Joshua B Rubin

Joshua B Rubin

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Joshua B Rubin

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To each, his/her own.

Neuro Oncol 2019 Oct;21(10):1217-1218

Kennedy Krieger Institute and Departments of Neurology and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1093/neuonc/noz143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784261PMC
October 2019

Altered hemodynamics contribute to local but not remote functional connectivity disruption due to glioma growth.

J Cereb Blood Flow Metab 2018 Oct 18:271678X18803948. Epub 2018 Oct 18.

1 Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.

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http://dx.doi.org/10.1177/0271678X18803948DOI Listing
October 2018

Focused ultrasound combined with microbubble-mediated intranasal delivery of gold nanoclusters to the brain.

J Control Release 2018 09 26;286:145-153. Epub 2018 Jul 26.

Department of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA; Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO 63108, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2018.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138562PMC
September 2018

Focused ultrasound-enabled delivery of radiolabeled nanoclusters to the pons.

J Control Release 2018 08 1;283:143-150. Epub 2018 Jun 1.

Department of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA; Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO 63108, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2018.05.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035767PMC
August 2018

Fetal microchimerism in human brain tumors.

Brain Pathol 2018 07 17;28(4):484-494. Epub 2017 Oct 17.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.

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http://doi.wiley.com/10.1111/bpa.12557
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http://dx.doi.org/10.1111/bpa.12557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884742PMC
July 2018

Resistance-promoting effects of ependymoma treatment revealed through genomic analysis of multiple recurrences in a single patient.

Cold Spring Harb Mol Case Stud 2018 04 2;4(2). Epub 2018 Apr 2.

Institute for Genomic Medicine, Nationwide Children's Hospital, and The Ohio State University College of Medicine, Columbus, Ohio 43205, USA.

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http://molecularcasestudies.cshlp.org/lookup/doi/10.1101/mcs
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http://dx.doi.org/10.1101/mcs.a002444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880262PMC
April 2018

A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration.

Nat Med 2018 03 12;24(3):338-351. Epub 2018 Feb 12.

Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1038/nm.4483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908710PMC
March 2018

Females have the survival advantage in glioblastoma.

Neuro Oncol 2018 03;20(4):576-577

Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.

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http://dx.doi.org/10.1093/neuonc/noy002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909625PMC
March 2018

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis.

Cancer Cell 2018 02;33(2):292-308.e7

Division of Experimental Hematology and Cancer Biology, Brain Tumor Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Key Laboratory of Birth Defects, Children's Hospital of Fudan University, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813693PMC
February 2018

Cooperative p16 and p21 action protects female astrocytes from transformation.

Acta Neuropathol Commun 2018 02 20;6(1):12. Epub 2018 Feb 20.

Department of Pediatrics, Washington University School of Medicine, Campus Box 8208, 660 South Euclid Ave, St Louis, MO, 63110, USA.

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http://dx.doi.org/10.1186/s40478-018-0513-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819173PMC
February 2018

Pediatric low-grade gliomas: a brave new world.

Neuro Oncol 2018 01;20(2):149-150

Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1093/neuonc/nox221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777489PMC
January 2018

Intertumoral Heterogeneity within Medulloblastoma Subgroups.

Authors:
Florence M G Cavalli Marc Remke Ladislav Rampasek John Peacock David J H Shih Betty Luu Livia Garzia Jonathon Torchia Carolina Nor A Sorana Morrissy Sameer Agnihotri Yuan Yao Thompson Claudia M Kuzan-Fischer Hamza Farooq Keren Isaev Craig Daniels Byung-Kyu Cho Seung-Ki Kim Kyu-Chang Wang Ji Yeoun Lee Wieslawa A Grajkowska Marta Perek-Polnik Alexandre Vasiljevic Cecile Faure-Conter Anne Jouvet Caterina Giannini Amulya A Nageswara Rao Kay Ka Wai Li Ho-Keung Ng Charles G Eberhart Ian F Pollack Ronald L Hamilton G Yancey Gillespie James M Olson Sarah Leary William A Weiss Boleslaw Lach Lola B Chambless Reid C Thompson Michael K Cooper Rajeev Vibhakar Peter Hauser Marie-Lise C van Veelen Johan M Kros Pim J French Young Shin Ra Toshihiro Kumabe Enrique López-Aguilar Karel Zitterbart Jaroslav Sterba Gaetano Finocchiaro Maura Massimino Erwin G Van Meir Satoru Osuka Tomoko Shofuda Almos Klekner Massimo Zollo Jeffrey R Leonard Joshua B Rubin Nada Jabado Steffen Albrecht Jaume Mora Timothy E Van Meter Shin Jung Andrew S Moore Andrew R Hallahan Jennifer A Chan Daniela P C Tirapelli Carlos G Carlotti Maryam Fouladi José Pimentel Claudia C Faria Ali G Saad Luca Massimi Linda M Liau Helen Wheeler Hideo Nakamura Samer K Elbabaa Mario Perezpeña-Diazconti Fernando Chico Ponce de León Shenandoah Robinson Michal Zapotocky Alvaro Lassaletta Annie Huang Cynthia E Hawkins Uri Tabori Eric Bouffet Ute Bartels Peter B Dirks James T Rutka Gary D Bader Jüri Reimand Anna Goldenberg Vijay Ramaswamy Michael D Taylor

Cancer Cell 2017 06;31(6):737-754.e6

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163053PMC
June 2017

Cell-intrinsic, Bmal1-dependent Circadian Regulation of Temozolomide Sensitivity in Glioblastoma.

J Biol Rhythms 2017 04 16;32(2):121-129. Epub 2017 Mar 16.

Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1177/0748730417696788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410359PMC
April 2017

Reprogramming Medulloblastoma-Propagating Cells by a Combined Antagonism of Sonic Hedgehog and CXCR4.

Cancer Res 2017 03 28;77(6):1416-1426. Epub 2016 Dec 28.

Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505622PMC
March 2017

The Fallacy of Univariate Solutions to Complex Systems Problems.

Front Neurosci 2016 8;10:267. Epub 2016 Jun 8.

Department of Psychiatry, Washington University School of MedicineSt. Louis, MO, USA; Department of Neurology, Washington University School of MedicineSt. Louis, MO, USA; Department of Pediatrics, Washington University School of MedicineSt. Louis, MO, USA; Department of Radiology, Washington University School of MedicineSt. Louis, MO, USA; Department of Neuroscience, Washington University School of MedicineSt. Louis, MO, USA.

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http://dx.doi.org/10.3389/fnins.2016.00267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896944PMC
July 2016

Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma.

Cancer Cell 2016 05;29(5):669-683

Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Brain Tumor Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 25229, USA; Key Laboratory of Birth Defects, Children's Hospital of Fudan University, Shanghai 201102, China. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.03.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946168PMC
May 2016

Intersections at the crossroads: Neurofibromatosis type 1, cAMP, sex, and glioma risk.

Authors:
Joshua B Rubin

Mol Cell Oncol 2016 May 3;3(3):e1069917. Epub 2015 Aug 3.

Department of Pediatrics, Anatomy and Neurobiology, Washington University School of Medicine , St Louis, MO.

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http://dx.doi.org/10.1080/23723556.2015.1069917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909402PMC
May 2016

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.

Authors:
Eric M Thompson Thomas Hielscher Eric Bouffet Marc Remke Betty Luu Sridharan Gururangan Roger E McLendon Darell D Bigner Eric S Lipp Sebastien Perreault Yoon-Jae Cho Gerald Grant Seung-Ki Kim Ji Yeoun Lee Amulya A Nageswara Rao Caterina Giannini Kay Ka Wai Li Ho-Keung Ng Yu Yao Toshihiro Kumabe Teiji Tominaga Wieslawa A Grajkowska Marta Perek-Polnik David C Y Low Wan Tew Seow Kenneth T E Chang Jaume Mora Ian F Pollack Ronald L Hamilton Sarah Leary Andrew S Moore Wendy J Ingram Andrew R Hallahan Anne Jouvet Michelle Fèvre-Montange Alexandre Vasiljevic Cecile Faure-Conter Tomoko Shofuda Naoki Kagawa Naoya Hashimoto Nada Jabado Alexander G Weil Tenzin Gayden Takafumi Wataya Tarek Shalaby Michael Grotzer Karel Zitterbart Jaroslav Sterba Leos Kren Tibor Hortobágyi Almos Klekner Bognár László Tímea Pócza Peter Hauser Ulrich Schüller Shin Jung Woo-Youl Jang Pim J French Johan M Kros Marie-Lise C van Veelen Luca Massimi Jeffrey R Leonard Joshua B Rubin Rajeev Vibhakar Lola B Chambless Michael K Cooper Reid C Thompson Claudia C Faria Alice Carvalho Sofia Nunes José Pimentel Xing Fan Karin M Muraszko Enrique López-Aguilar David Lyden Livia Garzia David J H Shih Noriyuki Kijima Christian Schneider Jennifer Adamski Paul A Northcott Marcel Kool David T W Jones Jennifer A Chan Ana Nikolic Maria Luisa Garre Erwin G Van Meir Satoru Osuka Jeffrey J Olson Arman Jahangiri Brandyn A Castro Nalin Gupta William A Weiss Iska Moxon-Emre Donald J Mabbott Alvaro Lassaletta Cynthia E Hawkins Uri Tabori James Drake Abhaya Kulkarni Peter Dirks James T Rutka Andrey Korshunov Stefan M Pfister Roger J Packer Vijay Ramaswamy Michael D Taylor

Lancet Oncol 2016 04 12;17(4):484-495. Epub 2016 Mar 12.

Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045150058
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http://dx.doi.org/10.1016/S1470-2045(15)00581-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907853PMC
April 2016

An integrative view on sex differences in brain tumors.

Cell Mol Life Sci 2015 Sep 19;72(17):3323-42. Epub 2015 May 19.

Department of Pediatrics, Washington University School of Medicine, St Louis, USA.

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http://dx.doi.org/10.1007/s00018-015-1930-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531141PMC
September 2015

Not so Fast: Co-Requirements for Sonic Hedgehog Induced Brain Tumorigenesis.

Cancers (Basel) 2015 Aug 6;7(3):1484-98. Epub 2015 Aug 6.

Department of Pediatrics, Division of Hematology/Oncology, Washington University in St. Louis School of Medicine, Campus Box 8208, 660 South Euclid Ave, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.3390/cancers7030848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586781PMC
August 2015

Targeting brain tumor cAMP: the case for sex-specific therapeutics.

Front Pharmacol 2015 28;6:153. Epub 2015 Jul 28.

Department of Pediatrics, Washington University School of Medicine St Louis, MO, USA ; Department of Anatomy and Neurobiology, Washington University School of Medicine St Louis, MO, USA.

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http://dx.doi.org/10.3389/fphar.2015.00153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516881PMC
August 2015

Sexual selection and cancer biology.

Authors:
Joshua B Rubin

Oncotarget 2015 Jun;6(18):15714-5

Departments of Pediatrics and Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599216PMC
http://dx.doi.org/10.18632/oncotarget.4592DOI Listing
June 2015

PDE7B is a novel, prognostically significant mediator of glioblastoma growth whose expression is regulated by endothelial cells.

PLoS One 2014 9;9(9):e107397. Epub 2014 Sep 9.

Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107397PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159344PMC
May 2015

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma.

Nat Med 2014 Sep 24;20(9):1035-42. Epub 2014 Aug 24.

1] Department of Pediatrics, Brain Tumor Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. [2] Department of Pediatrics, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China. [3] Key Laboratory of Birth Defects, Children's Hospital of Fudan University, Shanghai, China.

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http://dx.doi.org/10.1038/nm.3666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334261PMC
September 2014

Reply: To PMID 24375753.

Ann Neurol 2014 May 28;75(5):800-1. Epub 2014 Apr 28.

Department of Neurology, Washington University School of Medicine, St Louis, MO.

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http://dx.doi.org/10.1002/ana.24156DOI Listing
May 2014

Cytogenetic prognostication within medulloblastoma subgroups.

J Clin Oncol 2014 Mar 3;32(9):886-96. Epub 2014 Feb 3.

David J.H. Shih, Marc Remke, Vijay Ramaswamy, Betty Luu, Yuan Yao, Xin Wang, Adrian M. Dubuc, Livia Garzia, John Peacock, Stephen C. Mack, Xiaochong Wu, Adi Rolider, A. Sorana Morrissy, Florence M.G. Cavalli, Claudia C. Faria, Stephen W. Scherer, Uri Tabori, Cynthia E. Hawkins, David Malkin, Eric Bouffet, James T. Rutka, and Michael D. Taylor, Hospital for Sick Children; David J.H. Shih, Marc Remke, Vijay Ramaswamy, Yuan Yao, Xin Wang, Adrian M. Dubuc, John Peacock, Stephen C. Mack, and Michael D. Taylor, University of Toronto, Toronto; Boleslaw Lach, McMaster University, Hamilton, Ontario; Jennifer A. Chan, University of Calgary, Calgary, Alberta; Steffen Albrecht, Adam Fontebasso, and Nada Jabado, McGill University, Montreal, Quebec, Canada; Paul A. Northcott, Andrey Korshunov, Marcel Kool, David T.W. Jones, and Stefan M. Pfister, German Cancer Research Center; Stefan M. Pfister, University Hospital Heidelberg, Heidelberg; Ulrich Schüller, Ludwig-Maximilians-University, Munich; Stefan Rutkowski, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Karel Zitterbart, Masaryk University School of Medicine; Karel Zitterbart and Leos Kren, University Hospital Brno, Brno, Czech Republic; Toshihiro Kumabe and Teiji Tominaga, Tohoku University Graduate School of Medicine, Sendai, Japan; Young Shin Ra, University of Ulsan, Asan Medical Center; Ji-Yeoun Lee, Byung-Kyu Cho, Seung-Ki Kim, and Kyu-Chang Wang, Seoul National University Children's Hospital, Seoul; Shin Jung, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital and Medical School, Chonnam, South Korea; Peter Hauser and Miklós Garami, Semmelweis University, Budapest; László Bognár and Almos Klekner, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary; Shenandoah Robinson, Boston Children's Hospital; Scott L. Pomeroy, Harvard Medical School, Boston, MA; Ali G. Saad, University of Arkansas for Medical Sciences, Little

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http://dx.doi.org/10.1200/JCO.2013.50.9539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948094PMC
March 2014

Sex Is a major determinant of neuronal dysfunction in neurofibromatosis type 1.

Ann Neurol 2014 Feb 6;75(2):309-16. Epub 2014 Feb 6.

Departments of Neurology, Washington University School of Medicine, Box 8111, 660 South Euclid Avenue, St Louis, MO.

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http://dx.doi.org/10.1002/ana.24093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172335PMC
February 2014

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.

Acta Neuropathol 2013 Dec 31;126(6):917-29. Epub 2013 Oct 31.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00401-013-1198-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830749PMC
December 2013

Hitting Them Where They Live: Targeting the Glioblastoma Perivascular Stem Cell Niche.

Curr Pathobiol Rep 2013 Jun;1(2):101-110

Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Ave. St Louis, MO 63110.

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http://dx.doi.org/10.1007/s40139-013-0012-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677798PMC
June 2013

Antiangiogenic agents for nonmalignant brain tumors.

J Neurol Surg B Skull Base 2013 Jun 13;74(3):136-41. Epub 2013 Mar 13.

Department of Neurosurgery, Washington University School of Medicine, Saint Louis, Missouri, USA.

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http://dx.doi.org/10.1055/s-0033-1338262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709924PMC
June 2013

Opportunities and challenges for successful use of bevacizumab in pediatrics.

Front Oncol 2013 29;3:92. Epub 2013 Apr 29.

Division of Pediatric Hematology and Oncology, Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine St. Louis, MO, USA.

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http://dx.doi.org/10.3389/fonc.2013.00092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638307PMC
May 2013

Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migration.

Mol Cancer 2013 Mar 5;12:18. Epub 2013 Mar 5.

Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, 2015 Uppergate Drive NE, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1186/1476-4598-12-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599655PMC
March 2013

Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentiation within the adult CNS.

Acta Neuropathol 2012 Dec 30;124(6):847-60. Epub 2012 Aug 30.

Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1007/s00401-012-1034-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508279PMC
December 2012

CXCL12 mediates trophic interactions between endothelial and tumor cells in glioblastoma.

PLoS One 2012 12;7(3):e33005. Epub 2012 Mar 12.

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033005PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299723PMC
August 2012

Subgroup-specific structural variation across 1,000 medulloblastoma genomes.

Authors:
Paul A Northcott David J H Shih John Peacock Livia Garzia A Sorana Morrissy Thomas Zichner Adrian M Stütz Andrey Korshunov Jüri Reimand Steven E Schumacher Rameen Beroukhim David W Ellison Christian R Marshall Anath C Lionel Stephen Mack Adrian Dubuc Yuan Yao Vijay Ramaswamy Betty Luu Adi Rolider Florence M G Cavalli Xin Wang Marc Remke Xiaochong Wu Readman Y B Chiu Andy Chu Eric Chuah Richard D Corbett Gemma R Hoad Shaun D Jackman Yisu Li Allan Lo Karen L Mungall Ka Ming Nip Jenny Q Qian Anthony G J Raymond Nina T Thiessen Richard J Varhol Inanc Birol Richard A Moore Andrew J Mungall Robert Holt Daisuke Kawauchi Martine F Roussel Marcel Kool David T W Jones Hendrick Witt Africa Fernandez-L Anna M Kenney Robert J Wechsler-Reya Peter Dirks Tzvi Aviv Wieslawa A Grajkowska Marta Perek-Polnik Christine C Haberler Olivier Delattre Stéphanie S Reynaud François F Doz Sarah S Pernet-Fattet Byung-Kyu Cho Seung-Ki Kim Kyu-Chang Wang Wolfram Scheurlen Charles G Eberhart Michelle Fèvre-Montange Anne Jouvet Ian F Pollack Xing Fan Karin M Muraszko G Yancey Gillespie Concezio Di Rocco Luca Massimi Erna M C Michiels Nanne K Kloosterhof Pim J French Johan M Kros James M Olson Richard G Ellenbogen Karel Zitterbart Leos Kren Reid C Thompson Michael K Cooper Boleslaw Lach Roger E McLendon Darell D Bigner Adam Fontebasso Steffen Albrecht Nada Jabado Janet C Lindsey Simon Bailey Nalin Gupta William A Weiss László Bognár Almos Klekner Timothy E Van Meter Toshihiro Kumabe Teiji Tominaga Samer K Elbabaa Jeffrey R Leonard Joshua B Rubin Linda M Liau Erwin G Van Meir Maryam Fouladi Hideo Nakamura Giuseppe Cinalli Miklós Garami Peter Hauser Ali G Saad Achille Iolascon Shin Jung Carlos G Carlotti Rajeev Vibhakar Young Shin Ra Shenandoah Robinson Massimo Zollo Claudia C Faria Jennifer A Chan Michael L Levy Poul H B Sorensen Matthew Meyerson Scott L Pomeroy Yoon-Jae Cho Gary D Bader Uri Tabori Cynthia E Hawkins Eric Bouffet Stephen W Scherer James T Rutka David Malkin Steven C Clifford Steven J M Jones Jan O Korbel Stefan M Pfister Marco A Marra Michael D Taylor

Nature 2012 Aug;488(7409):49-56

Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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http://is.muni.cz/repo/990835/nature11327.pdf
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http://www.nature.com/doifinder/10.1038/nature11327
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http://dx.doi.org/10.1038/nature11327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683624PMC
August 2012

Oligodendrogliomas in children.

J Neurooncol 2012 Jan 13;106(2):377-82. Epub 2011 Aug 13.

Department of Radiation Oncology and Mallinckrodt Institute of Radiology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1007/s11060-011-0674-6DOI Listing
January 2012

CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastoma.

Cancer Res 2012 Jan 3;72(1):122-32. Epub 2011 Nov 3.

Department of Pediatrics, Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520097PMC
January 2012

Why does Jack, and not Jill, break his crown? Sex disparity in brain tumors.

Biol Sex Differ 2012 Jan 25;3. Epub 2012 Jan 25.

Department of Pediatrics, Division of Pediatric Hematology-Oncology, Washington University School of Medicine, CB 8208, 660 South Euclid Ave, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1186/2042-6410-3-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293746PMC
January 2012

Glioblastoma in children: a single-institution experience.

Int J Radiat Oncol Biol Phys 2011 Jul 8;80(4):1117-21. Epub 2011 Jan 8.

Department of Radiation Oncology and Mallinkrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2010.03.013DOI Listing
July 2011

Treating brain tumors with PDE4 inhibitors.

Trends Pharmacol Sci 2011 Jun 28;32(6):337-44. Epub 2011 Mar 28.

Department of Pediatrics, Campus Box 8208, 660 South Euclid Ave, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.tips.2011.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106141PMC
June 2011

Radiation therapy for pilocytic astrocytomas of childhood.

Int J Radiat Oncol Biol Phys 2011 Mar 24;79(3):829-34. Epub 2010 Apr 24.

Department of Radiation Oncology, Washington University School of Medicine and Saint Louis Children's Hospital, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2009.11.015DOI Listing
March 2011

Postoperative imaging surveillance in pediatric pilocytic astrocytomas.

J Neurosurg Pediatr 2010 Oct;6(4):346-52

Department of Neurosurgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.3171/2010.7.PEDS10129DOI Listing
October 2010

Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1.

Cancer Res 2010 Jul 15;70(14):5717-27. Epub 2010 Jun 15.

Department of Pediatrics, Molecular Imaging Center, Mallinckrodt Institute of Radiology, Developmental Biology, and Anatomy and Neurobiology, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-3769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905483PMC
July 2010

CXCL12 alone is insufficient for gliomagenesis in Nf1 mutant mice.

J Neuroimmunol 2010 Jul;224(1-2):108-13

Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.jneuroim.2010.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910179PMC
July 2010

Highlights from the latest articles in glioma immunotherapy.

Immunotherapy 2010 Jan;2(1):9-12

Department of Pediatrics, Division of Hematology/Oncology, Washington University School of Medicine, Campus Box 8208, 660 South Euclid Ave, St Louis, MO 63110, USA.

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http://dx.doi.org/10.2217/imt.09.73DOI Listing
January 2010

Brainstem glioma presenting as pruritus in children with neurofibromatosis-1.

J Pediatr Hematol Oncol 2009 Dec;31(12):972-6

Department of Neurology, Washington University School of Medicine, St Louis, MO 63119, USA.

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December 2009

Chemokine signaling in cancer: one hump or two?

Authors:
Joshua B Rubin

Semin Cancer Biol 2009 Apr 17;19(2):116-22. Epub 2008 Oct 17.

Department of Pediatrics/Division of Pediatric Hematology and Oncology, Campus Box 8208, 660 South Euclid Avenue, Washington University School of Medicine, St Louis, MO 63110, USA. rubin

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http://dx.doi.org/10.1016/j.semcancer.2008.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694237PMC
April 2009

Morphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons.

J Neurosci 2009 Feb;29(8):2534-44

Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5865-08.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664553PMC
February 2009

Only in congenial soil: the microenvironment in brain tumorigenesis.

Authors:
Joshua B Rubin

Brain Pathol 2009 Jan;19(1):144-9

Department of Pediatrics, Division of Pediatric Hematology/Oncology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1111/j.1750-3639.2008.00235.xDOI Listing
January 2009

Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.

Clin Cancer Res 2008 Dec;14(23):7717-25

Department of Pediatrics, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-0827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615415PMC
December 2008

Use of thalidomide to diminish growth velocity in a life-threatening congenital intracranial hemangioma.

J Neurosurg Pediatr 2008 Aug;2(2):125-9

Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737696PMC
August 2008

Pathological expression of CXCL12 at the blood-brain barrier correlates with severity of multiple sclerosis.

Am J Pathol 2008 Mar 14;172(3):799-808. Epub 2008 Feb 14.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.2353/ajpath.2008.070918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258272PMC
March 2008

Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma.

Cancer Res 2008 Mar;68(5):1520-8

Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-5916DOI Listing
March 2008

Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo.

Cancer Res 2007 Jan;67(2):651-8

Department of Pediatrics, and Neurology and Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-2762DOI Listing
January 2007

Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies.

Cancer Res 2005 Dec;65(24):11392-9

Department of Pediatrics, Division of Pediatric Hematology/Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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December 2005

A feasibility trial of antiangiogenic (metronomic) chemotherapy in pediatric patients with recurrent or progressive cancer.

J Pediatr Hematol Oncol 2005 Nov;27(11):573-81

Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Pediatric Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1097/01.mph.0000183863.10792.d4DOI Listing
November 2005

Neurofibromatosis type 1 - a model for nervous system tumour formation?

Nat Rev Cancer 2005 07;5(7):557-64

Department of Pediatrics, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1038/nrc1653DOI Listing
July 2005

Immune and nervous system CXCL12 and CXCR4: parallel roles in patterning and plasticity.

Trends Immunol 2004 Jun;25(6):306-14

Division of Infectious Diseases, Departments of Pathology and Immunology and Anatomy and Neurobiology, Washington University School of Medicine, Campus Box 8051, 660 South Euclid Avenue, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.it.2004.04.002DOI Listing
June 2004

Perfusion MRI of U87 brain tumors in a mouse model.

Magn Reson Med 2004 May;51(5):893-9

Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1002/mrm.20029DOI Listing
May 2004

A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.

Proc Natl Acad Sci U S A 2003 Nov 31;100(23):13513-8. Epub 2003 Oct 31.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.2235846100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC263845PMC
November 2003

Growth, survival and migration: the Trk to cancer.

Cancer Treat Res 2003 ;115:1-18

Department of Pediatric Oncology, Dana Farber Cancer Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1007/0-306-48158-8_1DOI Listing
July 2003

Medulloblastoma: a problem of developmental biology.

Cancer Cell 2002 Jul;2(1):7-8

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/s1535-6108(02)00090-9DOI Listing
July 2002

Cerebellar proteoglycans regulate sonic hedgehog responses during development.

Development 2002 May;129(9):2223-32

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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May 2002

Successful antiangiogenic therapy of giant cell angioblastoma with interferon alfa 2b: report of 2 cases.

Pediatrics 2002 Feb;109(2):E37

Department of Surgery, Children's Hospital, Boston, Massachusetts 02115, USA.

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February 2002