Joseph M Salvino

Joseph M Salvino

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Joseph M Salvino

Joseph M Salvino

Publications by authors named "Joseph M Salvino"

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Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6.

J Med Chem 2020 Jan 19;63(1):295-308. Epub 2019 Dec 19.

Roy and Diana Vagelos Laboratories, Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b01540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952581PMC
January 2020

Identification of a Novel Allosteric Modulator of the Human Dopamine Transporter.

ACS Chem Neurosci 2019 Aug 24;10(8):3718-3730. Epub 2019 Jun 24.

Department of Pharmacology and Physiology , Drexel University College of Medicine , Philadelphia , Pennsylvania 19102 , United States.

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http://dx.doi.org/10.1021/acschemneuro.9b00262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703927PMC
August 2019

Development of a novel inducer for EBV lytic therapy.

Bioorg Med Chem Lett 2019 Aug 22;29(16):2259-2264. Epub 2019 Jun 22.

The Wistar Institute, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.06.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690763PMC
August 2019

Metabolic control of BRISC-SHMT2 assembly regulates immune signalling.

Nature 2019 06 29;570(7760):194-199. Epub 2019 May 29.

Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1038/s41586-019-1232-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914362PMC
June 2019

Identification of Novel Allosteric Modulators of Glutamate Transporter EAAT2.

ACS Chem Neurosci 2018 03 30;9(3):522-534. Epub 2017 Nov 30.

Department of Pharmacology and Physiology , Drexel University College of Medicine , Philadelphia , Pennsylvania 19102 , United States.

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http://dx.doi.org/10.1021/acschemneuro.7b00308DOI Listing
March 2018

Inhibition of CXCR1 reduces cell motility and viability in pancreatic adenocarcinoma epithelial cells.

Biochem Biophys Res Commun 2018 01 21;495(3):2264-2269. Epub 2017 Dec 21.

Department of Pharmacology & Physiology, College of Medicine, Drexel University, 245 North 15th Street, MS 488, Philadelphia, PA 19102, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.12.116DOI Listing
January 2018

Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer.

Cancer Res 2017 05 24;77(9):2439-2452. Epub 2017 Feb 24.

Department of Pharmacology & Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462524PMC
May 2017

Novel small molecule guanidine Sigma1 inhibitors for advanced prostate cancer.

Bioorg Med Chem Lett 2017 05 18;27(10):2216-2220. Epub 2017 Mar 18.

Department of Pharmacology and Physiology, Drexel University College of Medicine, 245 N 15th Street, Philadelphia, PA 19102-1101, USA.

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http://dx.doi.org/10.1016/j.bmcl.2017.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714280PMC
May 2017

Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells.

Mol Cancer Res 2016 06 21;14(6):518-27. Epub 2016 Mar 21.

Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania. Pathology and Laboratory Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania. The Biology of Prostate Cancer Program, Sidney Kimmel Cancer Center, Philadelphia, Pennsylvania.

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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-16
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070649PMC
http://dx.doi.org/10.1158/1541-7786.MCR-16-0013DOI Listing
June 2016

Identification of a new class of small molecules that efficiently reactivate latent Epstein-Barr Virus.

ACS Chem Biol 2014 Mar 19;9(3):785-95. Epub 2014 Feb 19.

The Wistar Institute , Philadelphia, Pennsylvania 19104, United States.

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http://dx.doi.org/10.1021/cb4006326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159771PMC
March 2014

Selecting, Acquiring, and Using Small Molecule Libraries for High-Throughput Screening.

Curr Protoc Chem Biol 2012;4:177-191. Epub 2012 Sep 1.

NIH Chemical Genomics Center, National Human Genome Research Institute, 9800 Medical Center Drive, MSC 3370 Bethesda, MD 20892-3370 USA.

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http://dx.doi.org/10.1002/9780470559277.ch110252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687755PMC
September 2012

Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor.

Bioorg Med Chem Lett 2011 Apr 13;21(7):1991-6. Epub 2011 Feb 13.

Euroscreen SA, 47 rue Adrienne Bolland, Gosselies, Belgium.

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http://dx.doi.org/10.1016/j.bmcl.2011.02.033DOI Listing
April 2011

Knowledge based prediction of ligand binding modes and rational inhibitor design for kinase drug discovery.

J Med Chem 2008 Sep 19;51(17):5149-71. Epub 2008 Aug 19.

Department of Medicinal Chemistry, Cephalon, Inc., 145 Brandywine Parkway, West Chester, Pennsylvania 19380, USA.

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http://dx.doi.org/10.1021/jm800475yDOI Listing
September 2008

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2006.

J Comb Chem 2007 Nov-Dec;9(6):855-902. Epub 2007 Sep 19.

Adolor Corporation, 700 Pennsylvania Drive, Exton, Pennsylvania 19341, USA.

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http://dx.doi.org/10.1021/cc700111eDOI Listing
February 2008

Knowledge-based chemoinformatic approaches to drug discovery.

Drug Discov Today 2006 Dec 2;11(23-24):1107-14. Epub 2006 Nov 2.

Department of Chemistry, Cephalon, 145 Brandywine Parkway, West Chester, PA 19380, USA.

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http://dx.doi.org/10.1016/j.drudis.2006.10.012DOI Listing
December 2006

Comprehensive survey of combinatorial library synthesis: 2005.

J Comb Chem 2006 Sep-Oct;8(5):597-635

Adolor Corporation, 700 Pennsylvania Drive, Exton, Pennsylvania 19341, USA.

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http://dx.doi.org/10.1021/cc060095mDOI Listing
November 2006

The solid-phase synthesis and use of N-monosubstituted piperazines in chemical library synthesis.

J Comb Chem 2003 May-Jun;5(3):260-6

Combinatorial Chemistry Department, Adolor Corporation, 371 Phoenixville Pike, Malvern, Pennsylvania 19355, USA.

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http://dx.doi.org/10.1021/cc020060wDOI Listing
February 2004

The development and application of tetrafluorophenol-activated resins for rapid amine derivatization.

Methods Enzymol 2003 ;369:151-63

Adolor Corporation, 700 Pennsylvania Drive, Exton, Pennsylvania 19345, USA.

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http://dx.doi.org/10.1016/S0076-6879(03)69008-7DOI Listing
February 2004

Parallel Synthesis of Aldehydes and Ketone Facilitated by a New Solid-Phase Weinreb Amide.

J Org Chem 1999 Mar;64(6):1823-1830

Lead Discovery Department, Rhone-Poulenc Rorer, 500 Arcola Road, Collegeville, Pennsylvania 19426.

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http://dx.doi.org/10.1021/jo981431rDOI Listing
March 1999