Publications by authors named "Joshua B Friedman"

3 Publications

  • Page 1 of 1

Fatality Review and the Role of the Forensic Psychiatrist.

J Am Acad Psychiatry Law 2021 Sep 21;49(3):396-405. Epub 2021 Jul 21.

Dr. Hatters Friedman is the Phillip Resnick Professor of Forensic Psychiatry, and Professor of Reproductive Biology, Pediatrics, and Law, Case Western Reserve University, Cleveland, Ohio. Dr. Beaman is Assistant Clinical Professor, Chair, Department of Psychiatry and Behavioral Sciences, Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma. Dr. Friedman is Assistant Professor of Pediatrics, Case Western Reserve University, and Co-Director, Child Protection Team, Cleveland Clinic Foundation, Cleveland, Ohio.

Multidisciplinary Fatality Review teams have operated for decades in the United States and across the developed world. Goals of these teams include examining individual deaths in the community to determine preventability and to make recommendations for future prevention. Fatality Review teams initially focused on child deaths but have expanded to include deaths from domestic violence, elder abuse, overdose, and maternal mortality. Case reviews include data from various agencies that have had contact with victims and perpetrators prior to the deaths. Cause of death and preventability are analyzed. Preventable deaths often include those with risk from mental illness or addiction. Recommendations made by Fatality Review teams have led to important changes for mental health services and prevention, including the Safe Haven laws for neonaticide prevention, suicide and homicide prevention, child murder prevention, firearm laws, and domestic violence screening. Fatality Review teams, which already include law enforcement and forensic pathologists, can benefit from collaboration with forensic psychiatrists because of their specialized knowledge about the intersection of mental illness and violence, should forensic psychiatrists have an opportunity to join them.
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http://dx.doi.org/10.29158/JAAPL.210027-21DOI Listing
September 2021

Parents who kill their children.

Pediatr Rev 2010 Feb;31(2):e10-6

Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1542/pir.31-2-e10DOI Listing
February 2010

C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer.

Int J Cancer 2004 Aug;111(1):72-5

Department of Genetics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA.

Transforming growth factor (TGF) beta mediates a tumor suppressor pathway in human colon epithelial cells. We were interested in identifying and characterizing novel genes regulated by the TGF beta pathway in the colon. We employed expression microarrays to identify transcripts induced by TGF beta in Vaco 330, a colon adenoma cell line. We then used expression microarrays to determine which of these TGF beta induced transcripts are down-regulated in metastatic colon cancer. Northern analysis and real-time reverse transcription PCR confirmed and quantified our findings from the microarrays. These analyses highlighted C8orf4 as induced by TGF beta in colon cells. Moreover, C8orf4 is expressed in most normal colon mucosa samples, and is not expressed in most colon cancer metastases or colon cancer cell lines. Colon cancer primary tumors showed reduced expression of C8orf4 relative to normal mucosa, possibly reflecting contributions of C8orf4 expression in stromal cells. C8orf4 is a gene regulated by TGF beta signaling and loss in advanced colon cancer suggests C8orf4 may play a role in colon cell differentiation or growth regulation.
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http://dx.doi.org/10.1002/ijc.20235DOI Listing
August 2004
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