Publications by authors named "Joseph W St Geme"

81Publications

Kingella negevensis shares multiple putative virulence factors with Kingella kingae.

PLoS One 2020 30;15(10):e0241511. Epub 2020 Oct 30.

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0241511PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598479PMC
October 2020

Leading from the Middle: Benefits of a Physician Leadership Program.

J Pediatr 2020 04;219:4-6.e1

Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2019.12.016DOI Listing
April 2020

Virulence determinants of the emerging pathogen Kingella kingae.

Curr Opin Microbiol 2020 04 5;54:37-42. Epub 2020 Feb 5.

The Children's Hospital of Philadelphia, Philadelphia, PA, USA; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mib.2020.01.009DOI Listing
April 2020

Kingella kingae Surface Polysaccharides Promote Resistance to Neutrophil Phagocytosis and Killing.

mBio 2019 06 25;10(3). Epub 2019 Jun 25.

Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/mBio.00631-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593399PMC
June 2019

Expanding the Pipeline for Pediatric Physician-Scientists.

J Pediatr 2019 04;207:3-7.e1

Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Children's Hospital of Philadelphia, Philadelphia, PA. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2019.01.025DOI Listing
April 2019

Clinical Features and Outcomes of Children with Culture-Negative Septic Arthritis.

J Pediatric Infect Dis Soc 2019 Jul;8(3):228-234

Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1093/jpids/piy034DOI Listing
July 2019

Kingella kingae Surface Polysaccharides Promote Resistance to Human Serum and Virulence in a Juvenile Rat Model.

Infect Immun 2018 06 22;86(6). Epub 2018 May 22.

Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/IAI.00100-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964502PMC
June 2018

Defining the Mechanical Determinants of Kingella kingae Adherence to Host Cells.

J Bacteriol 2017 12 31;199(23). Epub 2017 Oct 31.

Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/JB.00314-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686590PMC
December 2017

Hematogenous Osteomyelitis in Infants and Children: Imaging of a Changing Disease.

Radiology 2017 06;283(3):629-643

From the Departments of Radiology (D.J., J.D.) and Pediatrics (J.W.S.G.), Children's Hospital of Philadelphia, Philadelphia, Pa; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (D.J., J.W.S.G.); Department of Pediatric Orthopaedic Surgery, Texas Children's Hospital, Houston, Tex (J.P.D.); Department of Orthopedic Surgery, Baylor College of Medicine, Houston, Tex (J.P.D.); Department of Radiology and Medical Imaging, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (T.L.); and Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio (T.L.).

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http://dx.doi.org/10.1148/radiol.2017151929DOI Listing
June 2017

Maintenance of Certification Part 4: From Trial to Tribute.

J Pediatr 2017 06 28;185:4-5.e1. Epub 2017 Mar 28.

Children's Hospital of Philadelphia, Philadelphia, PA; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1016/j.jpeds.2017.03.016DOI Listing
June 2017

The Type a and Type b Polysaccharide Capsules Predominate in an International Collection of Invasive Isolates.

mSphere 2017 Mar-Apr;2(2). Epub 2017 Mar 15.

Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1128/mSphere.00060-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352833PMC
March 2017

Pediatric Hospital Medicine: A Proposed New Subspecialty.

Pediatrics 2017 Mar;139(3)

Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.

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http://dx.doi.org/10.1542/peds.2016-1823DOI Listing
March 2017

Maintenance of Certification-A Prescription for Improved Child Health.

JAMA Pediatr 2017 04;171(4):317-319

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania4Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1001/jamapediatrics.2016.4686DOI Listing
April 2017

The HMW1 and HMW2 Adhesins Enhance the Ability of Nontypeable Haemophilus influenzae To Colonize the Upper Respiratory Tract of Rhesus Macaques.

Infect Immun 2016 10 19;84(10):2771-8. Epub 2016 Sep 19.

The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/IAI.00153-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038090PMC
October 2016

Early-Life Intranasal Colonization with Nontypeable Haemophilus influenzae Exacerbates Juvenile Airway Disease in Mice.

Infect Immun 2016 07 23;84(7):2022-2030. Epub 2016 Jun 23.

Duke University School of Medicine, Department of Pediatrics, Durham, North Carolina, USA.

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http://dx.doi.org/10.1128/IAI.01539-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936370PMC
July 2016

Genetic and Molecular Basis of Kingella kingae Encapsulation.

Infect Immun 2016 06 24;84(6):1775-1784. Epub 2016 May 24.

Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/IAI.00128-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907139PMC
June 2016

Authorship Concerns and Who Truly Owns a Research Idea?

Pediatrics 2015 Nov 12;136(5):969-73. Epub 2015 Oct 12.

Department of Pediatrics, Children's Mercy Hospital, University of Missouri, Kansas City, Missouri.

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http://pediatrics.aappublications.org/content/136/5/969.full
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http://pediatrics.aappublications.org/cgi/doi/10.1542/peds.2
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http://dx.doi.org/10.1542/peds.2015-1421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621797PMC
November 2015

Unconventional N-Linked Glycosylation Promotes Trimeric Autotransporter Function in Kingella kingae and Aggregatibacter aphrophilus.

mBio 2015 Aug 25;6(4). Epub 2015 Aug 25.

The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/mBio.01206-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550697PMC
August 2015

Structural determinants of the interaction between the TpsA and TpsB proteins in the Haemophilus influenzae HMW1 two-partner secretion system.

J Bacteriol 2015 May 16;197(10):1769-80. Epub 2015 Mar 16.

Department of Pediatrics and Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA Department of Pediatrics, Children's Hospital of Philadelphia, and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/JB.00039-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402395PMC
May 2015

Diversity and inclusion training in pediatric departments.

Pediatrics 2015 Apr 9;135(4):707-13. Epub 2015 Mar 9.

Boston Children's Hospital, Harvard University, Boston, Massachusetts.

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http://dx.doi.org/10.1542/peds.2014-1653DOI Listing
April 2015

A 33-month-old with fever and altered mental status.

Pediatrics 2015 Jan 8;135(1):120-5. Epub 2014 Dec 8.

Divisions of General Pediatrics, Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; and Infectious Disease, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania;

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http://dx.doi.org/10.1542/peds.2014-2405DOI Listing
January 2015

Necrotizing fasciitis caused by Haemophilus influenzae serotype f.

J Clin Microbiol 2014 Sep 2;52(9):3471-4. Epub 2014 Jul 2.

Division of Infectious Disease, Duke University Medical Center, Durham, North Carolina, USA.

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http://dx.doi.org/10.1128/JCM.01460-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313188PMC
September 2014

The HMW1C-like glycosyltransferases--an enzyme family with a sweet tooth for simple sugars.

PLoS Pathog 2014 Apr 10;10(4):e1003977. Epub 2014 Apr 10.

The Department of Pediatrics, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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https://dx.plos.org/10.1371/journal.ppat.1003977
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http://dx.doi.org/10.1371/journal.ppat.1003977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983070PMC
April 2014

Structural determinants of the interaction between the Haemophilus influenzae Hap autotransporter and fibronectin.

Microbiology (Reading) 2014 Jun 31;160(Pt 6):1182-1190. Epub 2014 Mar 31.

Department of Pediatrics, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1099/mic.0.077784-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039244PMC
June 2014

The Haemophilus cryptic genospecies Cha adhesin has at least two variants that differ in host cell binding, bacterial aggregation, and biofilm formation properties.

J Bacteriol 2014 May 28;196(9):1780-8. Epub 2014 Feb 28.

Duke University Medical Center Department of Pediatrics and Department of Molecular Genetics and Microbiology, Durham, North Carolina, USA.

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http://dx.doi.org/10.1128/JB.01409-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993323PMC
May 2014

Characterization of the Kingella kingae polysaccharide capsule and exopolysaccharide.

PLoS One 2013 30;8(9):e75409. Epub 2013 Sep 30.

Department of Pediatrics and Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075409PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787102PMC
May 2014

Inactivation of Haemophilus influenzae lipopolysaccharide biosynthesis genes interferes with outer membrane localization of the hap autotransporter.

J Bacteriol 2012 Apr 27;194(7):1815-22. Epub 2012 Jan 27.

Departments of Pediatrics and Molecular Genetics and Microbiology, Duke University Medical Center, Children’s Health Center, Durham, NC, USA

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http://jb.asm.org/cgi/doi/10.1128/JB.06316-11
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http://dx.doi.org/10.1128/JB.06316-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302475PMC
April 2012

Structural insights into the glycosyltransferase activity of the Actinobacillus pleuropneumoniae HMW1C-like protein.

J Biol Chem 2011 Nov 9;286(44):38546-57. Epub 2011 Sep 9.

Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204, USA.

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http://dx.doi.org/10.1074/jbc.M111.237602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207471PMC
November 2011

Crystal structure of the Haemophilus influenzae Hap adhesin reveals an intercellular oligomerization mechanism for bacterial aggregation.

EMBO J 2011 Aug 12;30(18):3864-74. Epub 2011 Aug 12.

State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui-Jin Hospital affiliated to Shanghai JiaoTong University School of Medicine, PR China.

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http://dx.doi.org/10.1038/emboj.2011.279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173798PMC
August 2011

Kingella kingae: an emerging pathogen in young children.

Pediatrics 2011 Mar 14;127(3):557-65. Epub 2011 Feb 14.

Clinical Microbiology Laboratory, Soroka University Medical Center, Ben-Gurion University of Negev, Beer-Sheva 84101, Israel.

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http://dx.doi.org/10.1542/peds.2010-1867DOI Listing
March 2011

Structure and function of the Haemophilus influenzae autotransporters.

Front Cell Infect Microbiol 2011 28;1. Epub 2011 Sep 28.

Department of Pediatrics, Children's Health Center, Duke University Medical Center Durham, NC, USA.

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http://journal.frontiersin.org/article/10.3389/fcimb.2011.00
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http://dx.doi.org/10.3389/fcimb.2011.00005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417375PMC
March 2015

Adhesive activity of the haemophilus cryptic genospecies cha autotransporter is modulated by variation in tandem Peptide repeats.

J Bacteriol 2011 Jan 29;193(2):329-39. Epub 2010 Oct 29.

Department of Pediatrics, Duke University Medical Center, Children's Health Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1128/JB.00933-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019818PMC
January 2011

The Haemophilus influenzae HMW1C protein is a glycosyltransferase that transfers hexose residues to asparagine sites in the HMW1 adhesin.

PLoS Pathog 2010 May 27;6(5):e1000919. Epub 2010 May 27.

Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, United States of America.

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https://dx.plos.org/10.1371/journal.ppat.1000919
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http://dx.doi.org/10.1371/journal.ppat.1000919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877744PMC
May 2010

Examination of type IV pilus expression and pilus-associated phenotypes in Kingella kingae clinical isolates.

Infect Immun 2010 Apr 9;78(4):1692-9. Epub 2010 Feb 9.

Department of Molecular Microbiology, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1128/IAI.00908-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849430PMC
April 2010

Structural determinants of autoproteolysis of the Haemophilus influenzae Hap autotransporter.

Infect Immun 2009 Nov 17;77(11):4704-13. Epub 2009 Aug 17.

Department of Pediatrics, Duke University, Durham, NC 27710, USA.

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http://dx.doi.org/10.1128/IAI.00598-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772505PMC
November 2009

A prototype two-partner secretion pathway: the Haemophilus influenzae HMW1 and HMW2 adhesin systems.

Trends Microbiol 2009 Aug 5;17(8):355-60. Epub 2009 Aug 5.

Department of Pediatrics, Duke University Medical Center, Children's Health Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.tim.2009.06.002DOI Listing
August 2009

Structural basis for the differential binding affinities of the HsfBD1 and HsfBD2 domains in the Haemophilus influenzae Hsf adhesin.

J Bacteriol 2009 Aug 12;191(16):5068-75. Epub 2009 Jun 12.

Department of Pediatrics, Duke University Medical Center, Children's Health Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1128/JB.00395-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725572PMC
August 2009

Expression of Kingella kingae type IV pili is regulated by sigma54, PilS, and PilR.

J Bacteriol 2009 Aug 22;191(15):4976-86. Epub 2009 May 22.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://jb.asm.org/cgi/doi/10.1128/JB.00123-09
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http://dx.doi.org/10.1128/JB.00123-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715724PMC
August 2009

Repetitive architecture of the Haemophilus influenzae Hia trimeric autotransporter.

J Mol Biol 2008 Dec 11;384(4):824-36. Epub 2008 Oct 11.

Institute of Structural and Molecular Biology at UCL/Birkbeck, London, UK.

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http://dx.doi.org/10.1016/j.jmb.2008.09.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597055PMC
December 2008

Kingella kingae expresses type IV pili that mediate adherence to respiratory epithelial and synovial cells.

J Bacteriol 2008 Nov 29;190(21):7157-63. Epub 2008 Aug 29.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://jb.asm.org/cgi/doi/10.1128/JB.00884-08
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http://dx.doi.org/10.1128/JB.00884-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2580711PMC
November 2008

The Haemophilus influenzae HMW1 adhesin is a glycoprotein with an unusual N-linked carbohydrate modification.

J Biol Chem 2008 Sep 11;283(38):26010-5. Epub 2008 Jul 11.

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M801819200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258857PMC
September 2008

Identification of a novel trimeric autotransporter adhesin in the cryptic genospecies of Haemophilus.

J Bacteriol 2008 Jun 18;190(12):4313-20. Epub 2008 Apr 18.

Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1128/JB.01963-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446753PMC
June 2008

The structure of the Haemophilus influenzae HMW1 pro-piece reveals a structural domain essential for bacterial two-partner secretion.

J Biol Chem 2007 Oct 14;282(42):31076-84. Epub 2007 Aug 14.

Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204, USA.

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http://dx.doi.org/10.1074/jbc.M705750200DOI Listing
October 2007

Structure of the Haemophilus influenzae HMW1B translocator protein: evidence for a twin pore.

J Bacteriol 2007 Oct 10;189(20):7497-502. Epub 2007 Aug 10.

Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA.

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http://dx.doi.org/10.1128/JB.00541-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2168432PMC
October 2007

Identification and characterization of an RTX toxin in the emerging pathogen Kingella kingae.

J Bacteriol 2007 Jan 10;189(2):430-6. Epub 2006 Nov 10.

Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63310, USA.

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http://dx.doi.org/10.1128/JB.01319-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797395PMC
January 2007

Trimeric autotransporters require trimerization of the passenger domain for stability and adhesive activity.

J Bacteriol 2006 Aug;188(15):5400-7

Edward Mallinckrodt Department of Pediatrics and Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1128/JB.00164-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1540040PMC
August 2006

Surface anchoring of a bacterial adhesin secreted by the two-partner secretion pathway.

Mol Microbiol 2006 Jul 12;61(2):470-83. Epub 2006 Jun 12.

Edward Mallinckrodt Department of Pediatrics , Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2006.05236.xDOI Listing
July 2006

The Haemophilus influenzae Type b hcsA and hcsB gene products facilitate transport of capsular polysaccharide across the outer membrane and are essential for virulence.

J Bacteriol 2006 Jun;188(11):3870-7

Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1128/JB.01968-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482897PMC
June 2006

Structure of the outer membrane translocator domain of the Haemophilus influenzae Hia trimeric autotransporter.

EMBO J 2006 Jun 11;25(11):2297-304. Epub 2006 May 11.

Institute of Structural Molecular Biology at UCL/Birkbeck, London, UK.

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http://dx.doi.org/10.1038/sj.emboj.7601132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1478200PMC
June 2006

Translocator proteins in the two-partner secretion family have multiple domains.

J Biol Chem 2006 Jun 28;281(26):18051-8. Epub 2006 Apr 28.

The Edward Mallinckrodt Department of Pediatrics and the Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1074/jbc.M600036200DOI Listing
June 2006

Distribution of bacterial proteins in biofilms formed by non-typeable Haemophilus influenzae.

J Histochem Cytochem 2006 Jul 20;54(7):829-42. Epub 2006 Mar 20.

Ahmanson Advanced Electron Microscopy and Imaging Center, House Ear Institute, Los Angeles, CA 90057, USA.

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http://journals.sagepub.com/doi/10.1369/jhc.6A6922.2006
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http://dx.doi.org/10.1369/jhc.6A6922.2006DOI Listing
July 2006

Architecture and adhesive activity of the Haemophilus influenzae Hsf adhesin.

J Bacteriol 2005 Jul;187(13):4656-64

Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, Missouri 63110, USA.

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http://jb.asm.org/cgi/doi/10.1128/JB.187.13.4656-4664.2005
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http://dx.doi.org/10.1128/JB.187.13.4656-4664.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1151757PMC
July 2005

Trimeric autotransporters: a distinct subfamily of autotransporter proteins.

Trends Microbiol 2005 May;13(5):199-205

Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0966842X0500074
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http://dx.doi.org/10.1016/j.tim.2005.03.004DOI Listing
May 2005

Recent advances in otitis media. 5. Microbiology and immunology.

Ann Otol Rhinol Laryngol Suppl 2005 Jan;194:60-85

Department of Pediatrics, St Louis University School of Medicine, Missouri, USA.

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January 2005

Evidence for conservation of architecture and physical properties of Omp85-like proteins throughout evolution.

Proc Natl Acad Sci U S A 2004 Oct 20;101(40):14497-502. Epub 2004 Sep 20.

The Edward Mallinckrodt Department of Pediatrics and Department of Molecular Microbiology, Washington University School of Medicine, Campus Box 8208, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1073/pnas.0404679101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC521957PMC
October 2004

Developing community-specific recommendations for first-line treatment of acute otitis media: is high-dose amoxicillin necessary?

Pediatrics 2004 Aug;114(2):342-7

Division of General Medical Sciences, Washington University School of Medicine, St Louis, Missouri, USA.

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http://dx.doi.org/10.1542/peds.114.2.342DOI Listing
August 2004

Evolutionary and functional relationships among the nontypeable Haemophilus influenzae HMW family of adhesins.

J Bacteriol 2004 Jul;186(13):4209-17

Edward Mallinckrodt Department of Pediatrics, Washington University Medical School, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1128/JB.186.13.4209-4217.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC421621PMC
July 2004

Structural basis for host recognition by the Haemophilus influenzae Hia autotransporter.

EMBO J 2004 Mar 18;23(6):1245-56. Epub 2004 Mar 18.

Institute of Structural Molecular Biology, Birkbeck and University College London, Malet Street, London, UK.

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http://emboj.embopress.org/cgi/doi/10.1038/sj.emboj.7600142
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http://dx.doi.org/10.1038/sj.emboj.7600142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC381414PMC
March 2004

The Haemophilus influenzae Hia autotransporter contains an unusually short trimeric translocator domain.

J Biol Chem 2004 Apr 15;279(15):14679-85. Epub 2004 Jan 15.

Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M311496200
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http://dx.doi.org/10.1074/jbc.M311496200DOI Listing
April 2004

Invasive disease due to nontypeable Haemophilus influenzae among children in Arkansas.

J Clin Microbiol 2003 Jul;41(7):3064-9

Department of Pediatrics, University of Arkansas for Medical Sciences/Arkansas Children's Hospital, Little Rock, Arkansas, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165342PMC
http://dx.doi.org/10.1128/jcm.41.7.3064-3069.2003DOI Listing
July 2003

The Haemophilus influenzae HMW1 adhesin is glycosylated in a process that requires HMW1C and phosphoglucomutase, an enzyme involved in lipooligosaccharide biosynthesis.

Mol Microbiol 2003 May;48(3):737-51

The Edward Mallinckrodt Department of Pediatrics and Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Ave., Campus Box 8208, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1046/j.1365-2958.2003.03450.xDOI Listing
May 2003

Prevalence and distribution of adhesins in invasive non-type b encapsulated Haemophilus influenzae.

Infect Immun 2003 Apr;71(4):1635-42

Department of Infectious Diseases, St. Jude Children's Research Hospital, 332 N. Lauderdale Street, Memphis, TN 38105, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152026PMC
http://dx.doi.org/10.1128/iai.71.4.1635-1642.2003DOI Listing
April 2003

Chromosomal expression of the Haemophilus influenzae Hap autotransporter allows fine-tuned regulation of adhesive potential via inhibition of intermolecular autoproteolysis.

J Bacteriol 2003 Mar;185(5):1608-15

Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, and Division of Infectious Diseases, St. Louis Children's Hospital, St. Louis, Missouri 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC148083PMC
http://dx.doi.org/10.1128/jb.185.5.1608-1615.2003DOI Listing
March 2003

The Haemophilus influenzae Hia autotransporter harbours two adhesive pockets that reside in the passenger domain and recognize the same host cell receptor.

Mol Microbiol 2002 Nov;46(3):731-43

Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, Division of Infectious Diseases, St Louis Children's Hospital, 660 South Euclid Ave., Campus Box 8208, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1046/j.1365-2958.2002.03189.xDOI Listing
November 2002

The pathogenesis of disease due to nontypeable Haemophilus influenzae.

Methods Mol Med 2003 ;71:1-28

Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1385/1-59259-321-6:01DOI Listing
March 2003

Immunization with Haemophilus influenzae Hap adhesin protects against nasopharyngeal colonization in experimental mice.

J Infect Dis 2002 Oct 16;186(8):1115-21. Epub 2002 Sep 16.

Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1086/344233DOI Listing
October 2002

The Haemophilus influenzae Hap autotransporter binds to fibronectin, laminin, and collagen IV.

Infect Immun 2002 Sep;70(9):4902-7

Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC128251PMC
http://dx.doi.org/10.1128/iai.70.9.4902-4907.2002DOI Listing
September 2002

Molecular and cellular determinants of non-typeable Haemophilus influenzae adherence and invasion.

Authors:
Joseph W St Geme

Cell Microbiol 2002 Apr;4(4):191-200

Edward Mallinckrodt Department of Pediatrics and Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63117, USA.

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http://dx.doi.org/10.1046/j.1462-5822.2002.00180.xDOI Listing
April 2002