Joshua C Denny

Joshua C Denny

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Joshua C Denny

Joshua C Denny

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Leveraging Human Genetics to Identify Safety Signals Prior to Drug Marketing Approval and Clinical Use.

Drug Saf 2020 Jun;43(6):567-582

Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1007/s40264-020-00915-6DOI Listing
June 2020

Evaluating the Utility of Polygenic Risk Scores in Identifying High-Risk Individuals for Eight Common Cancers.

JNCI Cancer Spectr 2020 Jun 12;4(3):pkaa021. Epub 2020 Mar 12.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1093/jncics/pkaa021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306192PMC
June 2020

Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways.

Kidney Int 2020 May 17;97(5):1032-1041. Epub 2020 Feb 17.

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Renal Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2020.01.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265573PMC
May 2020

medExtractR: A targeted, customizable approach to medication extraction from electronic health records.

J Am Med Inform Assoc 2020 Mar;27(3):407-418

Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1093/jamia/ocz207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025369PMC
March 2020

Cost-aware active learning for named entity recognition in clinical text.

J Am Med Inform Assoc 2019 11;26(11):1314-1322

School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

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http://dx.doi.org/10.1093/jamia/ocz102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798575PMC
November 2019

Mapping ICD-10 and ICD-10-CM Codes to Phecodes: Workflow Development and Initial Evaluation.

JMIR Med Inform 2019 Nov 29;7(4):e14325. Epub 2019 Nov 29.

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States.

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http://dx.doi.org/10.2196/14325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911227PMC
November 2019

Cox regression increases power to detect genotype-phenotype associations in genomic studies using the electronic health record.

BMC Genomics 2019 Nov 4;20(1):805. Epub 2019 Nov 4.

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1186/s12864-019-6192-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829851PMC
November 2019

The "All of Us" Research Program. Reply.

N Engl J Med 2019 11;381(19):1884-1885

National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1056/NEJMc1912496DOI Listing
November 2019

Translational Health Disparities Research in a Data-Rich World.

Health Equity 2019 8;3(1):588-600. Epub 2019 Nov 8.

Data Science Institute and Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.

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http://dx.doi.org/10.1089/heq.2019.0042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844128PMC
November 2019

Phenotyping through Semi-Supervised Tensor Factorization (PSST).

AMIA Annu Symp Proc 2018 5;2018:564-573. Epub 2018 Dec 5.

Emory University, Atlanta, GA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371355PMC
October 2019

Detecting time-evolving phenotypic topics via tensor factorization on electronic health records: Cardiovascular disease case study.

J Biomed Inform 2019 10 22;98:103270. Epub 2019 Aug 22.

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbi.2019.103270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783385PMC
October 2019

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.

Authors:
Amand F Schmidt Michael V Holmes David Preiss Daniel I Swerdlow Spiros Denaxas Ghazaleh Fatemifar Rupert Faraway Chris Finan Dennis Valentine Zammy Fairhurst-Hunter Fernando Pires Hartwig Bernardo Lessa Horta Elina Hypponen Christine Power Max Moldovan Erik van Iperen Kees Hovingh Ilja Demuth Kristina Norman Elisabeth Steinhagen-Thiessen Juri Demuth Lars Bertram Christina M Lill Stefan Coassin Johann Willeit Stefan Kiechl Karin Willeit Dan Mason John Wright Richard Morris Goya Wanamethee Peter Whincup Yoav Ben-Shlomo Stela McLachlan Jackie F Price Mika Kivimaki Catherine Welch Adelaida Sanchez-Galvez Pedro Marques-Vidal Andrew Nicolaides Andrie G Panayiotou N Charlotte Onland-Moret Yvonne T van der Schouw Giuseppe Matullo Giovanni Fiorito Simonetta Guarrera Carlotta Sacerdote Nicholas J Wareham Claudia Langenberg Robert A Scott Jian'an Luan Martin Bobak Sofia Malyutina Andrzej Pająk Ruzena Kubinova Abdonas Tamosiunas Hynek Pikhart Niels Grarup Oluf Pedersen Torben Hansen Allan Linneberg Tine Jess Jackie Cooper Steve E Humphries Murray Brilliant Terrie Kitchner Hakon Hakonarson David S Carrell Catherine A McCarty Kirchner H Lester Eric B Larson David R Crosslin Mariza de Andrade Dan M Roden Joshua C Denny Cara Carty Stephen Hancock John Attia Elizabeth Holliday Rodney Scott Peter Schofield Martin O'Donnell Salim Yusuf Michael Chong Guillaume Pare Pim van der Harst M Abdullah Said Ruben N Eppinga Niek Verweij Harold Snieder Tim Christen D O Mook-Kanamori Stefan Gustafsson Lars Lind Erik Ingelsson Raha Pazoki Oscar Franco Albert Hofman Andre Uitterlinden Abbas Dehghan Alexander Teumer Sebastian Baumeister Marcus Dörr Markus M Lerch Uwe Völker Henry Völzke Joey Ward Jill P Pell Tom Meade Ingrid E Christophersen Anke H Maitland-van der Zee Ekaterina V Baranova Robin Young Ian Ford Archie Campbell Sandosh Padmanabhan Michiel L Bots Diederick E Grobbee Philippe Froguel Dorothée Thuillier Ronan Roussel Amélie Bonnefond Bertrand Cariou Melissa Smart Yanchun Bao Meena Kumari Anubha Mahajan Jemma C Hopewell Sudha Seshadri Caroline Dale Rui Providencia E Costa Paul M Ridker Daniel I Chasman Alex P Reiner Marylyn D Ritchie Leslie A Lange Alex J Cornish Sara E Dobbins Kari Hemminki Ben Kinnersley Marc Sanson Karim Labreche Matthias Simon Melissa Bondy Philip Law Helen Speedy James Allan Ni Li Molly Went Niels Weinhold Gareth Morgan Pieter Sonneveld Björn Nilsson Hartmut Goldschmidt Amit Sud Andreas Engert Markus Hansson Harry Hemingway Folkert W Asselbergs Riyaz S Patel Brendan J Keating Naveed Sattar Richard Houlston Juan P Casas Aroon D Hingorani

BMC Cardiovasc Disord 2019 10 29;19(1):240. Epub 2019 Oct 29.

Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK.

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http://dx.doi.org/10.1186/s12872-019-1187-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820948PMC
October 2019

Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol.

Clin Pharmacol Ther 2019 09 23;106(3):623-631. Epub 2019 May 23.

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1002/cpt.1439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941886PMC
September 2019

The "All of Us" Research Program.

N Engl J Med 2019 08;381(7):668-676

From the Departments of Biomedical Informatics and Medicine, Vanderbilt University Medical Center, Nashville (J.C.D.); the National Center for Advancing Translational Sciences (J.L.R.) and the All of Us Research Program (G.J., E.D.), National Institutes of Health, Bethesda, MD; the Institute for Genomic Medicine and Department of Neurology, Columbia University Irving Medical Center, New York (D.B.G.); and the Broad Institute, Cambridge (A.P., J.W.S.), and the Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston (J.W.S.) - both in Massachusetts.

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http://dx.doi.org/10.1056/NEJMsr1809937DOI Listing
August 2019

A Decision-Theoretic Approach to Panel-Based, Preemptive Genotyping.

MDM Policy Pract 2019 Jul-Dec;4(2):2381468319864337. Epub 2019 Aug 17.

Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1177/2381468319864337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699004PMC
August 2019

Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects.

Circulation 2019 07 25;140(4):270-279. Epub 2019 Jun 25.

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, United Kingdom (D.G., P.E., E.E., A.D., I.T.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687408PMC
July 2019

Case 40-2018: A Woman with Recurrent Sinusitis, Cough, and Bronchiectasis.

N Engl J Med 2019 04;380(14):1382-1383

Vanderbilt University Medical Center, Nashville, TN

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http://www.nejm.org/doi/10.1056/NEJMc1901268
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http://dx.doi.org/10.1056/NEJMc1901268DOI Listing
April 2019

GRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish.

Am J Hum Genet 2019 03 28;104(3):503-519. Epub 2019 Feb 28.

Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Data Science Institute, Vanderbilt University, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407495PMC
March 2019

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

Authors:
Ayush Giri Jacklyn N Hellwege Jacob M Keaton Jihwan Park Chengxiang Qiu Helen R Warren Eric S Torstenson Csaba P Kovesdy Yan V Sun Otis D Wilson Cassianne Robinson-Cohen Christianne L Roumie Cecilia P Chung Kelly A Birdwell Scott M Damrauer Scott L DuVall Derek Klarin Kelly Cho Yu Wang Evangelos Evangelou Claudia P Cabrera Louise V Wain Rojesh Shrestha Brian S Mautz Elvis A Akwo Muralidharan Sargurupremraj Stéphanie Debette Michael Boehnke Laura J Scott Jian'an Luan Jing-Hua Zhao Sara M Willems Sébastien Thériault Nabi Shah Christopher Oldmeadow Peter Almgren Ruifang Li-Gao Niek Verweij Thibaud S Boutin Massimo Mangino Ioanna Ntalla Elena Feofanova Praveen Surendran James P Cook Savita Karthikeyan Najim Lahrouchi Chunyu Liu Nuno Sepúlveda Tom G Richardson Aldi Kraja Philippe Amouyel Martin Farrall Neil R Poulter Markku Laakso Eleftheria Zeggini Peter Sever Robert A Scott Claudia Langenberg Nicholas J Wareham David Conen Colin Neil Alexander Palmer John Attia Daniel I Chasman Paul M Ridker Olle Melander Dennis Owen Mook-Kanamori Pim van der Harst Francesco Cucca David Schlessinger Caroline Hayward Tim D Spector Marjo-Riitta Jarvelin Branwen J Hennig Nicholas J Timpson Wei-Qi Wei Joshua C Smith Yaomin Xu Michael E Matheny Edward E Siew Cecilia Lindgren Karl-Heinz Herzig George Dedoussis Joshua C Denny Bruce M Psaty Joanna M M Howson Patricia B Munroe Christopher Newton-Cheh Mark J Caulfield Paul Elliott J Michael Gaziano John Concato Peter W F Wilson Philip S Tsao Digna R Velez Edwards Katalin Susztak Christopher J O'Donnell Adriana M Hung Todd L Edwards

Nat Genet 2019 01 21;51(1):51-62. Epub 2018 Dec 21.

Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.

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http://www.nature.com/articles/s41588-018-0303-9
Publisher Site
http://dx.doi.org/10.1038/s41588-018-0303-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365102PMC
January 2019

Learning from Longitudinal Data in Electronic Health Record and Genetic Data to Improve Cardiovascular Event Prediction.

Sci Rep 2019 01 24;9(1):717. Epub 2019 Jan 24.

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1038/s41598-018-36745-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345960PMC
January 2019

Pulling the covers in electronic health records for an association study with self-reported sleep behaviors.

Chronobiol Int 2018 11 5;35(12):1702-1712. Epub 2018 Sep 5.

a Department of Biomedical Informatics , Vanderbilt University Medical Center , Nashville , Tennessee , USA.

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http://dx.doi.org/10.1080/07420528.2018.1508152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282811PMC
November 2018

Simmering Below the Surface: Sweet's Syndrome with Multiple Myeloma.

Am J Med 2018 09 2;131(9):1058-1060. Epub 2018 May 2.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tenn.

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http://dx.doi.org/10.1016/j.amjmed.2018.04.014DOI Listing
September 2018

Association of ST2 polymorphisms with atopy, asthma, and leukemia.

J Allergy Clin Immunol 2018 09 19;142(3):991-993.e3. Epub 2018 May 19.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tenn; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129405PMC
September 2018

PRECISION MEDICINE: FROM DIPLOTYPES TO DISPARITIES TOWARDS IMPROVED HEALTH AND THERAPIES.

Pac Symp Biocomput 2018 ;23:389-399

Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, 44106, USA,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182117PMC
August 2018

PregOMICS-Leveraging systems biology and bioinformatics for drug repurposing in maternal-child health.

Am J Reprod Immunol 2018 08 4;80(2):e12971. Epub 2018 May 4.

Section of Infectious Disease, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1111/aji.12971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105384PMC
August 2018

An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease.

Cell Host Microbe 2018 08;24(2):308-323.e6

Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA; Division of Infectious Diseases, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093297PMC
August 2018

Multi-ethnic genome-wide association study for atrial fibrillation.

Authors:
Carolina Roselli Mark D Chaffin Lu-Chen Weng Stefanie Aeschbacher Gustav Ahlberg Christine M Albert Peter Almgren Alvaro Alonso Christopher D Anderson Krishna G Aragam Dan E Arking John Barnard Traci M Bartz Emelia J Benjamin Nathan A Bihlmeyer Joshua C Bis Heather L Bloom Eric Boerwinkle Erwin B Bottinger Jennifer A Brody Hugh Calkins Archie Campbell Thomas P Cappola John Carlquist Daniel I Chasman Lin Y Chen Yii-Der Ida Chen Eue-Keun Choi Seung Hoan Choi Ingrid E Christophersen Mina K Chung John W Cole David Conen James Cook Harry J Crijns Michael J Cutler Scott M Damrauer Brian R Daniels Dawood Darbar Graciela Delgado Joshua C Denny Martin Dichgans Marcus Dörr Elton A Dudink Samuel C Dudley Nada Esa Tonu Esko Markku Eskola Diane Fatkin Stephan B Felix Ian Ford Oscar H Franco Bastiaan Geelhoed Raji P Grewal Vilmundur Gudnason Xiuqing Guo Namrata Gupta Stefan Gustafsson Rebecca Gutmann Anders Hamsten Tamara B Harris Caroline Hayward Susan R Heckbert Jussi Hernesniemi Lynne J Hocking Albert Hofman Andrea R V R Horimoto Jie Huang Paul L Huang Jennifer Huffman Erik Ingelsson Esra Gucuk Ipek Kaoru Ito Jordi Jimenez-Conde Renee Johnson J Wouter Jukema Stefan Kääb Mika Kähönen Yoichiro Kamatani John P Kane Adnan Kastrati Sekar Kathiresan Petra Katschnig-Winter Maryam Kavousi Thorsten Kessler Bas L Kietselaer Paulus Kirchhof Marcus E Kleber Stacey Knight Jose E Krieger Michiaki Kubo Lenore J Launer Jari Laurikka Terho Lehtimäki Kirsten Leineweber Rozenn N Lemaitre Man Li Hong Euy Lim Henry J Lin Honghuang Lin Lars Lind Cecilia M Lindgren Marja-Liisa Lokki Barry London Ruth J F Loos Siew-Kee Low Yingchang Lu Leo-Pekka Lyytikäinen Peter W Macfarlane Patrik K Magnusson Anubha Mahajan Rainer Malik Alfredo J Mansur Gregory M Marcus Lauren Margolin Kenneth B Margulies Winfried März David D McManus Olle Melander Sanghamitra Mohanty Jay A Montgomery Michael P Morley Andrew P Morris Martina Müller-Nurasyid Andrea Natale Saman Nazarian Benjamin Neumann Christopher Newton-Cheh Maartje N Niemeijer Kjell Nikus Peter Nilsson Raymond Noordam Heidi Oellers Morten S Olesen Marju Orho-Melander Sandosh Padmanabhan Hui-Nam Pak Guillaume Paré Nancy L Pedersen Joanna Pera Alexandre Pereira David Porteous Bruce M Psaty Sara L Pulit Clive R Pullinger Daniel J Rader Lena Refsgaard Marta Ribasés Paul M Ridker Michiel Rienstra Lorenz Risch Dan M Roden Jonathan Rosand Michael A Rosenberg Natalia Rost Jerome I Rotter Samir Saba Roopinder K Sandhu Renate B Schnabel Katharina Schramm Heribert Schunkert Claudia Schurman Stuart A Scott Ilkka Seppälä Christian Shaffer Svati Shah Alaa A Shalaby Jaemin Shim M Benjamin Shoemaker Joylene E Siland Juha Sinisalo Moritz F Sinner Agnieszka Slowik Albert V Smith Blair H Smith J Gustav Smith Jonathan D Smith Nicholas L Smith Elsayed Z Soliman Nona Sotoodehnia Bruno H Stricker Albert Sun Han Sun Jesper H Svendsen Toshihiro Tanaka Kahraman Tanriverdi Kent D Taylor Maris Teder-Laving Alexander Teumer Sébastien Thériault Stella Trompet Nathan R Tucker Arnljot Tveit Andre G Uitterlinden Pim Van Der Harst Isabelle C Van Gelder David R Van Wagoner Niek Verweij Efthymia Vlachopoulou Uwe Völker Biqi Wang Peter E Weeke Bob Weijs Raul Weiss Stefan Weiss Quinn S Wells Kerri L Wiggins Jorge A Wong Daniel Woo Bradford B Worrall Pil-Sung Yang Jie Yao Zachary T Yoneda Tanja Zeller Lingyao Zeng Steven A Lubitz Kathryn L Lunetta Patrick T Ellinor

Nat Genet 2018 06 11;50(9):1225-1233. Epub 2018 Jun 11.

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41588-018-0133-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136836PMC
June 2018

Disease Heritability Studies Harness the Healthcare System to Achieve Massive Scale.

Cell 2018 06;173(7):1568-1570

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1016/j.cell.2018.05.053DOI Listing
June 2018

Benefit of Preemptive Pharmacogenetic Information on Clinical Outcome.

Clin Pharmacol Ther 2018 05 13;103(5):787-794. Epub 2018 Mar 13.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1002/cpt.1035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134843PMC
May 2018

Correction: Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

PLoS Genet 2018 05 11;14(5):e1007345. Epub 2018 May 11.

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http://dx.doi.org/10.1371/journal.pgen.1007345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947884PMC
May 2018

Calcium channel blockers as drug repurposing candidates for gestational diabetes: Mining large scale genomic and electronic health records data to repurpose medications.

Pharmacol Res 2018 04 12;130:44-51. Epub 2018 Feb 12.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, United States; Department of Medicine, Vanderbilt University Medical Center, United States. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2018.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965292PMC
April 2018

Phenome-wide association study identifies marked increased in burden of comorbidities in African Americans with systemic lupus erythematosus.

Arthritis Res Ther 2018 04 10;20(1):69. Epub 2018 Apr 10.

Department of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, T3113 MCN, Nashville, TN, 37232, USA.

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http://dx.doi.org/10.1186/s13075-018-1561-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894248PMC
April 2018

Evaluation of a Novel System to Enhance Clinicians' Recognition of Preadmission Adverse Drug Reactions.

Appl Clin Inform 2018 04 9;9(2):313-325. Epub 2018 May 9.

Department of Biomedical Informatics, Vanderbilt University Medical Center and Vanderbilt University School of Medicine, Nashville, Tennessee, United States.

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http://dx.doi.org/10.1055/s-0038-1646963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943080PMC
April 2018

Genome-wide and Phenome-wide Approaches to Understand Variable Drug Actions in Electronic Health Records.

Clin Transl Sci 2018 03 17;11(2):112-122. Epub 2017 Nov 17.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1111/cts.12522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866959PMC
March 2018

The Influence of Big (Clinical) Data and Genomics on Precision Medicine and Drug Development.

Clin Pharmacol Ther 2018 03 5;103(3):409-418. Epub 2018 Feb 5.

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1002/cpt.951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805632PMC
March 2018

Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.

JACC Cardiovasc Interv 2018 01 1;11(2):181-191. Epub 2017 Nov 1.

Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida; Department of Medicine, Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida.

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http://dx.doi.org/10.1016/j.jcin.2017.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775044PMC
January 2018

An integrative functional genomics framework for effective identification of novel regulatory variants in genome-phenome studies.

Genome Med 2018 01 29;10(1). Epub 2018 Jan 29.

Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, 7000 Fannin St. Suite 820, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1186/s13073-018-0513-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789733PMC
January 2018

Exome-wide association study of plasma lipids in >300,000 individuals.

Authors:
Dajiang J Liu Gina M Peloso Haojie Yu Adam S Butterworth Xiao Wang Anubha Mahajan Danish Saleheen Connor Emdin Dewan Alam Alexessander Couto Alves Philippe Amouyel Emanuele Di Angelantonio Dominique Arveiler Themistocles L Assimes Paul L Auer Usman Baber Christie M Ballantyne Lia E Bang Marianne Benn Joshua C Bis Michael Boehnke Eric Boerwinkle Jette Bork-Jensen Erwin P Bottinger Ivan Brandslund Morris Brown Fabio Busonero Mark J Caulfield John C Chambers Daniel I Chasman Y Eugene Chen Yii-Der Ida Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu John M Connell Francesco Cucca L Adrienne Cupples Scott M Damrauer Gail Davies Ian J Deary George Dedoussis Joshua C Denny Anna Dominiczak Marie-Pierre Dubé Tapani Ebeling Gudny Eiriksdottir Tõnu Esko Aliki-Eleni Farmaki Mary F Feitosa Marco Ferrario Jean Ferrieres Ian Ford Myriam Fornage Paul W Franks Timothy M Frayling Ruth Frikke-Schmidt Lars G Fritsche Philippe Frossard Valentin Fuster Santhi K Ganesh Wei Gao Melissa E Garcia Christian Gieger Franco Giulianini Mark O Goodarzi Harald Grallert Niels Grarup Leif Groop Megan L Grove Vilmundur Gudnason Torben Hansen Tamara B Harris Caroline Hayward Joel N Hirschhorn Oddgeir L Holmen Jennifer Huffman Yong Huo Kristian Hveem Sehrish Jabeen Anne U Jackson Johanna Jakobsdottir Marjo-Riitta Jarvelin Gorm B Jensen Marit E Jørgensen J Wouter Jukema Johanne M Justesen Pia R Kamstrup Stavroula Kanoni Fredrik Karpe Frank Kee Amit V Khera Derek Klarin Heikki A Koistinen Jaspal S Kooner Charles Kooperberg Kari Kuulasmaa Johanna Kuusisto Markku Laakso Timo Lakka Claudia Langenberg Anne Langsted Lenore J Launer Torsten Lauritzen David C M Liewald Li An Lin Allan Linneberg Ruth J F Loos Yingchang Lu Xiangfeng Lu Reedik Mägi Anders Malarstig Ani Manichaikul Alisa K Manning Pekka Mäntyselkä Eirini Marouli Nicholas G D Masca Andrea Maschio James B Meigs Olle Melander Andres Metspalu Andrew P Morris Alanna C Morrison Antonella Mulas Martina Müller-Nurasyid Patricia B Munroe Matt J Neville Jonas B Nielsen Sune F Nielsen Børge G Nordestgaard Jose M Ordovas Roxana Mehran Christoper J O'Donnell Marju Orho-Melander Cliona M Molony Pieter Muntendam Sandosh Padmanabhan Colin N A Palmer Dorota Pasko Aniruddh P Patel Oluf Pedersen Markus Perola Annette Peters Charlotta Pisinger Giorgio Pistis Ozren Polasek Neil Poulter Bruce M Psaty Daniel J Rader Asif Rasheed Rainer Rauramaa Dermot F Reilly Alex P Reiner Frida Renström Stephen S Rich Paul M Ridker John D Rioux Neil R Robertson Dan M Roden Jerome I Rotter Igor Rudan Veikko Salomaa Nilesh J Samani Serena Sanna Naveed Sattar Ellen M Schmidt Robert A Scott Peter Sever Raquel S Sevilla Christian M Shaffer Xueling Sim Suthesh Sivapalaratnam Kerrin S Small Albert V Smith Blair H Smith Sangeetha Somayajula Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Kathleen E Stirrups Nathan Stitziel Konstantin Strauch Heather M Stringham Praveen Surendran Hayato Tada Alan R Tall Hua Tang Jean-Claude Tardif Kent D Taylor Stella Trompet Philip S Tsao Jaakko Tuomilehto Anne Tybjaerg-Hansen Natalie R van Zuydam Anette Varbo Tibor V Varga Jarmo Virtamo Melanie Waldenberger Nan Wang Nick J Wareham Helen R Warren Peter E Weeke Joshua Weinstock Jennifer Wessel James G Wilson Peter W F Wilson Ming Xu Hanieh Yaghootkar Robin Young Eleftheria Zeggini He Zhang Neil S Zheng Weihua Zhang Yan Zhang Wei Zhou Yanhua Zhou Magdalena Zoledziewska Joanna M M Howson John Danesh Mark I McCarthy Chad A Cowan Goncalo Abecasis Panos Deloukas Kiran Musunuru Cristen J Willer Sekar Kathiresan

Nat Genet 2017 Dec 30;49(12):1758-1766. Epub 2017 Oct 30.

Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709146PMC
December 2017

A common deletion in the haptoglobin gene associated with blood cholesterol levels among Chinese women.

J Hum Genet 2017 Oct 29;62(10):911-914. Epub 2017 Jun 29.

Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1038/jhg.2017.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824713PMC
October 2017

A comparison of rule-based and machine learning approaches for classifying patient portal messages.

Int J Med Inform 2017 09 23;105:110-120. Epub 2017 Jun 23.

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1016/j.ijmedinf.2017.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546247PMC
September 2017

Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium.

Sci Rep 2017 09 12;7(1):11303. Epub 2017 Sep 12.

Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41598-017-09396-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595875PMC
September 2017

Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults.

Pharmacogenet Genomics 2017 07;27(7):247-254

aDepartment of Medicine bVanderbilt Translational and Clinical Cardiovascular Research Group cDepartment of Neurology dDepartment of Pediatrics eInstitute for Clinical and Translational Research fDepartment of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee gDepartment of General Oncology hDepartment of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas iDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA jDepartment of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1097/FPC.0000000000000284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502740PMC
July 2017

An active learning-enabled annotation system for clinical named entity recognition.

BMC Med Inform Decis Mak 2017 Jul 5;17(Suppl 2):82. Epub 2017 Jul 5.

School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.

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http://dx.doi.org/10.1186/s12911-017-0466-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506567PMC
July 2017

Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

Authors:
Ingrid E Christophersen Michiel Rienstra Carolina Roselli Xiaoyan Yin Bastiaan Geelhoed John Barnard Honghuang Lin Dan E Arking Albert V Smith Christine M Albert Mark Chaffin Nathan R Tucker Molong Li Derek Klarin Nathan A Bihlmeyer Siew-Kee Low Peter E Weeke Martina Müller-Nurasyid J Gustav Smith Jennifer A Brody Maartje N Niemeijer Marcus Dörr Stella Trompet Jennifer Huffman Stefan Gustafsson Claudia Schurmann Marcus E Kleber Leo-Pekka Lyytikäinen Ilkka Seppälä Rainer Malik Andrea R V R Horimoto Marco Perez Juha Sinisalo Stefanie Aeschbacher Sébastien Thériault Jie Yao Farid Radmanesh Stefan Weiss Alexander Teumer Seung Hoan Choi Lu-Chen Weng Sebastian Clauss Rajat Deo Daniel J Rader Svati H Shah Albert Sun Jemma C Hopewell Stephanie Debette Ganesh Chauhan Qiong Yang Bradford B Worrall Guillaume Paré Yoichiro Kamatani Yanick P Hagemeijer Niek Verweij Joylene E Siland Michiaki Kubo Jonathan D Smith David R Van Wagoner Joshua C Bis Siegfried Perz Bruce M Psaty Paul M Ridker Jared W Magnani Tamara B Harris Lenore J Launer M Benjamin Shoemaker Sandosh Padmanabhan Jeffrey Haessler Traci M Bartz Melanie Waldenberger Peter Lichtner Marina Arendt Jose E Krieger Mika Kähönen Lorenz Risch Alfredo J Mansur Annette Peters Blair H Smith Lars Lind Stuart A Scott Yingchang Lu Erwin B Bottinger Jussi Hernesniemi Cecilia M Lindgren Jorge A Wong Jie Huang Markku Eskola Andrew P Morris Ian Ford Alex P Reiner Graciela Delgado Lin Y Chen Yii-Der Ida Chen Roopinder K Sandhu Man Li Eric Boerwinkle Lewin Eisele Lars Lannfelt Natalia Rost Christopher D Anderson Kent D Taylor Archie Campbell Patrik K Magnusson David Porteous Lynne J Hocking Efthymia Vlachopoulou Nancy L Pedersen Kjell Nikus Marju Orho-Melander Anders Hamsten Jan Heeringa Joshua C Denny Jennifer Kriebel Dawood Darbar Christopher Newton-Cheh Christian Shaffer Peter W Macfarlane Stefanie Heilmann-Heimbach Peter Almgren Paul L Huang Nona Sotoodehnia Elsayed Z Soliman Andre G Uitterlinden Albert Hofman Oscar H Franco Uwe Völker Karl-Heinz Jöckel Moritz F Sinner Henry J Lin Xiuqing Guo Martin Dichgans Erik Ingelsson Charles Kooperberg Olle Melander Ruth J F Loos Jari Laurikka David Conen Jonathan Rosand Pim van der Harst Marja-Liisa Lokki Sekar Kathiresan Alexandre Pereira J Wouter Jukema Caroline Hayward Jerome I Rotter Winfried März Terho Lehtimäki Bruno H Stricker Mina K Chung Stephan B Felix Vilmundur Gudnason Alvaro Alonso Dan M Roden Stefan Kääb Daniel I Chasman Susan R Heckbert Emelia J Benjamin Toshihiro Tanaka Kathryn L Lunetta Steven A Lubitz Patrick T Ellinor

Nat Genet 2017 07;49(8):1286

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http://dx.doi.org/10.1038/ng0817-1286cDOI Listing
July 2017

Identifying Metastases-related Information from Pathology Reports of Lung Cancer Patients.

AMIA Jt Summits Transl Sci Proc 2017 26;2017:268-277. Epub 2017 Jul 26.

School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, Texas.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543353PMC
July 2017

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

Authors:
Ingrid E Christophersen Michiel Rienstra Carolina Roselli Xiaoyan Yin Bastiaan Geelhoed John Barnard Honghuang Lin Dan E Arking Albert V Smith Christine M Albert Mark Chaffin Nathan R Tucker Molong Li Derek Klarin Nathan A Bihlmeyer Siew-Kee Low Peter E Weeke Martina Müller-Nurasyid J Gustav Smith Jennifer A Brody Maartje N Niemeijer Marcus Dörr Stella Trompet Jennifer Huffman Stefan Gustafsson Claudia Schurmann Marcus E Kleber Leo-Pekka Lyytikäinen Ilkka Seppälä Rainer Malik Andrea R V R Horimoto Marco Perez Juha Sinisalo Stefanie Aeschbacher Sébastien Thériault Jie Yao Farid Radmanesh Stefan Weiss Alexander Teumer Seung Hoan Choi Lu-Chen Weng Sebastian Clauss Rajat Deo Daniel J Rader Svati H Shah Albert Sun Jemma C Hopewell Stephanie Debette Ganesh Chauhan Qiong Yang Bradford B Worrall Guillaume Paré Yoichiro Kamatani Yanick P Hagemeijer Niek Verweij Joylene E Siland Michiaki Kubo Jonathan D Smith David R Van Wagoner Joshua C Bis Siegfried Perz Bruce M Psaty Paul M Ridker Jared W Magnani Tamara B Harris Lenore J Launer M Benjamin Shoemaker Sandosh Padmanabhan Jeffrey Haessler Traci M Bartz Melanie Waldenberger Peter Lichtner Marina Arendt Jose E Krieger Mika Kähönen Lorenz Risch Alfredo J Mansur Annette Peters Blair H Smith Lars Lind Stuart A Scott Yingchang Lu Erwin B Bottinger Jussi Hernesniemi Cecilia M Lindgren Jorge A Wong Jie Huang Markku Eskola Andrew P Morris Ian Ford Alex P Reiner Graciela Delgado Lin Y Chen Yii-Der Ida Chen Roopinder K Sandhu Man Li Eric Boerwinkle Lewin Eisele Lars Lannfelt Natalia Rost Christopher D Anderson Kent D Taylor Archie Campbell Patrik K Magnusson David Porteous Lynne J Hocking Efthymia Vlachopoulou Nancy L Pedersen Kjell Nikus Marju Orho-Melander Anders Hamsten Jan Heeringa Joshua C Denny Jennifer Kriebel Dawood Darbar Christopher Newton-Cheh Christian Shaffer Peter W Macfarlane Stefanie Heilmann-Heimbach Peter Almgren Paul L Huang Nona Sotoodehnia Elsayed Z Soliman Andre G Uitterlinden Albert Hofman Oscar H Franco Uwe Völker Karl-Heinz Jöckel Moritz F Sinner Henry J Lin Xiuqing Guo Martin Dichgans Erik Ingelsson Charles Kooperberg Olle Melander Ruth J F Loos Jari Laurikka David Conen Jonathan Rosand Pim van der Harst Marja-Liisa Lokki Sekar Kathiresan Alexandre Pereira J Wouter Jukema Caroline Hayward Jerome I Rotter Winfried März Terho Lehtimäki Bruno H Stricker Mina K Chung Stephan B Felix Vilmundur Gudnason Alvaro Alonso Dan M Roden Stefan Kääb Daniel I Chasman Susan R Heckbert Emelia J Benjamin Toshihiro Tanaka Kathryn L Lunetta Steven A Lubitz Patrick T Ellinor

Nat Genet 2017 Jun 17;49(6):946-952. Epub 2017 Apr 17.

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585859PMC
June 2017

Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

PLoS Genet 2017 May 12;13(5):e1006728. Epub 2017 May 12.

Epidemiology, Gilling School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446189PMC
May 2017