Joshua N Goldstein

Joshua N Goldstein

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Joshua N Goldstein

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New and expanding ventricular hemorrhage predicts poor outcome in acute intracerebral hemorrhage.

Neurology 2019 Aug 1;93(9):e879-e888. Epub 2019 Aug 1.

From the Ottawa Stroke Program (V.Y., D.D.), Department of Medicine (Neurology), Department of Radiology (C.L.), Ottawa Methods Center (T.R., D.F.), and Ottawa Hospital Research Institute (T.R., D.F., D.D.), University of Ottawa, Ontario; Calgary Stroke Program (A.M.D., M.D.H.), Department of Clinical Neurosciences, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta; Division of Neuroradiology and Department of Medical Imaging (R.I.A.), Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Department of Neurology (D.R.-L., C.A.M.), Hospital Universitari Vall d'Hebron, Barcelona; Department of Neurology (Y.S.), Dr. Josep Trueta University Hospital, Institut d'Investigació Biomèdica Girona Foundation, Spain; Department of Neurology (I.D.), Elblandklinikum Meissen Academic Teaching Hospital of Technische University, Dresden, Germany; Interventional Stroke and Cerebrovascular Treatment Center and 2nd Department of Neurology (A.K.), Institute of Psychiatry and Neurology, and Department of Experimental and Clinical Pharmacology, Warsaw, Poland; Department of Medicine (J.-M.B.), Charles LeMoyne Hospital, University of Sherbrooke, Longueuil, Quebec; Department of Neurology (G.G.), Dalhousie University, Halifax, Nova Scotia, Canada; Department of Neurology (P.S., R.B.), All India Institute of Medical Sciences, New Delhi; Apollo Gleneagles Hospitals (J.R.), Kolkata, India; Department of Neurology (C.S.K.), Boston Medical Center; and Department of Neurology (A.D.W., C.D.A., M.E.G., S.M.G., A.V., J.R.), Henry and Allison McCance Center for Brain Health (J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000008007DOI Listing
August 2019

and cortical superficial siderosis in CAA: Meta-analysis and potential mechanisms.

Neurology 2019 Jul 26;93(4):e358-e371. Epub 2019 Jun 26.

From the Hemorrhagic Stroke Research Program, Department of Neurology (A.C., M.P., A.B., M.E.G., J.N.G., J.R., S.M.G., A.V.), Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston; Alzheimer Center and the Neuroscience Campus Amsterdam and Departments of Radiology and Nuclear Medicine (H.I.Z., F.B.), VU University Medical Center, the Netherlands; Karolinska Institutet (S.S., L.-O.W.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (K.K., J.R.C.), Mayo Clinic, Rochester, MN; Department of Medicine (Neurology) (A.S.), McMaster University and Population Health Research Institute, Hamilton, Canada; Memory, Aging and Cognition Center (S.H., Y.L.C., J.R.C., C.C.), National University Health System, Singapore; Department of Pharmacology (S.H., Y.L.C., J.R.C., C.C.), National University of Singapore; Department of Nuclear Medicine and Centre for PET (P.A.Y.), The University of Melbourne, Parkville, Australia; Department of Neuroradiology (G.B.), Université Paris-Descartes, INSERM U894, CH Sainte-Anne, Paris, France; Department of Neurology and Neuroscience Center (H.K.N., D.L.N., S.W.S.), Samsung Medical Center, Seoul, Republic of Korea; UCL Institutes of Neurology and Healthcare Engineering (F.B.), London, UK; and Center for Genomic Medicine (J.R.) and Division of Neurocritical Care and Emergency Neurology (J.R.), Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000007818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669935PMC
July 2019

The White Whale.

Stroke 2019 May;50(5):1043-1044

From the Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/STROKEAHA.119.025262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6578575PMC
May 2019

Cerebral small vessel disease in patients with spontaneous cerebellar hemorrhage.

J Neurol 2019 Mar 8;266(3):625-630. Epub 2019 Jan 8.

Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, 175 Cambridge Street, #300, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s00415-018-09177-wDOI Listing
March 2019

Ischemic Stroke Transfer Patterns in the Northeast United States.

J Stroke Cerebrovasc Dis 2019 Feb 30;28(2):295-304. Epub 2018 Oct 30.

Massachusetts General Hospital and Harvard Medical School, Department of Neurology, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.09.048DOI Listing
February 2019

Emergency Neurology.

Semin Neurol 2019 02 11;39(1):3-4. Epub 2019 Feb 11.

Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

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http://dx.doi.org/10.1055/s-0039-1678571DOI Listing
February 2019

Spot and Diffuse Signs: Quantitative Markers of Intracranial Hematoma Expansion at Dual-Energy CT.

Radiology 2019 Jan 30;290(1):179-186. Epub 2018 Oct 30.

From the Cerebrovascular Research Laboratory, Spaulding Rehabilitation Hospital, 1575 Cambridge St, Boston, MA 02138 (C.O.T.); Departments of Radiology (C.O.T., S.L., D.K., R.H.J.B., L.D.B., J.T., M.L., J.M.R., R.G.) and Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, Mass; Departments of Physical Medicine and Rehabilitation (C.O.T.), Radiology (S.L., L.D.B., J.T., M.L., J.M.R., R.G.), and Emergency Medicine (J.N.G.), Harvard Medical School, Boston, Mass; Department of Technical Medicine, University of Twente, Enschede, the Netherlands (D.K., R.H.J.B.); Imaging Associates, Box Hill, Victoria, Australia (B.K.P.); Department of Radiology, Jewish General Hospital and McGill University, Montreal, Canada (R.F.); and Department of Radiology and Imaging Sciences, Emory University, Atlanta, Ga (R.H.).

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http://pubs.rsna.org/doi/10.1148/radiol.2018180322
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http://dx.doi.org/10.1148/radiol.2018180322DOI Listing
January 2019

Prothrombin Complex Concentrates for Perioperative Vitamin K Antagonist and Non-vitamin K Anticoagulant Reversal.

Anesthesiology 2018 12;129(6):1171-1184

From the Department of Anesthesiology, Cardiothoracic Intensive Care Unit, Duke University School of Medicine, Durham, North Carolina (J.H.L.) Department of Medicine, McMaster University, Hamilton, Ontario, Canada (J.D.) Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany (T.S.) Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts (J.N.G.) the Departments of Neurology and Surgery and Perioperative Care, Seton Dell Medical School Stroke Institute, Austin, Texas (T.J.M.).

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http://dx.doi.org/10.1097/ALN.0000000000002399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234087PMC
December 2018

The impact of prothrombin complex concentrates when treating DOAC-associated bleeding: a review.

Int J Emerg Med 2018 Dec 3;11(1):55. Epub 2018 Dec 3.

Department of Anesthesiology and Critical Care, Duke University School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1186/s12245-018-0215-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326120PMC
December 2018

Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data.

Lancet Neurol 2018 10 14;17(10):885-894. Epub 2018 Aug 14.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S14744422183025
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http://dx.doi.org/10.1016/S1474-4422(18)30253-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143589PMC
October 2018

Utilization of head CT during injury visits to United States emergency departments: 2012-2015.

Am J Emerg Med 2018 08 18;36(8):1463-1466. Epub 2018 May 18.

Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA; Center for Research in Emergency Department Operations (CREDO), Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.ajem.2018.05.018DOI Listing
August 2018

Response by Dowlatshahi et al to Letter Regarding Article, "Predicting Intracerebral Hemorrhage Expansion With Noncontrast Computed Tomography: The BAT Score".

Stroke 2018 08;49(8):e282

Division of Neurocritical Care and Emergency Neurology Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1161/STROKEAHA.118.022306DOI Listing
August 2018

Blood Pressure-Attained Analysis of ATACH 2 Trial.

Stroke 2018 06 22;49(6):1412-1418. Epub 2018 May 22.

Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan (K.T., H.Y.).

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http://dx.doi.org/10.1161/STROKEAHA.117.019845DOI Listing
June 2018

Rho-kinase inhibitors do not expand hematoma volume in acute experimental intracerebral hemorrhage.

Ann Clin Transl Neurol 2018 Jun 1;5(6):769-776. Epub 2018 May 1.

Neurovascular Research Laboratory Department of Radiology Massachusetts General Hospital Harvard Medical School Charlestown Massachusetts.

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http://dx.doi.org/10.1002/acn3.569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989779PMC
June 2018

Case 12-2018: A 30-Year-Old Woman with Cardiac Arrest.

N Engl J Med 2018 Apr;378(16):1538-1549

From the Departments of Emergency Medicine (J.N.G.), Medicine (D.M.D.), and Pathology (G.L.), Massachusetts General Hospital, the Department of Emergency Medicine, Brigham and Women's Hospital (T.B.E.), and the Departments of Emergency Medicine (J.N.G., T.B.E.), Medicine (D.M.D.), and Pathology (G.L.), Harvard Medical School - all in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1800322DOI Listing
April 2018

Outcome of intracerebral haemorrhage related to non-vitamin K antagonists oral anticoagulants versus vitamin K antagonists: a comprehensive systematic review and meta-analysis.

J Neurol Neurosurg Psychiatry 2018 03 13;89(3):263-270. Epub 2017 Oct 13.

Department of Hemorrhagic Stroke Research Group, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/jnnp-2017-316631DOI Listing
March 2018

Men Experience Higher Risk of Pneumonia and Death After Intracerebral Hemorrhage.

Neurocrit Care 2018 02;28(1):77-82

Center for Genomic Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s12028-017-0431-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775939PMC
February 2018

Cerebellar Hematoma Location: Implications for the Underlying Microangiopathy.

Stroke 2018 01 28;49(1):207-210. Epub 2017 Nov 28.

From the Department of Neurology, Hemorrhagic Stroke Research Program, Massachusetts General Hospital Stroke Research Center (M.P., S.M., L.X., A.C., A.M.A., M.J.L., M.E.G., S.M.G., A.V.), Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital (S.M., J.N.G., J.R.), and Division of Behavioral Neurology, Department of Neurology, Massachusetts General Hospital (A.B.), Harvard Medical School, Boston; Stroke Unit, C. Mondino National Neurological Institute, Pavia, Italy (A.M.); and Department of Neuroradiology, INSERM UMR 894, Centre Hospitalier Sainte-Anne, Université Paris-Descartes, France (G.B.).

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http://dx.doi.org/10.1161/STROKEAHA.117.019286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742084PMC
January 2018

Mixed-location cerebral hemorrhage/microbleeds: Underlying microangiopathy and recurrence risk.

Neurology 2018 01 15;90(2):e119-e126. Epub 2017 Dec 15.

From the Hemorrhagic Stroke Research Program (M.P., A.C., G.B., E.A., A.A., K.M.S., A.V., S.M.G., M.E.G.), Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston; NEUROFARBA Department (M.P., L.P.), Neuroscience Section, University of Florence, Italy; Université Paris-Descartes (G.B.), INSERM UMR 894, Department of Neuroradiology, Centre Hospitalier Sainte-Anne, France; and Division of Neurocritical Care and Emergency Neurology (J.N.G., J.R.), Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000004797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772153PMC
January 2018

Reversal of Oral Anticoagulants for Intracerebral Hemorrhage Patients: Best Strategies.

Semin Respir Crit Care Med 2017 12 20;38(6):726-736. Epub 2017 Dec 20.

Department of Pharmacy, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1055/s-0037-1607993DOI Listing
December 2017

Cortical superficial siderosis multifocality in cerebral amyloid angiopathy: A prospective study.

Neurology 2017 Nov 25;89(21):2128-2135. Epub 2017 Oct 25.

From the Hemorrhagic Stroke Research Program, Department of Neurology, Stroke Research Center (A.C., G.B., D.R., E.A., M.P., K.H., E.S.v.E., S.M.-R., A.A., A. Vashkevich, K.M.S., J.N.G., J.R., A. Viswanathan, S.M.G., M.E.G.), and Division of Neurocritical Care and Emergency Neurology (J.N.G., J.R.), Massachusetts General Hospital, Harvard Medical School, Boston; and Department of Neurology (E.A.), Carmel Medical Center, Haifa, Israel.

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http://dx.doi.org/10.1212/WNL.0000000000004665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696643PMC
November 2017

Chaplaincy Visitation and Spiritual Care after Intracerebral Hemorrhage.

J Health Care Chaplain 2017 Oct-Dec;23(4):156-166. Epub 2017 Apr 10.

a Department of Emergency Medicine , Massachusetts General Hospital , Boston , Massachusetts , USA.

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http://dx.doi.org/10.1080/08854726.2017.1304726DOI Listing
October 2017

Emergency Neurological Life Support: Status Epilepticus.

Neurocrit Care 2017 Sep;27(Suppl 1):152-158

Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1007/s12028-017-0460-1DOI Listing
September 2017

Blood pressure reduction and noncontrast CT markers of intracerebral hemorrhage expansion.

Neurology 2017 Aug 12;89(6):548-554. Epub 2017 Jul 12.

From the Department of Neurology, Division of Neurocritical Care and Emergency Neurology (A.M., J.M.R., J.N.G.), Neuroradiology Service, Department of Radiology (J.M.R.), the J.P. Kistler Stroke Research Center (A.M., G.B., J.M.R., M.J.J., A.V., K.S., S.M.G., J.R., J.N.G.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neuroradiology (G.B.), Université Paris Descartes, INSERM S894, DHU Neurovasc, Centre Hospitalier Sainte-Anne, Paris, France; Department of Neurosurgery (H.B.B.), Brain Center, Rudolf Magnus University Medical Center, Utrecht, the Netherlands; Zeenat Qureshi Stroke Research Center (M.R.A., A.I.Q.), University of Minnesota, Minneapolis; and Department of Public Health Sciences (C.C., R.H.M.), Medical University of South Carolina, Charleston.

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http://dx.doi.org/10.1212/WNL.0000000000004210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562954PMC
August 2017

Sex differences in intracerebral hemorrhage expansion and mortality.

J Neurol Sci 2017 Aug 31;379:112-116. Epub 2017 May 31.

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; J. P. Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, USA; Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2017.05.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538146PMC
August 2017

High-flow oxygen therapy for treatment of acute migraine: A randomized crossover trial.

Cephalalgia 2017 Jul 20;37(8):730-736. Epub 2016 May 20.

1 Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1177/0333102416651453DOI Listing
July 2017

Association Between Previous Use of Antiplatelet Therapy and Intracerebral Hemorrhage Outcomes.

Stroke 2017 07 8;48(7):1810-1817. Epub 2017 Jun 8.

From the Department of Neurology, Southern Illinois University School of Medicine, Springfield (N.I.K., F.M.S.); Department of Emergency Medicine (J.N.G.), Department of Neurology (L.H.S.), Massachusetts General Hospital, and Brigham and Women's Hospital Heart and Vascular Center (D.L.B.), Harvard Medical School, Boston; Duke Clinical Research Institute, Durham, NC (M.C., Y.X., R.A.M., E.D.P.); Department of Medicine (E.D.P.), and Department of Neurology (Y.X.), Duke University Medical Center, Durham, NC; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC (R.A.M.); Department of Medicine, Stanford University School of Medicine, CA (P.A.H.); Department of Medicine, Ronald-Reagan UCLA Medical Center (G.C.F.); and Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Alberta, Canada (E.E.S.).

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http://dx.doi.org/10.1161/STROKEAHA.117.016290DOI Listing
July 2017

Distribution of lacunes in cerebral amyloid angiopathy and hypertensive small vessel disease.

Neurology 2017 Jun 5;88(23):2162-2168. Epub 2017 May 5.

From the Hemorrhagic Stroke Research Program (M.P., G.B., P.F., E.A., A.C., K.H., A.A., K.M.S., A.V., S.M.G., M.E.G.), Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston; NEUROFARBA Department (M.P., L.P.), Neuroscience Section, University of Florence, Italy; Université Paris-Descartes (G.B.), INSERM UMR 894, Department of Neuroradiology, Centre Hospitalier Sainte-Anne, Paris, France; and Division of Neurocritical Care and Emergency Neurology (J.N.G., J.R.), Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000004007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467956PMC
June 2017

Significance of admission hypoalbuminemia in acute intracerebral hemorrhage.

J Neurol 2017 May 10;264(5):905-911. Epub 2017 Mar 10.

Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, USA.

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http://dx.doi.org/10.1007/s00415-017-8451-xDOI Listing
May 2017

Lymphopenia, Infectious Complications, and Outcome in Spontaneous Intracerebral Hemorrhage.

Neurocrit Care 2017 04;26(2):160-166

Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s12028-016-0367-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336513PMC
April 2017

Considering Blood Pressure Level in the Association Between Serum Calcium Level and the Size and Expansion in Patients With Intracerebral Hemorrhage-Reply.

JAMA Neurol 2017 04;74(4):483-484

J. P. Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1001/jamaneurol.2016.6011DOI Listing
April 2017

Intensive blood pressure lowering in patients with acute intracerebral haemorrhage: clinical outcomes and haemorrhage expansion. Systematic review and meta-analysis of randomised trials.

J Neurol Neurosurg Psychiatry 2017 Apr 18;88(4):339-345. Epub 2017 Feb 18.

Hemorrhagic Stroke Research Group, Massachusetts General Hospital, Boston, Massachusetts, USA

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http://dx.doi.org/10.1136/jnnp-2016-315346DOI Listing
April 2017

Noncontrast Computed Tomography Markers of Intracerebral Hemorrhage Expansion.

Stroke 2017 04 13;48(4):1120-1125. Epub 2017 Mar 13.

From the Hemorrhagic Stroke Research Program, Neurology Department (G.B., A.M., A.C., J.N.G.) and Emergency Medicine Department (J.N.G.), Massachusetts General Hospital, Harvard Medical School, Boston; Neuroradiology Department, Université Paris Descartes, INSERM S894, Centre Hospitalier Sainte-Anne, France (G.B.); and Ottawa Hospital Research Institute, Canada Faculty of Medicine, University of Ottawa, Ontario (D.D.).

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http://dx.doi.org/10.1161/STROKEAHA.116.015062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378158PMC
April 2017

MRI-visible perivascular spaces in cerebral amyloid angiopathy and hypertensive arteriopathy.

Neurology 2017 Mar 22;88(12):1157-1164. Epub 2017 Feb 22.

From the Hemorrhagic Stroke Research Program (A.C., G.B., M.P., E.A., E.S.v.E., K.H., A.A., K.M.S., S.M.-R., A.V., S.M.G., M.E.G.), Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston; Université Paris-Descartes (G.B.), INSERM UMR 894, Department of Neuroradiology, Centre Hospitalier Sainte-Anne, Paris, France; and Division of Neurocritical Care and Emergency Neurology (J.N.G., J.R.), Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000003746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373782PMC
March 2017

Association Between Serum Calcium Level and Extent of Bleeding in Patients With Intracerebral Hemorrhage.

JAMA Neurol 2016 Nov;73(11):1285-1290

Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Boston3J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston5Department of Emergency Medicine, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1001/jamaneurol.2016.2252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287716PMC
November 2016

New Oral Anticoagulants and Their Reversal Agents.

Curr Treat Options Neurol 2016 Nov;18(11):47

J. P. Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, 175 Cambridge Street, Suite 300, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s11940-016-0430-5DOI Listing
November 2016

Diagnosis and Management of Acute Intracerebral Hemorrhage.

Emerg Med Clin North Am 2016 Nov 3;34(4):883-899. Epub 2016 Sep 3.

J. P. Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA; Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Zero Emerson Place, Suite 3B, Boston, MA 02114, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089075PMC
http://dx.doi.org/10.1016/j.emc.2016.06.010DOI Listing
November 2016

Noncontrast Computed Tomography Hypodensities Predict Poor Outcome in Intracerebral Hemorrhage Patients.

Stroke 2016 10 6;47(10):2511-6. Epub 2016 Sep 6.

From the Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston (G.B., A.M., H.B.B., A.C., M.J.J., E.A., O.P.-N., A.A., A. Vashkevich, K.M.S., J.R., A. Viswanathan, M.E.G., S.M.G., J.N.G.); Department of Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, The Netherlands (H.B.B.); Stroke Service, Department of Neuroscience and Behavioral Sciences, Ribeirao Pre- to School of Medicine, University of Sao Paulo (O.P.-N.); Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (J.R., J.N.G.); Department of Emergency Medicine, Massachusetts General Hospital, Boston (J.N.G.).

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http://stroke.ahajournals.org/lookup/doi/10.1161/STROKEAHA.1
Publisher Site
http://dx.doi.org/10.1161/STROKEAHA.116.014425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039101PMC
October 2016

Intracranial atherosclerosis and cerebral small vessel disease in intracerebral hemorrhage patients.

J Neurol Sci 2016 Oct 1;369:324-329. Epub 2016 Sep 1.

Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2016.08.049DOI Listing
October 2016

Association Between Hypodensities Detected by Computed Tomography and Hematoma Expansion in Patients With Intracerebral Hemorrhage.

JAMA Neurol 2016 08;73(8):961-8

Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston3Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Harvard Medical Sch.

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http://dx.doi.org/10.1001/jamaneurol.2016.1218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584601PMC
August 2016

Outcome of patients receiving CPR in the ED of an urban academic hospital.

Am J Emerg Med 2016 Aug 26;34(8):1595-9. Epub 2016 May 26.

Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.ajem.2016.05.060DOI Listing
August 2016

Leukocyte Count and Intracerebral Hemorrhage Expansion.

Stroke 2016 06 21;47(6):1473-8. Epub 2016 Apr 21.

From the Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy (A.M., A. Pezzini, A. Padovani); Division of Neurocritical Care and Emergency Neurology, Department of Neurology (A.M., C.-L.P., C.D.A., M.J.J., J.N.G., J.R.), Hemorrhagic Stroke Research Center (A.M., C.-L.P., C.D.A., M.J.J., K.S., A.A., M.E.G., A.V., S.M.G., J.N.G., J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1161/STROKEAHA.116.013176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879062PMC
June 2016

Predicting Intracerebral Hemorrhage Growth With the Spot Sign: The Effect of Onset-to-Scan Time.

Stroke 2016 Mar 4;47(3):695-700. Epub 2016 Feb 4.

From the Department of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada (D.D., M.R.); Departments of Neurology (H.B.B., S.M.G., J.R.), Radiology (J.M.R.) and Emergency Medicine (J.N.G.), Massachusetts General Hospital and Harvard Medical School, Boston; Department of Neurosurgery, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands (H.B.B.); Department of Clinical Neurosciences, Hotchkiss Brain Institute and Calgary Stroke Program, University of Calgary, Calgary, Alberta, Canada (A.M.D., M.D.H.); Department of Medical Imaging, Sunnybrook Health Sciences Center, University of Toronto, Toronto, ON, Canada (R.I.A.); Health Sciences Library, University of Ottawa, Ottawa, Ontario, Canada (L.-A.U.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, CA (M.W.); Department of Neurology, University of California, San Francisco (J.C.H.); Department of Neurological Surgery, Nippon Medical School, Tokyo, Japan (Y.M.); Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (Yongjun Wang, X.Z., Yilong Wang, N.L.); Department of Neurosurgery, Tokai University, Japan (T. Sorimachi, M.M.); Department of Neurology, University of Heidelberg, Germany (T. Steiner, T.R.); Klinikum Frankfurt Höchst, Germany (T. Steiner); and Department of Medicine, McMaster University, Population Health Research Institute, Hamilton, Ontario, Canada (M.S.).

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http://dx.doi.org/10.1161/STROKEAHA.115.012012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766058PMC
March 2016

Lung-Protective Ventilation With Low Tidal Volumes and the Occurrence of Pulmonary Complications in Patients Without Acute Respiratory Distress Syndrome: A Systematic Review and Individual Patient Data Analysis.

Crit Care Med 2015 Oct;43(10):2155-63

1Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 2Program of Post-Graduation, Research and Innovation, Faculdade de Medicina do ABC (FMABC), Santo André, Brazil. 3Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil. 4Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN. 5Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA. 6School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. 7Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Peijas Hospital, Vantaa, Finland. 8Medical School, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil. 9Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA. 10Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. 11Department of Surgical Sciences and Integrated Diagnostics, IRCCS San Martino IST, University of Genoa, Genoa, Italy. 12Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/CCM.0000000000001189DOI Listing
October 2015

Rate of Contrast Extravasation on Computed Tomographic Angiography Predicts Hematoma Expansion and Mortality in Primary Intracerebral Hemorrhage.

Stroke 2015 Sep 4;46(9):2498-503. Epub 2015 Aug 4.

From the Department of Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands (H.B.B.); Center for Human Genetic Research (H.B.B., T.W.K.B., H.H.M., G.J.F., C.D.A., J.R.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (H.B.B., G.J.F., A. Viswanathan, C.D.A., J.N.G., J.R.), Hemorrhagic Stroke Research Group (H.B.B., T.W.K.B., H.H.M., G.J.F., A.M.A., A. Vashkevich, K.S., A. Viswanathan, C.D.A., S.M.G., J.N.G., J.R.), J. Philip Kistler Stroke Research Center (H.B.B., T.W.K.B., H.H.M., G.J.F., A.M.A., A. Vashkevich, K.S., A. Viswanathan, C.D.A., S.M.G., J.N.G., J.R.), Neuroradiology Service, Department of Radiology (V.A.C., S.R.P., C.J.O., R.G.G., J.M.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1161/STROKEAHA.115.009659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550492PMC
September 2015

Rare Coding Variation and Risk of Intracerebral Hemorrhage.

Stroke 2015 Aug 25;46(8):2299-301. Epub 2015 Jun 25.

From the Center for Human Genetic Research (F.R., G.J.F., C.D.A., W.J.D., T.W.K.B., M.R.R., J.R.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (F.R., G.J.F., C.D.A., W.J.D., T.W.K.B., M.R.R., J.R.), J. Philip Kistler Stroke Research Center (F.R., G.J.F., C.D.A., W.J.D., T.W.K.B., A.M.A., M.R.R., K.S., A.V., S.M.G., J.R.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (F.R., G.J.F., C.D.A., W.J.D., T.W.K.B., M.R.R., J.R.); Department of Biostatistical Sciences, Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC (D.M., W.M.B., C.D.L.); Quinnipiac University, Frank H. Netter MD School of Medicine, Hamden, CT (W.J.D.); Department of Environmental Health (G.S., R.D.) and Department of Neurology and Rehabilitation (D.W.), University of Cincinnati College of Medicine, OH; Department of Neurology, Harborview Medical Center, University of Washington, Seattle (D.L.T.); Department of Neurology, University of Florida College of Medicine, Jacksonville (S.L.S.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (M.S.); Department of Neurology, Mayo Clinic, Jacksonville, FL (J.F.M.); Department of Neurology, University of Michigan Health System, Ann Arbor (D.L.B.); and Departments of Neurology and Public Health Sciences, University of Virginia Health System, Charlottesville (B.B.W.).

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http://dx.doi.org/10.1161/STROKEAHA.115.009838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519408PMC
August 2015

Exception from informed consent: ethics and logistics.

Acad Emerg Med 2015 Mar 25;22(3):365-6. Epub 2015 Feb 25.

Academic Emergency Medicine, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1111/acem.12618DOI Listing
March 2015

Bleeding complications of targeted oral anticoagulants: what is the risk?

Hematology Am Soc Hematol Educ Program 2014 Dec 18;2014(1):504-9. Epub 2014 Nov 18.

Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1182/asheducation-2014.1.504DOI Listing
December 2014

Spot sign on 90-second delayed computed tomography angiography improves sensitivity for hematoma expansion and mortality: prospective study.

Stroke 2014 Nov 9;45(11):3293-7. Epub 2014 Oct 9.

From the Division of Neuroradiology, Department of Radiology (V.A.C., R.P., C.J.O., S.R.P., R.G.G., J.M.R.), Center for Human Genetic Research (H.B.B., J.R.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (H.B.B., J.R., J.N.G.), Department of Neurology, Hemorrhagic Stroke Research Group (H.B.B., J.R., J.N.G., S.M.G.), Department of Neurology, J. Philip Kistler Stroke Research Center (H.B.B., J.R., J.N.G.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Harvard Medical School, Boston; and Department of Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands (H.B.B.).

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http://dx.doi.org/10.1161/STROKEAHA.114.005570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213346PMC
November 2014

Reducing door-to-puncture times for intra-arterial stroke therapy: a pilot quality improvement project.

J Am Heart Assoc 2014 Nov 11;3(6):e000963. Epub 2014 Nov 11.

Division of Diagnostic Neuroradiology, Massachusetts General Hospital, Boston, MA (A.J.Y.) Division of Interventional Neuroradiology, Department of Radiology, Massachusetts General Hospital, Boston, MA (B.P.M., T.M.L.M., R.V.C., D.L.B., J.A.H., J.D.R., A.J.Y.).

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http://dx.doi.org/10.1161/JAHA.114.000963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338685PMC
November 2014

CT angiography spot sign in intracerebral hemorrhage predicts active bleeding during surgery.

Neurology 2014 Sep 6;83(10):883-9. Epub 2014 Aug 6.

From the Center for Human Genetic Research (H.B.B., M.R.R., G.J.F., J.R.) and the Departments of Neurology, Neurosurgery, Radiology, and Emergency Medicine (H.B.B., M.R.R., G.J.F., A.M.A., K.A.M., K.S., J.M.R., A.V., S.M.G., C.S.O., J.N.G., J.R.), Massachusetts General Hospital, Harvard Medical School, Boston; and the Department of Neurology & Neurosurgery, Brain Center Rudolf Magnus, and Department of Radiology (H.B.B., K.M.v.N., B.K.V., A.v.d.Z., G.J.E.R., C.J.M.K.), University Medical Center Utrecht, Utrecht University, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000000747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153853PMC
September 2014

APOE ε variants increase risk of warfarin-related intracerebral hemorrhage.

Neurology 2014 Sep 22;83(13):1139-46. Epub 2014 Aug 22.

From the Center for Human Genetic Research (G.J.F., F.R., H.B.B., T.W.K.B., W.J.D., V.V., M.R.R., L.P.C., A.M.A., K.S., A.V., S.M.G., A.B., J.R., C.D.A.), J. Philip Kistler Stroke Research Center (G.J.F., F.R., H.B.B., T.W.K.B., W.J.D., V.V., M.R.R., A.B., J.R., C.D.A.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (G.J.F., F.R., H.B.B., T.W.K.B., W.J.D., M.R.R., A.B., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (G.J.F., F.R., H.B.B., T.W.K.B., W.J.D., M.R.R., A.B., J.R., C.D.A.), Broad Institute, Cambridge, MA; Department of Epidemiology (G.J.F., P.K.), Harvard School of Public Health, Boston; Department of Neurology (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology (J.F.M.), Mayo Clinic, Jacksonville, FL; Stroke Program (D.L.B.), Department of Neurology, University of Michigan Health System, Ann Arbor; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Stroke Center (D.L.T.), Harborview Medical Center, University of Washington, Seattle; and University of Cincinnati College of Medicine (M.L.F., S.R.M., R.D., D.W.), OH.

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http://dx.doi.org/10.1212/WNL.0000000000000816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176027PMC
September 2014

Emergency reversal of anticoagulation: novel agents.

Curr Neurol Neurosci Rep 2014 Aug;14(8):471

Department of Emergency Medicine, Section of Medical Toxicology, University of Southern California, 1200 North State Street, Room 1011, Los Angeles, CA, 90033, USA,

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http://dx.doi.org/10.1007/s11910-014-0471-7DOI Listing
August 2014

Risk factors for computed tomography angiography spot sign in deep and lobar intracerebral hemorrhage are shared.

Stroke 2014 Jun 13;45(6):1833-5. Epub 2014 May 13.

From the Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA (F.R., G.J.F., C.D.A., T.W.K.B., J.R., H.B.B.); Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Boston, MA (F.R., G.J.F., C.D.A., T.W.K.B., J.R., H.B.B.); J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA (F.R., G.J.F., C.D.A., T.W.K.B., A.M.A., A. Vashkevich, K.A.M., K.S., A. Viswanathan, S.M.G., J.R., H.B.B.); Departments of Radiology (J.M.R.) and Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA; and Department of Neurosurgery, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands (H.B.B.).

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http://dx.doi.org/10.1161/STROKEAHA.114.005276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116606PMC
June 2014

Anatomic pattern of intracerebral hemorrhage expansion: relation to CT angiography spot sign and hematoma center.

Stroke 2014 Apr 6;45(4):1154-6. Epub 2014 Mar 6.

From the Hemorrhagic Stroke Research Program, Department of Neurology (G.B., A.D., H.B.B., P.F., A. Vashkevich, A.A., K.S., A. Viswanathan, M.E.G., S.M.G.), Division of Neuroradiology, Department of Radiology (J.M.R.), Department of Emergency Medicine (J.N.G.), and Division of Neurocritical Care and Emergency Neurology (J.R.), Massachusetts General Hospital, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard School of Public Health, Boston, MA (R.A.B.); and Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Alberta, Canada (E.E.S.).

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http://dx.doi.org/10.1161/STROKEAHA.114.004844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984947PMC
April 2014

Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage.

Am J Hum Genet 2014 Apr 20;94(4):511-21. Epub 2014 Mar 20.

Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA; The J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02141, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980413PMC
April 2014

Predicting hematoma expansion after primary intracerebral hemorrhage.

JAMA Neurol 2014 Feb;71(2):158-64

Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston3Hemorrhagic Stroke Research Group, Massachusetts General Hospital, Harvard Medical School, Boston4J. Philip Kis.

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http://dx.doi.org/10.1001/jamaneurol.2013.5433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131760PMC
February 2014

Improving door-to-needle times: a single center validation of the target stroke hypothesis.

Stroke 2014 Feb 7;45(2):504-8. Epub 2014 Jan 7.

From the Departments of Neurology (I.R., S.A., N.R., L.S.), Radiology (W.C., M.L.), and Emergency Medicine (J.G., J.M.), Massachusetts General Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/STROKEAHA.113.004073DOI Listing
February 2014

Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study.

Circulation 2013 Sep 9;128(11):1234-43. Epub 2013 Aug 9.

University of Texas Southwestern Medical Center, Dallas (R.S.); Seton/University of Texas Southwestern Clinical Research Institute of Austin, Dell Children's Medical Center, University Medical Center at Brackenridge, Austin, TX (T.J.M.); University of Rochester Medical Center, Rochester, NY (M.A.R.); CSL Behring LLC, King of Prussia, PA (A.M., B.L.D.); CSL Behring GmbH, Marburg, Germany (A.S.); and Massachusetts General Hospital, Boston (J.N.G.).

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http://circ.ahajournals.org/content/128/11/1234.full.pdf
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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.002283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701181PMC
September 2013