Joseph Y Cheung

Joseph Y Cheung

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Joseph Y Cheung

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The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2.

Sci Rep 2019 Oct 1;9(1):14132. Epub 2019 Oct 1.

Departments of Pediatrics, The Pennsylvania State University College of Medicine, P.O. Box 850, Hershey, Pennsylvania, 17033, USA.

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http://dx.doi.org/10.1038/s41598-019-50661-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773863PMC
October 2019

Letter by Feldman et al Regarding Article, "Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery".

Circulation 2019 07 1;140(1):e5-e6. Epub 2019 Jul 1.

Departments of Medicine and Human Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (A.M.F., G.S.G., J.Y.C.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.039321DOI Listing
July 2019

The central role of protein kinase C epsilon in cyanide cardiotoxicity and its treatment.

Toxicol Sci 2019 Jun 7. Epub 2019 Jun 7.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.

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http://dx.doi.org/10.1093/toxsci/kfz137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735853PMC
June 2019

Current Landscape of Heart Failure Gene Therapy.

J Am Heart Assoc 2019 05;8(10):e012239

1 Division of Cardiology The Department of Medicine Lewis Katz School of Medicine at Temple University Philadelphia PA.

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http://dx.doi.org/10.1161/JAHA.119.012239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585330PMC
May 2019

Role of Bcl2-associated Athanogene 3 in Turnover of Gap Junction Protein, Connexin 43, in Neonatal Cardiomyocytes.

Sci Rep 2019 05 21;9(1):7658. Epub 2019 May 21.

Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/s41598-019-44139-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529437PMC
May 2019

Lamin B is a target for selective nuclear PQC by BAG3: implication for nuclear envelopathies.

Cell Death Dis 2019 01 10;10(1):23. Epub 2019 Jan 10.

Department of Neuroscience, Center for Neurovirology, Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.

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http://www.nature.com/articles/s41419-018-1255-9
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http://dx.doi.org/10.1038/s41419-018-1255-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328609PMC
January 2019

Methylene Blue Counteracts HS-Induced Cardiac Ion Channel Dysfunction and ATP Reduction.

Cardiovasc Toxicol 2018 10;18(5):407-419

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.

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http://dx.doi.org/10.1007/s12012-018-9451-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126975PMC
October 2018

Transient Receptor Potential-Melastatin Channel Family Member 2: Friend or Foe.

Trans Am Clin Climatol Assoc 2017 ;128:308-329

PHILADELPHIA, PENNSYLVANIA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525431PMC
May 2018

Methylene blue counteracts cyanide cardiotoxicity: cellular mechanisms.

J Appl Physiol (1985) 2018 05 8;124(5):1164-1176. Epub 2018 Feb 8.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University College of Medicine , Hershey, Pennsylvania.

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http://dx.doi.org/10.1152/japplphysiol.00967.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050200PMC
May 2018

Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes.

J Cell Physiol 2018 Feb 31;233(2):748-758. Epub 2017 Jul 31.

Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcp.26002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673531PMC
February 2018

Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors.

Mol Pharmacol 2017 12 25;92(6):707-717. Epub 2017 Oct 25.

Life Sciences Institute (R.B., H.V.W., M.C.C., J.J.G.T.), Departments of Medicinal Chemistry (H.V.W., S.D.L., J.J.G.T.), Pharmacology (R.B., J.J.G.T.), Biological Chemistry (M.C.C., J.J.G.T.), and Vahlteich Medicinal Chemistry Core, College of Pharmacy (H.V.W., S.D.L.), University of Michigan, Ann Arbor, Michigan; Department of Chemistry, Georgia State University, Atlanta, Georgia (X.-Q.Y.); Center for Translational Medicine, Temple University, Philadelphia, Pennsylvania (A.C., J.S., J.Y.C, W.J.K.); and Department of Biological Sciences, Purdue University, West Lafayette Indiana (J.J.G.T.)

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http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.117
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http://dx.doi.org/10.1124/mol.117.110130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691592PMC
December 2017

HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy.

Sci Rep 2017 08 17;7(1):8572. Epub 2017 Aug 17.

Department of Neuroscience, Center for Neurovirology and Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41598-017-08736-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561171PMC
August 2017

Precision Medicine for Heart Failure: Lessons From Oncology.

Circ Heart Fail 2017 06;10(6)

From the Departments of Medicine (A.M.F., J.Y.C.), Genetics and Molecular Biochemistry (G.S.G.), and Neuroscience (K.K.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; Division of Cardiology, Duke University School of Medicine, Durham, NC (C.D.K.); and Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC (J.M.M.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643024PMC
June 2017

Evidence for the Role of BAG3 in Mitochondrial Quality Control in Cardiomyocytes.

J Cell Physiol 2017 Apr 19;232(4):797-805. Epub 2016 Jul 19.

Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcp.25476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663276PMC
April 2017

Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.

J Med Chem 2017 04 29;60(7):3052-3069. Epub 2017 Mar 29.

Department of Medicinal Chemistry, College of Pharmacy, ‡Departments of Pharmacology and Biological Chemistry, Life Sciences Institute, §Ph.D. Program in Chemical Biology, ⊥Vahlteich Medicinal Chemistry Core, University of Michigan , Ann Arbor, Michigan 48109, United States.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.7b00112
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http://dx.doi.org/10.1021/acs.jmedchem.7b00112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641445PMC
April 2017

Mitochondrial Ca Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity.

Mol Cell 2017 Mar 2;65(6):1014-1028.e7. Epub 2017 Mar 2.

Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA; Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357178PMC
March 2017

TRPM2 protects against tissue damage following oxidative stress and ischaemia-reperfusion.

J Physiol 2016 08 11;594(15):4181-91. Epub 2015 Nov 11.

Center of Translational Medicine and Department of Medicine, Temple University School of Medicine, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1113/JP270934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967758PMC
August 2016

GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes From ER Stress-Induced Apoptosis.

J Cell Biochem 2016 08 21;117(8):1813-21. Epub 2016 Jan 21.

Department of Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcb.25481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909508PMC
August 2016

β-arrestin-biased signaling through the β2-adrenergic receptor promotes cardiomyocyte contraction.

Proc Natl Acad Sci U S A 2016 07 27;113(28):E4107-16. Epub 2016 Jun 27.

Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107;

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http://dx.doi.org/10.1073/pnas.1606267113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948363PMC
July 2016

Methylene blue counteracts H2S toxicity-induced cardiac depression by restoring L-type Ca channel activity.

Am J Physiol Regul Integr Comp Physiol 2016 06 9;310(11):R1030-44. Epub 2016 Mar 9.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania;

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http://dx.doi.org/10.1152/ajpregu.00527.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935501PMC
June 2016

BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes.

J Mol Cell Cardiol 2016 Mar 19;92:10-20. Epub 2016 Jan 19.

Center of Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA; Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2016.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789075PMC
March 2016

An observational pre-post study of re-structuring Medicine inpatient teaching service: Improved continuity of care within constraint of 2011 duty hours.

Healthc (Amst) 2015 Sep 21;3(3):129-34. Epub 2015 May 21.

Department of Medicine and Department of Clinical Sciences, Temple University School of Medicine, 3401 N. Broad Street, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1016/j.hjdsi.2015.05.001DOI Listing
September 2015

Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor.

J Biol Chem 2015 Aug 1;290(34):20649-59. Epub 2015 Jun 1.

From the Life Sciences Institute and the Departments of Pharmacology and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109,

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http://www.jbc.org/content/290/34/20649.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.647370
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http://dx.doi.org/10.1074/jbc.M115.647370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543626PMC
August 2015

Cardiac Dysfunction in HIV-1 Transgenic Mouse: Role of Stress and BAG3.

Clin Transl Sci 2015 Aug 24;8(4):305-10. Epub 2015 Aug 24.

Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/cts.12331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841629PMC
August 2015

Regulation of L-type calcium channel by phospholemman in cardiac myocytes.

J Mol Cell Cardiol 2015 Jul 25;84:104-11. Epub 2015 Apr 25.

Center of Translational Medicine, Temple University School of Medicine, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468006PMC
July 2015

BAG3: a new player in the heart failure paradigm.

Heart Fail Rev 2015 Jul;20(4):423-34

Department of Neuroscience, Temple University School of Medicine, 3500 N. Broad Street, Suite 1150, Philadelphia, PA, 19140, USA.

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http://link.springer.com/content/pdf/10.1007%2Fs10741-015-94
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http://link.springer.com/10.1007/s10741-015-9487-6
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http://dx.doi.org/10.1007/s10741-015-9487-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463985PMC
July 2015

Ca²⁺ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance.

Am J Physiol Heart Circ Physiol 2015 Mar 9;308(6):H637-50. Epub 2015 Jan 9.

Center of Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania; Division of Nephrology, Temple University School of Medicine, Philadelphia, Pennsylvania;

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http://dx.doi.org/10.1152/ajpheart.00720.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360055PMC
March 2015

β-adrenergic receptor-mediated cardiac contractility is inhibited via vasopressin type 1A-receptor-dependent signaling.

Circulation 2014 Nov 9;130(20):1800-11. Epub 2014 Sep 9.

From the Center for Translational Medicine (D.G.T., E.G., J.S, R.L.C., L.A.G., W.J.K., J.Y.C.), Department of Pharmacology (D.G.T., W.J.K.), Cardiovascular Research Center (W.Z., V.D.M., L.A.B., C.A.M., C.D.T., R.C.C., S.R.H.), Department of Physiology (L.A.B., C.A.M., S.R.H., A.M.F.), Department of Clinical Sciences (D.Y.), and Department of Medicine (J.Y.C., A.M.F.), Temple University School of Medicine, Philadelphia, PA; and the Division of Cardiology, Fourth Military Medical University, Xian, People's Republic of China (X.L.).

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http://circ.ahajournals.org/content/early/2014/09/09/CIRCULA
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http://circ.ahajournals.org/cgi/doi/10.1161/CIRCULATIONAHA.1
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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.010434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229385PMC
November 2014

Induced overexpression of phospholemman S68E mutant improves cardiac contractility and mortality after ischemia-reperfusion.

Am J Physiol Heart Circ Physiol 2014 Apr 31;306(7):H1066-77. Epub 2014 Jan 31.

Center of Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania;

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http://dx.doi.org/10.1152/ajpheart.00861.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962630PMC
April 2014

Cardioprotection of controlled and cardiac-specific over-expression of A(2A)-adenosine receptor in the pressure overload.

PLoS One 2012 6;7(7):e39919. Epub 2012 Jul 6.

Department of Physiology, Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039919PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391213PMC
March 2013

Coordinated regulation of cardiac Na(+)/Ca (2+) exchanger and Na (+)-K (+)-ATPase by phospholemman (FXYD1).

Adv Exp Med Biol 2013 ;961:175-90

Center of Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1007/978-1-4614-4756-6_15DOI Listing
March 2013

Role of TRPM2 in cell proliferation and susceptibility to oxidative stress.

Am J Physiol Cell Physiol 2013 Mar 9;304(6):C548-60. Epub 2013 Jan 9.

Department of Pediatrics, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1152/ajpcell.00069.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671566PMC
March 2013

Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.

ACS Chem Biol 2012 Nov 21;7(11):1830-9. Epub 2012 Aug 21.

Life Sciences Institute and the Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/cb3003013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500392PMC
November 2012

Phospholemman deficiency in postinfarct hearts: enhanced contractility but increased mortality.

Clin Transl Sci 2012 Jun 27;5(3):235-42. Epub 2012 Mar 27.

Cardiovascular Division, Department of Medicine, University of Virginia Medical Center, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1111/j.1752-8062.2012.00403.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891564PMC
June 2012

Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density.

Am J Physiol Heart Circ Physiol 2011 Nov 2;301(5):H1932-40. Epub 2011 Sep 2.

Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1152/ajpheart.00755.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213957PMC
November 2011

Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.

Proc Natl Acad Sci U S A 2011 Nov 26;108(46):E1120-7. Epub 2011 Oct 26.

Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1109879108
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http://dx.doi.org/10.1073/pnas.1109879108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219155PMC
November 2011

Residues 248-252 and 300-304 of the cardiac Na+/Ca2+ exchanger are involved in its regulation by phospholemman.

Am J Physiol Cell Physiol 2011 Oct 6;301(4):C833-40. Epub 2011 Jul 6.

Division of Nephrology, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1152/ajpcell.00069.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191572PMC
October 2011

Regulation of in vivo cardiac contractility by phospholemman: role of Na+/Ca2+ exchange.

Am J Physiol Heart Circ Physiol 2011 Mar 30;300(3):H859-68. Epub 2010 Dec 30.

Division of Nephrology and Center of Translational Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1152/ajpheart.00894.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064295PMC
March 2011

Phospholemman: a novel cardiac stress protein.

Clin Transl Sci 2010 Aug;3(4):189-96

Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/j.1752-8062.2010.00213.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013348PMC
August 2010

Effects of cardiac-restricted overexpression of the A(2A) adenosine receptor on adriamycin-induced cardiotoxicity.

Am J Physiol Heart Circ Physiol 2010 Jun 2;298(6):H1738-47. Epub 2010 Apr 2.

Center for Translational Medicine, Dept. of Medicine, Jefferson Medical College, 1025 Walnut St, Suite 822 College, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1152/ajpheart.00688.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886639PMC
June 2010

Phospholemman and beta-adrenergic stimulation in the heart.

Am J Physiol Heart Circ Physiol 2010 Mar 11;298(3):H807-15. Epub 2009 Dec 11.

Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1152/ajpheart.00877.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838560PMC
March 2010

Induced overexpression of Na+/Ca2+ exchanger transgene: altered myocyte contractility, [Ca2+]i transients, SR Ca2+ contents, and action potential duration.

Am J Physiol Heart Circ Physiol 2009 Aug 12;297(2):H590-601. Epub 2009 Jun 12.

Department of Medicine, Division of Nephrology, Center of Translational Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1152/ajpheart.00190.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724197PMC
August 2009

Phospholemman regulates cardiac Na+/Ca2+ exchanger by interacting with the exchanger's proximal linker domain.

Am J Physiol Cell Physiol 2009 Apr 21;296(4):C911-21. Epub 2009 Jan 21.

Division of Nephrology, Thomas Jefferson Univ., 833 Chestnut St., Suite 700, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1152/ajpcell.00196.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670646PMC
April 2009

TRPC3 activation by erythropoietin is modulated by TRPC6.

J Biol Chem 2009 Feb 13;284(7):4567-81. Epub 2008 Dec 13.

Department of Pediatrics, the Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://www.jbc.org/content/284/7/4567.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M804734200
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http://dx.doi.org/10.1074/jbc.M804734200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640975PMC
February 2009

Regulation of cardiac myocyte contractility by phospholemman: Na+/Ca2+ exchange versus Na+ -K+ -ATPase.

Am J Physiol Heart Circ Physiol 2008 Oct 15;295(4):H1615-25. Epub 2008 Aug 15.

Division of Nephrology, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1152/ajpheart.00287.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593504PMC
October 2008

TRPC3 is the erythropoietin-regulated calcium channel in human erythroid cells.

J Biol Chem 2008 Apr 14;283(16):10385-95. Epub 2008 Feb 14.

Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1074/jbc.M710231200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447643PMC
April 2008

Regulation of cardiac contractility: high time for FXYD.

Authors:
Joseph Y Cheung

Am J Physiol Heart Circ Physiol 2008 Feb;294(2):H584-5

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http://dx.doi.org/10.1152/ajpheart.91430.2007DOI Listing
February 2008

Regulation of TRP channel TRPM2 by the tyrosine phosphatase PTPL1.

Am J Physiol Cell Physiol 2007 May 24;292(5):C1746-58. Epub 2007 Jan 24.

Department of Pediatrics, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1152/ajpcell.00569.2006DOI Listing
May 2007

Regulation of cardiac Na+/Ca2+ exchanger by phospholemman.

Ann N Y Acad Sci 2007 Mar;1099:119-34

Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1196/annals.1387.004DOI Listing
March 2007

Altered contractility and [Ca2+]i homeostasis in phospholemman-deficient murine myocytes: role of Na+/Ca2+ exchange.

Am J Physiol Heart Circ Physiol 2006 Nov 2;291(5):H2199-209. Epub 2006 Jun 2.

Dept. of Cellular and Molecular Physiology, Milton S. Hershey Medical Center, MC-H166, Hershey, PA 17003, USA.

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http://dx.doi.org/10.1152/ajpheart.01181.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1593220PMC
November 2006

Cytoplasmic tail of phospholemman interacts with the intracellular loop of the cardiac Na+/Ca2+ exchanger.

J Biol Chem 2006 Oct 18;281(42):32004-14. Epub 2006 Aug 18.

Department of Cellular and Molecular Physiology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1074/jbc.M606876200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1613256PMC
October 2006

Frequency division multiplexed multichannel high-speed fluorescence confocal microscope.

Biophys J 2006 Sep 30;91(6):2290-6. Epub 2006 Jun 30.

Department of Electrical Engineering, Pennsylvania State University, University Park, PA 16802, USA.

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http://dx.doi.org/10.1529/biophysj.106.083337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557554PMC
September 2006

Regulation of the transient receptor potential channel TRPM2 by the Ca2+ sensor calmodulin.

J Biol Chem 2006 Apr 6;281(14):9076-85. Epub 2006 Feb 6.

Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1074/jbc.M510422200DOI Listing
April 2006

Phospholemman inhibition of the cardiac Na+/Ca2+ exchanger. Role of phosphorylation.

J Biol Chem 2006 Mar 23;281(12):7784-92. Epub 2006 Jan 23.

Department of Cellular and Molecular Physiology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1074/jbc.M512092200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1405234PMC
March 2006

Serine 68 phospholemman phosphorylation during forskolin-induced swine carotid artery relaxation.

J Vasc Res 2005 Nov-Dec;42(6):483-91. Epub 2005 Sep 6.

Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1159/000088102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266286PMC
December 2005

Effects of sarcoplasmic reticulum Ca2+-ATPase overexpression in postinfarction rat myocytes.

J Appl Physiol (1985) 2005 Jun 27;98(6):2169-76. Epub 2005 Jan 27.

Dept. of Cellular & Molecular Physiology, Milton S. Hershey Medical Center, MC-H166, Hershey, PA 17003, USA.

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http://dx.doi.org/10.1152/japplphysiol.00013.2005DOI Listing
June 2005

Serine 68 of phospholemman is critical in modulation of contractility, [Ca2+]i transients, and Na+/Ca2+ exchange in adult rat cardiac myocytes.

Am J Physiol Heart Circ Physiol 2005 May 14;288(5):H2342-54. Epub 2005 Jan 14.

Department of Cellular and Molecular Physiology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1152/ajpheart.01133.2004DOI Listing
May 2005

Identification of an endogenous inhibitor of the cardiac Na+/Ca2+ exchanger, phospholemman.

J Biol Chem 2005 May 17;280(20):19875-82. Epub 2005 Mar 17.

Department of Cellular and Molecular Physiology, Pennsylvania State University, Hershey, 17033, USA.

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http://dx.doi.org/10.1074/jbc.M414703200DOI Listing
May 2005

Preinduced molecular chaperones in the endoplasmic reticulum protect cardiomyocytes from lethal injury.

Ann Clin Lab Sci 2004 ;34(4):449-57

Division of Laboratory Medicine, Geisinger Medical Center, 100 North Academy Ave, Danville, PA 17822, USA.

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April 2005

Identification of an N-terminal TRPC2 splice variant which inhibits calcium influx.

Cell Calcium 2005 Feb;37(2):173-82

The Henry Hood Research Program, The Sigfried and Janet Weis Center for Research, The Geisinger Clinic, Danville, PA 17822, USA.

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http://dx.doi.org/10.1016/j.ceca.2004.08.005DOI Listing
February 2005

Serine 68 phosphorylation of phospholemman: acute isoform-specific activation of cardiac Na/K ATPase.

Cardiovasc Res 2005 Jan;65(1):93-103

Cardiovascular Division, King's College London, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK.

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http://dx.doi.org/10.1016/j.cardiores.2004.09.005DOI Listing
January 2005

Erythropoietin-modulated calcium influx through TRPC2 is mediated by phospholipase Cgamma and IP3R.

Am J Physiol Cell Physiol 2004 Dec 25;287(6):C1667-78. Epub 2004 Aug 25.

Department of Pediatrics, Milton S. Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1152/ajpcell.00265.2004DOI Listing
December 2004

Exercise training improves cardiac function postinfarction: special emphasis on recent controversies on na+/ca2+ exchanger.

Exerc Sport Sci Rev 2004 Jul;32(3):83-9

Weis Center for Research, Geisinger Medical Center, Danville, PA 17822, USA.

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http://dx.doi.org/10.1097/00003677-200407000-00002DOI Listing
July 2004