Publications by authors named "Joshua Grossman"

8 Publications

  • Page 1 of 1

Improved individual and population-level HbA1c estimation using CGM data and patient characteristics.

J Diabetes Complications 2021 08 17;35(8):107950. Epub 2021 May 17.

Department of Management Science and Engineering, Stanford School of Engineering, Stanford, CA, USA; Division of Pediatric Endocrinology, Stanford School of Medicine, Stanford, CA, USA; Lucile Packard Children's Hospital, Stanford, CA, USA; Stanford Diabetes Research Center, Stanford School of Medicine, Stanford, CA, USA; Clinical Excellence Research Center, Stanford School of Medicine, Stanford, CA, USA. Electronic address:

Machine learning and linear regression models using CGM and participant data reduced HbA1c estimation error by up to 26% compared to the GMI formula, and exhibit superior performance in estimating the median of HbA1c at the cohort level, potentially of value for remote clinical trials interrupted by COVID-19.
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http://dx.doi.org/10.1016/j.jdiacomp.2021.107950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316291PMC
August 2021

Differentiation of Baboon () Induced-Pluripotent Stem Cells into Enucleated Red Blood Cells.

Cells 2019 10 19;8(10). Epub 2019 Oct 19.

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

As cell culture methods and stem cell biology have progressed, the in vitro production of cultured RBCs (cRBCs) has emerged as a viable option to produce cells for transfusion or to carry therapeutic cargoes. RBCs produced in culture can be quality-tested either by xeno-transfusion of human cells into immuno-deficient animals, or by transfusion of autologous cells in immuno-competent models. Although murine xeno-transfusion methods have improved, they must be complemented by studies in immuno-competent models. Non-human primates (NHPs) are important pre-clinical, large animal models due to their high biological and developmental similarities with humans, including their comparable hematopoietic and immune systems. Among NHPs, baboons are particularly attractive to validate cRBCs because of the wealth of data available on the characteristics of RBCs in this species that have been generated by past blood transfusion studies. We report here that we have developed a method to produce enucleated cRBCs by differentiation of baboon induced pluripotent stem cells (iPSCs). This method will enable the use of baboons to evaluate therapeutic cRBCs and generate essential pre-clinical data in an immuno-competent, large animal model. Production of the enucleated baboon cRBCs was achieved by adapting the PSC-RED protocol that we previously developed for human cells. Baboon-PSC-RED is an efficient chemically-defined method to differentiate iPSCs into cRBCs that are about 40% to 50% enucleated. PSC-RED is relatively low cost because it requires no albumin and only small amounts of recombinant transferrin.
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http://dx.doi.org/10.3390/cells8101282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829891PMC
October 2019

Erratum to: Scoring system for differentiating perforated and non-perforated pediatric appendicitis.

Emerg Radiol 2017 10;24(5):555

Department of Pediatrics, Albert Einstein College of Medicine, Montefiore Medical Center, 111 East 210th Street, Bronx, NY, USA.

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http://dx.doi.org/10.1007/s10140-017-1540-4DOI Listing
October 2017

Scoring system for differentiating perforated and non-perforated pediatric appendicitis.

Emerg Radiol 2017 Oct 7;24(5):547-554. Epub 2017 Jul 7.

Department of Pediatrics, Albert Einstein College of Medicine/Montefiore Medical Center, 111 East 210th Street, Bronx, NY, USA.

Objectives: Appendicitis is the most common indication for emergency pediatric surgery and its most significant complication is perforation. Perforated appendicitis (PA) may be managed conservatively, whereas non-perforated appendicitis (NP) is managed surgically. Recent studies have shown that ultrasound (US) is effective for differentiating between PA and NP, and does not expose pediatric patients to ionizing radiation. The purpose of this study is to enhance the accuracy of differentiation with a novel scoring system based on clinical, laboratory, and US findings.

Methods: This retrospective study included 243 patients aged 2-17 years who presented between 2006 and 2013 with surgically proven appendicitis, of whom 60 had perforation. Clinical and laboratory data were collected and US images evaluated by a pediatric radiologist. To create the scoring system, point values were assigned to each parameter. A randomly selected training sample of 137 subjects was used to create a scoring prediction model. The model was tested on the remaining 106 patients.

Results: Scores of ≥6, ≥11, and ≥15 yielded specificities of 64, 91, and 99%, and sensitivities of 96, 61, and 29%, respectively (p < 0.001).

Conclusions: We have designed a scoring system incorporating clinical, laboratory, and sonographic findings which can differentiate PA from NP with high specificity.
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http://dx.doi.org/10.1007/s10140-017-1535-1DOI Listing
October 2017

A welcome gift. A former patient provides the antidote to burnout.

Authors:
Joshua Grossman

Med Econ 2009 Nov;86(21):47

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November 2009

Is food love?

J Natl Med Assoc 2007 Apr;99(4):439

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2569644PMC
April 2007

Obesity prevention in pediatrics.

J Natl Med Assoc 2006 Oct;98(10):1714

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2569761PMC
October 2006
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