Publications by authors named "Joseph W Lewcock"

36 Publications

Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease.

Neuron 2020 12 22;108(5):801-821. Epub 2020 Oct 22.

German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany. Electronic address:

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December 2020

Leveraging preclinical models for the development of Alzheimer disease therapeutics.

Nat Rev Drug Discov 2020 07 8;19(7):447-462. Epub 2020 Apr 8.

Denali Therapeutics, South San Francisco, CA, USA.

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July 2020

Cell Death and Neurodegeneration.

Cold Spring Harb Perspect Biol 2020 02 3;12(2). Epub 2020 Feb 3.

Denali Therapeutics, South San Francisco, California 94080, USA.

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February 2020

Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD.

Neuron 2019 09 1;103(5):802-819.e11. Epub 2019 Jul 1.

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Stem Cell Program, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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September 2019

p190RhoGAP Filters Competing Signals to Resolve Axon Guidance Conflicts.

Neuron 2019 05 19;102(3):602-620.e9. Epub 2019 Mar 19.

Gene Expression Laboratory and the Howard Hughes Medical Institute, Salk Institute for Biological Studies, 10010 North Torrey Pines, La Jolla, CA 92037, USA. Electronic address:

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May 2019

SUPT4H1 Depletion Leads to a Global Reduction in RNA.

Cell Rep 2019 01;26(1):45-53.e4

Denali Therapeutics, 151 Oyster Point Boulevard, South San Francisco, CA 94080, USA. Electronic address:

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January 2019

Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration.

J Med Chem 2018 09 4;61(18):8078-8087. Epub 2018 Jun 4.

Denali Therapeutics , 151 Oyster Point Boulevard , South San Francisco , California 94080 , United States.

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September 2018

The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons.

J Neurosci 2017 11 9;37(46):11074-11084. Epub 2017 Oct 9.

Department of Neuroscience, Genentech, Inc., San Francisco, California 94080,

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November 2017

C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice.

Proc Natl Acad Sci U S A 2013 Nov 29;110(46):E4385-92. Epub 2013 Oct 29.

Ludwig Institute for Cancer Research, Department of Medicine and Neuroscience, University of California, San Diego, La Jolla, CA 92093.

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November 2013

Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration.

J Exp Med 2013 Nov 28;210(12):2553-67. Epub 2013 Oct 28.

Department of Neuroscience, 2 Department of Biomedical Imaging, 3 Department of Bioinformatics and Computational Biology, 4 Department of Protein Chemistry, 5 Department of Pathology, Genentech, Inc., South San Francisco, CA 94080.

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November 2013

JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis.

J Cell Biol 2013 Sep 26;202(5):747-63. Epub 2013 Aug 26.

Department of Neuroscience, 2 Department of Microchemical Proteomics, and 3 Department of Physiological Chemistry, Genentech, Inc., South San Francisco, CA 94080, USA.

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September 2013

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.

Proc Natl Acad Sci U S A 2013 Mar 19;110(10):4039-44. Epub 2013 Feb 19.

Neurodegeneration Laboratories, Department of Neuroscience, Gentech, Inc., South San Francisco, CA 94080, USA.

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March 2013

A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C.

PLoS One 2012 12;7(1):e30376. Epub 2012 Jan 12.

Department of Biochemical Pharmacology, Genentech, Inc., South San Francisco, California, United States of America.

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May 2012

DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity.

J Cell Biol 2011 Sep;194(5):751-64

Neurodegeneration Laboratories, Department of Neuroscience, Genentech, Inc., South San Francisco, CA 94080, USA.

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September 2011

ACS chemical neuroscience spotlight on CEP-1347.

ACS Chem Neurosci 2011 Jan 3;2(1):3-4. Epub 2010 Sep 3.

Department of Small Molecule Drug Discovery, Genentech, Inc., 1 DNA Way, South San Francisco, California, USA.

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January 2011