Joseph R Testa

Joseph R Testa

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Joseph R Testa

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RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance.

PLoS One 2019 3;14(10):e0222392. Epub 2019 Oct 3.

Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222392PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776433PMC
October 2019

Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide.

J Natl Cancer Inst 2018 12;110(12):1328-1341

QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1093/jnci/djy171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292796PMC
December 2018

The correlation between gain of chromosome 8q and survival in patients with clear and papillary renal cell carcinoma.

Ther Adv Urol 2018 Jan 31;10(1):3-10. Epub 2017 Oct 31.

Divisions of Pathology and Cancer Biology, Fox Chase Cancer Center-Temple Health System, Philadelphia, PA, USA.

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http://dx.doi.org/10.1177/1756287217732660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761913PMC
January 2018

Targeting MYC sensitizes malignant mesothelioma cells to PAK blockage-induced cytotoxicity.

Am J Cancer Res 2017 1;7(8):1724-1737. Epub 2017 Aug 1.

Cancer Biology Program, Fox Chase Cancer CenterPhiladelphia, Pennsylvania, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574944PMC
August 2017

, a tumor suppressor gene driving malignant mesothelioma.

Transl Lung Cancer Res 2017 Jun;6(3):270-278

Cancer Biology Program Fox Chase Cancer Center, Philadelphia, PA, USA.

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http://dx.doi.org/10.21037/tlcr.2017.05.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504107PMC
June 2017

Ribosomal Protein Rpl22 Controls the Dissemination of T-cell Lymphoma.

Cancer Res 2016 06 5;76(11):3387-96. Epub 2016 Apr 5.

Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891229PMC
June 2016

Genomic imbalances in peripheral blood confirm the diagnosis of myelodysplastic syndrome in a patient presenting with non-immune hemolytic anemia.

Leuk Res Rep 2016 13;5:23-6. Epub 2016 May 13.

Department of Pathology, Fox Chase Cancer Center - Temple University Health System, 333 Cottman Avenue, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.lrr.2016.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890200PMC
June 2016

Genomic Copy Number Alterations in Renal Cell Carcinoma with Sarcomatoid Features.

J Urol 2016 04 18;195(4 Pt 1):852-8. Epub 2015 Nov 18.

Cancer Biology Program and Blood Cell Development and Function Program (ED), Fox Chase Cancer Center, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2015.10.180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871784PMC
April 2016

Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice.

Carcinogenesis 2016 Feb 17;37(2):177-87. Epub 2015 Dec 17.

Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1093/carcin/bgv174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745643PMC
February 2016

Co-targeting of Akt and Myc inhibits viability of lymphoma cells from Lck-Dlx5 mice.

Cancer Biol Ther 2015 20;16(4):580-8. Epub 2015 Mar 20.

a Cancer Biology Program; Fox Chase Cancer Center ; Philadelphia , PA USA.

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http://dx.doi.org/10.1080/15384047.2015.1018495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622865PMC
January 2016

Germline BAP1 mutation in a family with high incidence of multiple primary cancers and a potential gene-environment interaction.

Cancer Lett 2015 Dec 26;369(2):261-5. Epub 2015 Sep 26.

Cancer Biology Program and Genomics Facility, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634709PMC
December 2015

Connecting molecular pathways to hereditary cancer risk syndromes.

Am Soc Clin Oncol Educ Book 2013 :81-90

From the Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA; Division of Hematology/Oncology, University of Toronto, and Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada; High Risk Pediatric Cancer Clinic, and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT.

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http://dx.doi.org/10.1200/EdBook_AM.2013.33.81DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889618PMC
November 2015

Inhibition of mesothelioma cancer stem-like cells with adenovirus-mediated NK4 gene therapy.

Int J Cancer 2015 Jul 27;137(2):481-90. Epub 2014 Dec 27.

Cancer Institute, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1002/ijc.29391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428975PMC
July 2015

The roles of chromatin-remodelers and epigenetic modifiers in kidney cancer.

Cancer Genet 2015 May 20;208(5):206-14. Epub 2015 Feb 20.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2015.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494076PMC
May 2015

Preclinical Efficacy for AKT Targeting in Clear Cell Carcinoma of the Ovary.

Mol Cancer Res 2015 Apr 17;13(4):795-806. Epub 2014 Dec 17.

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398602PMC
April 2015

SWOG S0722: phase II study of mTOR inhibitor everolimus (RAD001) in advanced malignant pleural mesothelioma (MPM).

J Thorac Oncol 2015 Feb;10(2):387-91

*Department of Medicine, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Orange, CA; †SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA; ‡Department of Medicine, Arizona Cancer Center, University of Arizona Tucson School of Medicine, Tucson, AZ; §Department of Medicine, University of California Davis Comprehensive Cancer Center, Sacramento, CA; ║Fox Chase Cancer Center, Philadelphia, PA; ¶Department of Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX; and #Department of Medicine, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI.

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http://dx.doi.org/10.1097/JTO.0000000000000360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304604PMC
February 2015

Copy neutral loss of heterozygosity in 20q in chronic lymphocytic leukemia/small lymphocytic lymphoma.

Cancer Genet 2014 Mar 15;207(3):98-102. Epub 2014 Feb 15.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA; Clinical Cytogenomics Laboratory, Fox Chase Cancer Center, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2014.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010307PMC
March 2014

Molecular cytogenetic analysis of the scleractinian coral Acropora solitaryensis Veron & Wallace 1984.

Zoolog Sci 2014 Feb;31(2):89-94

1 Division of Human Health and Medical Science, Graduate School of Kuroshio Science, Kochi University, Nankoku, Kochi 783-8505, Japan.

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http://dx.doi.org/10.2108/zsj.31.89DOI Listing
February 2014

NF-κB inhibition by bortezomib permits IFN-γ-activated RIP1 kinase-dependent necrosis in renal cell carcinoma.

Mol Cancer Ther 2013 Aug 8;12(8):1568-78. Epub 2013 May 8.

Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-12-1010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746800PMC
August 2013

Potential role of mTORC2 as a therapeutic target in clear cell carcinoma of the ovary.

Mol Cancer Ther 2013 Jul 24;12(7):1367-77. Epub 2013 Apr 24.

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1158/1535-7163.MCT-12-1185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852914PMC
July 2013

Diverse mechanisms of AKT pathway activation in human malignancy.

Curr Cancer Drug Targets 2013 Mar;13(3):234-44

Cancer Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111-2497, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678724PMC
http://dx.doi.org/10.2174/1568009611313030002DOI Listing
March 2013

BAP1 and cancer.

Nat Rev Cancer 2013 03;13(3):153-9

University of Hawaii Cancer Center, BSB200, 701 Ilalo Street, Honolulu, Hawaii 96813, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792854PMC
http://dx.doi.org/10.1038/nrc3459DOI Listing
March 2013

Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells.

Cancer Biol Ther 2012 Sep 24;13(11):1082-90. Epub 2012 Jul 24.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA.

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http://www.tandfonline.com/doi/abs/10.4161/cbt.21115
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http://dx.doi.org/10.4161/cbt.21115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461815PMC
September 2012

Identification of Akt interaction protein PHF20/TZP that transcriptionally regulates p53.

J Biol Chem 2012 Mar 14;287(14):11151-63. Epub 2012 Feb 14.

Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.

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http://dx.doi.org/10.1074/jbc.M111.333922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322870PMC
March 2012

Chromothripsis in a Case of -Deficient Chronic Lymphocytic Leukemia.

Leuk Res Rep 2012 Jan;1(1):4-6

Cancer Biology Program and Clinical Cytogenomics Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1016/j.lrr.2012.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735199PMC
January 2012

Factors that impact susceptibility to fiber-induced health effects.

J Toxicol Environ Health B Crit Rev 2011 ;14(1-4):246-66

Department of Medicine, Section of Genetic Medicine, University of Chicago, Chicago, Illinois 60637, USA.

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http://www.tandfonline.com/doi/abs/10.1080/10937404.2011.556
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http://dx.doi.org/10.1080/10937404.2011.556052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118508PMC
July 2011

Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin.

Mol Cancer 2010 Dec 15;9:314. Epub 2010 Dec 15.

Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1186/1476-4598-9-314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016286PMC
December 2010

Upregulation of DLX5 promotes ovarian cancer cell proliferation by enhancing IRS-2-AKT signaling.

Cancer Res 2010 Nov 2;70(22):9197-206. Epub 2010 Nov 2.

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018149PMC
November 2010

Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development.

Genesis 2010 Sep;48(9):531-9

Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1002/dvg.20657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944914PMC
September 2010

Metanephric adenofibroma: robotic partial nephrectomy of a large Wilms' tumor variant.

Can J Urol 2010 Aug;17(4):5309-12

Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.

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August 2010

Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E.

Cancer Cell 2010 Mar;17(3):249-61

School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15356108100003
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http://dx.doi.org/10.1016/j.ccr.2010.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901095PMC
March 2010

Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts.

J Biol Chem 2010 Feb 29;285(9):6377-89. Epub 2009 Dec 29.

Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.068452
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http://dx.doi.org/10.1074/jbc.M109.068452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825433PMC
February 2010

Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent.

BMC Cancer 2010 Feb 5;10:34. Epub 2010 Feb 5.

Cancer Genetics & Signaling Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1186/1471-2407-10-34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829496PMC
February 2010

Loss of GATA6 leads to nuclear deformation and aneuploidy in ovarian cancer.

Mol Cell Biol 2009 Sep 6;29(17):4766-77. Epub 2009 Jul 6.

Sylvester Comprehensive Cancer Center, Department of Medicine, and Department of Obstetrics and Gynecology, University of Miami School of Medicine, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1128/MCB.00087-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725711PMC
September 2009

FAS-associated factor 1 (FAF1): diverse functions and implications for oncogenesis.

Cell Cycle 2009 Aug 16;8(16):2528-34. Epub 2009 Aug 16.

Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739729PMC
http://dx.doi.org/10.4161/cc.8.16.9280DOI Listing
August 2009

DLX5 (distal-less homeobox 5) promotes tumor cell proliferation by transcriptionally regulating MYC.

J Biol Chem 2009 Jul 4;284(31):20593-601. Epub 2009 Jun 4.

Cancer Signaling and Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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http://dx.doi.org/10.1074/jbc.M109.021477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742824PMC
July 2009

Genomic events associated with progression of pleural malignant mesothelioma.

Int J Cancer 2009 Feb;124(3):589-99

Department of Cardiothoracic Surgery, Thoracic Surgery Laboratory, NYU Langone Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1002/ijc.23949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933144PMC
February 2009

A novel mechanism of late gene silencing drives SV40 transformation of human mesothelial cells.

Cancer Res 2008 Nov;68(22):9488-96

Thoracic Oncology Program, Cancer Center of Hawaii and Department of Pathology, University of Hawaii Medical School, Honolulu, Hawaii 96813, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666620PMC
November 2008

Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors.

Proc Natl Acad Sci U S A 2008 Jun 11;105(24):8387-92. Epub 2008 Jun 11.

Departments of Medical Oncology and Pathology and Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1073/pnas.0803383105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448846PMC
June 2008

Mesothelioma epidemiology, carcinogenesis, and pathogenesis.

Curr Treat Options Oncol 2008 Jun 15;9(2-3):147-57. Epub 2008 Aug 15.

Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA.

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http://dx.doi.org/10.1007/s11864-008-0067-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717086PMC
June 2008

HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra-1 pathway.

Am J Respir Cell Mol Biol 2008 Feb 13;38(2):209-17. Epub 2007 Sep 13.

University of Vermont College of Medicine, Department of Pathology, 89 Beaumont Avenue HSRF#216, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1165/rcmb.2007-0206OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2214675PMC
February 2008

Whole-genome profiling in liposarcomas reveals genetic alterations common to specific telomere maintenance mechanisms.

Cancer Res 2007 Oct;67(19):9221-8

Department of Laboratory Oncology Research, Curtis and Elizabeth Anderson Cancer Institute, Memorial Health University Medical Center, Savannah, Georgia 31404, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1133DOI Listing
October 2007

Protein kinase C phosphorylation disrupts Na+/H+ exchanger regulatory factor 1 autoinhibition and promotes cystic fibrosis transmembrane conductance regulator macromolecular assembly.

J Biol Chem 2007 Sep 5;282(37):27086-99. Epub 2007 Jul 5.

Basic Science Division and Population Science Division, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1074/jbc.M702019200DOI Listing
September 2007