Publications by authors named "Joseph Sung"

100Publications

Elucidation of Proteus mirabilis as a Key Bacterium in Crohn's Disease Inflammation.

Gastroenterology 2020 Oct 1. Epub 2020 Oct 1.

Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, LKS Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China; Center for Gut Microbiota Research, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2020.09.036DOI Listing
October 2020

Population-level configurations of gut mycobiome across six ethnicities in urban and rural China.

Gastroenterology 2020 Sep 18. Epub 2020 Sep 18.

Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Diseases, Kunming, Yunnan, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2020.09.014DOI Listing
September 2020

Use of metformin and aspirin is associated with delayed cancer incidence.

Cancer Epidemiol 2020 Sep 9;69:101808. Epub 2020 Sep 9.

Stanley Ho Big Data Decision Analytics Research Centre, The Chinese University of Hong Kong, Hong Kong, China; JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canep.2020.101808DOI Listing
September 2020

Human-Gut-DNA Virome Variations across Geography, Ethnicity, and Urbanization.

Cell Host Microbe 2020 Sep 2. Epub 2020 Sep 2.

Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, China; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China; Li Ka Shing Institute of Health Science, State Key Laboratory of Digestive Diseases, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chom.2020.08.005DOI Listing
September 2020

Artificial intelligence in health care: preparing for the fifth Industrial Revolution.

Med J Aust 2020 09 6;213(6):253-255.e1. Epub 2020 Sep 6.

Heart Research Institute, University of Sydney, Sydney, NSW.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5694/mja2.50755DOI Listing
September 2020

In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance.

Gastroenterology 2020 Aug 16. Epub 2020 Aug 16.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, Chinese University of Hong Kong, Hong Kong, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2020.08.016DOI Listing
August 2020

Short Message Service reminders reduce outpatient colonoscopy nonattendance rate: A randomized controlled study.

J Gastroenterol Hepatol 2020 Aug 16. Epub 2020 Aug 16.

Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.15218DOI Listing
August 2020

Collateral Effect of Coronavirus Disease 2019 Pandemic on Hospitalizations and Clinical Outcomes in Gastrointestinal and Liver Diseases: A Territory-wide Observational Study in Hong Kong.

Gastroenterology 2020 Jul 25. Epub 2020 Jul 25.

Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China; Institute of Digestive Diseases, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2020.07.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382332PMC
July 2020

Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites.

Gut 2020 Jul 21. Epub 2020 Jul 21.

State Key Laboratory of Digestive Disease, Institute of Digestive Disease and The Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2019-319664DOI Listing
July 2020

Fecal microbial DNA markers serve for screening colorectal neoplasm in asymptomatic subjects.

J Gastroenterol Hepatol 2020 Jul 7. Epub 2020 Jul 7.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.15171DOI Listing
July 2020

Altered Gut Archaea Composition and Interaction With Bacteria Are Associated With Colorectal Cancer.

Gastroenterology 2020 Oct 20;159(4):1459-1470.e5. Epub 2020 Jun 20.

State Key Laboratory of Digestive Disease, Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China SAR. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2020.06.042DOI Listing
October 2020

Luminal microbiota related to Crohn's disease recurrence after surgery.

Gut Microbes 2020 Nov 21;11(6):1713-1728. Epub 2020 Jun 21.

Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia and Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge , Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/19490976.2020.1778262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524166PMC
November 2020

Review article: bugs, inflammation and mood-a microbiota-based approach to psychiatric symptoms in inflammatory bowel diseases.

Aliment Pharmacol Ther 2020 07 11;52(2):247-266. Epub 2020 Jun 11.

Department of Medicine and Therapeutics, Institute of Digestive Disease, LKS Institute of Health Science, The Chinese University of Hong Kong, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apt.15787DOI Listing
July 2020

Artificial intelligence in gastroenterology: where are we heading?

Front Med 2020 Aug 26;14(4):511-517. Epub 2020 May 26.

Big Data Decision Analytic Cancer, The Chinese University of Hong Kong, Hong Kong, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11684-020-0742-4DOI Listing
August 2020

Aspirin Reduces Colorectal Tumor Development in Mice and Gut Microbes Reduce its Bioavailability and Chemopreventive Effects.

Gastroenterology 2020 Sep 6;159(3):969-983.e4. Epub 2020 May 6.

State Key Laboratory of Digestive Disease, Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2020.05.004DOI Listing
September 2020

Population-based screening and mass eradication of Helicobacter pylori infection to prevent gastric cancer: There are more questions than answers.

Authors:
Joseph J Y Sung

J Gastroenterol Hepatol 2020 Apr;35(4):521-522

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.15024DOI Listing
April 2020

Timing of Endoscopy for Acute Upper Gastrointestinal Bleeding.

N Engl J Med 2020 04;382(14):1299-1308

From the Institute of Digestive Disease, the Chinese University of Hong Kong, Shatin, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1912484DOI Listing
April 2020

Overview of guidance for endoscopy during the coronavirus disease 2019 pandemic.

J Gastroenterol Hepatol 2020 May 22;35(5):749-759. Epub 2020 Apr 22.

Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.15053DOI Listing
May 2020

Treatment of upper gastrointestinal bleeding in 2020: New techniques and outcomes.

Dig Endosc 2020 Mar 26. Epub 2020 Mar 26.

Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin New Territories, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/den.13674DOI Listing
March 2020

Covid-19 and the digestive system.

J Gastroenterol Hepatol 2020 May 19;35(5):744-748. Epub 2020 Apr 19.

Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.15047DOI Listing
May 2020

Biological characteristics associated with virulence in ribotype 002 in Hong Kong.

Emerg Microbes Infect 2020 17;9(1):631-638. Epub 2020 Mar 17.

Institute of Digestive Disease, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/22221751.2020.1739564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144233PMC
March 2020

Inflammatory bowel disease: Is East really differ from West?

Authors:
Joseph Sung

J Gastroenterol Hepatol 2020 Mar;35(3):357-358

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.15003DOI Listing
March 2020

Gastric microbes associated with gastric inflammation, atrophy and intestinal metaplasia 1 year after eradication.

Gut 2020 Sep 23;69(9):1572-1580. Epub 2020 Jan 23.

Department of Medicine and Therapeutics, Chinese University of Hong Kong, New Territories, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2019-319826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456733PMC
September 2020

A new scoring system for upper gastrointestinal bleeding: Too simple or still complicated?

J Gastroenterol Hepatol 2020 Jan;35(1)

Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.14959DOI Listing
January 2020

Development and Validation of the Asia-Pacific Proximal Colon Neoplasia Risk Score.

Clin Gastroenterol Hepatol 2020 Jan 7. Epub 2020 Jan 7.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong; The Institute of Digestive Disease, The Chinese University of Hong Kong; The State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cgh.2019.12.031DOI Listing
January 2020

A novel faecal marker for the non-invasive diagnosis of colorectal adenoma and cancer.

Gut 2020 Jul 27;69(7):1248-1257. Epub 2019 Nov 27.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, Hong Kong

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2019-318532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306980PMC
July 2020

Sessile serrated adenoma/polyps: Why we should be working flat out to understand more about these flat lesions?

J Gastroenterol Hepatol 2019 10;34(10):1667-1668

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, SAR, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.14891DOI Listing
October 2019

VSTM2A suppresses colorectal cancer and antagonizes Wnt signaling receptor LRP6.

Theranostics 2019 21;9(22):6517-6531. Epub 2019 Aug 21.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease and Li Ka Shing Institute of Health Sciences, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/thno.34989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771244PMC
October 2020

Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity.

Nat Microbiol 2019 12 9;4(12):2319-2330. Epub 2019 Sep 9.

Institute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41564-019-0541-3DOI Listing
December 2019

The Use of Biologics and Biosimilar in Asian patients with IBD: Are we ready?

J Gastroenterol Hepatol 2019 08;34(8):1269-1270

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, SAR, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.14817DOI Listing
August 2019

ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy.

Nat Commun 2019 07 29;10(1):3391. Epub 2019 Jul 29.

Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-11274-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662851PMC
July 2019

Use of direct oral anticoagulant in atrial fibrillation with gastrointestinal bleeding: Balancing gastrointestinal safety and cardiovascular risks.

J Gastroenterol Hepatol 2019 06;34(6):959-960

Division of Cardiology, Department of Medicine and Therapeutics, The Chines University of Hong Kong, Shatin, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.14701DOI Listing
June 2019

Global Increasing Incidence of Young-Onset Colorectal Cancer Across 5 Continents: A Joinpoint Regression Analysis of 1,922,167 Cases.

Cancer Epidemiol Biomarkers Prev 2019 08 21;28(8):1275-1282. Epub 2019 May 21.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-18-1111DOI Listing
August 2019

Differential colorectal cancer genomics between east and west.

J Gastroenterol Hepatol 2019 05;34(5):811-812

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.14675DOI Listing
May 2019

TTPAL Promotes Colorectal Tumorigenesis by Stabilizing TRIP6 to Activate Wnt/β-Catenin Signaling.

Cancer Res 2019 07 24;79(13):3332-3346. Epub 2019 Apr 24.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-18-2986DOI Listing
July 2019

When repeated Helicobacter pylori therapies fail, what should we do?

J Gastroenterol Hepatol 2019 Apr;34(4):627-628

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.14668DOI Listing
April 2019

Gut mucosal virome alterations in ulcerative colitis.

Gut 2019 07 6;68(7):1169-1179. Epub 2019 Mar 6.

Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2018-318131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582748PMC
July 2019

Real-time tracking of fluorescent magnetic spore-based microrobots for remote detection of toxins.

Sci Adv 2019 01 11;5(1):eaau9650. Epub 2019 Jan 11.

Department of Mechanical and Automation Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin NT, Hong Kong SAR, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciadv.aau9650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357761PMC
January 2019

The emerging role of big data in gastroenterology and hepatology.

J Gastroenterol Hepatol 2019 Feb;34(2):307-308

Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jgh.14606
Publisher Site
http://dx.doi.org/10.1111/jgh.14606DOI Listing
February 2019

Increasing Trend in Young-Onset Colorectal Cancer in Asia: More Cancers in Men and More Rectal Cancers.

Am J Gastroenterol 2019 02;114(2):322-329

Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14309/ajg.0000000000000133DOI Listing
February 2019

A population-based age-period-cohort study of colorectal cancer incidence comparing Asia against the West.

Cancer Epidemiol 2019 04 16;59:29-36. Epub 2019 Jan 16.

Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canep.2019.01.007DOI Listing
April 2019

Renaissance in gastroenterology and hepatology.

Authors:
Joseph Sung

J Gastroenterol Hepatol 2019 Jan;34(1):5-6

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.14582DOI Listing
January 2019

Systematic review with meta-analysis: review of donor features, procedures and outcomes in 168 clinical studies of faecal microbiota transplantation.

Aliment Pharmacol Ther 2019 02 9;49(4):354-363. Epub 2019 Jan 9.

Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/apt.15116
Publisher Site
http://dx.doi.org/10.1111/apt.15116DOI Listing
February 2019

Long-term use of low-dose aspirin for cancer prevention: A 10-year population cohort study in Hong Kong.

Int J Cancer 2019 07 7;145(1):267-273. Epub 2019 Jan 7.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ijc.32083
Publisher Site
http://dx.doi.org/10.1002/ijc.32083DOI Listing
July 2019

Risk of tuberculosis in patients with immune-mediated diseases on biological therapies: a population-based study in a tuberculosis endemic region.

Rheumatology (Oxford) 2019 05;58(5):803-810

Institute of Digestive Disease, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.

View Article

Download full-text PDF

Source
https://academic.oup.com/rheumatology/advance-article/doi/10
Publisher Site
http://dx.doi.org/10.1093/rheumatology/key364DOI Listing
May 2019

Low-dose aspirin can reduce colorectal cancer mortality after surgery: A 10-year follow-up of 13 528 colorectal cancer patients.

J Gastroenterol Hepatol 2019 Jun 14;34(6):1027-1034. Epub 2019 Jan 14.

Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jgh.14562
Publisher Site
http://dx.doi.org/10.1111/jgh.14562DOI Listing
June 2019

Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer.

Gut 2019 04 24;68(4):654-662. Epub 2018 Nov 24.

State Key Laboratory of Digestive Disease, Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2018-317178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580778PMC
April 2019

Adenoma detection rates in colonoscopies for positive fecal immunochemical tests versus direct screening colonoscopies.

Gastrointest Endosc 2019 03 16;89(3):607-613.e1. Epub 2018 Nov 16.

Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00165107183328
Publisher Site
http://dx.doi.org/10.1016/j.gie.2018.11.014DOI Listing
March 2019

Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling.

Nat Commun 2018 10 26;9(1):4490. Epub 2018 Oct 26.

Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41467-018-06931-6
Publisher Site
http://dx.doi.org/10.1038/s41467-018-06931-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203711PMC
October 2018

Low-dose imipramine for refractory functional dyspepsia: a randomised, double-blind, placebo-controlled trial.

Lancet Gastroenterol Hepatol 2018 12 22;3(12):837-844. Epub 2018 Oct 22.

Department of Medicine & Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S24681253183030
Publisher Site
http://dx.doi.org/10.1016/S2468-1253(18)30303-0DOI Listing
December 2018

Significant Medical and Surgical Morbidity in Perianal Crohn's Disease: Results from a Territory-Wide Study.

J Crohns Colitis 2018 Nov;12(12):1392-1398

Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, LKS Institute of Health Science, The Chinese University of Hong Kong, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ecco-jcc/jjy120DOI Listing
November 2018

Gastrointestinal disease burden and mortality: A public hospital-based study from 2005 to 2014.

J Gastroenterol Hepatol 2019 Jan 30;34(1):124-131. Epub 2018 Jul 30.

Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, LKS Institute of Health Science, Chinese University of Hong Kong, Hong Kong, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.14377DOI Listing
January 2019

Risk factors for advanced colorectal neoplasms in the proximal colon in 6218 subjects undergoing complete colonoscopy.

J Gastroenterol Hepatol 2019 Jan 12;34(1):113-119. Epub 2018 Jul 12.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.14357DOI Listing
January 2019

The effect of off-hours hospital admission on mortality and clinical outcomes for patients with upper gastrointestinal hemorrhage: A systematic review and meta-analysis of 20 cohorts.

United European Gastroenterol J 2018 Apr 14;6(3):367-381. Epub 2017 Sep 14.

Department of Surgery, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050640617732651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949970PMC
April 2018

Association Between Bacteremia From Specific Microbes and Subsequent Diagnosis of Colorectal Cancer.

Gastroenterology 2018 08 3;155(2):383-390.e8. Epub 2018 May 3.

State Key Laboratory of Digestive Disease, Institute of Digestive Disease, Li Ka Shing Institute of Health Sciences, and CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2018.04.028DOI Listing
August 2018

Alterations in Enteric Virome Are Associated With Colorectal Cancer and Survival Outcomes.

Gastroenterology 2018 08 22;155(2):529-541.e5. Epub 2018 Apr 22.

Institute of Digestive Disease and the Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2018.04.018DOI Listing
August 2018

Non-variceal upper gastrointestinal bleeding.

Nat Rev Dis Primers 2018 04 19;4:18020. Epub 2018 Apr 19.

Division of Gastroenterology, The Chinese University of Hong Kong, Hong Kong, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrdp.2018.20DOI Listing
April 2018

Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target.

Sci Transl Med 2018 04;10(437)

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, 999077, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.aap9840DOI Listing
April 2018

Risk of gastrointestinal bleeding and benefit from colorectal cancer reduction from long-term use of low-dose aspirin: A retrospective study of 612 509 patients.

J Gastroenterol Hepatol 2018 Oct 16;33(10):1728-1736. Epub 2018 May 16.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Sha Tin, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.14261DOI Listing
October 2018

Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers.

Microbiome 2018 04 11;6(1):70. Epub 2018 Apr 11.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40168-018-0451-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896039PMC
April 2018

CREPT facilitates colorectal cancer growth through inducing Wnt/β-catenin pathway by enhancing p300-mediated β-catenin acetylation.

Oncogene 2018 06 22;37(26):3485-3500. Epub 2018 Mar 22.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, Shenzhen Research Institute, The Chinese University of Hong Kong, Sha Tin, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-018-0161-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021369PMC
June 2018

Genomic analysis of liver cancer unveils novel driver genes and distinct prognostic features.

Theranostics 2018 12;8(6):1740-1751. Epub 2018 Feb 12.

Institute of Digestive Diseases and Department of Medicine & Therapeutics, State Key Laboratory of Digestive Diseases, LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/thno.22010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858179PMC
January 2019

DEAD-box helicase 27 promotes colorectal cancer growth and metastasis and predicts poor survival in CRC patients.

Oncogene 2018 05 14;37(22):3006-3021. Epub 2018 Mar 14.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-018-0196-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978808PMC
May 2018

A novel susceptibility locus in MST1 and gene-gene interaction network for Crohn's disease in the Chinese population.

J Cell Mol Med 2018 04 14;22(4):2368-2377. Epub 2018 Feb 14.

State Key Laboratory of Digestive Diseases, Institute of Digestive Diseases and Department of Medicine & Therapeutics, LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcmm.13530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867068PMC
April 2018

RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3.

Cancer Res 2018 04 26;78(8):1958-1971. Epub 2018 Jan 26.

Institute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-17-2683DOI Listing
April 2018

Forkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2-IRF2BPL-β-Catenin Signaling Axis.

Cancer Res 2018 04 26;78(7):1643-1656. Epub 2018 Jan 26.

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease and Li Ka Shing Institute of Health Sciences, Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-17-2403DOI Listing
April 2018

Cancer Risk in 2621 Chinese Patients with Inflammatory Bowel Disease: A Population-based Cohort Study.

Inflamm Bowel Dis 2017 11;23(11):2061-2068

1Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, China; 2Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China; 3Institute of Digestive Disease, Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China; 4Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China; 5Department of Medicine, Tuen Mun Hospital, Hong Kong, China; 6Department of Medicine, United Christian Hospital, Hong Kong, China 7Department of Medicine, Princess Margaret Hospital, Hong Kong, China; 8Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China; 9Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China; 10Department of Medicine, Tseung Kwan O Hospital, Hong Kong, China; 11Department of Medicine, Caritas Medical Centre, Hong Kong, China; 12Department of Medicine, North District Hospital, Hong Kong, China; 13Department of Medicine, Kwong Wah Hospital, Hong Kong, China; 14Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China; 15Department of Medicine, Yan Chai Hospital, Hong Kong, China; and 16Department of Gastroenterology, Chelsea and Westminster Hospital, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MIB.0000000000001240DOI Listing
November 2017

Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis.

FASEB J 2018 01 25;32(1):37-51. Epub 2017 Aug 25.

Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China;

View Article

Download full-text PDF

Source
http://www.fasebj.org/doi/10.1096/fj.201601393R
Publisher Site
http://dx.doi.org/10.1096/fj.201601393RDOI Listing
January 2018

Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice.

Gastroenterology 2017 12 18;153(6):1621-1633.e6. Epub 2017 Aug 18.

Institute of Digestive Disease, Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences and CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, Hong Kong. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2017.08.022DOI Listing
December 2017

Mucosal microbiome dysbiosis in gastric carcinogenesis.

Gut 2018 06 1;67(6):1024-1032. Epub 2017 Aug 1.

Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2017-314281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969346PMC
June 2018

Global temporal patterns of pancreatic cancer and association with socioeconomic development.

Sci Rep 2017 06 9;7(1):3165. Epub 2017 Jun 9.

Institute of Digestive Disease, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-02997-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466634PMC
June 2017