Joseph Lucas

Joseph Lucas

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Association of decision support for hospital discharge disposition with outcomes.

Am J Manag Care 2019 06;25(6):288-294

Remedy Partners, 300 Connecticut Ave, 3rd Floor, Norwalk, CT 06854. Email:

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June 2019

Chromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions.

Nat Commun 2019 06 24;10(1):2771. Epub 2019 Jun 24.

Division of Biological Sciences, 0377, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1038/s41467-019-10628-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591236PMC
June 2019

Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer's disease.

Sci Rep 2018 05 10;8(1):7490. Epub 2018 May 10.

Duke University Health System, Neurocognitive Disorders Program, Department of Psychiatry and the Duke Institute for Brain Sciences, Durham, NC, 27710, USA.

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http://dx.doi.org/10.1038/s41598-018-25377-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945611PMC
May 2018

High precision detection of conserved segments from synteny blocks.

PLoS One 2017 3;12(7):e0180198. Epub 2017 Jul 3.

IBENS, Département de Biologie, Ecole Normale Supérieure, CNRS, Inserm, PSL Research, University, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180198PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495381PMC
October 2017

Preliminary Outcomes from an Integrated Pediatric Mental Health Outpatient Clinic.

Child Adolesc Psychiatr Clin N Am 2017 10;26(4):761-770

Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, 2608 Erwin Road, Suite 300, Durham, NC 27705, USA.

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http://dx.doi.org/10.1016/j.chc.2017.06.008DOI Listing
October 2017

Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction.

PLoS One 2015 20;10(7):e0132259. Epub 2015 Jul 20.

Center for Applied Genomics and Precision Medicine, Duke University Medical Center, Durham, North Carolina, United States of America; Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132259PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507878PMC
April 2016

ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.

PLoS Genet 2015 Oct 9;11(10):e1005599. Epub 2015 Oct 9.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America; Center for Genomic and Computational Biology, Duke University Medical Center, Durham, North Carolina, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1005599
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http://dx.doi.org/10.1371/journal.pgen.1005599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599891PMC
October 2015

A comparison of models for predicting early hospital readmissions.

J Biomed Inform 2015 Aug 1;56:229-38. Epub 2015 Jun 1.

Dept. of Statistical Science, Duke University, Box 90251, Durham, NC 27708, USA; Dept. of Electrical and Computer Engineering, Duke University, Box 90291, Durham, NC 27708, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbi.2015.05.016DOI Listing
August 2015

A translatable predictor of human radiation exposure.

PLoS One 2014 25;9(9):e107897. Epub 2014 Sep 25.

Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, United States of America; Division of Hematology/Oncology, Department of Medicine, Broad Stem Cell Research Center, Jonnson Comprehensive Cancer Center, U.C.L.A., Los Angeles, CA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107897PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177872PMC
June 2015

Automated, quantitative analysis of histopathological staining in nuclei.

AMIA Jt Summits Transl Sci Proc 2014 7;2014:54-9. Epub 2014 Apr 7.

Quintiles, Durham, NC.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333705PMC
February 2015

Multiplex protein analysis to determine fibrosis stage and progression in patients with chronic hepatitis C.

Clin Gastroenterol Hepatol 2014 Dec 9;12(12):2113-20.e1-3. Epub 2014 May 9.

National Institute for Health Research Biomedical Research Unit in Gastrointestinal and Liver Diseases at Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, United Kingdom.

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http://dx.doi.org/10.1016/j.cgh.2014.04.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225180PMC
December 2014

PhylDiag: identifying complex synteny blocks that include tandem duplications using phylogenetic gene trees.

BMC Bioinformatics 2014 Aug 8;15:268. Epub 2014 Aug 8.

Ecole Normale Supérieure, Institut de Biologie de l'ENS, IBENS, 46 rue d'Ulm, 75005 Paris, France.

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http://dx.doi.org/10.1186/1471-2105-15-268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155083PMC
August 2014

3D trajectories adopted by coding and regulatory DNA elements: first-passage times for genomic interactions.

Cell 2014 Jul 3;158(2):339-352. Epub 2014 Jul 3.

Division of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.05.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113018PMC
July 2014

Comparing reference-based RNA-Seq mapping methods for non-human primate data.

BMC Genomics 2014 Jul 7;15:570. Epub 2014 Jul 7.

Center for Applied Genomics, Department of Medicine, Duke University, Durham, North Carolina, USA.

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http://dx.doi.org/10.1186/1471-2164-15-570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112205PMC
July 2014

Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis.

PLoS Pathog 2014 Jun 5;10(6):e1004149. Epub 2014 Jun 5.

Division of Infectious Diseases & International Health, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America; Duke Institute for Genome Sciences & Policy, Duke University, Durham, North Carolina, United States of America; Duke Clinical Research Institute, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047107PMC
June 2014

Bayesian joint analysis of heterogeneous genomics data.

Bioinformatics 2014 May 30;30(10):1370-6. Epub 2014 Jan 30.

G.S.Sanyal School of Telecommunications, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India, Computational Biology & Bioinformatics, Duke University, Durham, NC 27705, USA, Quintiles, Durham, NC 27703, USA and Electrical & Computer Engineering Department, Duke University, Durham, NC 27705, USA.

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http://dx.doi.org/10.1093/bioinformatics/btu064DOI Listing
May 2014

Patient clustering with uncoded text in electronic medical records.

AMIA Annu Symp Proc 2013 16;2013:592-9. Epub 2013 Nov 16.

Quintiles, Durham, NC.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900202PMC
May 2014

Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events.

J Am Coll Cardiol 2013 Oct 3;62(14):1267-1276. Epub 2013 Jul 3.

Institute for Genome Sciences & Policy, Duke University, Durham, North Carolina; Department of Medicine, Duke University, Durham, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2013.05.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786046PMC
October 2013

Clinical and biological relevance of genomic heterogeneity in chronic lymphocytic leukemia.

PLoS One 2013 28;8(2):e57356. Epub 2013 Feb 28.

Department of Medicine, Duke University, Durham, North Carolina, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057356PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585365PMC
September 2013

Bayesian Gaussian Copula Factor Models for Mixed Data.

J Am Stat Assoc 2013 Jun;108(502):656-665

Dept. of Statistical Science, Duke University, Durham, NC 27708 ( ).

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http://dx.doi.org/10.1080/01621459.2012.762328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753118PMC
June 2013

Stepwise epigenetic and phenotypic alterations poise CD8+ T cells to mediate airway hyperresponsiveness and inflammation.

J Immunol 2013 Apr 18;190(8):4056-65. Epub 2013 Mar 18.

Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.

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http://dx.doi.org/10.4049/jimmunol.1202640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622148PMC
April 2013

Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate.

Proc Natl Acad Sci U S A 2012 Dec 4;109(51):21028-33. Epub 2012 Dec 4.

Department of Molecular Biology, University of California at San Diego, La Jolla, CA 92093, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1211427109
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http://dx.doi.org/10.1073/pnas.1211427109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529039PMC
December 2012

How few? Bayesian statistics in injury biomechanics.

Stapp Car Crash J 2012 Oct;56:349-86

Duke University, Durham, NC, USA.

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October 2012

Susceptibility to vaccinia virus infection and spread in mice is determined by age at infection, allergen sensitization and mast cell status.

Int Arch Allergy Immunol 2012 26;158(2):196-205. Epub 2012 Jan 26.

Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.

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http://dx.doi.org/10.1159/000330647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291886PMC
August 2012

Time-dependent changes in non-COX-1-dependent platelet function with daily aspirin therapy.

J Thromb Thrombolysis 2012 Apr;33(3):246-57

Institute for Genome Sciences and Policy, Duke University, 905 S. Lasalle Dr., DUMC Box 3445, Durham, NC 27710, USA.

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http://dx.doi.org/10.1007/s11239-012-0683-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337886PMC
April 2012

Low-dose lipopolysaccharide affects lung allergic responses by regulating Jagged1 expression on antigen-pulsed dendritic cells.

Int Arch Allergy Immunol 2012 6;157(1):65-72. Epub 2011 Sep 6.

Department of Pediatrics, Division of Cell Biology, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA.

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http://dx.doi.org/10.1159/000324836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180653PMC
February 2012

Effect of genetic testing for risk of type 2 diabetes mellitus on health behaviors and outcomes: study rationale, development and design.

BMC Health Serv Res 2012 Jan 18;12:16. Epub 2012 Jan 18.

Center for Personalized Medicine, Duke University, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

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http://dx.doi.org/10.1186/1472-6963-12-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280160PMC
January 2012

SIGNATURE: a workbench for gene expression signature analysis.

BMC Bioinformatics 2011 Nov 14;12:443. Epub 2011 Nov 14.

Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX, USA.

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http://dx.doi.org/10.1186/1471-2105-12-443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251189PMC
November 2011

Transcription and recombination factories: common features?

Curr Opin Cell Biol 2011 Jun 17;23(3):318-24. Epub 2010 Dec 17.

Division of Biological Sciences, 0377 Department of Molecular Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.

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http://dx.doi.org/10.1016/j.ceb.2010.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070187PMC
June 2011

Detection of viruses via statistical gene expression analysis.

IEEE Trans Biomed Eng 2011 Mar 19;58(3):468-79. Epub 2010 Jul 19.

Department of Electrical and Computer Engineering, Duke University, Durham, NC 90291 USA.

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http://dx.doi.org/10.1109/TBME.2010.2059702DOI Listing
March 2011

Predicting Viral Infection From High-Dimensional Biomarker Trajectories.

J Am Stat Assoc 2011 Jan;106(496):1259-1279

Minhua Chen is Ph.D. Student, Electrical and Computer Engineering Department, Aimee Zaas is Associate Professor, Christopher Woods is Associate Professor, Geoffrey S. Ginsburg is Professor and Director of Genomic Medicine, and Joseph Lucas is Assistant Research Professor, Institute for Genome Sciences and Policy & Department of Medicine, David Dunson is Professor, Department of Statistical Science, and Lawrence Carin is Professor and Department Chair ( ), Electrical and Computer Engineering Department, Duke University, Durham, NC 27708-0291.

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http://dx.doi.org/10.1198/jasa.2011.ap10611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659825PMC
January 2011

Latent factor analysis to discover pathway-associated putative segmental aneuploidies in human cancers.

PLoS Comput Biol 2010 Sep 2;6(9):e1000920. Epub 2010 Sep 2.

Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA.

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http://dx.doi.org/10.1371/journal.pcbi.1000920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932681PMC
September 2010

A pathway-based classification of human breast cancer.

Proc Natl Acad Sci U S A 2010 Apr 24;107(15):6994-9. Epub 2010 Mar 24.

Duke Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.0912708107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872436PMC
April 2010

Blood gene expression signatures predict invasive candidiasis.

Sci Transl Med 2010 Mar;2(21):21ra17

Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA.

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http://dx.doi.org/10.1126/scitranslmed.3000715DOI Listing
March 2010

NF-kappaB-dependent induction of cathelicidin-related antimicrobial peptide in murine mast cells by lipopolysaccharide.

Int Arch Allergy Immunol 2009 11;150(2):122-32. Epub 2009 May 11.

Program in Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.

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http://dx.doi.org/10.1159/000218115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814151PMC
October 2009

Jagged1 on dendritic cells and Notch on CD4+ T cells initiate lung allergic responsiveness by inducing IL-4 production.

J Immunol 2009 Sep 10;183(5):2995-3003. Epub 2009 Aug 10.

Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.

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http://dx.doi.org/10.4049/jimmunol.0900692DOI Listing
September 2009

Cross-study projections of genomic biomarkers: an evaluation in cancer genomics.

PLoS One 2009 19;4(2):e4523. Epub 2009 Feb 19.

Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004523PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638006PMC
April 2009

A bayesian analysis strategy for cross-study translation of gene expression biomarkers.

Stat Appl Genet Mol Biol 2009 4;8:Article 11. Epub 2009 Feb 4.

Duke Institute for Genome Sciences and Policy.

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http://dx.doi.org/10.2202/1544-6115.1436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861325PMC
March 2009

High-Dimensional Sparse Factor Modeling: Applications in Gene Expression Genomics.

J Am Stat Assoc 2008 12;103(484):1438-1456

Assistant Professor of Econometrics and Statistics, The University of Chicago, Graduate School of Business, Chicago, IL 60637,

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http://dx.doi.org/10.1198/016214508000000869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017385PMC
December 2008

The genomic analysis of lactic acidosis and acidosis response in human cancers.

PLoS Genet 2008 Dec 5;4(12):e1000293. Epub 2008 Dec 5.

Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585811PMC
December 2008

The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation.

Genes Dev 2008 Dec;22(24):3422-34

Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1101/gad.1720008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2607075PMC
December 2008

Contribution of allergen-specific and nonspecific nasal responses to early-phase and late-phase nasal responses.

J Allergy Clin Immunol 2008 Mar 21;121(3):718-24. Epub 2007 Dec 21.

Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA.

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http://dx.doi.org/10.1016/j.jaci.2007.11.002DOI Listing
March 2008

Effect of chemically modified IL-13 short interfering RNA on development of airway hyperresponsiveness in mice.

J Allergy Clin Immunol 2008 Jan 22;121(1):88-94. Epub 2007 Oct 22.

Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA.

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http://dx.doi.org/10.1016/j.jaci.2007.08.029DOI Listing
January 2008

Statistical estimation of statistical mechanical models: helix-coil theory and peptide helicity prediction.

J Comput Biol 2007 Dec;14(10):1287-310

Institute of Statistics and Decision Sciences, Duke University, Durham, NC 27708, USA.

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http://dx.doi.org/10.1089/cmb.2007.0008DOI Listing
December 2007

Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness.

Am J Respir Crit Care Med 2006 Jan 28;173(1):56-63. Epub 2005 Sep 28.

Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.

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http://dx.doi.org/10.1164/rccm.200503-361OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662982PMC
January 2006

Protein kinase C alpha, betaI, and betaII isozymes regulate cytokine production in mast cells through MEKK2/ERK5-dependent and -independent pathways.

Cell Immunol 2005 Nov 23;238(1):10-8. Epub 2006 Jan 23.

Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA.

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http://dx.doi.org/10.1016/j.cellimm.2005.12.001DOI Listing
November 2005

Transforming growth factor-beta antagonizes alveolar type II cell proliferation induced by keratinocyte growth factor.

Am J Respir Cell Mol Biol 2004 Dec 27;31(6):679-86. Epub 2004 Aug 27.

National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.

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http://dx.doi.org/10.1165/rcmb.2004-0182OCDOI Listing
December 2004

Identification of multiple cell cycle regulatory functions of p57Kip2 in human T lymphocytes.

J Immunol 2004 Aug;173(4):2383-91

Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA.

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http://dx.doi.org/10.4049/jimmunol.173.4.2383DOI Listing
August 2004

Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells.

Mol Cancer Res 2004 Feb;2(2):105-14

Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA.

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February 2004

MEF2C regulates c-Jun but not TNF-alpha gene expression in stimulated mast cells.

Eur J Immunol 2003 Oct;33(10):2903-9

Department of Pediatrics, National Jewish Medical and Research Center, Denver, Co 80206, USA.

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http://dx.doi.org/10.1002/eji.200324127DOI Listing
October 2003

Cell fusion and plasticity.

Cytotechnology 2003 Mar;41(2-3):103-9

Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO, U.S.A.

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http://dx.doi.org/10.1023/A:1024870605447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466689PMC
March 2003