Joseph R Arron

Joseph R Arron

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Joseph R Arron

Joseph R Arron

Publications by authors named "Joseph R Arron"

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Beyond type 2 cytokines in asthma - new insights from old clinical trials.

Expert Opin Ther Targets 2020 May 30;24(5):463-475. Epub 2020 Mar 30.

Genentech, Inc., South San Francisco, CA, USA.

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http://dx.doi.org/10.1080/14728222.2020.1744567DOI Listing
May 2020

ACE2, TMPRSS2 AND FURIN GENE EXPRESSION IN THE AIRWAYS OF PEOPLE WITH ASTHMA - IMPLICATIONS FOR COVID-19.

J Allergy Clin Immunol 2020 May 22. Epub 2020 May 22.

National Institute for Health Research (NIHR) Leicester Biomedical Research Centre (Respiratory theme) and College of Life Sciences, University of Leicester, UK.

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http://dx.doi.org/10.1016/j.jaci.2020.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243787PMC
May 2020

30 Years of Biotherapeutics Development-What Have We Learned?

Annu Rev Immunol 2020 Apr;38:249-287

Research-Biology, Genentech, South San Francisco, California 94080, USA; email:

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http://dx.doi.org/10.1146/annurev-immunol-101619-031510DOI Listing
April 2020

Airway pathological heterogeneity in asthma: Visualization of disease microclusters using topological data analysis.

J Allergy Clin Immunol 2018 11 14;142(5):1457-1468. Epub 2018 Mar 14.

Department of Infection Immunity and Inflammation, Institute for Lung Health, University of Leicester, Glenfield Hospital, Leicester, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2017.12.982DOI Listing
November 2018

Interleukin-13 in Asthma and Other Eosinophilic Disorders.

Front Med (Lausanne) 2017 19;4:139. Epub 2017 Sep 19.

Immunology Discovery, Genentech, Inc., South San Francisco, CA, United States.

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http://dx.doi.org/10.3389/fmed.2017.00139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627038PMC
September 2017

Seasonal variability of severe asthma exacerbations and clinical benefit from lebrikizumab.

J Allergy Clin Immunol 2017 05 24;139(5):1682-1684.e3. Epub 2017 Feb 24.

Genentech, Inc, South San Francisco, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.01.028DOI Listing
May 2017

A CEACAM6-High Airway Neutrophil Phenotype and CEACAM6-High Epithelial Cells Are Features of Severe Asthma.

J Immunol 2017 04 8;198(8):3307-3317. Epub 2017 Mar 8.

Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester LE3 9QP, United Kingdom;

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http://dx.doi.org/10.4049/jimmunol.1600606DOI Listing
April 2017

Relationships among aeroallergen sensitization, peripheral blood eosinophils, and periostin in pediatric asthma development.

J Allergy Clin Immunol 2017 Mar 5;139(3):790-796. Epub 2016 Jul 5.

Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Wisconsin School of Medicine & Public Health, Madison, Wis.

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http://dx.doi.org/10.1016/j.jaci.2016.05.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215990PMC
March 2017

IL-13 is a therapeutic target in radiation lung injury.

Sci Rep 2016 12 22;6:39714. Epub 2016 Dec 22.

Radiation Oncology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/srep39714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177927PMC
December 2016

Fit-for-purpose biomarker immunoassay qualification and validation: three case studies.

Bioanalysis 2016 Nov 7;8(22):2329-2340. Epub 2016 Oct 7.

Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.4155/bio-2016-0184DOI Listing
November 2016

Biomarkers in the clinical development of asthma therapies.

Biomark Med 2016 14;10(2):165-76. Epub 2016 Jan 14.

Department of Immunology Discovery, Genentech, Inc., South San Francisco, CA, USA.

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http://dx.doi.org/10.2217/bmm.15.116DOI Listing
October 2016

Reduced epithelial suppressor of cytokine signalling 1 in severe eosinophilic asthma.

Eur Respir J 2016 09 23;48(3):715-25. Epub 2016 Jun 23.

Centre for Infection and Immunity, Health Sciences Building, Queens University Belfast, Belfast, UK

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http://dx.doi.org/10.1183/13993003.00400-2015DOI Listing
September 2016

Reducing the risk of failure: biomarker-guided trial design.

Nat Rev Drug Discov 2016 Aug 15;15(8):517-8. Epub 2016 Jul 15.

Immunology Discovery, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1038/nrd.2016.124DOI Listing
August 2016

Roles of Periostin in Respiratory Disorders.

Am J Respir Crit Care Med 2016 05;193(9):949-56

6 Genentech Inc. (a member of the Roche Group), South San Francisco, California.

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http://dx.doi.org/10.1164/rccm.201510-2032PPDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872656PMC
May 2016

Reply.

J Allergy Clin Immunol 2016 Feb 10;137(2):648-9. Epub 2015 Dec 10.

Division of Pulmonary/Critical Care Medicine, University of California San Francisco, Calif.

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http://dx.doi.org/10.1016/j.jaci.2015.09.044DOI Listing
February 2016

Stratified medicine in inflammatory disorders: From theory to practice.

Clin Immunol 2015 Nov 28;161(1):11-22. Epub 2015 Apr 28.

Department of Immunology, Genentech, Inc., One DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2015.04.006DOI Listing
November 2015

The airway microbiome in patients with severe asthma: Associations with disease features and severity.

J Allergy Clin Immunol 2015 Oct 26;136(4):874-84. Epub 2015 Jul 26.

Division of Pulmonary, Critical Care, Allergy & Sleep Medicine, University of California San Francisco, San Francisco, Calif.

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http://dx.doi.org/10.1016/j.jaci.2015.05.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600429PMC
October 2015

Asthma biomarkers: what constitutes a 'gold standard'?

Thorax 2015 Feb 28;70(2):105-7. Epub 2014 Nov 28.

Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.

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http://dx.doi.org/10.1136/thoraxjnl-2014-206069DOI Listing
February 2015

A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production.

Nat Immunol 2014 Dec 2;15(12):1162-70. Epub 2014 Nov 2.

Department of Microbiology and Immunology, Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/ni.3026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233009PMC
December 2014

Interleukin-18 has antipermeablity and antiangiogenic activities in the eye: reciprocal suppression with VEGF.

J Cell Physiol 2014 Aug;229(8):974-83

Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://doi.wiley.com/10.1002/jcp.24575
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http://dx.doi.org/10.1002/jcp.24575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364659PMC
August 2014

The role of periostin in tissue remodeling across health and disease.

Cell Mol Life Sci 2014 Apr 22;71(7):1279-88. Epub 2013 Oct 22.

Program in Developmental Biology and Neonatal Medicine, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1007/s00018-013-1494-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949008PMC
April 2014

Noninvasive biomarkers that predict treatment benefit from biologic therapies in asthma.

Ann Am Thorac Soc 2013 Dec;10 Suppl:S206-13

1 Genentech, Inc., South San Francisco, California.

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http://dx.doi.org/10.1513/AnnalsATS.201303-047AWDOI Listing
December 2013

Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids.

J Allergy Clin Immunol 2013 Sep 29;132(3):567-574.e12. Epub 2013 May 29.

Genentech, South San Francisco, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.03.051DOI Listing
September 2013

Redefining approaches to asthma: developing targeted biologic therapies.

Adv Pharmacol 2013 ;66:1-49

Genentech, Inc., South San Francisco, CA, USA.

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http://dx.doi.org/10.1016/B978-0-12-404717-4.00001-9DOI Listing
August 2013

A qPCR-based metric of Th2 airway inflammation in asthma.

Clin Transl Allergy 2013 Jul 17;3(1):24. Epub 2013 Jul 17.

Cardiovascular Research Institute, University of California, San Francisco, USA.

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http://dx.doi.org/10.1186/2045-7022-3-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724712PMC
July 2013

Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study.

Am J Respir Crit Care Med 2013 Apr;187(8):804-11

Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1164/rccm.201208-1414OCDOI Listing
April 2013

Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation.

J Allergy Clin Immunol 2012 Dec 22;130(6):1335-43.e5. Epub 2012 Aug 22.

Department of Immunology, Tissue Growth, and Repair Biomarker Discovery, Genentech, South San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.jaci.2012.06.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511596PMC
December 2012

Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma.

J Allergy Clin Immunol 2012 Jan 5;129(1):104-11.e1-9. Epub 2011 Oct 5.

Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S009167491101397
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http://dx.doi.org/10.1016/j.jaci.2011.08.031DOI Listing
January 2012

Monitoring ocular drug therapy by analysis of aqueous samples.

Ophthalmology 2009 Nov 22;116(11):2158-64. Epub 2009 Aug 22.

Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1016/j.ophtha.2009.04.038DOI Listing
November 2009

Promising bone-related therapeutic targets for rheumatoid arthritis.

Nat Rev Rheumatol 2009 Oct;5(10):543-8

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1038/nrrheum.2009.175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797318PMC
October 2009

T-helper type 2-driven inflammation defines major subphenotypes of asthma.

Am J Respir Crit Care Med 2009 Sep 29;180(5):388-95. Epub 2009 May 29.

Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, CA 94143-0111, USA.

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http://dx.doi.org/10.1164/rccm.200903-0392OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742757PMC
September 2009

Breaking into bone biology: target practice.

Nat Med 2009 Feb;15(2):144-5

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nm0209-144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742415PMC
February 2009

Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice.

Nature 2007 Mar 11;446(7131):79-82. Epub 2007 Feb 11.

The Department of Pathology, King's College London, London SE1 9RT, UK.

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http://www.nature.com/articles/nature05557
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http://dx.doi.org/10.1038/nature05557DOI Listing
March 2007

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

Nature 2006 Jun 22;441(7093):595-600. Epub 2006 Mar 22.

Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/nature04678DOI Listing
June 2006

TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology.

Bioessays 2003 Nov;25(11):1096-105

Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1002/bies.10352DOI Listing
November 2003

TRAF-mediated TNFR-family signaling.

Curr Protoc Immunol 2002 Nov;Chapter 11:Unit 11.9D

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/0471142735.im1109ds51DOI Listing
November 2002

Distinct molecular mechanism for initiating TRAF6 signalling.

Nature 2002 Jul;418(6896):443-7

Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nature00888DOI Listing
July 2002