Publications by authors named "Joshy George"

66Publications

Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE).

Authors:
Aline Talhouk Joshy George Chen Wang Timothy Budden Tuan Zea Tan Derek S Chiu Stefan Kommoss Huei San Leong Stephanie Chen Maria P Intermaggio Blake Gilks Tayyebeh M Nazeran Mila Volchek Wafaa Elatre Rex C Bentley Janine Senz Amy Lum Veronica Chow Hanwei Sudderuddin Robertson Mackenzie Samuel C Y Leong Geyi Liu Dustin Johnson Billy Chen Aocs Group Jennifer Alsop Susana N Banerjee Sabine Behrens Clara Bodelon Alison H Brand Louise Brinton Michael E Carney Yoke-Eng Chiew Kara L Cushing-Haugen Cezary Cybulski Darren Ennis Sian Fereday Renée T Fortner Jesús García-Donas Aleksandra Gentry-Maharaj Rosalind Glasspool Teodora Goranova Casey S Greene Paul Haluska Holly R Harris Joy Hendley Brenda Y Hernandez Esther Herpel Mercedes Jimenez-Linan Chloe Karpinskyj Scott H Kaufmann Gary L Keeney Catherine J Kennedy Martin Köbel Jennifer M Koziak Melissa C Larson Jenny Lester Liz-Anne Lewsley Jolanta Lissowska Jan Lubiński Hugh Luk Geoff Macintyre Sven Mahner Iain A McNeish Janusz Menkiszak Nikilyn Nevins Ana Osorio Oleg Oszurek José Palacios Samantha Hinsley Celeste L Pearce Malcolm C Pike Anna M Piskorz Isabelle Ray-Coquard Valerie Rhenius Cristina Rodriguez-Antona Raghwa Sharma Mark E Sherman Dilrini De Silva Naveena Singh Peter Sinn Dennis Slamon Honglin Song Helen Steed Euan A Stronach Pamela J Thompson Aleksandra Tołoczko Britton Trabert Nadia Traficante Chiu-Chen Tseng Martin Widschwendter Lynne R Wilkens Stacey J Winham Boris Winterhoff Alicia Beeghly-Fadiel Javier Benitez Andrew Berchuck James D Brenton Robert Brown Jenny Chang-Claude Georgia Chenevix-Trench Anna deFazio Peter A Fasching María J García Simon A Gayther Marc T Goodman Jacek Gronwald Michelle J Henderson Beth Y Karlan Linda E Kelemen Usha Menon Sandra Orsulic Paul D P Pharoah Nicolas Wentzensen Anna H Wu Joellen M Schildkraut Mary Anne Rossing Gottfried E Konecny David G Huntsman Ruby Yun-Ju Huang Ellen L Goode Susan J Ramus Jennifer A Doherty David D Bowtell Michael S Anglesio

Clin Cancer Res 2020 Oct 17;26(20):5411-5423. Epub 2020 Jun 17.

British Columbia's Gynecological Cancer Research Program (OVCARE), BC Cancer, Vancouver General Hospital, and University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-20-0103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572656PMC
October 2020

Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis.

Cell Rep 2019 11;29(9):2672-2688.e7

The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA; Institute for Systems Genomics, UConn Health, Farmington, CT, USA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.10.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936330PMC
November 2019

A computational method to aid the design and analysis of single cell RNA-seq experiments for cell type identification.

BMC Bioinformatics 2019 Jun 6;20(Suppl 11):275. Epub 2019 Jun 6.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA.

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http://dx.doi.org/10.1186/s12859-019-2817-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551246PMC
June 2019

Elements of a successful hospital-based deceased donation programme in India: Zero to eighty-five in two years.

Natl Med J India 2018 Jul-Aug;31(4):201-205

Department of Hospital Administration, Lakeshore Hospital, Kochi, Kerala, India.

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http://dx.doi.org/10.4103/0970-258X.258217DOI Listing
October 2019

Tracing source, distribution and health risk of potentially harmful elements (PHEs) in street dust of Durgapur, India.

Ecotoxicol Environ Saf 2018 Jun 22;154:280-293. Epub 2018 Feb 22.

Department of Environmental Studies, Institute of Science (Siksha-Bhavana), Visva-Bharati, Santiniketan 731235, West Bengal, India. Electronic address:

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http://dx.doi.org/10.1016/j.ecoenv.2018.02.042DOI Listing
June 2018

Expression and function of ABCG2 and XIAP in glioblastomas.

J Neurooncol 2017 05 21;133(1):47-57. Epub 2017 Apr 21.

The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA.

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http://dx.doi.org/10.1007/s11060-017-2422-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627495PMC
May 2017

Bioavailability and health risk of some potentially toxic elements (Cd, Cu, Pb and Zn) in street dust of Asansol, India.

Ecotoxicol Environ Saf 2017 Apr 9;138:231-241. Epub 2017 Jan 9.

Department of Environmental Studies, Institute of Science(Siksha-Bhavana),Visva-Bharati, Santiniketan, West Bengal 731235, India. Electronic address:

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http://dx.doi.org/10.1016/j.ecoenv.2017.01.008DOI Listing
April 2017

A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers.

Cancer Res 2017 02 6;77(4):971-981. Epub 2016 Dec 6.

Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales Australia, Kensington, New South Wales, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2906DOI Listing
February 2017

Computational inference of a genomic pluripotency signature in human and mouse stem cells.

Biol Direct 2016 09 17;11:47. Epub 2016 Sep 17.

The Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT, 06032, USA.

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http://dx.doi.org/10.1186/s13062-016-0148-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027095PMC
September 2016

Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells.

Nat Commun 2016 07 11;7:12166. Epub 2016 Jul 11.

The Jackson Laboratory for Mammalian Genetics, 600 Main Street, Bar Harbor, Maine 04609, USA.

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http://www.nature.com/articles/ncomms12166
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http://dx.doi.org/10.1038/ncomms12166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942573PMC
July 2016

multiClust: An R-package for Identifying Biologically Relevant Clusters in Cancer Transcriptome Profiles.

Cancer Inform 2016 12;15:103-14. Epub 2016 Jun 12.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

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http://dx.doi.org/10.4137/CIN.S38000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907340PMC
June 2016

Pericytes Promote Malignant Ovarian Cancer Progression in Mice and Predict Poor Prognosis in Serous Ovarian Cancer Patients.

Clin Cancer Res 2016 Apr 20;22(7):1813-24. Epub 2015 Nov 20.

Epithelial Stem Cell Biology Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia. Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1931DOI Listing
April 2016

CD73 is associated with poor prognosis in high-grade serous ovarian cancer.

Cancer Res 2015 Nov 11;75(21):4494-503. Epub 2015 Sep 11.

Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Québec, Canada. Institut du Cancer de Montréal, Montréal, Québec, Canada. Faculté de Pharmacie, Université de Montréal, Québec, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-3569DOI Listing
November 2015

Whole-genome characterization of chemoresistant ovarian cancer.

Nature 2015 May;521(7553):489-94

1] Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia [2] Department of Pathology, University of Melbourne, Parkville, Victoria 3052, Australia [3] Sir Peter MacCallum Cancer Centre Department of Oncology, University of Melbourne, Parkville, Victoria 3052, Australia [4] Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London W12 0HS, UK [5] Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1038/nature14410DOI Listing
May 2015

Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition.

Mol Cancer Ther 2015 Jun 7;14(6):1495-503. Epub 2015 Apr 7.

Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0039DOI Listing
June 2015

Efficient molecular subtype classification of high-grade serous ovarian cancer.

J Pathol 2015 Jul 30;236(3):272-7. Epub 2015 Apr 30.

The Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1002/path.4536DOI Listing
July 2015

The genomic landscape of phaeochromocytoma.

J Pathol 2015 May 2;236(1):78-89. Epub 2015 Feb 2.

The Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia; The Department of Pathology, University of Melbourne, Parkville, VIC, Australia.

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http://dx.doi.org/10.1002/path.4503DOI Listing
May 2015

Human exposure risks for metals in soil near a coal-fired power-generating plant.

Arch Environ Contam Toxicol 2015 Apr 24;68(3):451-61. Epub 2014 Dec 24.

Environmental Management Division, CSIR-Central Institute of Mining and Fuel Research (Digwadih Campus), Dhanbad, 828108, India.

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http://dx.doi.org/10.1007/s00244-014-0111-xDOI Listing
April 2015

Genomic classification of serous ovarian cancer with adjacent borderline differentiates RAS pathway and TP53-mutant tumors and identifies NRAS as an oncogenic driver.

Clin Cancer Res 2014 Dec 14;20(24):6618-30. Epub 2014 Oct 14.

Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia. Crown Princess Mary Cancer Centre, Westmead Hospital, Sydney, New South Wales, Australia. University of Sydney, Westmead Hospital, Sydney, New South Wales, Australia. Westmead Institute for Cancer Research, Westmead Millennium Institute, Westmead Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1292DOI Listing
December 2014

ABCA transporter gene expression and poor outcome in epithelial ovarian cancer.

J Natl Cancer Inst 2014 Jul 23;106(7). Epub 2014 Jun 23.

Affiliations of authors: Children's Cancer Institute Australia, Randwick, Australia (ELH, AJR, RTW, CF, MDN, MH, MJH); Department of Gynaecological Oncology and Westmead Institute for Cancer Research (BG, CE, AOCSG, AdF), Crown Princess Mary Cancer Centre and Westmead Institute for Cancer Research (PH) University of Sydney at the Westmead Millennium Institute, Westmead Hospital, Sydney, Australia; Queensland Institute of Medical Research, Brisbane, Australia (YL, JB, SEJ, XC, AOCSG, GC-T, SM); Peter MacCallum Cancer Centre, Melbourne, Australia (JG, AOCSG, DDB); Vesalius Research Center, VIB, Leuven, Belgium (DL); Department of Oncology, University of Leuven and University Hospitals Leuven, Leuven, Belgium (ED, SL, IV); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA (BK, JL, SO, CW); Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany (PF, MWB, AH); University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA (PF); Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan (ABE, KM, SH); Department of Gynecology (TN), and Department of Pathology and Molecular Diagnostics (YY), Aichi Cancer Center Central Hospital, Nagoya, Aichi, Japan; Department of Obstetrics and Gynecology (TP, YB), and Knight Cancer Institute (TP, YB), Oregon Health & Science University, Portland, OR; Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Erlangen, Germany (FH); Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/Knappschaft GmbH, Essen, Germany (FH); De

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http://dx.doi.org/10.1093/jnci/dju149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110473PMC
July 2014

A signature predicting poor prognosis in gastric and ovarian cancer represents a coordinated macrophage and stromal response.

Clin Cancer Res 2014 May 21;20(10):2761-72. Epub 2014 Mar 21.

Authors' Affiliations: Cancer Genetics and Genomics Laboratory; Molecular Genomics Core Facility; Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne; Sir Peter MacCallum Department of Oncology; Department of Medicine, Royal Melbourne Hospital; National ICT Australia (NICTA); Department of Pathology, The University of Melbourne, Parkville, Australia; Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School; Cellular and Molecular Research, National Cancer Centre; Cancer Science Institute of Singapore, National University of Singapore; Genome Institute of Singapore, Singapore; and Faculty of Medicine in the Galilee, Bar Ilan University, Zfat, IsraelAuthors' Affiliations: Cancer Genetics and Genomics Laboratory; Molecular Genomics Core Facility; Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne; Sir Peter MacCallum Department of Oncology; Department of Medicine, Royal Melbourne Hospital; National ICT Australia (NICTA); Department of Pathology, The University of Melbourne, Parkville, Australia; Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School; Cellular and Molecular Research, National Cancer Centre; Cancer Science Institute of Singapore, National University of Singapore; Genome Institute of Singapore, Singapore; and Faculty of Medicine in the Galilee, Bar Ilan University, Zfat, IsraelAuthors' Affiliations: Cancer Genetics and Genomics Laboratory; Molecular Genomics Core Facility; Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne; Sir Peter MacCallum Department of Oncology; Department of Medicine, Royal Melbourne Hospital; National ICT Australia (NICTA); Department of Pathology, The University of Melbourne, Parkville, Australia; Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School; Cellular and Molecular Research, National Cancer Centre; Cancer Science Institute of Singapore, National University of Singapore; Genome Institute of Singapore, Singapore; and Fa

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http://clincancerres.aacrjournals.org/content/early/2014/04/
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http://clincancerres.aacrjournals.org/content/early/2014/03/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-13-3049DOI Listing
May 2014

Synthetic lethality between CCNE1 amplification and loss of BRCA1.

Proc Natl Acad Sci U S A 2013 Nov 11;110(48):19489-94. Epub 2013 Nov 11.

Department of Research, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia.

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http://dx.doi.org/10.1073/pnas.1314302110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845173PMC
November 2013

Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1-amplified ovarian cancer.

Clin Cancer Res 2013 Nov 4;19(21):5960-71. Epub 2013 Sep 4.

Authors' Affiliations: Peter MacCallum Cancer Centre, East Melbourne; Victorian Cancer Cytogenetics Service, St Vincent's Hospital, Melbourne; Sir Peter MacCallum Department of Oncology; Departments of Pathology, Biochemistry and Molecular Biology, and Medicine; Centre for Translational Pathology, University of Melbourne, Parkville, Victoria, Australia; Dana-Farber Cancer Institute, Boston; and The Broad Institute of Harvard and MIT, Cambridge, Massachusetts.

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http://clincancerres.aacrjournals.org/content/early/2013/08/
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http://clincancerres.aacrjournals.org/content/19/21/5960.ful
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-13-1337DOI Listing
November 2013

Identifying associations between genomic alterations in tumors.

Methods Mol Biol 2013 ;1049:9-19

Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/978-1-62703-547-7_2DOI Listing
March 2014

Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study.

Lancet Oncol 2013 Aug 9;14(9):853-62. Epub 2013 Jul 9.

Division of Epidemiology, Department of Health Research and Policy, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1016/S1470-2045(13)70253-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006367PMC
August 2013

Assessment of human health risks from heavy metals in outdoor dust samples in a coal mining area.

Environ Geochem Health 2013 Jun 6;35(3):347-56. Epub 2012 Nov 6.

Environmental Management Division, CSIR-Central Institute of Mining and Fuel Research (Digwadih Campus), Dhanbad, 828108, India.

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http://dx.doi.org/10.1007/s10653-012-9499-2DOI Listing
June 2013

Evaluation of the co-application of fly ash and sewage sludge on soil biological and biochemical quality.

Environ Technol 2012 Apr-May;33(7-9):897-905

Environmental Management Division, Central Institute of Mining and Fuel Research (Digwadih Campus), [Erstwhile Central Fuel Research Institute], Dhanbad, India.

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http://www.tandfonline.com/doi/abs/10.1080/09593330.2011.602
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http://dx.doi.org/10.1080/09593330.2011.602432DOI Listing
August 2012

Vascular normalization by loss of Siah2 results in increased chemotherapeutic efficacy.

Cancer Res 2012 Apr 21;72(7):1694-704. Epub 2012 Feb 21.

Cancer Genomics and Genetics, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3310DOI Listing
April 2012

Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells.

Genes Dev 2007 Oct;21(20):2545-57

Gene Regulation Laboratory, Genome Institute of Singapore, Singapore 138672.

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http://dx.doi.org/10.1101/gad.1588207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000320PMC
October 2007