Joshua M Akey

Joshua M Akey

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Joshua M Akey

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Identifying and Interpreting Apparent Neanderthal Ancestry in African Individuals.

Cell 2020 Feb 30;180(4):677-687.e16. Epub 2020 Jan 30.

The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.01.012DOI Listing
February 2020

The long walk to African genomics.

Genome Biol 2019 06 27;20(1):130. Epub 2019 Jun 27.

Lewis-Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University, South Drive, Princeton, NJ, 08544, USA.

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http://dx.doi.org/10.1186/s13059-019-1740-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598360PMC
June 2019

Massive variation of short tandem repeats with functional consequences across strains of .

Genome Res 2018 08 3;28(8):1169-1178. Epub 2018 Jul 3.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1101/gr.231753.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071631PMC
August 2018

Evolution of DNAase I Hypersensitive Sites in MHC Regulatory Regions of Primates.

Genetics 2018 06 18;209(2):579-589. Epub 2018 Apr 18.

Department of Genome Sciences, University of Washington, Seattle, Washington 98125

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http://dx.doi.org/10.1534/genetics.118.301028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972428PMC
June 2018

Outstanding questions in the study of archaic hominin admixture.

PLoS Genet 2018 05 31;14(5):e1007349. Epub 2018 May 31.

Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978786PMC
May 2018

Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture.

Cell 2018 03 15;173(1):53-61.e9. Epub 2018 Mar 15.

Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA; The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.

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http://dx.doi.org/10.1016/j.cell.2018.02.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866234PMC
March 2018

Selection plays the hand it was dealt: evidence that human adaptation commonly targets standing genetic variation.

Genome Biol 2017 08 1;18(1):139. Epub 2017 Aug 1.

Department of Genome Sciences, University of Washington, Seattle, WA, 98195, USA.

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http://dx.doi.org/10.1186/s13059-017-1280-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537971PMC
August 2017

Human RECQ Helicase Pathogenic Variants, Population Variation and "Missing" Diseases.

Hum Mutat 2017 02 9;38(2):193-203. Epub 2016 Dec 9.

Department of Genome Sciences, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1002/humu.23148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518694PMC
February 2017

Impacts of Neanderthal-Introgressed Sequences on the Landscape of Human Gene Expression.

Cell 2017 02;168(5):916-927.e12

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.01.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219754PMC
February 2017

Tracing the peopling of the world through genomics.

Nature 2017 01;541(7637):302-310

Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350 Copenhagen K, Denmark.

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http://dx.doi.org/10.1038/nature21347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772775PMC
January 2017

Detecting Sources of Transcriptional Heterogeneity in Large-Scale RNA-Seq Data Sets.

Genetics 2016 Dec 11;204(4):1391-1396. Epub 2016 Oct 11.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195

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http://dx.doi.org/10.1534/genetics.116.193714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161273PMC
December 2016

Archaic Hominin Admixture Facilitated Adaptation to Out-of-Africa Environments.

Curr Biol 2016 12 10;26(24):3375-3382. Epub 2016 Nov 10.

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2016.10.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764441PMC
December 2016

Editorial overview: Genetics of human origin: New horizons in human population genetics.

Curr Opin Genet Dev 2016 12 23;41:v-vi. Epub 2016 Nov 23.

Department of Human Genetics, University of Chicago, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2016.11.002DOI Listing
December 2016

Robust Inference of Identity by Descent from Exome-Sequencing Data.

Am J Hum Genet 2016 Nov 13;99(5):1106-1116. Epub 2016 Oct 13.

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097937PMC
November 2016

Population genetics: A map of human wanderlust.

Nature 2016 10 21;538(7624):179-180. Epub 2016 Sep 21.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1038/nature19472DOI Listing
October 2016

Human Diversity in a Cell Surface Receptor that Inhibits Autophagy.

Curr Biol 2016 07 23;26(14):1791-801. Epub 2016 Jun 23.

Department of Microbiology, University of Washington, Seattle, WA 98195, USA; Department of Immunology, University of Washington, Seattle, WA 98195, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://www.cell.com/current-biology/pdf/S0960-9822(16)30454-
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http://linkinghub.elsevier.com/retrieve/pii/S096098221630454
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http://dx.doi.org/10.1016/j.cub.2016.05.003DOI Listing
July 2016

A flexible method for estimating the fraction of fitness influencing mutations from large sequencing data sets.

Genome Res 2016 06 14;26(6):834-43. Epub 2016 Apr 14.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195-5065, USA.

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http://dx.doi.org/10.1101/gr.203059.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889975PMC
June 2016

The phenotypic legacy of admixture between modern humans and Neandertals.

Science 2016 Feb;351(6274):737-41

Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA. Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA. Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA. Center for Quantitative Sciences, Vanderbilt University, Nashville, TN, USA.

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http://dx.doi.org/10.1126/science.aad2149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849557PMC
February 2016

Patterns of deleterious variation between human populations reveal an unbalanced load.

Proc Natl Acad Sci U S A 2016 Jan 19;113(4):809-11. Epub 2016 Jan 19.

Department of Genome Sciences, University of Washington, Seattle, WA 98195

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http://dx.doi.org/10.1073/pnas.1524016113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743776PMC
January 2016

Methods and models for unravelling human evolutionary history.

Nat Rev Genet 2015 Dec 10;16(12):727-40. Epub 2015 Nov 10.

Department of Genome Sciences, University of Washington, 3720 15th Avenue NE, box 355065, Seattle, Washington 98195-5065, USA.

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http://dx.doi.org/10.1038/nrg4005DOI Listing
December 2015

Small Amounts of Archaic Admixture Provide Big Insights into Human History.

Cell 2015 Oct;163(2):281-4

Department of Genome Sciences, University of Washington, 3720 15th Avenue Northeast, Box 355065, Seattle, WA 98195-5065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.09.042DOI Listing
October 2015

Comprehensive identification and analysis of human accelerated regulatory DNA.

Genome Res 2015 Sep 23;25(9):1245-55. Epub 2015 Jun 23.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA;

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http://dx.doi.org/10.1101/gr.192591.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561485PMC
September 2015

The origins, determinants, and consequences of human mutations.

Science 2015 Sep 24;349(6255):1478-83. Epub 2015 Sep 24.

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1126/science.aaa9119DOI Listing
September 2015

Complex history of admixture between modern humans and Neandertals.

Am J Hum Genet 2015 Mar 12;96(3):448-53. Epub 2015 Feb 12.

Department of Genome Sciences, University of Washington, 3720 15(th) Avenue NE, PO Box 355065, Seattle WA 98195-5065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375686PMC
March 2015

Estimates of continental ancestry vary widely among individuals with the same mtDNA haplogroup.

Am J Hum Genet 2015 Feb 22;96(2):183-93. Epub 2015 Jan 22.

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Department of Pediatrics, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320259PMC
February 2015

Global and disease-associated genetic variation in the human Fanconi anemia gene family.

Hum Mol Genet 2014 Dec 7;23(25):6815-25. Epub 2014 Aug 7.

Department of Genome Sciences and Department of Pathology, University of Washington, Seattle, WA 98195, USA

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http://dx.doi.org/10.1093/hmg/ddu400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245043PMC
December 2014

Heritable variation of mRNA decay rates in yeast.

Genome Res 2014 Dec 25;24(12):2000-10. Epub 2014 Sep 25.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA;

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http://dx.doi.org/10.1101/gr.175802.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248316PMC
December 2014

Characteristics of neutral and deleterious protein-coding variation among individuals and populations.

Am J Hum Genet 2014 Oct;95(4):421-36

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185119PMC
October 2014

Human evolution: genomic gifts from archaic hominins.

Curr Biol 2014 Sep;24(18):R845-R848

Department of Genome Sciences, University of Washington, 3720 15th Ave NE, Box 355065, Seattle WA 98195-5065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.07.079DOI Listing
September 2014

Evolution and genetic architecture of chromatin accessibility and function in yeast.

PLoS Genet 2014 Jul 3;10(7):e1004427. Epub 2014 Jul 3.

Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081003PMC
July 2014

Resurrecting surviving Neandertal lineages from modern human genomes.

Science 2014 Feb 29;343(6174):1017-21. Epub 2014 Jan 29.

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1126/science.1245938DOI Listing
February 2014

Selection and adaptation in the human genome.

Annu Rev Genomics Hum Genet 2013 3;14:467-89. Epub 2013 Jul 3.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195-5065; email:

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http://dx.doi.org/10.1146/annurev-genom-091212-153509DOI Listing
December 2013

Signatures of natural selection on genetic variants affecting complex human traits.

Appl Transl Genom 2013 Dec 7;2:78-94. Epub 2013 Nov 7.

Department of Genetics and Institute for Quantitative Biomedical Sciences, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S22120661130001
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http://dx.doi.org/10.1016/j.atg.2013.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121263PMC
December 2013

Identification and antiviral activity of common polymorphisms in the APOBEC3 locus in human populations.

Virology 2013 Sep 10;443(2):329-37. Epub 2013 Jun 10.

Molecular and Cellular Biology Program, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.virol.2013.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722276PMC
September 2013

Great ape genetic diversity and population history.

Nature 2013 Jul 3;499(7459):471-5. Epub 2013 Jul 3.

Institut de Biologia Evolutiva, CSIC-Universitat Pompeu Fabra, PRBB, Doctor Aiguader 88, Barcelona, Catalonia 08003, Spain.

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http://dx.doi.org/10.1038/nature12228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822165PMC
July 2013

Exploring signatures of positive selection in pigmentation candidate genes in populations of East Asian ancestry.

BMC Evol Biol 2013 Jul 12;13:150. Epub 2013 Jul 12.

Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada.

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http://dx.doi.org/10.1186/1471-2148-13-150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727976PMC
July 2013

Marker panels for genealogy-based mapping, breed demographics, and inference-of-ancestry in the dog.

Anim Biotechnol 2012 ;23(4):241-52

Veterinary Genetics Laboratory, University of California, Davis, USA.

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http://dx.doi.org/10.1080/10495398.2012.717151DOI Listing
April 2013

Adaptive evolution of the FADS gene cluster within Africa.

PLoS One 2012 19;7(9):e44926. Epub 2012 Sep 19.

Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044926PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446990PMC
March 2013

A Grand Challenge in Evolutionary and Population Genetics: New Paradigms for Exploring the Past and Charting the Future in the Post-Genomic era.

Front Genet 2011 21;2:47. Epub 2011 Jul 21.

Department of Genome Sciences, University of Washington Seattle, WA, USA.

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http://dx.doi.org/10.3389/fgene.2011.00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268600PMC
October 2012

Clusters of adaptive evolution in the human genome.

Front Genet 2011 9;2:50. Epub 2011 Sep 9.

Department of Genome Sciences, University of Washington Seattle, WA, USA.

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http://dx.doi.org/10.3389/fgene.2011.00050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268603PMC
October 2012

Personal and population genomics of human regulatory variation.

Genome Res 2012 Sep;22(9):1689-97

Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1101/gr.134890.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431486PMC
September 2012

On the prospects of whole-genome association mapping in Saccharomyces cerevisiae.

Genetics 2012 Aug 5;191(4):1345-53. Epub 2012 Jun 5.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1534/genetics.112.141168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416012PMC
August 2012

Parallel selection: evolution's surprising predictability.

Authors:
Joshua M Akey

Curr Biol 2012 May;22(10):R407-9

Department of Genome Sciences, University of Washington, Seattle, WA 98195-5065, USA.

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http://dx.doi.org/10.1016/j.cub.2012.04.014DOI Listing
May 2012

Understanding human evolutionary history: a meeting report of the Swedish Royal Academy of Sciences symposium of modern human genetic variation.

Authors:
Joshua M Akey

Investig Genet 2012 Mar 24;3. Epub 2012 Mar 24.

Department of Genome Sciences, University of Washington, Foege Building S-303 1705 NE Pacific, Seattle, WA 98195-5065, USA.

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http://dx.doi.org/10.1186/2041-2223-3-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333475PMC
March 2012

Copy number variation in the domestic dog.

Mamm Genome 2012 Feb 4;23(1-2):144-63. Epub 2011 Dec 4.

The Center for Human and Molecular Genetics, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, W491, Columbus, OH 43205, USA.

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http://dx.doi.org/10.1007/s00335-011-9369-8DOI Listing
February 2012

A powerful and flexible statistical framework for testing hypotheses of allele-specific gene expression from RNA-seq data.

Genome Res 2011 Oct 26;21(10):1728-37. Epub 2011 Aug 26.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1101/gr.119784.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202289PMC
October 2011

The promise and limitations of population exomics for human evolution studies.

Genome Biol 2011 Sep 14;12(9):127. Epub 2011 Sep 14.

Department of Genome Sciences, University of Washington, 3720 15th Ave NE, Box 355065, Seattle, WA 98195-5065, USA.

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http://genomebiology.biomedcentral.com/articles/10.1186/gb-2
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http://dx.doi.org/10.1186/gb-2011-12-9-127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308040PMC
September 2011

A high-resolution integrated map of copy number polymorphisms within and between breeds of the modern domesticated dog.

BMC Genomics 2011 Aug 16;12:414. Epub 2011 Aug 16.

Department of Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA.

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http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2164-12-414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166287PMC
August 2011

Parallel adaptive divergence among geographically diverse human populations.

PLoS Genet 2011 Jun 16;7(6):e1002127. Epub 2011 Jun 16.

Department of Genome Sciences, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1371/journal.pgen.1002127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116918PMC
June 2011

Estimators of the human effective sex ratio detect sex biases on different timescales.

Am J Hum Genet 2010 Dec 25;87(6):848-56. Epub 2010 Nov 25.

Department of Genome Sciences, University of Washington, Seattle, 98195, USA.

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http://dx.doi.org/10.1016/j.ajhg.2010.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997380PMC
December 2010

Signatures of positive selection apparent in a small sample of human exomes.

Genome Res 2010 Oct 6;20(10):1327-34. Epub 2010 Aug 6.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195-5065, USA.

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http://genome.cshlp.org/cgi/doi/10.1101/gr.106161.110
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http://dx.doi.org/10.1101/gr.106161.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945181PMC
October 2010

Tracking footprints of artificial selection in the dog genome.

Proc Natl Acad Sci U S A 2010 Jan 11;107(3):1160-5. Epub 2010 Jan 11.

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1073/pnas.0909918107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824266PMC
January 2010

Population genomics of intron splicing in 38 Saccharomyces cerevisiae genome sequences.

Genome Biol Evol 2009 Nov 17;1:466-78. Epub 2009 Nov 17.

Department of Genome Sciences, University of Washington, USA.

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http://dx.doi.org/10.1093/gbe/evp046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839277PMC
November 2009

Inherited variation in gene expression.

Annu Rev Genomics Hum Genet 2009 ;10:313-32

Department of Genome Sciences, University of Washington, Seattle, Washington, 98195, USA.

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http://dx.doi.org/10.1146/annurev-genom-082908-150121DOI Listing
October 2009

Population genomic analysis of ALMS1 in humans reveals a surprisingly complex evolutionary history.

Mol Biol Evol 2009 Jun 11;26(6):1357-67. Epub 2009 Mar 11.

Department of Genome Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1093/molbev/msp045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734137PMC
June 2009

Constructing genomic maps of positive selection in humans: where do we go from here?

Authors:
Joshua M Akey

Genome Res 2009 May;19(5):711-22

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1101/gr.086652.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647533PMC
May 2009

Genome-wide insights into the patterns and determinants of fine-scale population structure in humans.

Am J Hum Genet 2009 May;84(5):641-50

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.ajhg.2009.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681007PMC
May 2009

The genomic architecture of segmental duplications and associated copy number variants in dogs.

Genome Res 2009 Mar 7;19(3):491-9. Epub 2009 Jan 7.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1101/gr.084715.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661811PMC
March 2009

Mapping gene expression quantitative trait loci by singular value decomposition and independent component analysis.

BMC Bioinformatics 2008 May 20;9:244. Epub 2008 May 20.

Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA.

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http://bmcbioinformatics.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/1471-2105-9-244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424053PMC
May 2008

The evolution of gene expression QTL in Saccharomyces cerevisiae.

PLoS One 2007 Aug 1;2(7):e678. Epub 2007 Aug 1.

Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000678PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1925141PMC
August 2007

On the design and analysis of gene expression studies in human populations.

Nat Genet 2007 Jul;39(7):807-8; author reply 808-9

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http://dx.doi.org/10.1038/ng0707-807DOI Listing
July 2007

Gene-expression variation within and among human populations.

Am J Hum Genet 2007 Mar 11;80(3):502-9. Epub 2007 Jan 11.

Department of Biostatistics, University of Washington, Seattle, WA 98195-7730, USA.

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http://dx.doi.org/10.1086/512017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821107PMC
March 2007

Adaptive evolution in humans revealed by the negative correlation between the polymorphism and fixation phases of evolution.

Proc Natl Acad Sci U S A 2007 Mar 26;104(10):3907-12. Epub 2007 Feb 26.

Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1073/pnas.0605565104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820682PMC
March 2007

Genomic insights into positive selection.

Trends Genet 2006 Aug 30;22(8):437-46. Epub 2006 Jun 30.

Department of Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.tig.2006.06.005DOI Listing
August 2006

Genomic signatures of positive selection in humans and the limits of outlier approaches.

Genome Res 2006 Aug 6;16(8):980-9. Epub 2006 Jul 6.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1101/gr.5157306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1524870PMC
August 2006

TRPV6 exhibits unusual patterns of polymorphism and divergence in worldwide populations.

Hum Mol Genet 2006 Jul 22;15(13):2106-13. Epub 2006 May 22.

Department of Genome Sciences, University of Washington, Seattle, WA 98195-7730, USA.

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http://dx.doi.org/10.1093/hmg/ddl134DOI Listing
July 2006

Sequence diversity, natural selection and linkage disequilibrium in the human T cell receptor alpha/delta locus.

Hum Genet 2006 Apr 20;119(3):255-66. Epub 2006 Jan 20.

Department of Genome Sciences, University of Washington, 357730, Seattle, WA, 98195-7730, USA.

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http://dx.doi.org/10.1007/s00439-005-0111-zDOI Listing
April 2006

High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans.

Curr Biol 2006 Jan;16(1):95-100

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1016/j.cub.2005.11.045DOI Listing
January 2006

Fitting background-selection predictions to levels of nucleotide variation and divergence along the human autosomes.

Genome Res 2005 Sep;15(9):1211-21

Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1101/gr.3413205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1199535PMC
September 2005

Multiple locus linkage analysis of genomewide expression in yeast.

PLoS Biol 2005 Aug 26;3(8):e267. Epub 2005 Jul 26.

Department of Biostatistics, University of Washington, Seattle, Washington, USA.

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https://dx.plos.org/10.1371/journal.pbio.0030267
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http://dx.doi.org/10.1371/journal.pbio.0030267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180512PMC
August 2005

Genome-wide scans for loci under selection in humans.

Hum Genomics 2005 Jun;2(2):113-25

University of Washington, Seattle, Washington, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525256PMC
http://dx.doi.org/10.1186/1479-7364-2-2-113DOI Listing
June 2005

Population history and natural selection shape patterns of genetic variation in 132 genes.

PLoS Biol 2004 Oct 7;2(10):e286. Epub 2004 Sep 7.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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http://dx.doi.org/10.1371/journal.pbio.0020286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC515367PMC
October 2004

Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors.

Nat Genet 2003 Sep 3;35(1):57-64. Epub 2003 Aug 3.

Howard Hughes Medical Institute and Division of Human Biology, Fred Hutchinson Cancer Research Center, Mailstop D4-100, 1100 Fairview Avenue North, Seattle, Washington 98103 USA.

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http://www.nature.com/articles/ng1222
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September 2003