Joseph W Lewcock

Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination.

Authors:

Mar Bosch-Queralt Ludovico Cantuti-Castelvetri Alkmini Damkou Martina Schifferer Kai Schlepckow Ioannis Alexopoulos Dieter Lütjohann Christian Klose Lenka Vaculčiaková Takahiro Masuda Marco Prinz Kathryn M Monroe Gilbert Di Paolo Joseph W Lewcock Christian Haass Mikael Simons

Nat Metab 2021 Feb 18;3(2):211-227. Epub 2021 Feb 18.

Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.

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February 2021

Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease.

Authors:

Joseph W Lewcock Kai Schlepckow Gilbert Di Paolo Sabina Tahirovic Kathryn M Monroe Christian Haass

Neuron 2020 12 22;108(5):801-821. Epub 2020 Oct 22.

German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany. Electronic address:

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December 2020

Leveraging preclinical models for the development of Alzheimer disease therapeutics.

Authors:

Kimberly Scearce-Levie Pascal E Sanchez Joseph W Lewcock

Nat Rev Drug Discov 2020 07 8;19(7):447-462. Epub 2020 Apr 8.

Denali Therapeutics, South San Francisco, CA, USA.

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July 2020

Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia.

Authors:

Benjamin J Andreone Laralynne Przybyla Ceyda Llapashtica Anil Rana Sonnet S Davis Bettina van Lengerich Karin Lin Ju Shi Yuan Mei Giuseppe Astarita Gilbert Di Paolo Thomas Sandmann Kathryn M Monroe Joseph W Lewcock

Nat Neurosci 2020 08 8;23(8):927-938. Epub 2020 Jun 8.

Denali Therapeutics, South San Francisco, California, CA, USA.

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August 2020

Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.

EMBO Mol Med 2020 04 10;12(4):e11227. Epub 2020 Mar 10.

German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.

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April 2020

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.

Neuron 2020 03 2;105(5):837-854.e9. Epub 2020 Jan 2.

Denali Therapeutics, South San Francisco, CA 94080, USA. Electronic address:

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March 2020

Cell Death and Neurodegeneration.

Authors:

Benjamin J Andreone Martin Larhammar Joseph W Lewcock

Cold Spring Harb Perspect Biol 2020 02 3;12(2). Epub 2020 Feb 3.

Denali Therapeutics, South San Francisco, California 94080, USA.

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February 2020

Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD.

Authors:

Mark Y Fang Sebastian Markmiller Anthony Q Vu Ashkan Javaherian William E Dowdle Philippe Jolivet Paul J Bushway Nicholas A Castello Ashmita Baral Michelle Y Chan Jeremy W Linsley Drew Linsley Mark Mercola Steven Finkbeiner Eric Lecuyer Joseph W Lewcock Gene W Yeo

Neuron 2019 09 1;103(5):802-819.e11. Epub 2019 Jul 1.

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Stem Cell Program, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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September 2019

p190RhoGAP Filters Competing Signals to Resolve Axon Guidance Conflicts.

Authors:

Dario Bonanomi Fabiola Valenza Onanong Chivatakarn Matthew J Sternfeld Shawn P Driscoll Aaron Aslanian Karen Lettieri Miriam Gullo Aurora Badaloni Joseph W Lewcock Tony Hunter Samuel L Pfaff

Neuron 2019 05 19;102(3):602-620.e9. Epub 2019 Mar 19.

Gene Expression Laboratory and the Howard Hughes Medical Institute, Salk Institute for Biological Studies, 10010 North Torrey Pines, La Jolla, CA 92037, USA. Electronic address:

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May 2019

SUPT4H1 Depletion Leads to a Global Reduction in RNA.

Authors:

Adam Naguib Thomas Sandmann Fei Yi Ryan J Watts Joseph W Lewcock William E Dowdle

Cell Rep 2019 01;26(1):45-53.e4

Denali Therapeutics, 151 Oyster Point Boulevard, South San Francisco, CA 94080, USA. Electronic address:

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January 2019

Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain.

Proc Natl Acad Sci U S A 2018 10 15;115(44):11244-11249. Epub 2018 Oct 15.

Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080;

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October 2018

Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration.

Authors:

Michael Siu Arundhati Sengupta Ghosh Joseph W Lewcock

J Med Chem 2018 09 4;61(18):8078-8087. Epub 2018 Jun 4.

Denali Therapeutics , 151 Oyster Point Boulevard , South San Francisco , California 94080 , United States.

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September 2018

The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons.

Authors:

Martin Larhammar Sarah Huntwork-Rodriguez York Rudhard Arundhati Sengupta-Ghosh Joseph W Lewcock

J Neurosci 2017 11 9;37(46):11074-11084. Epub 2017 Oct 9.

Department of Neuroscience, Genentech, Inc., San Francisco, California 94080,

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November 2017

Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.

Authors:

Snahel Patel William J Meilandt Rebecca I Erickson Jinhua Chen Gauri Deshmukh Anthony A Estrada Reina N Fuji Paul Gibbons Amy Gustafson Seth F Harris Jose Imperio Wendy Liu Xingrong Liu Yichin Liu Joseph P Lyssikatos Changyou Ma Jianping Yin Joseph W Lewcock Michael Siu

J Med Chem 2017 10 20;60(19):8083-8102. Epub 2017 Sep 20.

Department of Chemistry, WuXi AppTec Co., Ltd. , 288 Fute Zhonglu, Wai Gao Qiao Free Trade Zone, Shanghai 200131, P. R. China.

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October 2017

Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease.

Sci Transl Med 2017 Aug;9(403)

Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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August 2017

Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.

Authors:

Martin Larhammar Sarah Huntwork-Rodriguez Zhiyu Jiang Hilda Solanoy Arundhati Sengupta Ghosh Bei Wang Joshua S Kaminker Kevin Huang Jeffrey Eastham-Anderson Michael Siu Zora Modrusan Madeline M Farley Marc Tessier-Lavigne Joseph W Lewcock Trent A Watkins

Elife 2017 04 25;6. Epub 2017 Apr 25.

Department of Neuroscience, Genentech, Inc., San Francisco, United States.

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April 2017

Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12).

J Med Chem 2015 Oct 2;58(20):8182-99. Epub 2015 Oct 2.

Department of Chemistry, WuXi AppTec Co., Ltd. , 288 Fute Zhonglu, Wai Gao Qiao Free Trade Zone, Shanghai, 200131, P. R. China.

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October 2015

Identification of 12/15-lipoxygenase as a regulator of axon degeneration through high-content screening.

Authors:

York Rudhard Arundhati Sengupta Ghosh Beatrix Lippert Alexander Böcker Mehdi Pedaran Joachim Krämer Hai Ngu Oded Foreman Yichin Liu Joseph W Lewcock

J Neurosci 2015 Feb;35(7):2927-41

Departments of Neuroscience,

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February 2015

Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.

J Med Chem 2015 Jan 23;58(1):401-18. Epub 2014 Oct 23.

Departments of †Discovery Chemistry, ‡Neurosciences, §Drug Metabolism and Pharmacokinetics, and ∥Biochemical and Cellular Pharmacology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.

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January 2015

C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice.

Authors:

Christian S Lobsiger Severine Boillée Christine Pozniak Amir M Khan Melissa McAlonis-Downes Joseph W Lewcock Don W Cleveland

Proc Natl Acad Sci U S A 2013 Nov 29;110(46):E4385-92. Epub 2013 Oct 29.

Ludwig Institute for Cancer Research, Department of Medicine and Neuroscience, University of California, San Diego, La Jolla, CA 92093.

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November 2013

Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration.

Authors:

Christine D Pozniak Arundhati Sengupta Ghosh Alvin Gogineni Jesse E Hanson Seung-Hye Lee Jessica L Larson Hilda Solanoy Daisy Bustos Hong Li Hai Ngu Adrian M Jubb Gai Ayalon Jiansheng Wu Kimberly Scearce-Levie Qiang Zhou Robby M Weimer Donald S Kirkpatrick Joseph W Lewcock

J Exp Med 2013 Nov 28;210(12):2553-67. Epub 2013 Oct 28.

Department of Neuroscience, 2 Department of Biomedical Imaging, 3 Department of Bioinformatics and Computational Biology, 4 Department of Protein Chemistry, 5 Department of Pathology, Genentech, Inc., South San Francisco, CA 94080.

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November 2013

JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis.

Authors:

Sarah Huntwork-Rodriguez Bei Wang Trent Watkins Arundhati Sengupta Ghosh Christine D Pozniak Daisy Bustos Kim Newton Donald S Kirkpatrick Joseph W Lewcock

J Cell Biol 2013 Sep 26;202(5):747-63. Epub 2013 Aug 26.

Department of Neuroscience, 2 Department of Microchemical Proteomics, and 3 Department of Physiological Chemistry, Genentech, Inc., South San Francisco, CA 94080, USA.

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September 2013