spectrometry-Based Multiplexing for the Analysis of Biomarkers in Drug Development and Clinical Diagnostics- How Much is too Much?

Microchem J 2012 Nov;105:32-38

iC42 Clinical Research & Development, Department of Anesthesiology, University of Colorado, Aurora, Colorado 80045, United States.

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http://dx.doi.org/10.1016/j.microc.2012.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640576PMC
November 2012

How unbiased is non-targeted metabolomics and is targeted pathway screening the solution?

Curr Pharm Biotechnol 2011 Jul;12(7):1053-66

iC42 Clinical Research and Development, Department of Anesthesiology, University of Colorado Denver, Aurora, Colorado 80045-7503, USA.

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http://dx.doi.org/10.2174/138920111795909078DOI Listing
July 2011

Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns.

J Mass Spectrom 2011 Jul;46(7):615-24

iC42 Clinical Research & Development, Department of Anesthesiology, University of Colorado Denver, Aurora, Colorado 80045-7503, USA.

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http://doi.wiley.com/10.1002/jms.1930
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http://dx.doi.org/10.1002/jms.1930DOI Listing
July 2011

Biomarkers of immunosuppressant organ toxicity after transplantation: status, concepts and misconceptions.

Expert Opin Drug Metab Toxicol 2011 Feb;7(2):175-200

University of Colorado, Department of Anesthesiology, 1999 North Fitzsimons Parkway, Bioscience East, Suite 100, Aurora, CO 80045-7503, USA.

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http://dx.doi.org/10.1517/17425255.2011.544249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079351PMC
February 2011

Quantification of 15-F2t-isoprostane in human plasma and urine: results from enzyme-linked immunoassay and liquid chromatography/tandem mass spectrometry cannot be compared.

Rapid Commun Mass Spectrom 2011 Feb;25(4):463-8

Clinical Research and Development, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045-7503, USA.

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http://dx.doi.org/10.1002/rcm.4871DOI Listing
February 2011

Effects of lovastatin on breast cancer cells: a proteo-metabonomic study.

Breast Cancer Res 2010 5;12(2):R16. Epub 2010 Mar 5.

Department of Anesthesiology, Clinical Research and Development, University of Colorado-Denver, 12401 East 17th Avenue, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1186/bcr2485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879560PMC
September 2010

Development and validation of a sensitive assay for the quantification of imatinib using LC/LC-MS/MS in human whole blood and cell culture.

Biomed Chromatogr 2009 Dec;23(12):1251-8

Clinical Research and Development, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045-7503, USA.

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http://dx.doi.org/10.1002/bmc.1247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044679PMC
December 2009

Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells.

Br J Pharmacol 2009 Sep 6;158(2):588-600. Epub 2009 Aug 6.

Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO 80045, USA.

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http://dx.doi.org/10.1111/j.1476-5381.2009.00345.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757699PMC
September 2009

A metabonomic and proteomic analysis of changes in IMCD3 cells chronically adapted to hypertonicity.

Nephron Physiol 2008 5;109(1):p1-10. Epub 2008 May 5.

Department of Anesthesiology, School of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

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http://dx.doi.org/10.1159/000129074DOI Listing
August 2008

Development and validation of an assay for the quantification of 11 nucleotides using LC/LC-electrospray ionization-MS.

Anal Biochem 2007 Jun 4;365(2):230-9. Epub 2007 Apr 4.

Clinical Research and Development, Department of Anesthesiology, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA.

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http://ac.els-cdn.com/S0003269707001674/1-s2.0-S000326970700
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http://www.carbohydratetesting.com/media/_orphansbackup/5d59
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S000326970700167
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http://dx.doi.org/10.1016/j.ab.2007.03.018DOI Listing
June 2007

Impact of organ preservation using HTK for graft flush and subsequent storage in UW in rat kidney transplantation.

Eur Surg Res 2006 17;38(4):388-98. Epub 2006 Jul 17.

Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA.

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http://dx.doi.org/10.1159/000094600DOI Listing
October 2006

H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants.

Kidney Int 2005 Mar;67(3):1142-51

Department of Anesthesiology, Biomedical MRI/MRS, University of Colorado Health Sciences Center, Denver, Colorado, USA.

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http://dx.doi.org/10.1111/j.1523-1755.2005.00181.xDOI Listing
March 2005

Organ-specific response to inhibition of mitochondrial metabolism by cyclosporine in the rat.

Transpl Int 2003 Oct 24;16(10):748-55. Epub 2003 Jun 24.

Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado, USA.

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http://dx.doi.org/10.1007/s00147-003-0631-1DOI Listing
October 2003