Joshua W Knowles

Joshua W Knowles

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Joshua W Knowles

Publications by authors named "Joshua W Knowles"

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Polygenic risk scores in coronary artery disease.

Curr Opin Cardiol 2019 Jul;34(4):435-440

Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1097/HCO.0000000000000629DOI Listing
July 2019

Trends in overall, cardiovascular and cancer-related mortality among individuals with diabetes reported on death certificates in the United States between 2007 and 2017.

Diabetologia 2019 Jul 22;62(7):1185-1194. Epub 2019 Apr 22.

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 750 Welch Road no. 210, Palo Alto, CA, 94304, USA.

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http://dx.doi.org/10.1007/s00125-019-4870-9DOI Listing
July 2019

No evidence of a causal association of type 2 diabetes and glucose metabolism with atrial fibrillation.

Diabetologia 2019 May 27;62(5):800-804. Epub 2019 Feb 27.

Department of Medicine, Division of Cardiovascular Medicine, Falk Cardiovascular Research Center, Stanford University School of Medicine, 300 Pasteur Drive, CV 273, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1007/s00125-019-4836-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451665PMC
May 2019

Body composition and atrial fibrillation: a Mendelian randomization study.

Eur Heart J 2019 Apr;40(16):1277-1282

Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA, USA.

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https://academic.oup.com/eurheartj/advance-article/doi/10.10
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http://dx.doi.org/10.1093/eurheartj/ehz003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475522PMC
April 2019

Impact of race/ethnicity on insulin resistance and hypertriglyceridaemia.

Diab Vasc Dis Res 2019 Mar;16(2):153-159

1 Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1177/1479164118813890DOI Listing
March 2019

Association of Statin Adherence With Mortality in Patients With Atherosclerotic Cardiovascular Disease.

JAMA Cardiol 2019 Feb 13. Epub 2019 Feb 13.

Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University, Stanford, California.

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http://cardiology.jamanetwork.com/article.aspx?doi=10.1001/j
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http://dx.doi.org/10.1001/jamacardio.2018.4936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439552PMC
February 2019

Safety and Efficacy of PCSK9 Inhibitors After Heart Transplantation.

Can J Cardiol 2019 Jan 14;35(1):104.e1-104.e3. Epub 2018 Nov 14.

Stanford University, Division of Cardiovascular Medicine, Heart Transplantation, Palo Alto, California, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2018.11.004DOI Listing
January 2019

Genetic Testing and Risk Scores: Impact on Familial Hypercholesterolemia.

Front Cardiovasc Med 2019 29;6. Epub 2019 Jan 29.

Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University, Stanford, CA, United States.

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http://dx.doi.org/10.3389/fcvm.2019.00005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361766PMC
January 2019

Large Q and S waves in lead III on the electrocardiogram distinguish patients with hypertrophic cardiomyopathy from athletes.

Heart 2018 11 21;104(22):1871-1877. Epub 2018 Apr 21.

Stanford University School of Medicine, Stanford Center for Inherited Cardiovascular Disease, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1136/heartjnl-2017-312647DOI Listing
November 2018

Frequency of Statin Use in Patients With Low-Density Lipoprotein Cholesterol ≥190 mg/dl from the Veterans Affairs Health System.

Am J Cardiol 2018 Sep 7;122(5):756-761. Epub 2018 Jun 7.

Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University, Stanford, California; Veterans Affairs Health System, Palo Alto, California.

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http://dx.doi.org/10.1016/j.amjcard.2018.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538561PMC
September 2018

First Trimester Plasma Glucose Values in Women without Diabetes are Associated with Risk for Congenital Heart Disease in Offspring.

J Pediatr 2018 04 15;195:275-278. Epub 2017 Dec 15.

Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA; Division of Pediatric Cardiology, Stanford University School of Medicine, Stanford, CA. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2017.10.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869072PMC
April 2018

Cardiovascular disease: The rise of the genetic risk score.

PLoS Med 2018 03 30;15(3):e1002546. Epub 2018 Mar 30.

Center for Inherited Cardiovascular Disease, Stanford University, Stanford, California, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1002546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877829PMC
March 2018

Relationship between simple markers of insulin resistance and coronary artery calcification.

J Clin Lipidol 2017 Jul - Aug;11(4):1007-1012. Epub 2017 Jun 6.

Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1016/j.jacl.2017.05.013DOI Listing
February 2018

Induced Pluripotent Stem Cell-Derived Endothelial Cells in Insulin Resistance and Metabolic Syndrome.

Arterioscler Thromb Vasc Biol 2017 11 20;37(11):2038-2042. Epub 2017 Jul 20.

From the Department of Medicine and Cardiovascular Institute (I.C.-O., T.Q., J.W.K.) and Department of Cardiothoracic Surgery and Cardiovascular Institute (N.F.H.), Stanford University School of Medicine, CA; and Veterans Affairs Palo Alto Health Care System, CA (N.F.H.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669062PMC
November 2017

Is ACS in Young Patients a "Canary in the Coal Mine" for Familial Hypercholesterolemia?

J Am Coll Cardiol 2017 10;70(14):1741-1743

Department of Medicine, Stanford University, Stanford, California.

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http://dx.doi.org/10.1016/j.jacc.2017.08.019DOI Listing
October 2017

Leveraging Human Genetics to Understand the Relation of LDL Cholesterol with Type 2 Diabetes.

Clin Chem 2017 07 17;63(7):1187-1189. Epub 2017 May 17.

Department of Medicine, Division of Cardiovascular Medicine.

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http://dx.doi.org/10.1373/clinchem.2016.268565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704957PMC
July 2017

Cascade Screening for Familial Hypercholesterolemia and the Use of Genetic Testing.

JAMA 2017 07;318(4):381-382

Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia.

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http://dx.doi.org/10.1001/jama.2017.8543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166431PMC
July 2017

Access to Nonstatin Lipid-Lowering Therapies in Patients at High Risk of Atherosclerotic Cardiovascular Disease.

Circulation 2017 05 26;135(22):2204-2206. Epub 2017 Apr 26.

From Stanford University, CA (J.W.K.); The FH Foundation, Pasadena, CA (J.W.K., L.K., K.A.W.); Atomo, Inc., Austin, TX (W.B.H., K.D.M.); Preventive Cardiology Inc., Boca Raton, FL (S.J.B.); and Baylor College of Medicine, Houston, TX (C.M.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.027705DOI Listing
May 2017

Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.

Cell Stem Cell 2017 04 22;20(4):518-532.e9. Epub 2016 Dec 22.

Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.stem.2016.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384872PMC
April 2017

The role of registries and genetic databases in familial hypercholesterolemia.

Curr Opin Lipidol 2017 Apr;28(2):152-160

aThe FH Foundation, Pasadena, California, USA bFundacion Hipercolesterolemia Familiar, Madrid, Spain cDivision of Cardiovascular Medicine and Cardiovascular Institute Stanford University, Stanford University Falk Cardiovascular Research Center, Stanford, California, USA.

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http://dx.doi.org/10.1097/MOL.0000000000000398DOI Listing
April 2017

Association Between Intensity of Statin Therapy and Mortality in Patients With Atherosclerotic Cardiovascular Disease.

JAMA Cardiol 2017 01;2(1):47-54

Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University, Stanford, California4Division of Cardiovascular Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, California.

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http://dx.doi.org/10.1001/jamacardio.2016.4052DOI Listing
January 2017

Use of high-intensity statins for patients with atherosclerotic cardiovascular disease in the Veterans Affairs Health System: Practice impact of the new cholesterol guidelines.

Am Heart J 2016 Dec 29;182:97-102. Epub 2016 Sep 29.

Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University, Stanford, CA; Veterans Affairs Health System, Palo Alto, CA. Electronic address:

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http://dx.doi.org/10.1016/j.ahj.2016.09.007DOI Listing
December 2016

Novel Therapies for Familial Hypercholesterolemia.

Curr Treat Options Cardiovasc Med 2016 Nov;18(11):64

Stanford University School of Medicine and Cardiovascular Institute, Falk CVRC, 300 Pasteur Drive, MC 5406, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1007/s11936-016-0486-2DOI Listing
November 2016

Metabolic Markers to Predict Incident Diabetes Mellitus in Statin-Treated Patients (from the Treating to New Targets and the Stroke Prevention by Aggressive Reduction in Cholesterol Levels Trials).

Am J Cardiol 2016 Nov 12;118(9):1275-1281. Epub 2016 Aug 12.

Division of Cardiovascular Medicine and Cardiovascular Institute, Department of Medicine, Stanford University, Stanford, California.

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http://dx.doi.org/10.1016/j.amjcard.2016.07.054DOI Listing
November 2016

Interdisciplinary psychosocial care for families with inherited cardiovascular diseases.

Trends Cardiovasc Med 2016 10 28;26(7):647-53. Epub 2016 Apr 28.

Agnes Ginges Centre for Molecular Cardiology, Centenary Institute, Locked Bag 6, Newtown, Sydney, New South Wales, Australia; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.tcm.2016.04.010DOI Listing
October 2016

Hypertriglyceridemia: A simple approach to identify insulin resistance and enhanced cardio-metabolic risk in patients with prediabetes.

Diabetes Res Clin Pract 2016 Oct 6;120:156-61. Epub 2016 Aug 6.

Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University School of Medicine, Falk CVRC, 300 Pasteur Drive, Stanford, CA 94305-5406, USA. Electronic address:

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http://dx.doi.org/10.1016/j.diabres.2016.07.024DOI Listing
October 2016

Standards of Evidence and Mechanistic Inference in Autosomal Recessive Hypercholesterolemia.

Arterioscler Thromb Vasc Biol 2016 08;36(8):1465-6

From the Divisions of Pediatric Cardiology (J.R.P.) and Cardiovascular Medicine (J.W.K.), Stanford Cardiovascular Institute, Stanford University School of Medicine, CA; and The FH Foundation, Pasadena, CA (J.W.K.).

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http://dx.doi.org/10.1161/ATVBAHA.116.307714DOI Listing
August 2016

Enough Evidence, Time to Act!

Circulation 2016 Jul;134(1):20-3

From Stanford University, Division of Cardiovascular Medicine and Stanford Cardiovascular Institute, CA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023010DOI Listing
July 2016

Statins in Familial Hypercholesterolemia: Translating Evidence to Action.

Authors:
Joshua W Knowles

J Am Coll Cardiol 2016 07;68(3):261-264

Division of Cardiovascular Medicine and Stanford Cardiovascular Institute, Stanford University, Stanford, California. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.05.024DOI Listing
July 2016

Treatment Gaps in Adults With Heterozygous Familial Hypercholesterolemia in the United States: Data From the CASCADE-FH Registry.

Circ Cardiovasc Genet 2016 Jun 24;9(3):240-9. Epub 2016 Mar 24.

From the University of Pennsylvania, Philadelphia (E.M.d., D.J.R.); University of Texas Southwestern, Dallas (Z.S.A.); Duke Clinical Research Institute, Durham, NC (E.C.O., P.S., M.T.R.); The FH Foundation, South Pasadena, CA (I.K., C.D.A., K.W.); New York University School of Medicine (C.B.N.); Mid America Heart Institute, Kansas City, MO (Y.P.); Preventive Cardiology Inc, Boca Raton, FL (S.J.B.); Massachusetts General Hospital, Boston (L.C. Hemphill); The Rogosin Institute, New York, NY (L.C. Hudgins); Nemours Cardiac Center, Wilmington, DE (S.S.G.); Thomas Jefferson University Hospital, Philadelphia, PA (D.D.); West Virginia University, Morgantown (W.N.); Baylor College of Medicine, Houston, TX (C.M.B.); Vanderbilt University School of Medicine, Nashville, TN (M.F.L.); Oregon Health and Science University, Portland, OR (P.B.D., M.D.S.); University of Kansas Medical Center (P.M.M.); and Stanford University, CA (J.W.K.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315030PMC
June 2016

Impact of Septal Reduction on Left Atrial Size and Diastole in Hypertrophic Cardiomyopathy.

Echocardiography 2016 May 1;33(5):686-94. Epub 2016 Mar 1.

Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California.

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http://dx.doi.org/10.1111/echo.13158DOI Listing
May 2016

Cardiometabolic Effects of Glucagon-Like Peptide-1 Agonists.

Curr Atheroscler Rep 2016 Feb;18(2)

Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University School of Medicine, Falk CVRC, Room CV273, MC 5406, 300 Pasteur Drive, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1007/s11883-016-0558-5DOI Listing
February 2016

Maternal Midpregnancy Glucose Levels and Risk of Congenital Heart Disease in Offspring.

JAMA Pediatr 2015 Dec;169(12):1112-6

Department of Pediatrics, Stanford University School of Medicine, Stanford, California.

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http://dx.doi.org/10.1001/jamapediatrics.2015.2831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996656PMC
December 2015

Familial Hypercholesterolemia and the 2013 American College of Cardiology/American Heart Association Guidelines: Myths, Oversimplification, and Misinterpretation Versus Facts.

Am J Cardiol 2015 Aug 9;116(3):481-4. Epub 2015 May 9.

The FH Foundation, South Pasadena, California; Sections of Cardiovascular Research and Cardiology, Baylor College of Medicine, Houston, Texas; Center for Cardiovascular Disease Prevention, Houston Methodist DeBakey Heart and Vascular Center and Baylor College of Medicine, Houston, Texas.

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https://linkinghub.elsevier.com/retrieve/pii/S00029149150126
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http://dx.doi.org/10.1016/j.amjcard.2015.04.062DOI Listing
August 2015

Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes.

Diabetes 2015 Jul 6;64(7):2676-84. Epub 2015 May 6.

Molecular Epidemiology, Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.2337/db14-1710DOI Listing
July 2015

Prevalence and prognostic role of right ventricular involvement in stress-induced cardiomyopathy.

J Card Fail 2015 May 19;21(5):419-425. Epub 2015 Feb 19.

Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Palo Alto, California.

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http://dx.doi.org/10.1016/j.cardfail.2015.02.001DOI Listing
May 2015

PCSK9 inhibition: current concepts and lessons from human genetics.

Curr Atheroscler Rep 2015 Mar;17(3):487

Division of Cardiovascular Medicine, Stanford University, 300 Pasteur Dr, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1007/s11883-015-0487-8DOI Listing
March 2015

Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.

Diabetes 2014 Jun 2;63(6):2158-71. Epub 2013 Dec 2.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, U.K.Department of Genomics of Common Disease, Imperial College London, London, U.K.

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http://dx.doi.org/10.2337/db13-0949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030103PMC
June 2014

How does morphology impact on diastolic function in hypertrophic cardiomyopathy? A single centre experience.

BMJ Open 2014 Jun 12;4(6):e004814. Epub 2014 Jun 12.

Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA Stanford Cardiovascular Institute, Stanford Cardiovascular Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1136/bmjopen-2014-004814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067898PMC
June 2014

Re: "Temporal relationship between uric acid concentration and risk of diabetes in a community-based study population".

Am J Epidemiol 2014 May 26;179(9):1147-8. Epub 2014 Mar 26.

Division of Cardiovascular Medicine and Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA.

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http://dx.doi.org/10.1093/aje/kwu055DOI Listing
May 2014

Latent obstruction and left atrial size are predictors of clinical deterioration leading to septal reduction in hypertrophic cardiomyopathy.

J Card Fail 2014 Apr 29;20(4):236-43. Epub 2014 Jan 29.

Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Palo Alto, California; Stanford Cardiovascular Institute, Palo Alto, California.

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http://dx.doi.org/10.1016/j.cardfail.2014.01.014DOI Listing
April 2014

Unexplained double-chambered left ventricle associated with contracting right ventricular aneurysm and right atrial enlargement.

Echocardiography 2014 Mar 3;31(3):E80-4. Epub 2013 Dec 3.

Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.

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http://dx.doi.org/10.1111/echo.12467DOI Listing
March 2014

Prevalence and clinical correlates of right ventricular dysfunction in patients with hypertrophic cardiomyopathy.

Am J Cardiol 2014 Jan 4;113(2):361-7. Epub 2013 Oct 4.

Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California.

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http://dx.doi.org/10.1016/j.amjcard.2013.09.045DOI Listing
January 2014

Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.

Diabetes 2013 Oct 8;62(10):3589-98. Epub 2013 Jul 8.

Genetics of Complex Traits, University of Exeter Medical School, Exeter, U.K.

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http://dx.doi.org/10.2337/db13-0128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781444PMC
October 2013

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.

Authors:
Marcel den Hoed Mark Eijgelsheim Tõnu Esko Bianca J J M Brundel David S Peal David M Evans Ilja M Nolte Ayellet V Segrè Hilma Holm Robert E Handsaker Harm-Jan Westra Toby Johnson Aaron Isaacs Jian Yang Alicia Lundby Jing Hua Zhao Young Jin Kim Min Jin Go Peter Almgren Murielle Bochud Gabrielle Boucher Marilyn C Cornelis Daniel Gudbjartsson David Hadley Pim van der Harst Caroline Hayward Martin den Heijer Wilmar Igl Anne U Jackson Zoltán Kutalik Jian'an Luan John P Kemp Kati Kristiansson Claes Ladenvall Mattias Lorentzon May E Montasser Omer T Njajou Paul F O'Reilly Sandosh Padmanabhan Beate St Pourcain Tuomo Rankinen Perttu Salo Toshiko Tanaka Nicholas J Timpson Veronique Vitart Lindsay Waite William Wheeler Weihua Zhang Harmen H M Draisma Mary F Feitosa Kathleen F Kerr Penelope A Lind Evelin Mihailov N Charlotte Onland-Moret Ci Song Michael N Weedon Weijia Xie Loic Yengo Devin Absher Christine M Albert Alvaro Alonso Dan E Arking Paul I W de Bakker Beverley Balkau Cristina Barlassina Paola Benaglio Joshua C Bis Nabila Bouatia-Naji Søren Brage Stephen J Chanock Peter S Chines Mina Chung Dawood Darbar Christian Dina Marcus Dörr Paul Elliott Stephan B Felix Krista Fischer Christian Fuchsberger Eco J C de Geus Philippe Goyette Vilmundur Gudnason Tamara B Harris Anna-Liisa Hartikainen Aki S Havulinna Susan R Heckbert Andrew A Hicks Albert Hofman Suzanne Holewijn Femke Hoogstra-Berends Jouke-Jan Hottenga Majken K Jensen Asa Johansson Juhani Junttila Stefan Kääb Bart Kanon Shamika Ketkar Kay-Tee Khaw Joshua W Knowles Angrad S Kooner Jan A Kors Meena Kumari Lili Milani Päivi Laiho Edward G Lakatta Claudia Langenberg Maarten Leusink Yongmei Liu Robert N Luben Kathryn L Lunetta Stacey N Lynch Marcello R P Markus Pedro Marques-Vidal Irene Mateo Leach Wendy L McArdle Steven A McCarroll Sarah E Medland Kathryn A Miller Grant W Montgomery Alanna C Morrison Martina Müller-Nurasyid Pau Navarro Mari Nelis Jeffrey R O'Connell Christopher J O'Donnell Ken K Ong Anne B Newman Annette Peters Ozren Polasek Anneli Pouta Peter P Pramstaller Bruce M Psaty Dabeeru C Rao Susan M Ring Elizabeth J Rossin Diana Rudan Serena Sanna Robert A Scott Jaban S Sehmi Stephen Sharp Jordan T Shin Andrew B Singleton Albert V Smith Nicole Soranzo Tim D Spector Chip Stewart Heather M Stringham Kirill V Tarasov André G Uitterlinden Liesbeth Vandenput Shih-Jen Hwang John B Whitfield Cisca Wijmenga Sarah H Wild Gonneke Willemsen James F Wilson Jacqueline C M Witteman Andrew Wong Quenna Wong Yalda Jamshidi Paavo Zitting Jolanda M A Boer Dorret I Boomsma Ingrid B Borecki Cornelia M van Duijn Ulf Ekelund Nita G Forouhi Philippe Froguel Aroon Hingorani Erik Ingelsson Mika Kivimaki Richard A Kronmal Diana Kuh Lars Lind Nicholas G Martin Ben A Oostra Nancy L Pedersen Thomas Quertermous Jerome I Rotter Yvonne T van der Schouw W M Monique Verschuren Mark Walker Demetrius Albanes David O Arnar Themistocles L Assimes Stefania Bandinelli Michael Boehnke Rudolf A de Boer Claude Bouchard W L Mark Caulfield John C Chambers Gary Curhan Daniele Cusi Johan Eriksson Luigi Ferrucci Wiek H van Gilst Nicola Glorioso Jacqueline de Graaf Leif Groop Ulf Gyllensten Wen-Chi Hsueh Frank B Hu Heikki V Huikuri David J Hunter Carlos Iribarren Bo Isomaa Marjo-Riitta Jarvelin Antti Jula Mika Kähönen Lambertus A Kiemeney Melanie M van der Klauw Jaspal S Kooner Peter Kraft Licia Iacoviello Terho Lehtimäki Marja-Liisa L Lokki Braxton D Mitchell Gerjan Navis Markku S Nieminen Claes Ohlsson Neil R Poulter Lu Qi Olli T Raitakari Eric B Rimm John D Rioux Federica Rizzi Igor Rudan Veikko Salomaa Peter S Sever Denis C Shields Alan R Shuldiner Juha Sinisalo Alice V Stanton Ronald P Stolk David P Strachan Jean-Claude Tardif Unnur Thorsteinsdottir Jaako Tuomilehto Dirk J van Veldhuisen Jarmo Virtamo Jorma Viikari Peter Vollenweider Gérard Waeber Elisabeth Widen Yoon Shin Cho Jesper V Olsen Peter M Visscher Cristen Willer Lude Franke Jeanette Erdmann John R Thompson Arne Pfeufer Nona Sotoodehnia Christopher Newton-Cheh Patrick T Ellinor Bruno H Ch Stricker Andres Metspalu Markus Perola Jacques S Beckmann George Davey Smith Kari Stefansson Nicholas J Wareham Patricia B Munroe Ody C M Sibon David J Milan Harold Snieder Nilesh J Samani Ruth J F Loos

Nat Genet 2013 Jun 14;45(6):621-31. Epub 2013 Apr 14.

Medical Research Council MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

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http://www.nature.com/protocolexchange/system/uploads/2514/o
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http://www.nature.com/doifinder/10.1038/ng.2610
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http://dx.doi.org/10.1038/ng.2610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696959PMC
June 2013

Role of international registries in enhancing the care of familial hypercholesterolaemia.

Int J Evid Based Healthc 2013 Jun;11(2):134-9

Office of Population Health Genomics, Public Health and Clinical Services Division, Western Australian Department of Health, Perth, WA 6004, Australia.

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http://dx.doi.org/10.1111/1744-1609.12023DOI Listing
June 2013

Large-scale association analysis identifies new risk loci for coronary artery disease.

Authors:
Panos Deloukas Stavroula Kanoni Christina Willenborg Martin Farrall Themistocles L Assimes John R Thompson Erik Ingelsson Danish Saleheen Jeanette Erdmann Benjamin A Goldstein Kathleen Stirrups Inke R König Jean-Baptiste Cazier Asa Johansson Alistair S Hall Jong-Young Lee Cristen J Willer John C Chambers Tõnu Esko Lasse Folkersen Anuj Goel Elin Grundberg Aki S Havulinna Weang K Ho Jemma C Hopewell Niclas Eriksson Marcus E Kleber Kati Kristiansson Per Lundmark Leo-Pekka Lyytikäinen Suzanne Rafelt Dmitry Shungin Rona J Strawbridge Gudmar Thorleifsson Emmi Tikkanen Natalie Van Zuydam Benjamin F Voight Lindsay L Waite Weihua Zhang Andreas Ziegler Devin Absher David Altshuler Anthony J Balmforth Inês Barroso Peter S Braund Christof Burgdorf Simone Claudi-Boehm David Cox Maria Dimitriou Ron Do Alex S F Doney NourEddine El Mokhtari Per Eriksson Krista Fischer Pierre Fontanillas Anders Franco-Cereceda Bruna Gigante Leif Groop Stefan Gustafsson Jörg Hager Göran Hallmans Bok-Ghee Han Sarah E Hunt Hyun M Kang Thomas Illig Thorsten Kessler Joshua W Knowles Genovefa Kolovou Johanna Kuusisto Claudia Langenberg Cordelia Langford Karin Leander Marja-Liisa Lokki Anders Lundmark Mark I McCarthy Christa Meisinger Olle Melander Evelin Mihailov Seraya Maouche Andrew D Morris Martina Müller-Nurasyid Kjell Nikus John F Peden N William Rayner Asif Rasheed Silke Rosinger Diana Rubin Moritz P Rumpf Arne Schäfer Mohan Sivananthan Ci Song Alexandre F R Stewart Sian-Tsung Tan Gudmundur Thorgeirsson C Ellen van der Schoot Peter J Wagner George A Wells Philipp S Wild Tsun-Po Yang Philippe Amouyel Dominique Arveiler Hanneke Basart Michael Boehnke Eric Boerwinkle Paolo Brambilla Francois Cambien Adrienne L Cupples Ulf de Faire Abbas Dehghan Patrick Diemert Stephen E Epstein Alun Evans Marco M Ferrario Jean Ferrières Dominique Gauguier Alan S Go Alison H Goodall Villi Gudnason Stanley L Hazen Hilma Holm Carlos Iribarren Yangsoo Jang Mika Kähönen Frank Kee Hyo-Soo Kim Norman Klopp Wolfgang Koenig Wolfgang Kratzer Kari Kuulasmaa Markku Laakso Reijo Laaksonen Ji-Young Lee Lars Lind Willem H Ouwehand Sarah Parish Jeong E Park Nancy L Pedersen Annette Peters Thomas Quertermous Daniel J Rader Veikko Salomaa Eric Schadt Svati H Shah Juha Sinisalo Klaus Stark Kari Stefansson David-Alexandre Trégouët Jarmo Virtamo Lars Wallentin Nicholas Wareham Martina E Zimmermann Markku S Nieminen Christian Hengstenberg Manjinder S Sandhu Tomi Pastinen Ann-Christine Syvänen G Kees Hovingh George Dedoussis Paul W Franks Terho Lehtimäki Andres Metspalu Pierre A Zalloua Agneta Siegbahn Stefan Schreiber Samuli Ripatti Stefan S Blankenberg Markus Perola Robert Clarke Bernhard O Boehm Christopher O'Donnell Muredach P Reilly Winfried März Rory Collins Sekar Kathiresan Anders Hamsten Jaspal S Kooner Unnur Thorsteinsdottir John Danesh Colin N A Palmer Robert Roberts Hugh Watkins Heribert Schunkert Nilesh J Samani

Nat Genet 2013 Jan 2;45(1):25-33. Epub 2012 Dec 2.

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January 2013

Exploring predisposition and treatment response--the promise of genomics.

Prog Cardiovasc Dis 2012 Jul-Aug;55(1):56-63

Biomedical Informatics Training Program, Stanford University, Stanford, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821164PMC
October 2012

The evolution and refinement of traditional risk factors for cardiovascular disease.

Cardiol Rev 2012 May-Jun;20(3):118-29

Division of Cardiovascular Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.

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May 2012

Use and overuse of left ventriculography.

Am Heart J 2012 Apr 29;163(4):617-23.e1. Epub 2012 Mar 29.

Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305-5406, USA.

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April 2012

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

Authors:
Heribert Schunkert Inke R König Sekar Kathiresan Muredach P Reilly Themistocles L Assimes Hilma Holm Michael Preuss Alexandre F R Stewart Maja Barbalic Christian Gieger Devin Absher Zouhair Aherrahrou Hooman Allayee David Altshuler Sonia S Anand Karl Andersen Jeffrey L Anderson Diego Ardissino Stephen G Ball Anthony J Balmforth Timothy A Barnes Diane M Becker Lewis C Becker Klaus Berger Joshua C Bis S Matthijs Boekholdt Eric Boerwinkle Peter S Braund Morris J Brown Mary Susan Burnett Ian Buysschaert John F Carlquist Li Chen Sven Cichon Veryan Codd Robert W Davies George Dedoussis Abbas Dehghan Serkalem Demissie Joseph M Devaney Patrick Diemert Ron Do Angela Doering Sandra Eifert Nour Eddine El Mokhtari Stephen G Ellis Roberto Elosua James C Engert Stephen E Epstein Ulf de Faire Marcus Fischer Aaron R Folsom Jennifer Freyer Bruna Gigante Domenico Girelli Solveig Gretarsdottir Vilmundur Gudnason Jeffrey R Gulcher Eran Halperin Naomi Hammond Stanley L Hazen Albert Hofman Benjamin D Horne Thomas Illig Carlos Iribarren Gregory T Jones J Wouter Jukema Michael A Kaiser Lee M Kaplan John J P Kastelein Kay-Tee Khaw Joshua W Knowles Genovefa Kolovou Augustine Kong Reijo Laaksonen Diether Lambrechts Karin Leander Guillaume Lettre Mingyao Li Wolfgang Lieb Christina Loley Andrew J Lotery Pier M Mannucci Seraya Maouche Nicola Martinelli Pascal P McKeown Christa Meisinger Thomas Meitinger Olle Melander Pier Angelica Merlini Vincent Mooser Thomas Morgan Thomas W Mühleisen Joseph B Muhlestein Thomas Münzel Kiran Musunuru Janja Nahrstaedt Christopher P Nelson Markus M Nöthen Oliviero Olivieri Riyaz S Patel Chris C Patterson Annette Peters Flora Peyvandi Liming Qu Arshed A Quyyumi Daniel J Rader Loukianos S Rallidis Catherine Rice Frits R Rosendaal Diana Rubin Veikko Salomaa M Lourdes Sampietro Manj S Sandhu Eric Schadt Arne Schäfer Arne Schillert Stefan Schreiber Jürgen Schrezenmeir Stephen M Schwartz David S Siscovick Mohan Sivananthan Suthesh Sivapalaratnam Albert Smith Tamara B Smith Jaapjan D Snoep Nicole Soranzo John A Spertus Klaus Stark Kathy Stirrups Monika Stoll W H Wilson Tang Stephanie Tennstedt Gudmundur Thorgeirsson Gudmar Thorleifsson Maciej Tomaszewski Andre G Uitterlinden Andre M van Rij Benjamin F Voight Nick J Wareham George A Wells H-Erich Wichmann Philipp S Wild Christina Willenborg Jaqueline C M Witteman Benjamin J Wright Shu Ye Tanja Zeller Andreas Ziegler Francois Cambien Alison H Goodall L Adrienne Cupples Thomas Quertermous Winfried März Christian Hengstenberg Stefan Blankenberg Willem H Ouwehand Alistair S Hall Panos Deloukas John R Thompson Kari Stefansson Robert Roberts Unnur Thorsteinsdottir Christopher J O'Donnell Ruth McPherson Jeanette Erdmann Nilesh J Samani

Nat Genet 2011 Mar 6;43(4):333-8. Epub 2011 Mar 6.

Universität zu Lübeck, Medizinische Klinik II, Lübeck, Germany.

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March 2011

Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies.

Authors:
Themistocles L Assimes Hilma Hólm Sekar Kathiresan Muredach P Reilly Gudmar Thorleifsson Benjamin F Voight Jeanette Erdmann Christina Willenborg Dhananjay Vaidya Changchun Xie Chris C Patterson Thomas M Morgan Mary Susan Burnett Mingyao Li Mark A Hlatky Joshua W Knowles John R Thompson Devin Absher Carlos Iribarren Alan Go Stephen P Fortmann Stephen Sidney Neil Risch Hua Tang Richard M Myers Klaus Berger Monika Stoll Svati H Shah Gudmundur Thorgeirsson Karl Andersen Aki S Havulinna J Enrique Herrera Nauder Faraday Yoonhee Kim Brian G Kral Rasika A Mathias Ingo Ruczinski Bhoom Suktitipat Alexander F Wilson Lisa R Yanek Lewis C Becker Patrick Linsel-Nitschke Wolfgang Lieb Inke R König Christian Hengstenberg Marcus Fischer Klaus Stark Wibke Reinhard Janina Winogradow Martina Grassl Anika Grosshennig Michael Preuss Stefan Schreiber H-Erich Wichmann Christa Meisinger Jean Yee Yechiel Friedlander Ron Do James B Meigs Gordon Williams David M Nathan Calum A MacRae Liming Qu Robert L Wilensky William H Matthai Atif N Qasim Hakon Hakonarson Augusto D Pichard Kenneth M Kent Lowell Satler Joseph M Lindsay Ron Waksman Christopher W Knouff Dawn M Waterworth Max C Walker Vincent E Mooser Jaume Marrugat Gavin Lucas Isaac Subirana Joan Sala Rafael Ramos Nicola Martinelli Oliviero Olivieri Elisabetta Trabetti Giovanni Malerba Pier Franco Pignatti Candace Guiducci Daniel Mirel Melissa Parkin Joel N Hirschhorn Rosanna Asselta Stefano Duga Kiran Musunuru Mark J Daly Shaun Purcell Sandra Eifert Peter S Braund Benjamin J Wright Anthony J Balmforth Stephen G Ball Willem H Ouwehand Panos Deloukas Michael Scholz Francois Cambien Andreas Huge Thomas Scheffold Veikko Salomaa Domenico Girelli Christopher B Granger Leena Peltonen Pascal P McKeown David Altshuler Olle Melander Joseph M Devaney Stephen E Epstein Daniel J Rader Roberto Elosua James C Engert Sonia S Anand Alistair S Hall Andreas Ziegler Christopher J O'Donnell John A Spertus David Siscovick Stephen M Schwartz Diane Becker Unnur Thorsteinsdottir Kari Stefansson Heribert Schunkert Nilesh J Samani Thomas Quertermous

J Am Coll Cardiol 2010 Nov;56(19):1552-63

Department of Medicine, Stanford University School of Medicine, Stanford, California 94304-1334, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084526PMC
November 2010

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

Authors:
Iris M Heid Anne U Jackson Joshua C Randall Thomas W Winkler Lu Qi Valgerdur Steinthorsdottir Gudmar Thorleifsson M Carola Zillikens Elizabeth K Speliotes Reedik Mägi Tsegaselassie Workalemahu Charles C White Nabila Bouatia-Naji Tamara B Harris Sonja I Berndt Erik Ingelsson Cristen J Willer Michael N Weedon Jian'an Luan Sailaja Vedantam Tõnu Esko Tuomas O Kilpeläinen Zoltán Kutalik Shengxu Li Keri L Monda Anna L Dixon Christopher C Holmes Lee M Kaplan Liming Liang Josine L Min Miriam F Moffatt Cliona Molony George Nicholson Eric E Schadt Krina T Zondervan Mary F Feitosa Teresa Ferreira Hana Lango Allen Robert J Weyant Eleanor Wheeler Andrew R Wood Karol Estrada Michael E Goddard Guillaume Lettre Massimo Mangino Dale R Nyholt Shaun Purcell Albert Vernon Smith Peter M Visscher Jian Yang Steven A McCarroll James Nemesh Benjamin F Voight Devin Absher Najaf Amin Thor Aspelund Lachlan Coin Nicole L Glazer Caroline Hayward Nancy L Heard-Costa Jouke-Jan Hottenga Asa Johansson Toby Johnson Marika Kaakinen Karen Kapur Shamika Ketkar Joshua W Knowles Peter Kraft Aldi T Kraja Claudia Lamina Michael F Leitzmann Barbara McKnight Andrew P Morris Ken K Ong John R B Perry Marjolein J Peters Ozren Polasek Inga Prokopenko Nigel W Rayner Samuli Ripatti Fernando Rivadeneira Neil R Robertson Serena Sanna Ulla Sovio Ida Surakka Alexander Teumer Sophie van Wingerden Veronique Vitart Jing Hua Zhao Christine Cavalcanti-Proença Peter S Chines Eva Fisher Jennifer R Kulzer Cecile Lecoeur Narisu Narisu Camilla Sandholt Laura J Scott Kaisa Silander Klaus Stark Mari-Liis Tammesoo Tanya M Teslovich Nicholas John Timpson Richard M Watanabe Ryan Welch Daniel I Chasman Matthew N Cooper John-Olov Jansson Johannes Kettunen Robert W Lawrence Niina Pellikka Markus Perola Liesbeth Vandenput Helene Alavere Peter Almgren Larry D Atwood Amanda J Bennett Reiner Biffar Lori L Bonnycastle Stefan R Bornstein Thomas A Buchanan Harry Campbell Ian N M Day Mariano Dei Marcus Dörr Paul Elliott Michael R Erdos Johan G Eriksson Nelson B Freimer Mao Fu Stefan Gaget Eco J C Geus Anette P Gjesing Harald Grallert Jürgen Grässler Christopher J Groves Candace Guiducci Anna-Liisa Hartikainen Neelam Hassanali Aki S Havulinna Karl-Heinz Herzig Andrew A Hicks Jennie Hui Wilmar Igl Pekka Jousilahti Antti Jula Eero Kajantie Leena Kinnunen Ivana Kolcic Seppo Koskinen Peter Kovacs Heyo K Kroemer Vjekoslav Krzelj Johanna Kuusisto Kirsti Kvaloy Jaana Laitinen Olivier Lantieri G Mark Lathrop Marja-Liisa Lokki Robert N Luben Barbara Ludwig Wendy L McArdle Anne McCarthy Mario A Morken Mari Nelis Matt J Neville Guillaume Paré Alex N Parker John F Peden Irene Pichler Kirsi H Pietiläinen Carl G P Platou Anneli Pouta Martin Ridderstråle Nilesh J Samani Jouko Saramies Juha Sinisalo Jan H Smit Rona J Strawbridge Heather M Stringham Amy J Swift Maris Teder-Laving Brian Thomson Gianluca Usala Joyce B J van Meurs Gert-Jan van Ommen Vincent Vatin Claudia B Volpato Henri Wallaschofski G Bragi Walters Elisabeth Widen Sarah H Wild Gonneke Willemsen Daniel R Witte Lina Zgaga Paavo Zitting John P Beilby Alan L James Mika Kähönen Terho Lehtimäki Markku S Nieminen Claes Ohlsson Lyle J Palmer Olli Raitakari Paul M Ridker Michael Stumvoll Anke Tönjes Jorma Viikari Beverley Balkau Yoav Ben-Shlomo Richard N Bergman Heiner Boeing George Davey Smith Shah Ebrahim Philippe Froguel Torben Hansen Christian Hengstenberg Kristian Hveem Bo Isomaa Torben Jørgensen Fredrik Karpe Kay-Tee Khaw Markku Laakso Debbie A Lawlor Michel Marre Thomas Meitinger Andres Metspalu Kristian Midthjell Oluf Pedersen Veikko Salomaa Peter E H Schwarz Tiinamaija Tuomi Jaakko Tuomilehto Timo T Valle Nicholas J Wareham Alice M Arnold Jacques S Beckmann Sven Bergmann Eric Boerwinkle Dorret I Boomsma Mark J Caulfield Francis S Collins Gudny Eiriksdottir Vilmundur Gudnason Ulf Gyllensten Anders Hamsten Andrew T Hattersley Albert Hofman Frank B Hu Thomas Illig Carlos Iribarren Marjo-Riitta Jarvelin W H Linda Kao Jaakko Kaprio Lenore J Launer Patricia B Munroe Ben Oostra Brenda W Penninx Peter P Pramstaller Bruce M Psaty Thomas Quertermous Aila Rissanen Igor Rudan Alan R Shuldiner Nicole Soranzo Timothy D Spector Ann-Christine Syvanen Manuela Uda André Uitterlinden Henry Völzke Peter Vollenweider James F Wilson Jacqueline C Witteman Alan F Wright Gonçalo R Abecasis Michael Boehnke Ingrid B Borecki Panos Deloukas Timothy M Frayling Leif C Groop Talin Haritunians David J Hunter Robert C Kaplan Kari E North Jeffrey R O'Connell Leena Peltonen David Schlessinger David P Strachan Joel N Hirschhorn Themistocles L Assimes H-Erich Wichmann Unnur Thorsteinsdottir Cornelia M van Duijn Kari Stefansson L Adrienne Cupples Ruth J F Loos Inês Barroso Mark I McCarthy Caroline S Fox Karen L Mohlke Cecilia M Lindgren

Nat Genet 2010 Nov 10;42(11):949-60. Epub 2010 Oct 10.

Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, Regensburg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000924PMC
November 2010

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Authors:
Elizabeth K Speliotes Cristen J Willer Sonja I Berndt Keri L Monda Gudmar Thorleifsson Anne U Jackson Hana Lango Allen Cecilia M Lindgren Jian'an Luan Reedik Mägi Joshua C Randall Sailaja Vedantam Thomas W Winkler Lu Qi Tsegaselassie Workalemahu Iris M Heid Valgerdur Steinthorsdottir Heather M Stringham Michael N Weedon Eleanor Wheeler Andrew R Wood Teresa Ferreira Robert J Weyant Ayellet V Segrè Karol Estrada Liming Liang James Nemesh Ju-Hyun Park Stefan Gustafsson Tuomas O Kilpeläinen Jian Yang Nabila Bouatia-Naji Tõnu Esko Mary F Feitosa Zoltán Kutalik Massimo Mangino Soumya Raychaudhuri Andre Scherag Albert Vernon Smith Ryan Welch Jing Hua Zhao Katja K Aben Devin M Absher Najaf Amin Anna L Dixon Eva Fisher Nicole L Glazer Michael E Goddard Nancy L Heard-Costa Volker Hoesel Jouke-Jan Hottenga Asa Johansson Toby Johnson Shamika Ketkar Claudia Lamina Shengxu Li Miriam F Moffatt Richard H Myers Narisu Narisu John R B Perry Marjolein J Peters Michael Preuss Samuli Ripatti Fernando Rivadeneira Camilla Sandholt Laura J Scott Nicholas J Timpson Jonathan P Tyrer Sophie van Wingerden Richard M Watanabe Charles C White Fredrik Wiklund Christina Barlassina Daniel I Chasman Matthew N Cooper John-Olov Jansson Robert W Lawrence Niina Pellikka Inga Prokopenko Jianxin Shi Elisabeth Thiering Helene Alavere Maria T S Alibrandi Peter Almgren Alice M Arnold Thor Aspelund Larry D Atwood Beverley Balkau Anthony J Balmforth Amanda J Bennett Yoav Ben-Shlomo Richard N Bergman Sven Bergmann Heike Biebermann Alexandra I F Blakemore Tanja Boes Lori L Bonnycastle Stefan R Bornstein Morris J Brown Thomas A Buchanan Fabio Busonero Harry Campbell Francesco P Cappuccio Christine Cavalcanti-Proença Yii-Der Ida Chen Chih-Mei Chen Peter S Chines Robert Clarke Lachlan Coin John Connell Ian N M Day Martin den Heijer Jubao Duan Shah Ebrahim Paul Elliott Roberto Elosua Gudny Eiriksdottir Michael R Erdos Johan G Eriksson Maurizio F Facheris Stephan B Felix Pamela Fischer-Posovszky Aaron R Folsom Nele Friedrich Nelson B Freimer Mao Fu Stefan Gaget Pablo V Gejman Eco J C Geus Christian Gieger Anette P Gjesing Anuj Goel Philippe Goyette Harald Grallert Jürgen Grässler Danielle M Greenawalt Christopher J Groves Vilmundur Gudnason Candace Guiducci Anna-Liisa Hartikainen Neelam Hassanali Alistair S Hall Aki S Havulinna Caroline Hayward Andrew C Heath Christian Hengstenberg Andrew A Hicks Anke Hinney Albert Hofman Georg Homuth Jennie Hui Wilmar Igl Carlos Iribarren Bo Isomaa Kevin B Jacobs Ivonne Jarick Elizabeth Jewell Ulrich John Torben Jørgensen Pekka Jousilahti Antti Jula Marika Kaakinen Eero Kajantie Lee M Kaplan Sekar Kathiresan Johannes Kettunen Leena Kinnunen Joshua W Knowles Ivana Kolcic Inke R König Seppo Koskinen Peter Kovacs Johanna Kuusisto Peter Kraft Kirsti Kvaløy Jaana Laitinen Olivier Lantieri Chiara Lanzani Lenore J Launer Cecile Lecoeur Terho Lehtimäki Guillaume Lettre Jianjun Liu Marja-Liisa Lokki Mattias Lorentzon Robert N Luben Barbara Ludwig Paolo Manunta Diana Marek Michel Marre Nicholas G Martin Wendy L McArdle Anne McCarthy Barbara McKnight Thomas Meitinger Olle Melander David Meyre Kristian Midthjell Grant W Montgomery Mario A Morken Andrew P Morris Rosanda Mulic Julius S Ngwa Mari Nelis Matt J Neville Dale R Nyholt Christopher J O'Donnell Stephen O'Rahilly Ken K Ong Ben Oostra Guillaume Paré Alex N Parker Markus Perola Irene Pichler Kirsi H Pietiläinen Carl G P Platou Ozren Polasek Anneli Pouta Suzanne Rafelt Olli Raitakari Nigel W Rayner Martin Ridderstråle Winfried Rief Aimo Ruokonen Neil R Robertson Peter Rzehak Veikko Salomaa Alan R Sanders Manjinder S Sandhu Serena Sanna Jouko Saramies Markku J Savolainen Susann Scherag Sabine Schipf Stefan Schreiber Heribert Schunkert Kaisa Silander Juha Sinisalo David S Siscovick Jan H Smit Nicole Soranzo Ulla Sovio Jonathan Stephens Ida Surakka Amy J Swift Mari-Liis Tammesoo Jean-Claude Tardif Maris Teder-Laving Tanya M Teslovich John R Thompson Brian Thomson Anke Tönjes Tiinamaija Tuomi Joyce B J van Meurs Gert-Jan van Ommen Vincent Vatin Jorma Viikari Sophie Visvikis-Siest Veronique Vitart Carla I G Vogel Benjamin F Voight Lindsay L Waite Henri Wallaschofski G Bragi Walters Elisabeth Widen Susanna Wiegand Sarah H Wild Gonneke Willemsen Daniel R Witte Jacqueline C Witteman Jianfeng Xu Qunyuan Zhang Lina Zgaga Andreas Ziegler Paavo Zitting John P Beilby I Sadaf Farooqi Johannes Hebebrand Heikki V Huikuri Alan L James Mika Kähönen Douglas F Levinson Fabio Macciardi Markku S Nieminen Claes Ohlsson Lyle J Palmer Paul M Ridker Michael Stumvoll Jacques S Beckmann Heiner Boeing Eric Boerwinkle Dorret I Boomsma Mark J Caulfield Stephen J Chanock Francis S Collins L Adrienne Cupples George Davey Smith Jeanette Erdmann Philippe Froguel Henrik Grönberg Ulf Gyllensten Per Hall Torben Hansen Tamara B Harris Andrew T Hattersley Richard B Hayes Joachim Heinrich Frank B Hu Kristian Hveem Thomas Illig Marjo-Riitta Jarvelin Jaakko Kaprio Fredrik Karpe Kay-Tee Khaw Lambertus A Kiemeney Heiko Krude Markku Laakso Debbie A Lawlor Andres Metspalu Patricia B Munroe Willem H Ouwehand Oluf Pedersen Brenda W Penninx Annette Peters Peter P Pramstaller Thomas Quertermous Thomas Reinehr Aila Rissanen Igor Rudan Nilesh J Samani Peter E H Schwarz Alan R Shuldiner Timothy D Spector Jaakko Tuomilehto Manuela Uda André Uitterlinden Timo T Valle Martin Wabitsch Gérard Waeber Nicholas J Wareham Hugh Watkins James F Wilson Alan F Wright M Carola Zillikens Nilanjan Chatterjee Steven A McCarroll Shaun Purcell Eric E Schadt Peter M Visscher Themistocles L Assimes Ingrid B Borecki Panos Deloukas Caroline S Fox Leif C Groop Talin Haritunians David J Hunter Robert C Kaplan Karen L Mohlke Jeffrey R O'Connell Leena Peltonen David Schlessinger David P Strachan Cornelia M van Duijn H-Erich Wichmann Timothy M Frayling Unnur Thorsteinsdottir Gonçalo R Abecasis Inês Barroso Michael Boehnke Kari Stefansson Kari E North Mark I McCarthy Joel N Hirschhorn Erik Ingelsson Ruth J F Loos

Nat Genet 2010 Nov 10;42(11):937-48. Epub 2010 Oct 10.

Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.

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November 2010

Hundreds of variants clustered in genomic loci and biological pathways affect human height.

Authors:
Hana Lango Allen Karol Estrada Guillaume Lettre Sonja I Berndt Michael N Weedon Fernando Rivadeneira Cristen J Willer Anne U Jackson Sailaja Vedantam Soumya Raychaudhuri Teresa Ferreira Andrew R Wood Robert J Weyant Ayellet V Segrè Elizabeth K Speliotes Eleanor Wheeler Nicole Soranzo Ju-Hyun Park Jian Yang Daniel Gudbjartsson Nancy L Heard-Costa Joshua C Randall Lu Qi Albert Vernon Smith Reedik Mägi Tomi Pastinen Liming Liang Iris M Heid Jian'an Luan Gudmar Thorleifsson Thomas W Winkler Michael E Goddard Ken Sin Lo Cameron Palmer Tsegaselassie Workalemahu Yurii S Aulchenko Asa Johansson M Carola Zillikens Mary F Feitosa Tõnu Esko Toby Johnson Shamika Ketkar Peter Kraft Massimo Mangino Inga Prokopenko Devin Absher Eva Albrecht Florian Ernst Nicole L Glazer Caroline Hayward Jouke-Jan Hottenga Kevin B Jacobs Joshua W Knowles Zoltán Kutalik Keri L Monda Ozren Polasek Michael Preuss Nigel W Rayner Neil R Robertson Valgerdur Steinthorsdottir Jonathan P Tyrer Benjamin F Voight Fredrik Wiklund Jianfeng Xu Jing Hua Zhao Dale R Nyholt Niina Pellikka Markus Perola John R B Perry Ida Surakka Mari-Liis Tammesoo Elizabeth L Altmaier Najaf Amin Thor Aspelund Tushar Bhangale Gabrielle Boucher Daniel I Chasman Constance Chen Lachlan Coin Matthew N Cooper Anna L Dixon Quince Gibson Elin Grundberg Ke Hao M Juhani Junttila Lee M Kaplan Johannes Kettunen Inke R König Tony Kwan Robert W Lawrence Douglas F Levinson Mattias Lorentzon Barbara McKnight Andrew P Morris Martina Müller Julius Suh Ngwa Shaun Purcell Suzanne Rafelt Rany M Salem Erika Salvi Serena Sanna Jianxin Shi Ulla Sovio John R Thompson Michael C Turchin Liesbeth Vandenput Dominique J Verlaan Veronique Vitart Charles C White Andreas Ziegler Peter Almgren Anthony J Balmforth Harry Campbell Lorena Citterio Alessandro De Grandi Anna Dominiczak Jubao Duan Paul Elliott Roberto Elosua Johan G Eriksson Nelson B Freimer Eco J C Geus Nicola Glorioso Shen Haiqing Anna-Liisa Hartikainen Aki S Havulinna Andrew A Hicks Jennie Hui Wilmar Igl Thomas Illig Antti Jula Eero Kajantie Tuomas O Kilpeläinen Markku Koiranen Ivana Kolcic Seppo Koskinen Peter Kovacs Jaana Laitinen Jianjun Liu Marja-Liisa Lokki Ana Marusic Andrea Maschio Thomas Meitinger Antonella Mulas Guillaume Paré Alex N Parker John F Peden Astrid Petersmann Irene Pichler Kirsi H Pietiläinen Anneli Pouta Martin Ridderstråle Jerome I Rotter Jennifer G Sambrook Alan R Sanders Carsten Oliver Schmidt Juha Sinisalo Jan H Smit Heather M Stringham G Bragi Walters Elisabeth Widen Sarah H Wild Gonneke Willemsen Laura Zagato Lina Zgaga Paavo Zitting Helene Alavere Martin Farrall Wendy L McArdle Mari Nelis Marjolein J Peters Samuli Ripatti Joyce B J van Meurs Katja K Aben Kristin G Ardlie Jacques S Beckmann John P Beilby Richard N Bergman Sven Bergmann Francis S Collins Daniele Cusi Martin den Heijer Gudny Eiriksdottir Pablo V Gejman Alistair S Hall Anders Hamsten Heikki V Huikuri Carlos Iribarren Mika Kähönen Jaakko Kaprio Sekar Kathiresan Lambertus Kiemeney Thomas Kocher Lenore J Launer Terho Lehtimäki Olle Melander Tom H Mosley Arthur W Musk Markku S Nieminen Christopher J O'Donnell Claes Ohlsson Ben Oostra Lyle J Palmer Olli Raitakari Paul M Ridker John D Rioux Aila Rissanen Carlo Rivolta Heribert Schunkert Alan R Shuldiner David S Siscovick Michael Stumvoll Anke Tönjes Jaakko Tuomilehto Gert-Jan van Ommen Jorma Viikari Andrew C Heath Nicholas G Martin Grant W Montgomery Michael A Province Manfred Kayser Alice M Arnold Larry D Atwood Eric Boerwinkle Stephen J Chanock Panos Deloukas Christian Gieger Henrik Grönberg Per Hall Andrew T Hattersley Christian Hengstenberg Wolfgang Hoffman G Mark Lathrop Veikko Salomaa Stefan Schreiber Manuela Uda Dawn Waterworth Alan F Wright Themistocles L Assimes Inês Barroso Albert Hofman Karen L Mohlke Dorret I Boomsma Mark J Caulfield L Adrienne Cupples Jeanette Erdmann Caroline S Fox Vilmundur Gudnason Ulf Gyllensten Tamara B Harris Richard B Hayes Marjo-Riitta Jarvelin Vincent Mooser Patricia B Munroe Willem H Ouwehand Brenda W Penninx Peter P Pramstaller Thomas Quertermous Igor Rudan Nilesh J Samani Timothy D Spector Henry Völzke Hugh Watkins James F Wilson Leif C Groop Talin Haritunians Frank B Hu Robert C Kaplan Andres Metspalu Kari E North David Schlessinger Nicholas J Wareham David J Hunter Jeffrey R O'Connell David P Strachan H-Erich Wichmann Ingrid B Borecki Cornelia M van Duijn Eric E Schadt Unnur Thorsteinsdottir Leena Peltonen André G Uitterlinden Peter M Visscher Nilanjan Chatterjee Ruth J F Loos Michael Boehnke Mark I McCarthy Erik Ingelsson Cecilia M Lindgren Gonçalo R Abecasis Kari Stefansson Timothy M Frayling Joel N Hirschhorn

Nature 2010 Oct 29;467(7317):832-8. Epub 2010 Sep 29.

Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter EX1 2LU, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955183PMC
October 2010

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.

Diabetes 2010 May 25;59(5):1266-75. Epub 2010 Feb 25.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

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