Joseph M Metzger

Joseph M Metzger

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Joseph M Metzger

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Gene Transfer of Calcium-Binding Proteins into Adult Cardiac Myocytes.

Methods Mol Biol 2019 ;1929:187-205

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA.

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http://dx.doi.org/10.1007/978-1-4939-9030-6_12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507422PMC
June 2019

Cytoplasmic nucleic acid-based XNAs directly enhance live cardiac cell function by a Ca cycling-independent mechanism via the sarcomere.

J Mol Cell Cardiol 2019 May 5;130:1-9. Epub 2019 Mar 5.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2019.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502668PMC
May 2019

Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury.

JACC Basic Transl Sci 2019 Apr 29;4(2):275-287. Epub 2019 Apr 29.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota.

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http://dx.doi.org/10.1016/j.jacbts.2019.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488758PMC
April 2019

Exacerbation of dystrophic cardiomyopathy by phospholamban deficiency mediated chronically increased cardiac Ca cycling in vivo.

Am J Physiol Heart Circ Physiol 2018 12 17;315(6):H1544-H1552. Epub 2018 Aug 17.

Department of Integrative Biology and Physiology, University of Minnesota Medical School , Minneapolis, Minnesota.

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https://www.physiology.org/doi/10.1152/ajpheart.00341.2018
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http://dx.doi.org/10.1152/ajpheart.00341.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336973PMC
December 2018

Discovery of Orally Bioavailable and Liver-Targeted Hypoxia-Inducible Factor Prolyl Hydroxylase (HIF-PHD) Inhibitors for the Treatment of Anemia.

ACS Med Chem Lett 2018 Dec 13;9(12):1193-1198. Epub 2018 Nov 13.

Departments of Medicinal Chemistry, Discovery Process Chemistry, Immunology, In Vitro Pharmacology, In Vivo Pharmacology, Basic Pharmaceutical Sciences, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and Chemical Modeling and Informatics, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.

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http://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00274
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http://dx.doi.org/10.1021/acsmedchemlett.8b00274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296170PMC
December 2018

Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers.

Skelet Muscle 2018 10 10;8(1):31. Epub 2018 Oct 10.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, 6-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.

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http://dx.doi.org/10.1186/s13395-018-0177-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180502PMC
October 2018

Investigation of human iPSC-derived cardiac myocyte functional maturation by single cell traction force microscopy.

PLoS One 2018 4;13(4):e0194909. Epub 2018 Apr 4.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194909PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884520PMC
July 2018

TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility.

Biophys J 2018 04;114(7):1646-1656

Department of Integrative Biology and Physiology, College of Medicine, University of Minnesota, Minneapolis, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2018.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954295PMC
April 2018

All-Atom Molecular Dynamics-Based Analysis of Membrane-Stabilizing Copolymer Interactions with Lipid Bilayers Probed under Constant Surface Tensions.

J Phys Chem B 2017 11 20;121(47):10657-10664. Epub 2017 Nov 20.

Integrative Biology and Physiology, University of Minnesota Medical School , Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acs.jpcb.7b08938DOI Listing
November 2017

Quantifying Binding of Ethylene Oxide-Propylene Oxide Block Copolymers with Lipid Bilayers.

Langmuir 2017 11 25;33(44):12624-12634. Epub 2017 Oct 25.

Department of Chemical Engineering and Materials Science, ‡Department of Integrative Biology and Physiology, and §Department of Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acs.langmuir.7b02279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055234PMC
November 2017

PEO-PPO Diblock Copolymers Protect Myoblasts from Hypo-Osmotic Stress In Vitro Dependent on Copolymer Size, Composition, and Architecture.

Biomacromolecules 2017 Jul 14;18(7):2090-2101. Epub 2017 Jun 14.

Department of Chemical Engineering and Materials Science, ‡Department of Integrative Biology and Physiology, and §Department of Medicine, Cardiovascular Division, University of Minnesota , Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acs.biomac.7b00419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640256PMC
July 2017

Chemical End Group Modified Diblock Copolymers Elucidate Anchor and Chain Mechanism of Membrane Stabilization.

Mol Pharm 2017 07 12;14(7):2333-2339. Epub 2017 Jun 12.

Integrative Biology and Physiology, University of Minnesota Medical School , Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.7b00197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648059PMC
July 2017

Molecular inotropy mediated by cardiac miR-based PDE4D/PRKAR1α/phosphoprotein signaling.

Sci Rep 2016 11 11;6:36803. Epub 2016 Nov 11.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, 6-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455 USA.

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http://dx.doi.org/10.1038/srep36803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105063PMC
November 2016

The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter's Syndrome Type II Phenotype.

J Pharmacol Exp Ther 2016 10 18;359(1):194-206. Epub 2016 Jul 18.

Departments of Hypertension (C.H., X.Z., L.-Y.P., J.X., A.C., O.P., C.G., K.S., C.R., S.R., K.A.S., J.M.M., M.A.-G.), Ion Channels (B.T.P., J.P.F., B.T.-F., J.L., M.K., G.J.K., M.L.G.), Drug Metabolism (V.T., K.O., J.O.), and Medicinal Chemistry (H.T., A.P.), Merck Research Laboratories, Kenilworth, New Jersey

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http://dx.doi.org/10.1124/jpet.116.235150DOI Listing
October 2016

Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes.

Biochim Biophys Acta 2016 Jul 11;1863(7 Pt B):1829-38. Epub 2015 Nov 11.

Department of Integrative Biology and Physiology, University of Minnesota Medical School Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2015.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864165PMC
July 2016

Sarcomere neutralization in inherited cardiomyopathy: small-molecule proof-of-concept to correct hyper-Ca2+-sensitive myofilaments.

Am J Physiol Heart Circ Physiol 2016 07 13;311(1):H36-43. Epub 2016 May 13.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota

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http://dx.doi.org/10.1152/ajpheart.00981.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967205PMC
July 2016

A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.

Cell 2016 May 21;165(5):1147-1159. Epub 2016 Apr 21.

Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati 45247, OH, USA; Cincinnati Children's Hospital Medical Center, Howard Hughes Medical Institute, Cincinnati 45247, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874838PMC
May 2016

Effects of Modified Parvalbumin EF-Hand Motifs on Cardiac Myocyte Contractile Function.

Biophys J 2016 05;110(9):2094-105

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2016.03.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940608PMC
May 2016

Inexpensive, serotype-independent protocol for native and bioengineered recombinant adeno-associated virus purification.

J Biol Methods 2016;3(2). Epub 2016 May 3.

Department of Integrative Biology & Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.14440/jbm.2016.102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902285PMC
May 2016

Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in Mice.

JACC Basic Transl Sci 2016 04 18;1(3):122-130. Epub 2016 Apr 18.

Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota.

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https://linkinghub.elsevier.com/retrieve/pii/S2452302X160003
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http://dx.doi.org/10.1016/j.jacbts.2016.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965806PMC
April 2016

Factor XII full and partial null in rat confers robust antithrombotic efficacy with no bleeding.

Blood Coagul Fibrinolysis 2015 Dec;26(8):893-902

aIn Vivo Pharmacology bCardiometabolic Diseases cGenetically Engineered Models, Merck Sharp & Dohme Corp., Kenilworth, New Jersey dRNA Therapeutics; Merck Sharp & Dohme Corp., West Point, Pennsylvania, USA *Current affiliation: Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1097/MBC.0000000000000337DOI Listing
December 2015

Membrane-stabilizing copolymers confer marked protection to dystrophic skeletal muscle in vivo.

Mol Ther Methods Clin Dev 2015 11;2:15042. Epub 2015 Nov 11.

Department of Integrative Biology and Physiology, University of Minnesota , Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1038/mtm.2015.42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641511PMC
December 2015

Myocardial performance and adaptive energy pathways in a torpid mammalian hibernator.

Am J Physiol Regul Integr Comp Physiol 2015 Aug 27;309(4):R368-77. Epub 2015 May 27.

Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota; and

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http://dx.doi.org/10.1152/ajpregu.00365.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538225PMC
August 2015

Severe dystrophic cardiomyopathy caused by the enteroviral protease 2A-mediated C-terminal dystrophin cleavage fragment.

Sci Transl Med 2015 Jul;7(294):294ra106

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa4804DOI Listing
July 2015

APSselect: Year One a Success!

Physiologist 2015 Jul;58(4):188-90

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July 2015

Contemporary cardiac issues in Duchenne muscular dystrophy. Working Group of the National Heart, Lung, and Blood Institute in collaboration with Parent Project Muscular Dystrophy.

Circulation 2015 May;131(18):1590-8

From Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (E.M.M.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (J.R.K., G.D.P.); Division of Cardiology, Children's Hospital of Wisconsin, Milwaukee (D.W.B.); Department of Pediatrics, Washington University, St. Louis, MO (C.E.C.); The Heart Center, Nationwide Children's Hospital, Columbus, OH (L.H.C., N.K.); Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia (D.D.); Division of Pulmonary Medicine, Children's Hospital of Pittsburgh, PA (J.D.F.); Center for Genetic Medicine Research (E.P.H.) and Division of Cardiology, Children's National Heart Institute, Center for Genetic Medicine Research (C.F.S.), Children's National Health System, Washington, DC; Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD (D.P.J.); Parent Project Muscular Dystrophy, Middletown, OH (K.K.); Division of Cardiac Critical Care, Children's Hospital of Philadelphia, PA (R.K.); Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis (J.M.M.); Department of Molecular and Cellular Biochemistry (J.A.R.-F.) and Division of Cardiovascular Medicine (S.V.R.), Ohio State University, Columbus; Division of Cardiovascular and Renal Products, US Food and Drug Administration, Silver Spring, MD (S.L.T.); Hugo W. Moser Research Institute, Kennedy Krieger Institute, Baltimore, MD (K.R.W.); and Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University, Nashville, TN (L.W.M.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.015151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573596PMC
May 2015

Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes.

Stem Cell Reports 2014 Oct 4;3(4):594-605. Epub 2014 Sep 4.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA; Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address:

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http://www.cell.com/stem-cell-reports/pdf/S2213-6711(14)0024
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http://linkinghub.elsevier.com/retrieve/pii/S221367111400242
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http://dx.doi.org/10.1016/j.stemcr.2014.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223713PMC
October 2014

Cell biology of sarcomeric protein engineering: disease modeling and therapeutic potential.

Anat Rec (Hoboken) 2014 Sep;297(9):1663-9

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota.

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http://dx.doi.org/10.1002/ar.22966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133785PMC
September 2014

Direct, differential effects of tamoxifen, 4-hydroxytamoxifen, and raloxifene on cardiac myocyte contractility and calcium handling.

PLoS One 2013 24;8(10):e78768. Epub 2013 Oct 24.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078768PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811994PMC
August 2014

Prominent heart organ-level performance deficits in a genetic model of targeted severe and progressive SERCA2 deficiency.

PLoS One 2013 4;8(11):e79609. Epub 2013 Nov 4.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America ; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079609PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817129PMC
August 2014

Differential effects of S100 proteins A2 and A6 on cardiac Ca(2+) cycling and contractile performance.

J Mol Cell Cardiol 2014 Jul 11;72:117-25. Epub 2014 Mar 11.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041381PMC
July 2014

Molecular determinants of cardiac myocyte performance as conferred by isoform-specific TnI residues.

Biophys J 2014 May;106(10):2105-14

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052262PMC
May 2014

Factor XIIa inhibition by Infestin-4: in vitro mode of action and in vivo antithrombotic benefit.

Thromb Haemost 2014 Apr 12;111(4):694-704. Epub 2013 Dec 12.

Zhu Chen, PhD, Cardiometabolic Diseases, Merck Research Laboratories, K15-3A-309, Galloping Hill Road, Kenilworth, NJ 07033, USA, Tel.: +1 908 740 0642, E-mail:

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http://dx.doi.org/10.1160/TH13-08-0668DOI Listing
April 2014

Uncoupling of increased cellular oxidative stress and myocardial ischemia reperfusion injury by directed sarcolemma stabilization.

J Mol Cell Cardiol 2014 Feb 19;67:26-37. Epub 2013 Dec 19.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2013.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920738PMC
February 2014

Calcium mishandling in diastolic dysfunction: mechanisms and potential therapies.

Biochim Biophys Acta 2013 Apr 27;1833(4):895-900. Epub 2012 Sep 27.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.bbamcr.2012.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586938PMC
April 2013

Noncanonical EF-hand motif strategically delays Ca2+ buffering to enhance cardiac performance.

Nat Med 2013 Mar 10;19(3):305-12. Epub 2013 Feb 10.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1038/nm.3079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727912PMC
March 2013

Cardiac involvement in the dystrophinopathies.

J Pediatr Rehabil Med 2008 ;1(3):211-23

University of Michigan School of Medicine, Department of Pediatrics, Ann Arbor, MI, USA.

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October 2012

Diastolic dysfunction and thin filament dysregulation resulting from excitation-contraction uncoupling in a mouse model of restrictive cardiomyopathy.

J Mol Cell Cardiol 2012 Sep 6;53(3):446-57. Epub 2012 Jun 6.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2012.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443869PMC
September 2012

Ex vivo stretch reveals altered mechanical properties of isolated dystrophin-deficient hearts.

PLoS One 2012 9;7(3):e32880. Epub 2012 Mar 9.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032880PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298453PMC
August 2012

pH-responsive titratable inotropic performance of histidine-modified cardiac troponin I.

Biophys J 2012 Apr 3;102(7):1570-9. Epub 2012 Apr 3.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1016/j.bpj.2012.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318134PMC
April 2012

Bombesin receptor subtype-3 (BRS-3) regulates glucose-stimulated insulin secretion in pancreatic islets across multiple species.

Endocrinology 2011 Nov 30;152(11):4106-15. Epub 2011 Aug 30.

Department of Diabetes and Obesity, Merck Research Laboratories, Rahway, New Jersey 07065, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2011-1440DOI Listing
November 2011

Age-dependent dystrophin loss and genetic reconstitution establish a molecular link between dystrophin and heart performance during aging.

Mol Ther 2011 Oct 5;19(10):1821-5. Epub 2011 Jul 5.

Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1038/mt.2011.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188736PMC
October 2011

Distinct pathophysiological mechanisms of cardiomyopathy in hearts lacking dystrophin or the sarcoglycan complex.

FASEB J 2011 Sep 10;25(9):3106-14. Epub 2011 Jun 10.

Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1096/fj.10-178913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157690PMC
September 2011

Exercise and muscular dystrophy: implications and analysis of effects on musculoskeletal and cardiovascular systems.

Compr Physiol 2011 Jul;1(3):1353-63

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1002/cphy.c100062DOI Listing
July 2011

Gene transfer, expression, and sarcomeric incorporation of a headless myosin molecule in cardiac myocytes: evidence for a reserve in myofilament motor function.

Am J Physiol Heart Circ Physiol 2011 Feb 26;300(2):H574-82. Epub 2010 Nov 26.

Integrative Biology and Physiology, University of Minnesota School of Medicine, 6-125 Jackson Hall, 321 Church St. E, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1152/ajpheart.00786.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044057PMC
February 2011

Cardiac disease in mucopolysaccharidosis type I attributed to catecholaminergic and hemodynamic deficiencies.

Am J Physiol Heart Circ Physiol 2011 Jan 12;300(1):H356-65. Epub 2010 Nov 12.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, University of Minnesota Academic Health Center, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1152/ajpheart.00774.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023247PMC
January 2011

Influence of genetic background on ex vivo and in vivo cardiac function in several commonly used inbred mouse strains.

Physiol Genomics 2010 Oct 13;42A(2):103-13. Epub 2010 Jul 13.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00071.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957793PMC
October 2010

Parvalbumin: Targeting calcium handling in cardiac diastolic dysfunction.

Gen Physiol Biophys 2009 ;28 Spec No Focus:F3-6

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

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August 2010

Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations.

Physiol Genomics 2010 Jul 27;42(2):287-99. Epub 2010 Apr 27.

Department of Integrative Biology and Physiology, University of Minnesota Academic Health Center, 321 Church Street SE, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00033.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032286PMC
July 2010

Aesthetic cardiology: adipose-derived stem cells for myocardial repair.

Curr Stem Cell Res Ther 2010 Jun;5(2):145-52

Department of Integrative Biology & Physiology, University of Minnesota Medical School, 6-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896012PMC
http://dx.doi.org/10.2174/157488810791268654DOI Listing
June 2010

Ca2+-independent positive molecular inotropy for failing rabbit and human cardiac muscle by alpha-myosin motor gene transfer.

FASEB J 2010 Feb 2;24(2):415-24. Epub 2009 Oct 2.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1096/fj.09-140566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048941PMC
February 2010

Combinatorial effects of double cardiomyopathy mutant alleles in rodent myocytes: a predictive cellular model of myofilament dysregulation in disease.

PLoS One 2010 Feb 10;5(2):e9140. Epub 2010 Feb 10.

Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009140PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818843PMC
February 2010

Single histidine button in cardiac troponin I sustains heart performance in response to severe hypercapnic respiratory acidosis in vivo.

FASEB J 2009 May 13;23(5):1529-40. Epub 2009 Jan 13.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1096/fj.08-121996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669425PMC
May 2009

Cardiac consequences to skeletal muscle-centric therapeutics for Duchenne muscular dystrophy.

Trends Cardiovasc Med 2009 Feb;19(2):50-55

Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.tcm.2009.04.006DOI Listing
February 2009

Molecular cardiology in translation: gene, cell and chemical-based experimental therapeutics for the failing heart.

J Cardiovasc Transl Res 2008 Dec;1(4):317-27

Department of Integrative Biology & Physiology, University of Minnesota, Medical School, 6-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1007/s12265-008-9065-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759715PMC
December 2008

Single histidine-substituted cardiac troponin I confers protection from age-related systolic and diastolic dysfunction.

Cardiovasc Res 2008 Nov 16;80(2):209-18. Epub 2008 Jul 16.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, 1301 E. Catherine Street, 7727 Medical Science II, Ann Arbor, MI 48109-0622, USA.

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http://dx.doi.org/10.1093/cvr/cvn198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567875PMC
November 2008

Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor.

Brain Res 2008 Oct 15;1236:140-4. Epub 2008 Aug 15.

Department of Metabolic Disorders, Merck Research Laboratories, P.O. Box 2000, RY80M-213, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/j.brainres.2008.08.012DOI Listing
October 2008

Designing heart performance by gene transfer.

Physiol Rev 2008 Oct;88(4):1567-651

Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1152/physrev.00039.2007DOI Listing
October 2008

Parvalbumin isoforms for enhancing cardiac diastolic function.

Cell Biochem Biophys 2008 6;51(1):1-8. Epub 2008 May 6.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, 1301 E. Catherine St., 7727 Medical Science II, Ann Arbor, MI 48109-0622, USA.

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http://dx.doi.org/10.1007/s12013-008-9011-xDOI Listing
September 2008

Double oxygen-sensing vector system for robust hypoxia/ischemia-regulated gene induction in cardiac muscle in vitro and in vivo.

Mol Ther 2008 Sep 24;16(9):1594-601. Epub 2008 Jun 24.

Department of Molecular and Integrative Physiology, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1038/mt.2008.136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716210PMC
September 2008

Poloxamer 188 reduces the contraction-induced force decline in lumbrical muscles from mdx mice.

Am J Physiol Cell Physiol 2008 Jul 21;295(1):C146-50. Epub 2008 May 21.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2200, USA.

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http://dx.doi.org/10.1152/ajpcell.00017.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493563PMC
July 2008

Cardiac-directed parvalbumin transgene expression in mice shows marked heart rate dependence of delayed Ca2+ buffering action.

Physiol Genomics 2008 May 11;33(3):312-22. Epub 2008 Mar 11.

Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0644, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00302.2007DOI Listing
May 2008

Emergent dilated cardiomyopathy caused by targeted repair of dystrophic skeletal muscle.

Mol Ther 2008 May 15;16(5):832-5. Epub 2008 Apr 15.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109-0622, USA. 48109-0622, USA.

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http://dx.doi.org/10.1038/mt.2008.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592846PMC
May 2008

Allele and species dependent contractile defects by restrictive and hypertrophic cardiomyopathy-linked troponin I mutants.

J Mol Cell Cardiol 2008 May 26;44(5):891-904. Epub 2008 Feb 26.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2008.02.274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443058PMC
May 2008

Modulation of cardiac performance by motor protein gene transfer.

Ann N Y Acad Sci 2008 Mar;1123:96-104

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1196/annals.1420.011DOI Listing
March 2008

Tuning cardiac performance in ischemic heart disease and failure by modulating myofilament function.

J Mol Med (Berl) 2007 Sep 30;85(9):911-21. Epub 2007 Mar 30.

Department of Internal Medicine, University of Michigan, 1150 W. Medical Center Drive, 7301 MSRB III, Ann Arbor, MI 48109-0644, USA.

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http://dx.doi.org/10.1007/s00109-007-0181-6DOI Listing
September 2007

Parvalbumin isoforms differentially accelerate cardiac myocyte relaxation kinetics in an animal model of diastolic dysfunction.

Am J Physiol Heart Circ Physiol 2007 Sep 1;293(3):H1705-13. Epub 2007 Jun 1.

Department of Molecular and Integrative Physiology, University of Michigan, 1301 E. Catherine St., Ann Arbor, MI 48109-0622, USA.

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http://dx.doi.org/10.1152/ajpheart.00232.2007DOI Listing
September 2007

Non-canonical Wnt signaling enhances differentiation of Sca1+/c-kit+ adipose-derived murine stromal vascular cells into spontaneously beating cardiac myocytes.

J Mol Cell Cardiol 2007 Sep 10;43(3):362-70. Epub 2007 Jul 10.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109-0622, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2007.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2048991PMC
September 2007

Single amino acid substitutions define isoform-specific effects of troponin I on myofilament Ca2+ and pH sensitivity.

J Mol Cell Cardiol 2007 Aug 24;43(2):107-18. Epub 2007 May 24.

Department of Surgery, Cardiac Surgery Section, University of Michigan, 1150 W. Medical Center Drive, B560 MSRB II, Ann Arbor, MI 48109-0686, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2007.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043486PMC
August 2007

Cardiac transgenic and gene transfer strategies converge to support an important role for troponin I in regulating relaxation in cardiac myocytes.

Circ Res 2007 Aug 5;101(4):377-86. Epub 2007 Jul 5.

Department of Molecular and Integrative Physiology, 7730 Medical Science II, University of Michigan, Ann Arbor, MI 48109-0622, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.106.145557DOI Listing
August 2007

Systemic administration of micro-dystrophin restores cardiac geometry and prevents dobutamine-induced cardiac pump failure.

Mol Ther 2007 Jun 17;15(6):1086-92. Epub 2007 Apr 17.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1038/sj.mt.6300144DOI Listing
June 2007

Thin filament disinhibition by restrictive cardiomyopathy mutant R193H troponin I induces Ca2+-independent mechanical tone and acute myocyte remodeling.

Circ Res 2007 May 26;100(10):1494-502. Epub 2007 Apr 26.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1161/01.RES.0000268412.34364.50DOI Listing
May 2007