Publications by authors named "Joseph W Lynch"

98Publications

Proteostasis Regulators Restore Function of Epilepsy-Associated GABA Receptors.

Cell Chem Biol 2020 Sep 1. Epub 2020 Sep 1.

Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2020.08.012DOI Listing
September 2020

Effects of GluN2A and GluN2B gain-of-function epilepsy mutations on synaptic currents mediated by diheteromeric and triheteromeric NMDA receptors.

Neurobiol Dis 2020 07 1;140:104850. Epub 2020 Apr 1.

Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2020.104850DOI Listing
July 2020

Shisa7 is a GABA receptor auxiliary subunit controlling benzodiazepine actions.

Science 2019 10;366(6462):246-250

Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/science.aax5719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382361PMC
October 2019

The effects of insecticides on two splice variants of the glutamate-gated chloride channel receptor of the major malaria vector, Anopheles gambiae.

Br J Pharmacol 2020 01 31;177(1):175-187. Epub 2019 Oct 31.

Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1111/bph.14855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976876PMC
January 2020

SAHA (Vorinostat) Corrects Inhibitory Synaptic Deficits Caused by Missense Epilepsy Mutations to the GABA Receptor γ2 Subunit.

Front Mol Neurosci 2018 23;11:89. Epub 2018 Mar 23.

Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.

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http://dx.doi.org/10.3389/fnmol.2018.00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876238PMC
March 2018

Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus.

PLoS Pathog 2017 Oct 2;13(10):e1006663. Epub 2017 Oct 2.

Queensland Brain Institute, The University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1371/journal.ppat.1006663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638611PMC
October 2017

Inhibitory synapse deficits caused by familial α1 GABA receptor mutations in epilepsy.

Neurobiol Dis 2017 Dec 1;108:213-224. Epub 2017 Sep 1.

Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2017.08.020DOI Listing
December 2017

Physiological and pharmacological properties of inhibitory postsynaptic currents mediated by α5β1γ2, α5β2γ2 and α5β3γ2 GABA receptors.

Neuropharmacology 2017 Oct 27;125:243-253. Epub 2017 Jul 27.

Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2017.07.027DOI Listing
October 2017

Structure-Function Analysis of the GlyR α2 Subunit Autism Mutation p.R323L Reveals a Gain-of-Function.

Front Mol Neurosci 2017 23;10:158. Epub 2017 May 23.

Queensland Brain Institute, The University of QueenslandBrisbane, QLD, Australia.

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http://dx.doi.org/10.3389/fnmol.2017.00158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440463PMC
May 2017

Glycine Receptor Drug Discovery.

Adv Pharmacol 2017 21;79:225-253. Epub 2017 Mar 21.

Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1016/bs.apha.2017.01.003DOI Listing
December 2017

Rigor, reproducibility, and in vitro cerebrospinal fluid assays: The devil in the details.

Ann Neurol 2017 06 1;81(6):904-907. Epub 2017 Jun 1.

Program in Neuroscience, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, GA.

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http://dx.doi.org/10.1002/ana.24940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639705PMC
June 2017

Probing the Structural Mechanism of Partial Agonism in Glycine Receptors Using the Fluorescent Artificial Amino Acid, ANAP.

ACS Chem Biol 2017 03 2;12(3):805-813. Epub 2017 Feb 2.

Queensland Brain Institute, The University of Queensland , Brisbane, Queensland 4072, Australia.

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http://dx.doi.org/10.1021/acschembio.6b00926DOI Listing
March 2017

A Chemogenetic Receptor That Enhances the Magnitude and Frequency of Glycinergic Inhibitory Postsynaptic Currents without Inducing a Tonic Chloride Flux.

ACS Chem Neurosci 2017 03 15;8(3):460-467. Epub 2016 Dec 15.

Queensland Brain Institute and ‡School of Biomedical Sciences, The University of Queensland , Brisbane, QLD 4072, Australia.

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http://pubs.acs.org/doi/10.1021/acschemneuro.6b00382
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http://dx.doi.org/10.1021/acschemneuro.6b00382DOI Listing
March 2017

The Free Zinc Concentration in the Synaptic Cleft of Artificial Glycinergic Synapses Rises to At least 1 μM.

Front Mol Neurosci 2016 22;9:88. Epub 2016 Sep 22.

Queensland Brain Institute, The University of Queensland, BrisbaneQLD, Australia; School of Biomedical Sciences, The University of Queensland, BrisbaneQLD, Australia.

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http://dx.doi.org/10.3389/fnmol.2016.00088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031599PMC
September 2016

Ivermectin-Activated, Cation-Permeable Glycine Receptors for the Chemogenetic Control of Neuronal Excitation.

ACS Chem Neurosci 2016 12 27;7(12):1647-1657. Epub 2016 Sep 27.

Queensland Brain Institute, The University of Queensland , Brisbane, QLD 4072, Australia.

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http://dx.doi.org/10.1021/acschemneuro.6b00168DOI Listing
December 2016

Investigating the Mechanism by Which Gain-of-function Mutations to the α1 Glycine Receptor Cause Hyperekplexia.

J Biol Chem 2016 07 18;291(29):15332-41. Epub 2016 May 18.

From the Queensland Brain Institute and School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia 4072

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http://dx.doi.org/10.1074/jbc.M116.728592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946944PMC
July 2016

Generation of Functional Inhibitory Synapses Incorporating Defined Combinations of GABA(A) or Glycine Receptor Subunits.

Front Mol Neurosci 2015 23;8:80. Epub 2015 Dec 23.

Queensland Brain Institute, University of QueenslandBrisbane, QLD, Australia; School of Biomedical Sciences, University of QueenslandBrisbane, QLD, Australia.

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http://dx.doi.org/10.3389/fnmol.2015.00080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688394PMC
January 2016

Functional characterization of ivermectin binding sites in α1β2γ2L GABA(A) receptors.

Front Mol Neurosci 2015 25;8:55. Epub 2015 Sep 25.

Queensland Brain Institute, The University of Queensland Brisbane, QLD, Australia ; School of Biomedical Sciences, The University of Queensland Brisbane, QLD, Australia.

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http://dx.doi.org/10.3389/fnmol.2015.00055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585179PMC
October 2015

Investigating ion channel conformational changes using voltage clamp fluorometry.

Neuropharmacology 2015 Nov 31;98:3-12. Epub 2015 Mar 31.

Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2015.03.018DOI Listing
November 2015

Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity.

Br J Pharmacol 2015 Jul 11;172(14):3522-36. Epub 2015 May 11.

Queensland Brain Institute, University of Queensland, Brisbane, Qld, Australia.

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http://dx.doi.org/10.1111/bph.13142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507157PMC
July 2015

Selective Modulators of α5-Containing GABAA Receptors and their Therapeutic Significance.

Curr Drug Targets 2015 ;16(7):735-46

Queensland Brain Institute, The University of Queensland, Brisbane 4072, Queensland, Australia.

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http://dx.doi.org/10.2174/1389450116666150309120235DOI Listing
May 2016

A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models.

Neurobiol Dis 2015 Apr 11;76:87-97. Epub 2015 Feb 11.

Department of Pharmacology, School of Biomedical Sciences, The University of Queensland, Skerman Building, St Lucia, Queensland 4072, Australia. Electronic address:

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http://www.ilae.org/visitors/news/documents/Complement_recep
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http://linkinghub.elsevier.com/retrieve/pii/S096999611500024
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http://dx.doi.org/10.1016/j.nbd.2015.02.004DOI Listing
April 2015

Correlating structural and energetic changes in glycine receptor activation.

J Biol Chem 2015 Feb 8;290(9):5621-34. Epub 2015 Jan 8.

From the Queensland Brain Institute and

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http://dx.doi.org/10.1074/jbc.M114.616573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342475PMC
February 2015

Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations.

Neuropharmacology 2015 Feb;89:391-7

Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.

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http://dx.doi.org/10.1016/j.neuropharm.2014.10.026DOI Listing
February 2015

Phosphorylation mediated structural and functional changes in pentameric ligand-gated ion channels: implications for drug discovery.

Int J Biochem Cell Biol 2014 Aug 28;53:218-23. Epub 2014 May 28.

Queensland Brain Institute, The University of Queensland, St Lucia 4072, Australia; School of Biomedical Sciences, The University of Queensland, St Lucia 4072, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2014.05.028DOI Listing
August 2014

GABAA receptor α and γ subunits shape synaptic currents via different mechanisms.

J Biol Chem 2014 Feb 14;289(9):5399-411. Epub 2014 Jan 14.

From the Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia 4072.

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http://dx.doi.org/10.1074/jbc.M113.514695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937617PMC
February 2014

The impact of human hyperekplexia mutations on glycine receptor structure and function.

Mol Brain 2014 Jan 9;7. Epub 2014 Jan 9.

Queensland Brain Institute and School of Biomedical Sciences, The University of Queensland, Queensland 4072, Australia.

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http://dx.doi.org/10.1186/1756-6606-7-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895786PMC
January 2014

Analysis of hyperekplexia mutations identifies transmembrane domain rearrangements that mediate glycine receptor activation.

J Biol Chem 2013 Nov 4;288(47):33760-71. Epub 2013 Oct 4.

From the Queensland Brain Institute and.

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http://dx.doi.org/10.1074/jbc.M113.513804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837120PMC
November 2013

Phosphorylation of α3 glycine receptors induces a conformational change in the glycine-binding site.

ACS Chem Neurosci 2013 Oct 18;4(10):1361-70. Epub 2013 Jul 18.

Queensland Brain Institute and ‡School of Biomedical Sciences, The University of Queensland , Brisbane QLD 4072, Australia.

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http://dx.doi.org/10.1021/cn400097jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798985PMC
October 2013

Sesterterpene glycinyl-lactams: a new class of glycine receptor modulator from Australian marine sponges of the genus Psammocinia.

Org Biomol Chem 2013 Jul 11;11(28):4695-701. Epub 2013 Jun 11.

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.

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http://dx.doi.org/10.1039/c3ob40861bDOI Listing
July 2013

Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator.

Bioorg Med Chem 2013 Jul 1;21(14):4420-5. Epub 2013 May 1.

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.

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http://dx.doi.org/10.1016/j.bmc.2013.04.061DOI Listing
July 2013

Fluorescence-based high-throughput functional profiling of ligand-gated ion channels at the level of single cells.

PLoS One 2013 8;8(3):e58479. Epub 2013 Mar 8.

Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058479PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592791PMC
September 2013

The relative orientation of the TM3 and TM4 domains varies between α1 and α3 glycine receptors.

ACS Chem Neurosci 2013 Feb 28;4(2):248-54. Epub 2012 Nov 28.

Queensland Brain Institute, The University of Queensland, Brisbane QLD 4072, Australia.

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http://dx.doi.org/10.1021/cn300177gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582286PMC
February 2013

An outline of desensitization in pentameric ligand-gated ion channel receptors.

Cell Mol Life Sci 2013 Apr 31;70(7):1241-53. Epub 2012 Aug 31.

Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia.

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http://dx.doi.org/10.1007/s00018-012-1133-zDOI Listing
April 2013

Stoichiometry and subunit arrangement of α1β glycine receptors as determined by atomic force microscopy.

Biochemistry 2012 Jul 21;51(26):5229-31. Epub 2012 Jun 21.

Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.

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http://dx.doi.org/10.1021/bi300063mDOI Listing
July 2012

Ivermectin binding sites in human and invertebrate Cys-loop receptors.

Trends Pharmacol Sci 2012 Aug 5;33(8):432-41. Epub 2012 Jun 5.

Neurosensory Systems Group, Technical University of Darmstadt, Schnittspahnstrasse 3, 64287 Darmstadt, Germany.

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http://dx.doi.org/10.1016/j.tips.2012.05.002DOI Listing
August 2012

Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin.

Front Mol Neurosci 2012 7;5:60. Epub 2012 May 7.

Queensland Brain Institute, The University of Queensland, Brisbane QLD, Australia.

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http://dx.doi.org/10.3389/fnmol.2012.00060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345530PMC
October 2012

Distinct properties of glycine receptor β+/α- interface: unambiguously characterizing heteromeric interface reconstituted in homomeric protein.

J Biol Chem 2012 Jun 25;287(25):21244-52. Epub 2012 Apr 25.

Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales 2050, Australia.

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http://dx.doi.org/10.1074/jbc.M111.337741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375546PMC
June 2012

Incompatibility between a pair of residues from the pre-M1 linker and Cys-loop blocks surface expression of the glycine receptor.

J Biol Chem 2012 Mar 20;287(10):7535-42. Epub 2012 Jan 20.

Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, 2050 Australia.

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http://dx.doi.org/10.1074/jbc.M111.325126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293590PMC
March 2012

A comparison of glycine- and ivermectin-mediated conformational changes in the glycine receptor ligand-binding domain.

Int J Biochem Cell Biol 2012 Feb 11;44(2):335-40. Epub 2011 Nov 11.

Queensland Brain Institute and School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia.

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http://dx.doi.org/10.1016/j.biocel.2011.11.005DOI Listing
February 2012

Mechanism of action of the insecticides, lindane and fipronil, on glycine receptor chloride channels.

Br J Pharmacol 2012 Apr;165(8):2707-20

Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1111/j.1476-5381.2011.01722.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423232PMC
April 2012

Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel.

J Biol Chem 2011 Dec 27;286(51):43913-24. Epub 2011 Oct 27.

Queensland Brain Institute, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1074/jbc.M111.262634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243547PMC
December 2011

Function of hyperekplexia-causing α1R271Q/L glycine receptors is restored by shifting the affected residue out of the allosteric signalling pathway.

Br J Pharmacol 2012 Apr;165(7):2113-23

School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1111/j.1476-5381.2011.01701.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413849PMC
April 2012

Activation and desensitization induce distinct conformational changes at the extracellular-transmembrane domain interface of the glycine receptor.

J Biol Chem 2011 Nov 14;286(44):38814-24. Epub 2011 Sep 14.

Queensland Brain Institute and School of Biomedical Sciences, University of Queensland, Brisbane QLD 4072, Australia.

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http://dx.doi.org/10.1074/jbc.M111.273631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207466PMC
November 2011

Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors.

J Biol Chem 2010 Dec 11;285(51):40373-86. Epub 2010 Oct 11.

Queensland Brain Institute and School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.161513
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http://dx.doi.org/10.1074/jbc.M110.161513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001017PMC
December 2010

Chimera construction using multiple-template-based sequential PCRs.

J Neurosci Methods 2010 Oct 15;193(1):86-9. Epub 2010 Sep 15.

Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1016/j.jneumeth.2010.08.033DOI Listing
October 2010

A glycine residue essential for high ivermectin sensitivity in Cys-loop ion channel receptors.

Int J Parasitol 2010 Nov 14;40(13):1477-81. Epub 2010 Aug 14.

Queensland Brain Institute and School of Biomedical Sciences, The University of Queensland, Brisbane QLD, Australia.

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http://dx.doi.org/10.1016/j.ijpara.2010.07.010DOI Listing
November 2010

Exon-skipping splice variants of excitatory amino acid transporter-2 (EAAT2) form heteromeric complexes with full-length EAAT2.

J Biol Chem 2010 Oct 5;285(41):31313-24. Epub 2010 Aug 5.

School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane 4072, Australia.

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http://dx.doi.org/10.1074/jbc.M110.153494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951206PMC
October 2010

Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae.

Bioorg Med Chem 2010 Apr 6;18(8):2912-9. Epub 2010 Mar 6.

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.

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http://dx.doi.org/10.1016/j.bmc.2010.03.002DOI Listing
April 2010

An improved ivermectin-activated chloride channel receptor for inhibiting electrical activity in defined neuronal populations.

J Biol Chem 2010 May 22;285(20):14890-7. Epub 2010 Mar 22.

Queensland Brain Institute and School of Biomedical Sciences, The University of Queensland, Brisbane QLD 4072, Australia.

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http://dx.doi.org/10.1074/jbc.M110.107789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865309PMC
May 2010

High Throughput Techniques for Discovering New Glycine Receptor Modulators and their Binding Sites.

Front Mol Neurosci 2009 30;2:17. Epub 2009 Oct 30.

Queensland Brain Institute, The University of Queensland Brisbane, QLD, Australia.

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http://dx.doi.org/10.3389/neuro.02.017.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782790PMC
July 2011

Magnitude of a conformational change in the glycine receptor beta1-beta2 loop is correlated with agonist efficacy.

J Biol Chem 2009 Oct 30;284(40):27370-6. Epub 2009 Jul 30.

Queensland Brain Institute and School of Biomedical Sciences, University of Queensland, Brisbane QLD 4072, Australia.

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http://dx.doi.org/10.1074/jbc.M109.048405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785665PMC
October 2009

The M4 transmembrane segment contributes to agonist efficacy differences between alpha1 and alpha3 glycine receptors.

Mol Membr Biol 2009 Aug 20;26(5):321-32. Epub 2009 Jul 20.

Queensland Brain Institute and School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia.

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http://dx.doi.org/10.1080/09687680903120319DOI Listing
August 2009

Molecular determinants of beta-carboline inhibition of the glycine receptor.

J Neurochem 2009 Sep 8;110(5):1685-94. Epub 2009 Jul 8.

Queensland Brain Institute and School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06273.xDOI Listing
September 2009

Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domain.

J Biol Chem 2009 Jun 13;284(23):15847-56. Epub 2009 Mar 13.

Queensland Brain Institute and School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia.

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http://dx.doi.org/10.1074/jbc.M809343200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708881PMC
June 2009

Multiplexed labeling of viable cells for high-throughput analysis of glycine receptor function using flow cytometry.

Cytometry A 2009 May;75(5):440-9

Queensland Brain Institute, University of Queensland, Brisbane QLD 4072, Australia.

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http://dx.doi.org/10.1002/cyto.a.20703DOI Listing
May 2009

Optimizing the expression of recombinant alphabetagamma GABAA receptors in HEK293 cells for high-throughput screening.

J Biomol Screen 2009 Jan;14(1):86-91

Queensland Brain Institute, University of Queensland, Brisbane, Australia, School of Biomedical Sciences, University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1177/1087057108328017DOI Listing
January 2009

Distinct conformational changes in activated agonist-bound and agonist-free glycine receptor subunits.

J Neurochem 2009 Mar 24;108(6):1585-94. Epub 2009 Jan 24.

Queensland Brain Institute and School of Biomedical Sciences, The University of Queensland, Brisbane, Australia.

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http://doi.wiley.com/10.1111/j.1471-4159.2009.05930.x
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http://dx.doi.org/10.1111/j.1471-4159.2009.05930.xDOI Listing
March 2009

GABAA receptors containing gamma1 subunits contribute to inhibitory transmission in the central amygdala.

J Neurophysiol 2009 Jan 12;101(1):341-9. Epub 2008 Nov 12.

The Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia.

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http://dx.doi.org/10.1152/jn.90991.2008DOI Listing
January 2009

A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue.

J Neurosci 2008 Oct;28(43):10937-42

School of Biomedical Sciences and Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia.

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http://dx.doi.org/10.1523/JNEUROSCI.2540-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649377PMC
October 2008

Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine.

Biochem Pharmacol 2008 Oct 7;76(8):1014-23. Epub 2008 Aug 7.

Queensland Brain Institute and School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia.

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http://dx.doi.org/10.1016/j.bcp.2008.07.037DOI Listing
October 2008

Native glycine receptor subtypes and their physiological roles.

Authors:
Joseph W Lynch

Neuropharmacology 2009 Jan 3;56(1):303-9. Epub 2008 Aug 3.

Queensland Brain Institute and School of Biomedical Sciences, University of Queensland, Brisbane QLD 4072, Australia.

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January 2009

Dihydropyridine inhibition of the glycine receptor: subunit selectivity and a molecular determinant of inhibition.

Neuropharmacology 2009 Jan 9;56(1):318-27. Epub 2008 Jul 9.

School of Biomedical Sciences and Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.

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January 2009

Illuminating the structure and function of Cys-loop receptors.

Clin Exp Pharmacol Physiol 2008 Oct 25;35(10):1137-42. Epub 2008 May 25.

School of Biomedical Sciences and Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1111/j.1440-1681.2008.04954.xDOI Listing
October 2008

Subunit-specific potentiation of recombinant glycine receptors by NV-31, a bilobalide-derived compound.

Neurosci Lett 2008 Apr 16;435(2):147-51. Epub 2008 Feb 16.

School of Biomedical Sciences and Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.

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http://dx.doi.org/10.1016/j.neulet.2008.02.022DOI Listing
April 2008

Structure-activity analysis of ginkgolide binding in the glycine receptor pore.

J Neurochem 2008 May 21;105(4):1418-27. Epub 2008 Jan 21.

School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia.

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May 2008

Conformational variability of the glycine receptor M2 domain in response to activation by different agonists.

J Biol Chem 2007 Dec 2;282(49):36057-67. Epub 2007 Oct 2.

School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.

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December 2007

A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore.

J Neurochem 2007 Oct 20;103(2):580-9. Epub 2007 Aug 20.

School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia.

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October 2007

Molecular pharmacology of the glycine receptor chloride channel.

Curr Pharm Des 2007 ;13(23):2350-67

School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia.

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http://dx.doi.org/10.2174/138161207781368693DOI Listing
August 2007

Closed-state cross-linking of adjacent beta1 subunits in alpha1beta1 GABAa receptors via introduced 6' cysteines.

J Biol Chem 2007 Jun 3;282(23):16803-10. Epub 2007 Apr 3.

School of Biomedical Sciences, University of Queensland, Brisbane QLD 4072, Australia.

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June 2007

Tropisetron modulation of the glycine receptor: femtomolar potentiation and a molecular determinant of inhibition.

J Neurochem 2007 Feb 1;100(3):758-69. Epub 2006 Dec 1.

School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia.

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February 2007

Molecular determinants of ginkgolide binding in the glycine receptor pore.

J Neurochem 2006 Jul;98(2):395-407

School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia.

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July 2006

Glycine receptors: a new therapeutic target in pain pathways.

Curr Opin Investig Drugs 2006 Jan;7(1):48-53

School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia.

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January 2006

A picrotoxin-specific conformational change in the glycine receptor M2-M3 loop.

J Biol Chem 2005 Oct 18;280(43):35836-43. Epub 2005 Aug 18.

School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.

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October 2005

A yellow fluorescent protein-based assay for high-throughput screening of glycine and GABAA receptor chloride channels.

Neurosci Lett 2005 Jun 23;380(3):340-5. Epub 2005 Feb 23.

School of Biomedical Sciences, University of Queensland, Brisbane, Qld 4072, Australia.

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June 2005

Ligand-gated channels.

IEEE Trans Nanobioscience 2005 Mar;4(1):70-80

School of Medical Sciences at the University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1109/tnb.2004.842497DOI Listing
March 2005

Molecular structure and function of the glycine receptor chloride channel.

Authors:
Joseph W Lynch

Physiol Rev 2004 Oct;84(4):1051-95

School of Biomedical Sciences, Univ. of Queensland, Brisbane QLD 4072, Australia.

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October 2004

Comparison of taurine- and glycine-induced conformational changes in the M2-M3 domain of the glycine receptor.

J Biol Chem 2004 May 23;279(19):19559-65. Epub 2004 Feb 23.

School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.

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May 2004

Asymmetric contribution of alpha and beta subunits to the activation of alphabeta heteromeric glycine receptors.

J Neurochem 2003 Jul;86(2):498-507

Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia.

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July 2003

Insights into the structural basis for zinc inhibition of the glycine receptor.

J Biol Chem 2003 Aug 9;278(31):28985-92. Epub 2003 May 9.

Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.

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August 2003

Effects of polyunsaturated fatty acids on voltage-gated K+ and Na+ channels in rat olfactory receptor neurons.

Eur J Neurosci 2002 Dec;16(11):2085-94

Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, QLD, 4072, Australia.

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http://dx.doi.org/10.1046/j.1460-9568.2002.02288.xDOI Listing
December 2002

Comparative surface accessibility of a pore-lining threonine residue (T6') in the glycine and GABA(A) receptors.

J Biol Chem 2002 Nov 17;277(47):44845-53. Epub 2002 Sep 17.

Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.

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November 2002